Earlier onset of puberty in girls linked to obesity

(Press-News.org) Contact information: Nick Miller
nicholas.miller@cchmc.org
513-803-6035
Cincinnati Children's Hospital Medical Center
Earlier onset of puberty in girls linked to obesity CINCINNATI – New research in Pediatrics shows obesity is the largest predictor of earlier onset puberty in girls, which is affecting white girls much sooner than previously reported.

Published online Nov. 4, the multi-institutional study strengthens a growing body of research documenting the earlier onset of puberty in girls of all races.

"The impact of earlier maturation in girls has important clinical implications involving psychosocial and biologic outcomes," said Frank Biro, MD, lead investigator and a physician in the Division of Adolescent Medicine at Cincinnati Children's Hospital Medical Center. "The current study suggests clinicians may need to redefine the ages for both early and late maturation in girls."

Girls with earlier maturation are at risk for a multitude of challenges, including lower self-esteem, higher rates of depression, norm-breaking behaviors and lower academic achievement. Early maturation also results in greater risks of obesity, hypertension and several cancers – including breast, ovarian and endometrial cancer.

The study was conducted through the Breast Cancer and Environmental Research Program, established by the National Institute of Environmental Health Science. Pediatrics is the journal of the American Academy of Pediatrics.

Researchers at centers in the San Francisco Bay Area, Cincinnati and New York City examined the ages of 1,239 girls at the onset of breast development and the impact of body mass index and race/ethnicity. The girls ranged in age from 6 to 8 years at enrollment and were followed at regular intervals from 2004 to 2011. Researchers used well-established criteria of pubertal maturation, including the five stages of breast development known as the Tanner Breast Stages.

The girls were followed longitudinally, which involved multiple regular visits for each girl. Researchers said this method provided a good perspective of what happened to each girl and when it occurred.

Researchers found the respective ages at the onset of breast development varied by race, body mass index (obesity), and geographic location. Breast development began in white, non-Hispanic girls, at a median age of 9.7 years, earlier than previously reported. Black girls continue to experience breast development earlier than white girls, at a median age of 8.8 years. The median age for Hispanic girls in the study was 9.3 years, and 9.7 years for Asian girls. Body mass index was a stronger predictor of earlier puberty than race or ethnicity. Although the research team is still working to confirm the exact environmental and physiological factors behind the phenomenon, they conclude the earlier onset of puberty in white girls is likely caused by greater obesity.

### Other institutions collaborating on the study include: Kaiser Permanente Division of Research, Oakland, Calif.; Mount Sinai School of Medicine, New York; California Department of Public Health and the University of California at Berkeley and San Francisco; and the University of Cincinnati College of Medicine.

Funding support for the study came from: the Breast Cancer and the Environment Research Program of the National Institute of Environmental Health Sciences and the National Cancer Institute (grant numbers U01ES012770, U01ES012771, U01ES012800, U01ES012801, U01ES019435, U01ES019453, U01ES019454, U01ES019457), with additional support from the National Institute of Environmental Health Sciences (P01ES009584, P30ES006096); the National Center for Research Resources (UL1RR024131, UL1RR029887, UL1RR026314); the Molecular Epidemiology in Children's Environmental Health training grant (T32-ES10957); and the Avon Foundation.

About Cincinnati Children's: Cincinnati Children's Hospital Medical Center ranks third in the nation among all Honor Roll hospitals in U.S. News and World Report's 2013 Best Children's Hospitals ranking. It is ranked #1 for cancer and in the top 10 for nine of 10 pediatric specialties. Cincinnati Children's, a non-profit organization, is one of the top three recipients of pediatric research grants from the National Institutes of Health, and a research and teaching affiliate of the University of Cincinnati College of Medicine. The medical center is internationally recognized for improving child health and transforming delivery of care through fully integrated, globally recognized research, education and innovation. Additional information can be found at http://www.cincinnatichildrens.org. Connect on the Cincinnati Children's blog, via Facebook and on Twitter.