PRESS-NEWS.org - Press Release Distribution
PRESS RELEASES DISTRIBUTION

Results of the ARCTIC-INTERRUPTION trial presented at TCT 2013

New study finds patients who are event-free following PCI at 1 year may not need prolonged dual antiplatelet therapy

2013-10-31
(Press-News.org) Contact information: Judy Romero
jromero@crg.org
Cardiovascular Research Foundation
Results of the ARCTIC-INTERRUPTION trial presented at TCT 2013 New study finds patients who are event-free following PCI at 1 year may not need prolonged dual antiplatelet therapy SAN FRANCISCO, CA – October 31, 2013 – According to a new study, patients that do not experience a major cardiac event in the first year after receiving drug-eluting stent (DES) may not need to receive prolonged dual antiplatelet therapy (DAPT). Results from the ARCTIC-INTERRUPTION trial were presented today at the 25th annual Transcatheter Cardiovascular Therapeutics (TCT) scientific symposium. Sponsored by the Cardiovascular Research Foundation (CRF), TCT is the world's premier educational meeting specializing in interventional cardiovascular medicine.

The optimal length of time for DAPT after coronary stenting remains uncertain with an unknown safety to efficacy ratio of prolonged therapy. Currently there are discrepancies between international guidelines and high variability in routine practice. The ARCTIC-INTERRUPTION study was a prospective randomized trial that examined the benefit of the continuation of DAPT for up to two years.

ARCTIC-INTERRUPTION randomly assigned 1,259 patients without major events within the first year after coronary stenting to either a strategy of interruption of DAPT (n=624), or a strategy of continuation for an additional year (n=635). The primary endpoint was the composite of death, myocardial infarction, stent thrombosis, stroke, or urgent revascularization after one year.

The primary endpoint occurred in 3.8 percent of patients in the continuation group, as compared to 4.3 percent in the interruption group. The main secondary endpoint of stent thrombosis or any urgent revascularization occurred in 1.3 percent of patients in the continuation group and 1.6 percent of those in the interruption group. The rate of major bleeding events occurred in 1.1 percent of the patients in the continuation group compared to 0.2 percent in the interruption group.

"The ARCTIC-INTERRUPTION study suggests no ischemic benefit of DAPT continuation beyond one year after stenting in patients that do not experience an adverse event within the first year," said lead investigator Gilles Montalescot, MD, PhD. Dr. Montalescot is Professor of Cardiology at Centre Hospitalier Universitaire Pitié-Salpêtrière in Paris, France.

"Further, the study found significantly more major and minor bleeding events with DAPT continuation."

###

The ARCTIC-INTERRUPTION trial was sponsored by the ACTION study group. Dr. Montalescot reported research grants to the institution or consulting/lecture fees from Abbott Vascular, Accumetrics, AstraZeneca, Bayer, Biotronik, BMS, Boehringer-Ingelheim, Daiichi-Sankyo, Duke Institute, Eli Lilly and Company, Europa, Fédération Française de Cardiologie, Fondation de France, GSK, INSERM, Institut de France, Iroko, Lead-up, Menarini, Medtronic, Nanospheres, Novartis, Pfizer, ReCor Medical, Roche, Sanofi-Aventis, Stentys, Société Française de Cardiologie, Springer, The Medicines Company, The TIMI group, WebMD, and Wolters.

About CRF and TCT

The Cardiovascular Research Foundation (CRF) is an independent, academically focused nonprofit organization dedicated to improving the survival and quality of life for people with cardiovascular disease through research and education. Since its inception in 1991, CRF has played a major role in realizing dramatic improvements in the lives of countless numbers of patients by establishing the safe use of new technologies and therapies in interventional cardiovascular medicine. CRF is the sponsor of the Transcatheter Cardiovascular Therapeutics (TCT) scientific symposium. Celebrating its 25th anniversary this year, TCT is the world's premier educational meeting specializing in interventional cardiovascular medicine. For more information, visit http://www.crf.org and http://www.tctconference.com.

END



ELSE PRESS RELEASES FROM THIS DATE:

Women under 60 with diabetes at much greater risk for heart disease

2013-10-31
Women under 60 with diabetes at much greater risk for heart disease Results of a Johns Hopkins study published today in the journal Diabetes Care found that young and middle-aged women with type 2 diabetes are at much greater risk of coronary artery disease than ...

Results of DUTCH PEERS (TWENTE II) trial reported at TCT 2013

2013-10-31
Results of DUTCH PEERS (TWENTE II) trial reported at TCT 2013 Comparison of 2 third-generation drug-eluting stents establishes comparable safety and efficacy; demonstrates non-inferiorityof newest zotarolimus-eluting stent SAN FRANCISCO, CA – October 31, 2013 – Results ...

NASA sees Halloween Typhoon Krosa lashing Luzon, Philippines

2013-10-31
NASA sees Halloween Typhoon Krosa lashing Luzon, Philippines VIDEO: In this flyby animation of Oct. 30, NASA's TRMM satellite found precipitation falling at a rate ...

Pore formation in cell membranes linked to triggers of rheumatoid arthritis

2013-10-31
Pore formation in cell membranes linked to triggers of rheumatoid arthritis Discovery suggests new paths to treatments that stall or reverse protein modifications involved in the autoimmune disease Experiments by scientists at Johns Hopkins and in Boston have unraveled ...

A first step in learning by imitation, baby brains respond to another's actions

2013-10-31
A first step in learning by imitation, baby brains respond to another's actions Imitation may be the sincerest form of flattery for adults, but for babies it's their foremost tool for learning. As renowned people-watchers, babies often observe others demonstrate ...

Incurable brain cancer gene is silenced

2013-10-31
Incurable brain cancer gene is silenced Gene regulation technology increases survival rates in mice with glioblastoma Glioblastoma multiforme (GBM), the brain cancer that killed Sen. Edward Kennedy and kills approximately 13,000 Americans a year, is aggressive ...

Staph infections and eczema: What's the connection?

2013-10-31
Staph infections and eczema: What's the connection? New U-M-led research in animals pinpoints molecule from bacteria that may play key role in prompting skin inflammation &#8211 and could be a target for treatment ANN ARBOR, Mich. — For the millions ...

Listen up: Oysters may use sound to select a home

2013-10-31
Listen up: Oysters may use sound to select a home Oysters begin their lives as tiny drifters, but when they mature they settle on reefs. New research from North Carolina State University shows that the sounds of the reef may attract the young oysters, ...

Silent victims -- an epidemic of childhood exposure

2013-10-31
Silent victims -- an epidemic of childhood exposure Over 15 million children are exposed to intimate partner violence (IPV) each year, and the health consequences of this exposure are well-documented. The Institute of Medicine and the United States ...

Scientists call for action to tackle 'alarmingly' low survival of Kenyan women with cervical cancer

2013-10-31
Scientists call for action to tackle 'alarmingly' low survival of Kenyan women with cervical cancer Less than 7% of cervical cancer patients in Kenya are getting the optimum treatment needed to eradicate the disease, leading to unnecessary ...

LAST 30 PRESS RELEASES:

An electronic fiber for stretchable sensing

New image captures spooky bat signal in the sky

Cobalt single atom-phosphate functionalized reduced graphene oxide/perylenetetracarboxylic acid nanosheet heterojunctions for efficiently photocatalytic H2O2 production

World-first study shows Australian marsupials contaminated with harmful ‘forever chemicals’

Unlocking the brain’s hidden drainage system

Enhancing smoking cessation treatment for people living with HIV

Research spotlight: Mapping how gut neurons respond to bacteria, parasites and food allergy

Gordon and Betty Moore Foundation Experimental Physics Investigators awards to UCSB experimentalists opens the door to new insights and innovations

Meerkats get health benefit from mob membership

COVID-19 during pregnancy linked to higher risk of neurodevelopmental disorders in children

How a chorus of synchronized frequencies helps you digest your food

UAlbany researcher partners on $1.2 million NSF grant to explore tropical monsoon rainfall patterns

Checkup time for Fido? Wait might be longer in the country

Genetic variation impact scores: A new tool for earlier heart disease detection

The Lundquist Institute awarded $9 million to launch Community Center of Excellence for Regenerative Medicine

'Really bizarre and exciting': The quantum oscillations are coming from inside

Is AI becoming selfish?

New molten salt method gives old lithium batteries a second life

Leg, foot amputations increased 65% in Illinois hospitals between 2016-2023

Moffitt studies uncover complementary strategies to overcome resistance to KRAS G12Cinhibitors in lung cancer

National summit of experts charts unprecedented roadmap to reduce harms from firearms in new ways

Global environmental DNA (eDNA) surveys significantly expand known geographic and ecological niche ranges of marine fish, highlighting current biases in conservation and ecological modeling

Hundreds of animal studies on brain damage after stroke flagged for problematic images

Prize winner’s research reveals how complex neural circuits are correctly wired during brain development

Supershear rupture sustained in thick fault zone during 2025 Mandalay earthquake, study in research package shows

Study reveals how brain cell networks stabilize memory formation

CTE: More than just head trauma, suggests new study

New psychology study suggests chimpanzees might be rational thinkers

Study links genetic variants to higher 'bad' cholesterol and heart attack risk

Myanmar fault had ideal geometry to produce 2025 supershear earthquake

[Press-News.org] Results of the ARCTIC-INTERRUPTION trial presented at TCT 2013
New study finds patients who are event-free following PCI at 1 year may not need prolonged dual antiplatelet therapy