(Press-News.org) Contact information: Meng Zhao
eic@nrren.org
86-138-049-98773
Neural Regeneration Research
MiR-137, a new target for post-stroke depression?
MiRNAs likely play an important role in the occurrence and development of depression, and can be used as potential targets for treatment of depression. Studies have shown that miR-137 expression is downregulated in the brain from depression patients with suicidal behavior. Moreover, miR-137 expression is also downregulated in peripheral blood from stroke patients. However, it is not yet known if miRNAs are associated with post-stroke depression. To test this, Dr. Lixia Zhao and colleagues from Shandong Provincial Hospital, China used middle cerebral artery occlusion and chronic mild stress to establish a post-stroke depression model in rats. Compared with controls, the researchers found significantly lower miR-137 levels in the brain and peripheral blood from post-stroke depression rats. Injection of a miR-137 antagonist into the brain ventricles upregulated miR-137 levels, and improved behavioral changes in post-stroke depression rats. Luciferase assays showed miR-137 bound to the 3′UTR of Grin2A, regulating Grin2A expression in a neuronal cell line. Grin2A gene overexpression in the brain of post-stroke depression rats, noticeably suppressed the inhibitory effect of miR-137 on post-stroke depression. Overall, these results, published in the Neural Regeneration Research (Vol. 8, No. 26, 2013), show that miR-137 suppresses Grin2A protein expression through binding to Grin2A mRNA, thereby exerting an inhibitory effect on post-stroke depression. Our results offer a new therapeutic direction for post-stroke depression.
###
Article: " miR-137, a new target for post-stroke depression?," by Lixia Zhao1, 2, Huazi Li3, Ruiyou Guo2, Teng Ma2, Rongyao Hou2, Xiaowei Ma2, Yifeng Du1 (1 Department of Neurology, Shandong Provincial Hospital, Jinan 250021, Shandong Province, China; 2 Department of Neurology, Haici Hospital Affiliated to Medical College of Qingdao University, Qingdao 266033, Shandong Province, China; 3 Department of Medical Imaging, Haici Hospital Affiliated to Medical College of Qingdao University, Qingdao 266033, Shandong Province, China)
Zhao LX, Li HZ, Guo RY, Ma T, Hou RY, Ma XW, Du YF. miR-137, a new target for post-stroke depression? Neural Regen Res. 2013;8(26):2441-2448.
MiR-137, a new target for post-stroke depression?
2013-11-06
ELSE PRESS RELEASES FROM THIS DATE:
How does electrical stimulation modulate electrophysiological environment after SCI?
2013-11-06
How does electrical stimulation modulate electrophysiological environment after SCI?
An injury potential is the direct current potential difference between the site of spinal cord injury and the healthy nerves. Its initial amplitude is a significant indicator of ...
Why psychosis is frequently associated with Parkinson's disease?
2013-11-06
Why psychosis is frequently associated with Parkinson's disease?
Psychosis is a common non-motor symptom of Parkinson's disease whose pathogenesis remains poorly understood. Parkinson's disease in conjunction with psychosis has been shown to induce injury to extracorticospinal ...
Health benefits of wild blueberries abound: Study
2013-11-06
Health benefits of wild blueberries abound: Study
Wild blueberries: 2 cups a day may keep the doctor away
Wild blueberries are a rich source of phytochemicals called polyphenols, which have been reported by a growing number of studies to exert ...
U of M scientists solve major piece in the origin of biological complexity
2013-11-06
U of M scientists solve major piece in the origin of biological complexity
Evolving multicellular algae in the lab, researchers discover why it is better to go it alone during reproduction
Scientists have puzzled for centuries over how and why multicellular organisms ...
Comprehending comprehension
2013-11-06
Comprehending comprehension
Researchers find brain activity related to individual differences in reading comprehension
EVANSTON, Ill. --- What makes a good reader? First, you have to know how to read the words on a page and understand them -- but there's ...
Research helps identify young people with type 1 diabetes at risk of heart and kidney disease
2013-11-06
Research helps identify young people with type 1 diabetes at risk of heart and kidney disease
Screening could enable early intervention
Using a simple urine test, researchers can now identify young people with type 1 diabetes at risk of heart and kidney ...
Big beats bolster solar cell efficiency
2013-11-06
Big beats bolster solar cell efficiency
Playing pop and rock music improves the performance of solar cells, according to new research from scientists at Queen Mary University of London and Imperial College London.
The high frequencies and pitch ...
New report calls for sustained public endorsement and funding for human stem cell research
2013-11-06
New report calls for sustained public endorsement and funding for human stem cell research
The European Science Foundation reports on the scientific and policy issues surrounding human stem cell research across Europe
A strategic report from the European Science ...
Volume of nuclear waste could be reduced by 90 percent, says new research
2013-11-06
Volume of nuclear waste could be reduced by 90 percent, says new research
The researchers, from the University of Sheffield's Faculty of Engineering, have shown that mixing plutonium-contaminated waste with blast furnace slag and turning it into glass ...
Discovered a mechanism that induces migration of tumor cells in liver cancer
2013-11-06
Discovered a mechanism that induces migration of tumor cells in liver cancer
The findings will help to identify which patients benefit TGFb inhibitory therapy
Researchers from the Biological clues of the invasive and metastatic phenotype group ...