PRESS-NEWS.org - Press Release Distribution
PRESS RELEASES DISTRIBUTION

Results of the FREEDOM sub study reported at TCT 2013

Study examines the impact of insulin treatment status in diabetic patients with multivessel coronary artery disease

2013-11-01
(Press-News.org) Contact information: Judy Romero
jromero@crf.org
Cardiovascular Research Foundation
Results of the FREEDOM sub study reported at TCT 2013 Study examines the impact of insulin treatment status in diabetic patients with multivessel coronary artery disease SAN FRANCISCO, CA – October 31, 2013 – According to a recent study of diabetic patients who underwent revascularization for multi-vessel coronary artery disease (CAD), patients treated with insulin experienced more major adverse cardiovascular events after revascularization than those not treated with insulin.

The findings of a sub group analysis of the FREEDOM trial were presented today at the 25th annual Transcatheter Cardiovascular Therapeutics (TCT) scientific symposium. Sponsored by the Cardiovascular Research Foundation (CRF), TCT is the world's premier educational meeting specializing in interventional cardiovascular medicine.

The global prevalence of adult diabetes mellitus currently exceeds 6.4 percent (285 million) and is projected to increase to 7.7 percent (439 million) by 2030. In the United States, 26 percent of diabetics are treated with insulin; these patients comprise both patients with Type I diabetes as well as more advanced Type II diabetes. Insulin-treated patients are at increased risk for cardiovascular events after PCI and also have a higher risk of wound infection and mortality after coronary artery bypass surgery (CABG).

Results of the overall FREEDOM trial, which were first reported last year in the New England Journal of Medicine, found that coronary artery bypass grafting (CABG) reduces mortality and myocardial infarction rates compared to percutaneous coronary intervention (PCI), though it increases the chance of stroke. This FREEDOM sub group analysis examined the association of clinical outcomes after revascularization by insulin-treated diabetes mellitus (ITDM) status and the respective effect of CABG vs. PCI using first generation drug-eluting stents (PCI/DES). The primary endpoint was a composite of major adverse cardiac events including death, stroke and myocardial infarction analyzed using the logrank test and Cox regression to assess the interaction of treatment received and ITDM status.

A total of 1,850 diabetic patients with multi-vessel disease were randomized 1:1 to either CABG (894 patients) or PCI/DES (956 patients). Baseline and procedure characteristics were largely similar among the groups. A total of 602 patients (32.5 percent) had ITDM (PCI n=325, 34 percent; CABG n=277, 31 percent).

The estimated percentage of patients with a major adverse coronary event after five years was higher in the ITDM group compared to the non ITDM group (29 percent vs. 19 percent, respectively). Regardless of insulin treatment status, the estimated percentage of patients with major adverse coronary events after five years was higher among those that underwent PCI/DES (32 percent in the ITDM group and 25 percent in the non-ITDM group) compared to CABG (24 percent in the ITDM group and 16 percent in the non-ITDM group), although stroke rates were higher among CABG patients. In the ITDM group, the stroke rate was 7.5 for those who underwent CABG compared to 3.7 in those who had PCI/DES. In the non ITDM group, the stroke rate was 4.3 vs. 1.7 respectively.

"In patients with diabetes and multi-vessel coronary artery disease there are more major adverse cardiovascular events in patients treated with insulin than in those not treated with insulin," said study investigator George Dangas, MD, PhD. Dr. Dangas is Professor of Medicine at the Mount Sinai School of Medicine and Director of Cardiovascular Innovation at the Zena and Michael A. Wiener Cardiovascular Institute of the Mount Sinai Medical Center.

"However, the differences in clinical outcomes between CABG and PCI/DES were maintained regardless of the presence or absence of insulin treatment," Dr. Dangas said.

###

The FREEDOM trial was funded by NHLBI, NIH. Dr. Dangas reported no disclosures.

About CRF and TCT

The Cardiovascular Research Foundation (CRF) is an independent, academically focused nonprofit organization dedicated to improving the survival and quality of life for people with cardiovascular disease through research and education. Since its inception in 1991, CRF has played a major role in realizing dramatic improvements in the lives of countless numbers of patients by establishing the safe use of new technologies and therapies in interventional cardiovascular medicine. CRF is the sponsor of the Transcatheter Cardiovascular Therapeutics (TCT) scientific symposium. Celebrating its 25th anniversary this year, TCT is the world's premier educational meeting specializing in interventional cardiovascular medicine. For more information, visit http://www.crf.org and http://www.tctconference.com.

END



ELSE PRESS RELEASES FROM THIS DATE:

Largest ever study of male breast cancer treatment shows more mastectomy, less radiation than in female disease

2013-11-01
Largest ever study of male breast cancer treatment shows more mastectomy, less radiation than in female disease University of Colorado Cancer Center researchers used data from 4,276 cases of male breast cancer and 718,587 cases of female breast cancer to show that ...

Results of the HYBRID trial presented at TCT 2013

2013-11-01
Results of the HYBRID trial presented at TCT 2013 'Hybrid procedure' combining minimally invasive corornary artery bypass surgery (CABG) with percutaneous coronary intervention is feasible and safe compared with traditional CABG SAN FRANCISCO, CA – October 31, 2013 – A ...

Results of the TRANSLATE-POPS trial presented at TCT 2013

2013-11-01
Results of the TRANSLATE-POPS trial presented at TCT 2013 New study evaluates outcomes of providing access to platelet function testing in a clinical setting SAN FRANCISCO, CA – October 31, 2013 – According to a new study of heart attack patients treated with percutaneous ...

New methods improve quagga and zebra mussel identification

2013-11-01
New methods improve quagga and zebra mussel identification Reports identify new sampling and testing methods that improve accuracy in the detection of quagga and zebra mussels and outline procedures used to test for them DENVER - The earliest possible detection of quagga ...

Can putting your child before yourself make you a happier person?

2013-11-01
Can putting your child before yourself make you a happier person? Study explores the correlation between child-centric behavior and parental happiness and fulfillment Los Angeles, CA (October 31, 2013) While popular media often depicts highly-involved parents ...

US preterm birth rate drops to 15-year low

2013-11-01
US preterm birth rate drops to 15-year low US earns a 'C' on the 2013 March of Dimes Premature Birth Report Card Six states – Alaska, California, Maine, New Hampshire, Oregon and Vermont – earned an "A" on the March of Dimes 2013 Premature Birth Report ...

Non-radiologists perform majority of ultrasound-guided invasive procedures, study suggests

2013-11-01
Non-radiologists perform majority of ultrasound-guided invasive procedures, study suggests The November issue of the Journal of the American College of Radiology (JACR®) focuses on a variety of issues relating to clinical practice, practice management, health services ...

Risk of osteoporosis drug's side effects not significant, Loyola researchers find

2013-10-31
Risk of osteoporosis drug's side effects not significant, Loyola researchers find The risks of developing kidney failure and a calcium deficiency from the popular osteoporosis drug zoledronic acid are extremely rare, according to researchers at Loyola University ...

Study: Staggering turbines improves performance 33 percent

2013-10-31
Study: Staggering turbines improves performance 33 percent Research into the best ways to arrange wind turbines has produced staggering results — quite literally. The University of Delaware's Cristina Archer and her Atmosphere and Energy Research Group ...

Results of the CHILL-MI trial presented at TCT 2013

2013-10-31
Results of the CHILL-MI trial presented at TCT 2013 Therapeutic hypothermia is safe and feasible as adjunctive care for heart attack patients SAN FRANCISCO, CA – OCTOBER 30, 2013 – A clinical trial shows that rapidly cooling patients who have suffered ST-elevation myocardial ...

LAST 30 PRESS RELEASES:

Attitudes, not income, drive energy savings at home

The playbook for perfect polaritons

‘Disease in a dish’ study of progressive MS finds critical role for unusual type of brain cell

Solar-powered method lights the way to a ‘de-fossilized’ chemical industry

Screen time linked to lower academic achievement among Ontario elementary students

One-year outcomes after traumatic brain injury and early extracranial surgery in the TRACK-TBI Study

Enduring outcomes of COVID-19 work absences on the US labor market

Affirmative action repeal and racial and ethnic diversity in us medical school admissions

Cancer progression illuminated by new multi-omics tool

Screen time and standardized academic achievement tests in elementary school

GLP-1RA order fills and out-of-pocket costs by race, ethnicity, and indication

Study finds HEPA purifiers alone may not be enough to reduce viral exposure in schools

UVA Health developing way to ID people at risk of dangerous lung scarring even before symptoms appear

How can we know when curing cancer causes myocarditis?

Male infertility in Indian men linked to lifestyle choices and hormonal imbalances

An acoustofluidic device for sample preparation and detection of small extracellular vesicles

The advent of nanotechnology has ushered in a transformative era for oncology, offering unprecedented capabilities for targeted drug delivery and controlled release. This paradigm shift enhances thera

A prototype LED as thin as wallpaper — that glows like the sun

Transnational electoral participation of undocumented Mexican immigrants in the US

A new method to build more energy-efficient memory devices for a sustainable data future

Freely levitating rotor spins out ultraprecise sensors for classical and quantum physics

‘Chinese lantern’ structure shifts into more than a dozen shapes for various applications

Towards light-controlled electronic components

Tiny architects, titanic climate impact: scientists call for October 10 to become International Coccolithophore Day

Stress sensitivity makes suicidal thoughts more extreme and persistent among the university population

Lessons from Ascension’s shark troubles could help boost conservation

Fire provides long-lasting benefits to bird populations in Sierra Nevada National Parks

Menstrual cycle affects women’s reaction time but not as much as being active

Housing associations more effective than government in supporting unemployed in deprived areas

Biochar helps composting go greener by cutting greenhouse gas emissions

[Press-News.org] Results of the FREEDOM sub study reported at TCT 2013
Study examines the impact of insulin treatment status in diabetic patients with multivessel coronary artery disease