PRESS-NEWS.org - Press Release Distribution
PRESS RELEASES DISTRIBUTION

New genomic study provides a glimpse of how whales could adapt to ocean

The latest study was published online in Nature Genetics

2013-11-25
(Press-News.org) Contact information: Jia Liu
liujia@genomics.cn
BGI Shenzhen
New genomic study provides a glimpse of how whales could adapt to ocean The latest study was published online in Nature Genetics November 24, 2013, Shenzhen, China - In a paper published in Nature Genetics, researchers from Korea Institute of Ocean Science and Technology, Korea Genome Research Foundation, BGI, and other institutes presented the first high-depth minke whale genome and their new findings on how whales successfully adapted to ocean environment. The data yielded in this study will contribute to future studies of marine mammal diseases, conservation and evolution.

Whales roam throughout all of the world's oceans, living in the water but breathing air like humans. At the top of the food chain, whales are vital to the health of the marine environment, whereas 7 out of the 13 great whale species are endangered or vulnerable. The minke whale is the most abundant baleen whale. Its wide distribution makes it an ideal candidate for whole reference genome sequencing.

In this study, researchers conducted de novo sequencing on a minke whale with 128x average depth of coverage, and re-sequenced three minke whales, a fin whale (Balaenoptera physalus), a bottlenose dolphin, and a finless porpoise (Neophocaena phocaenoides). The yielded data may help to improve scientists' understanding of the evolutionary changes adapted to ocean environment from whole genome level.

The adaptation of whale to ocean life was notably marked by resistance to physiological stresses caused by a lack of oxygen, increased reactive oxygen species, and high salt level. In this study, researchers investigated a number of whale-specific genes that were strongly associated with stress resistance, such as the peroxiredoxin (PRDX) family, O-linked N-acetylglucosaminylation (O-GlcNAcylation). The results revealed that the gene families associated with stress-responsive proteins and anaerobic metabolism were expanded.

Perhaps the most dramatic environmental adaptation for a whale is deep diving, which can induce hypoxia. Under the hypoxic conditions, the body might produce more reactive oxygen species (ROS), harmful compounds that can damage DNA. Glutathione is a well-known antioxidant that prevents damage to important cellular components by ROS. In this study, researchers provided evidence to support that there is an increased ratio of reduced glutathione/glutathione disulfide when suffering hypoxic or oxidative stress.

Minke whales and other Mysticeti whale species grow baleen instead of teeth. It's previously reported that the genes ENAM, MMP, and AMEL might play a role in tooth enamel formation and biomineralization. This study showed that these genes may be pseudogenes with early stop codons in the baleen whales. In addition, researchers found that the gene families related to whale's body hair and sensory receptors were contracted, such as Keratin-related gene families associated with hair formation, several Hox genes that play an important role in the body plan and embryonic development.

Xuanmin Guang, project manager from BGI, said, "Minke whale is the first marine mammal that has been sequenced with such high-depth genome coverage. The genome data not only can help us know much more about the adaption mechanisms underlying minke whale, but also provides invaluable resource for marine mammal's future studies such as diseases control and prevention, species conservation,and protection."

### About BGI BGI was founded in 1999 with the mission of being a premier scientific partner to the global research community. The goal of BGI is to make leading-edge genomic science highly accessible through its investment in infrastructure that leverages the best available technology, economies of scale, and expert bioinformatics resources. BGI, which includes both private non-profit genomic research institutes and sequencing application commercial units, and its affiliates, BGI Americas, headquartered in Cambridge, MA, and BGI Europe, headquartered in Copenhagen, Denmark, have established partnerships and collaborations with leading academic and government research institutions as well as global biotechnology and pharmaceutical companies, supporting a variety of disease, agricultural, environmental, and related applications.

BGI has established a proven track record of excellence, delivering results with high efficiency and accuracy for innovative, high-profile research which has generated over 250 publications in top-tier journals such as Nature and Science. These accomplishments include sequencing one percent of the human genome for the International Human Genome Project, contributing 10 percent to the International Human HapMap Project, carrying out research to combat SARS and German deadly E. coli, playing a key role in the Sino-British Chicken Genome Project, and completing the sequence of the rice genome, the silkworm genome, the first Asian diploid genome, the potato genome, and, most recently, have sequenced the human Gut metagenome, and a significant proportion of the genomes for 1,000 genomes. For more information about BGI please visit http://www.genomics.cn.

Contact Information: Bicheng Yang, Ph.D.
Public Communication Officer
BGI+86-755-82639701yangbicheng@genomics.cn
http://www.genomics.cn


ELSE PRESS RELEASES FROM THIS DATE:

Scientists prove X-ray laser can solve protein structures from scratch

2013-11-25
Scientists prove X-ray laser can solve protein structures from scratch SLAC's linac coherent light source reaches key milestone in decoding biological structures that were out of reach A study shows for the first time that X-ray lasers can ...

X-rays reveal another feature of high-temperature superconductivity

2013-11-25
X-rays reveal another feature of high-temperature superconductivity Discovery of a giant resonance puts these materials further apart Classical and high-temperature superconductors differ hugely in the value of the critical temperatures at which ...

UNL scientists develop novel X-ray device

2013-11-25
UNL scientists develop novel X-ray device Research quality X-rays could have widespread applications Lincoln, Neb., Nov. 24 – Using a compact but powerful laser, a research team at the University of Nebraska-Lincoln has developed a new way to generate ...

Unusual greenhouse gases may have raised ancient Martian temperature

2013-11-25
Unusual greenhouse gases may have raised ancient Martian temperature Much like the Grand Canyon, Nanedi Valles snakes across the Martian surface suggesting that liquid water once crossed the landscape, according to a team of researchers who believe that molecular hydrogen ...

Study identifies protein essential for immune recognition, response to viral infection

2013-11-25
Study identifies protein essential for immune recognition, response to viral infection Mice lacking GEF-H1 protein expression unable to mount immune defense against influenza A Massachusetts General Hospital (MGH)-led research team has identified an immune ...

Even if emissions stop, carbon dioxide could warm Earth for centuries

2013-11-25
Even if emissions stop, carbon dioxide could warm Earth for centuries Even if carbon dioxide emissions came to a sudden halt, the carbon dioxide already in Earth's atmosphere could continue to warm our planet for hundreds of years, according to Princeton University-led ...

Scientists find brain region that helps you make up your mind

2013-11-25
Scientists find brain region that helps you make up your mind One of the smallest parts of the brain is getting a second look after new research suggests it plays a crucial role in decision making. A University of British Columbia study published today ...

Meat, egg and dairy nutrient essential for brain development

2013-11-25
Meat, egg and dairy nutrient essential for brain development Deficiency of asparagine synthetase caused by rare genetic disorder affects brain development This news release is available in French. Asparagine, found in foods such as meat, ...

PCBs still affecting our health decades later

2013-11-25
PCBs still affecting our health decades later Chemical banned by the US 3 decades ago hurts seniors' cognitive performance Although PCBs have been banned in the United States since 1979, University of Montreal and CHU Sainte-Justine researcher ...

Certain symptom clusters experienced after surgery for esophageal cancer predict poor prognosis

2013-11-25
Certain symptom clusters experienced after surgery for esophageal cancer predict poor prognosis A new study has found that several months after surgery for esophageal cancer, different symptoms cluster together in different types of patients. In addition, patients with certain ...

LAST 30 PRESS RELEASES:

Thirty-year mystery of dissonance in the “ringing” of black holes explained

Less intensive works best for agricultural soil

Arctic rivers project receives “national champion” designation from frontiers foundation

Computational biology paves the way for new ALS tests

Study offers new hope for babies born with opioid withdrawal syndrome

UT, Volkswagen Group of America celebrate research partnership

New Medicare program could dramatically improve affordability for cancer drugs – if patients enroll

Are ‘zombie’ skin cells harmful or helpful? The answer may be in their shapes

University of Cincinnati Cancer Center presents research at AACR 2025

Head and neck, breast, lung and survivorship studies headline Dana-Farber research at AACR Annual Meeting 2025

AACR: Researchers share promising results from MD Anderson clinical trials

New research explains why our waistlines expand in middle age

Advancements in muon detection: Taishan Antineutrino Observatory's innovative top veto tracker

Chips off the old block

Microvascular decompression combined with nerve combing for atypical trigeminal neuralgia

Cutting the complexity from digital carpentry

Lung immune cell type “quietly” controls inflammation in COVID-19

Fiscal impact of expanded Medicare coverage for GLP-1 receptor agonists to treat obesity

State and sociodemographic trends in US cigarette smoking with future projections

Young adults drive historic decline in smoking

NFCR congratulates Dr. Robert C. Bast, Jr. on receiving the AACR-Daniel D. Von Hoff Award for Outstanding Contributions to Education and Training in Cancer Research

Chimpanzee stem cells offer new insights into early embryonic development

This injected protein-like polymer helps tissues heal after a heart attack

FlexTech inaugural issue launches, pioneering interdisciplinary innovation in flexible technology

In Down syndrome mice, 40Hz light and sound improve cognition, neurogenesis, connectivity

Methyl eugenol: potential to inhibit oxidative stress, address related diseases, and its toxicological effects

A vascularized multilayer chip reveals shear stress-induced angiogenesis in diverse fluid conditions

AI helps unravel a cause of Alzheimer's disease and identify a therapeutic candidate

Coalition of Autism Scientists critiques US Department of Health and Human Services Autism Research Initiative

Structure dictates effectiveness, safety in nanomedicine

[Press-News.org] New genomic study provides a glimpse of how whales could adapt to ocean
The latest study was published online in Nature Genetics