PRESS-NEWS.org - Press Release Distribution
PRESS RELEASES DISTRIBUTION

Active component from wine-processed Fructus corni inhibits hippocampal neuron apoptosis

2013-11-27
(Press-News.org) Contact information: Meng Zhao
eic@nrren.org
86-138-049-98773
Neural Regeneration Research
Active component from wine-processed Fructus corni inhibits hippocampal neuron apoptosis

Studies have shown that Fructus corni has a protective effect on hepatocytes, and has anticancer, antioxidative, anti-inflammatory and antiseptic properties. 5-hydroxymethylfurfural, a compound extracted from wine-processed Fructus corni, has a protective effect on hippocampal neurons damaged by H2O2. Prof. Mingyan Wang and team from Nanjing University of Chinese Medicine for the first time, used cytobiological and molecular biology methods to investigate the molecular mechanisms underlying the neuroprotective effects of 5-hydroxymethylfurfural on rat hippocampal neurons injured by oxidative stress. Researchers found that 5-hydroxymethylfurfural could protect against H2O2-induced rat hippocampal neuron apoptosis by regulation of expression levels of the apoptosis-related genes p53, bcl-2, bax and caspases. This finding, published in the Neural Regeneration Research (Vol. 8, No. 28, 2013), provides theoretical evidence for the treatment of neurodegenerative disease with 5-hydroxymethylfurfural extracted from wine-processed Fructus corni and lays the foundations for clinical prevention and treatment of oxidative injury-related diseases in the brain.



INFORMATION:



Article: "5-Hydroxymethylfurfural from wine-processed Fructus corni inhibits hippocampal neuron apoptosis" by Hai Gu1, Zequn Jiang1, Mingyan Wang1, Haiying Jiang1, Fengming Zhao1, Xia Ding2, Baochang Cai1, Zhen Zhan1 (1 College of Basic Medical Sciences, Nanjing University of Chinese Medicine, Nanjing 210046, Jiangsu Province, China; 2 Department of Chemistry, Nanjing Agricultural University, Nanjing 210095, Jiangsu Province, China)

Gu H, Jiang ZQ, Wang MY, Jiang HY, Zhao FM, Ding X, Cai BC, Zhan Z. 5-Hydroxymethylfurfural from wine-processed Fructus corni inhibits hippocampal neuron apoptosis. Neural Regen Res. 2013;8(28):2605-2614.



ELSE PRESS RELEASES FROM THIS DATE:

The deadly news about all osteoporotic fractures

2013-11-27
The deadly news about all osteoporotic fractures It is well known that hip and vertebral fractures increase the risk of premature death. Until now, little has been known about the clinical impact of non-hip, non-vertebral fractures – so new ...

Occludin and connexin 43 expression in the pathogenesis of traumatic brain edema

2013-11-27
Occludin and connexin 43 expression in the pathogenesis of traumatic brain edema Understanding the pathogenesis of brain edema may allow for the prevention and treatment of edema in the field of neurosurgery, thus resulting in better treatments for intracranial ...

Chinese medicines that tonify the kidney inhibit dopaminergic neuron apoptosis

2013-11-27
Chinese medicines that tonify the kidney inhibit dopaminergic neuron apoptosis Parkinson's disease is a common neurodegenerative disease in the elderly, which is pathologically characterized by selective loss of dopaminergic neurons. Compound preparations of ...

Ocean rip currents claim more lives than other natural hazards

2013-11-27
Ocean rip currents claim more lives than other natural hazards Rip currents claim more lives in Australia on average each year than bushfires, floods, cyclones and sharks combined, UNSW research shows. Rip currents are the cause of an average ...

Teaching matter waves new tricks: Making magnets with ultra cold atoms

2013-11-27
Teaching matter waves new tricks: Making magnets with ultra cold atoms Magnets have fascinated mankind for millenia. From the Greek philosophers to scientists of the modern era, which saw the rise of quantum mechanics, magnets have been ...

New aggressive HIV strain leads to faster AIDS development

2013-11-27
New aggressive HIV strain leads to faster AIDS development A recently discovered HIV strain leads to significantly faster development of AIDS than currently prevalent forms, according to new research from Lund University in Sweden. The period from infection ...

New effect couples electricity and magnetism in materials

2013-11-27
New effect couples electricity and magnetism in materials In magneto-electric materials, electric and magnetic vibrations can be coupled to 'electromagnons' -- High hopes are placed on this technology, a breakthrough could now be achieved at the ...

New Collection from PLOS and DNDi highlights a decade of R&D into neglected tropical diseases

2013-11-27
New Collection from PLOS and DNDi highlights a decade of R&D into neglected tropical diseases As part of a collaborative initiative, PLOS and the Drugs for Neglected Diseases initiative (DNDi) are delighted to be launching a special Collection—PLOS & DNDi: a decade of Open ...

Subarctic lakes are drying up at a rate not seen in 200 years

2013-11-27
Subarctic lakes are drying up at a rate not seen in 200 years Quebec City, November 27, 2013 – The decrease in snowfall observed in recent years in Canada's subarctic regions has led to worrisome desiccation of the regions' lakes. This ...

Penn study shows automated prediction alert helps identify patients at risk for 30-day readmission

2013-11-27
Penn study shows automated prediction alert helps identify patients at risk for 30-day readmission Flagging tool aims to reduce hospital readmissions Philadelphia - An automated prediction tool which identifies newly admitted patients ...

LAST 30 PRESS RELEASES:

Antarctica’s only native insect’s unique survival mechanism

How Earth's early cycles shaped the chemistry of life

Ukraine war forces planes to take longer routes, raising CO2

Negative refraction of light using atoms instead of metamaterials

High BP may develop at different ages and paces in East & South Asian adults in the UK

Meet the newly discovered brain cell that allows you to remember objects

Engineered animals show new way to fight mercury pollution

The 3,000-year coral reef shutdown: a mysterious pause and a remarkable recovery

Worm surface chemistry reveals secrets to their development and survival

Splicing twins: unravelling the secrets of the minor spliceosome complex

500-year-old Transylvanian diaries show how the Little Ice Age completely changed life and death in the region

Overcoming nicotine withdrawal: Clues found in neural mechanisms of the brain

Survey: Women prefer female doctors, but finding one for heart health can be difficult

Leaf color mysteries unveiled: the role of BoYgl-2 in cabbage

NUS Medicine study: Inability of cells to recycle fats can spell disease

D2-GCN: a graph convolutional network with dynamic disentanglement for node classification

Female hoverflies beat males on long-distance migrations

Study finds consumer openness to smoke-impacted wines, offering new market opportunities

Why we need to expand the search for climate-friendly microalgae

Fewer forest fires burn in North America today than in the past—and that's a bad thing

Older people in England are happier now than before the COVID pandemic, new national study suggests

Texas A&M chemist wins NSF CAREER Award

Micro-nano plastics make other pollutants more dangerous to plants and intestinal cells

Study of female genital tract reveals key findings

Pitt Engineering Professor Fang Peng elected to National Academy of Engineering

Short-course radiation therapy effective for endometrial cancer patients

Breast cancer treatment advances with light-activated ‘smart bomb’

JSCAI article at THT 2025 sets the standard for training pathways in interventional heart failure

Engineering biological reaction crucibles to rapidly produce proteins

Minecraft: a gamechanger for children’s learning

[Press-News.org] Active component from wine-processed Fructus corni inhibits hippocampal neuron apoptosis