PRESS-NEWS.org - Press Release Distribution
PRESS RELEASES DISTRIBUTION

JCI early table of contents for Dec. 2, 2013

2013-12-02
(Press-News.org) Contact information: Corinne Williams
press_releases@the-jci.org
Journal of Clinical Investigation
JCI early table of contents for Dec. 2, 2013 Predicting outcome for high-dose IL-2 therapy in cancer patients

One of the most potent forms of immunotherapy for patients with metastatic melanoma and renal cell carcinoma is high-dose (HD) bolus IL-2 therapy. Approximately 15% of patients respond to HD IL-2 therapy, with almost 5% going into complete remission; however, use of HD IL-2 therapy is limited due to the toxic effects associated with treatment. Because HD IL-2-associated toxicity is severe, it would be beneficial for clinicians to determine if a patient would respond favorably to this treatment prior to side effect onset. Previous studies indicate that regulatory T cell (Treg) populations increase in patients undergoing HD IL-2 therapy, and in this issue of the Journal of Clinical Investigation, Lazlo Radvanyi and colleagues at M.D. Anderson Cancer Center performed an in depth analysis of Treg populations in melanoma patients undergoing HD IL-2 therapy. The authors identified a distinct population of Treg cells that expressed the inducible T cell costimulator (ICOS) that was highly proliferative following the first cycle of HD IL-2. Furthermore, melanoma patients with greater levels of ICOS+ Tregs in response to HD IL-2 had better clinical outcomes, suggesting that this Treg population may be useful to predict which patients would benefit from HD IL-2.

TITLE: IL-2 therapy promotes suppressive ICOS+ Treg expansion in melanoma patients

AUTHOR CONTACT: Lazlo Radvanyi
University of Texas M.D. Anderson Cancer Center, Houston, TX, USA
Phone: 713.563.9489; E-mail: lradvanyi@mdanderson.org

View this article at: http://www.jci.org/articles/view/46266?key=052e9f45d55cf479c3fe



Blocking antioxidants in cancer cells reduces tumor growth in mice

Many cancers have adapted to cope with high levels of immune system-produced free radicals, also referred to as reactive oxygen species, by overproducing antioxidant proteins. One of these proteins, superoxide dismutase 1 (SOD1), is overproduced in lung adenocarcinomas and has been implicated as a target for chemotherapy. In this issue of the Journal of Clinical Investigation, Navdeep Chandel and colleagues from Northwestern University report the effects of a SOD1 pharmacological inhibitor on non-small-cell lung cancer (NSCLC) cells. The inhibitor, called ATN-224, stunted the growth of human NSCLC cells in culture and induced their death. The researchers also found that ATN-224 inhibited other antioxidant proteins, which caused high levels of hydrogen peroxide inside the cells. The ability of cancer cells to produce hydrogen peroxide was required for ATN-224-dependent effects, because hydrogen peroxide activated cell death pathways. Furthermore, ATN-224 induced cancer cell death and reduced tumor sizes in a mouse model of lung adenocarcinoma. ATN-224 dependent effects in animals were improved when the inhibitor was used in combination with another drug that activates programmed cell death. This study suggests inhibition of antioxidants may be a viable chemotherapeutic option.

TITLE: Targeting SOD1 reduces experimental non–small-cell lung cancer

AUTHOR CONTACT: Navdeep Chandel
Northwestern University, Chicago, IL, USA
Phone: 312-503-2549; Fax: 312-503-0411; E-mail: nav@northwestern.edu

View this article at: http://www.jci.org/articles/view/71714?key=0c483873fa3d4323f67e

ALSO IN THIS ISSUE

TITLE: Platelets mediate lympho-venous hemostasis to maintain blood-lymphatic separation throughout life

AUTHOR CONTACT: Mark L. Kahn
University of Pennsylvania, Philadelphia, PA, USA
Phone: (215) 898-9007; E-mail: markkahn@mail.med.upenn.edu

View this article at: http://www.jci.org/articles/view/70422?key=e0bf1e8b4325529b8506

TITLE: Cardiac resynchronization sensitizes the sarcomere to calcium by reactivating GSK-3β

AUTHOR CONTACT: David A Kass
Johns Hopkins University School of Medicine, Baltimore, MD, USA
Phone: 410-955-7153; Fax: 410-502-2558; E-mail: dkass@jhmi.edu

View this article at: http://www.jci.org/articles/view/69253?key=fdd04e03e5fcde1d87d4

TITLE: Aptamer-targeted inhibition of mTOR in T cells enhances antitumor immunity

AUTHOR CONTACT: Eli Gilboa
University of Miami Miller School of Medicine, Miami, FL, USA
E-mail: egilboa@med.miami.edu

View this article at: http://www.jci.org/articles/view/69856?key=b82b38f62d3273213e0a

TITLE: Vaccine-induced monoclonal antibodies targeting circumsporozoite protein prevent Plasmodium falciparum infection

AUTHOR CONTACT: Lander Foquet
Ghent University and Hospital, Gent, UNK, BEL
Phone: +32476847580; E-mail: lander.foquet@ugent.be

View this article at: http://www.jci.org/articles/view/70349?key=d7a297ecf5c755cf8053

TITLE: Sprouty-2 regulates HIV-specific T cell polyfunctionality

AUTHOR CONTACT: Jonathan Schneck
John Hopkins School of Medicine, Baltimore, MD, USA
Phone: 410-614-4589; E-mail: jschnec1@jhmi.edu

View this article at: http://www.jci.org/articles/view/70510?key=32e2938b962265e8c5b3

TITLE: TTC7A mutations disrupt intestinal epithelial apicobasal polarity

AUTHOR CONTACT: Genevieve de Saint Basile
Institut National de la Santé et de la Recherche Médicale (INSERM), Paris, , FRA
Phone: 33 1 44 38 17 66; E-mail: genevieve.de-saint-basile@inserm.fr

View this article at: http://www.jci.org/articles/view/71471?key=019235d9662f574cd28e

INFORMATION:

END



ELSE PRESS RELEASES FROM THIS DATE:

Predicting outcome for high-dose IL-2 therapy in cancer patients

2013-12-02
Predicting outcome for high-dose IL-2 therapy in cancer patients One of the most potent forms of immunotherapy for patients with metastatic melanoma and renal cell carcinoma is high-dose (HD) bolus IL-2 therapy. Approximately 15% of patients respond to ...

Blocking antioxidants in cancer cells reduces tumor growth in mice

2013-12-02
Blocking antioxidants in cancer cells reduces tumor growth in mice Many cancers have adapted to cope with high levels of immune system-produced free radicals, also referred to as reactive oxygen species, by overproducing antioxidant proteins. One of these ...

Silent RNAs express themselves in ALS disease

2013-12-02
Silent RNAs express themselves in ALS disease RNA molecules, used by cells to make proteins, are generally thought to be "silent" when stowed in cytoplasmic granules. But a protein mutated in some ALS patients forms granules that permit translation of ...

First Nations adults have more than double the risk of end-stage kidney disease

2013-12-02
First Nations adults have more than double the risk of end-stage kidney disease First Nations adults with diabetes have more than double the risk of end-stage kidney disease compared with non–First Nations adults, found a new study in CMAJ (Canadian ...

Johns Hopkins researchers show how a modified pacemaker strengthens failing hearts

2013-12-02
Johns Hopkins researchers show how a modified pacemaker strengthens failing hearts Findings advance opportunities for a 'pacemaker in a bottle' Johns Hopkins heart researchers are unraveling the mystery of how a modified pacemaker used to treat many patients ...

Evolution, Civil War history entwine in plant fossil with a tragic past

2013-12-02
Evolution, Civil War history entwine in plant fossil with a tragic past Union Army forced freed slaves to dig canal where 120 million-year-old fossil plant was found COLLEGE PARK, Md – A fossil leaf fragment collected decades ago on a Virginia canal bank has been identified ...

Key found to restoring 'exhausted' HIV-fighting immune cells

2013-12-02
Key found to restoring 'exhausted' HIV-fighting immune cells Protein could prove a promising new drug target Researchers have identified a protein that causes loss of function in immune cells combatting HIV. The scientists report in a paper appearing online Dec. 2 in ...

New evidence that 'gout' strongly runs in the family

2013-12-02
New evidence that 'gout' strongly runs in the family It's historically known as 'the king of diseases and the disease of kings' and was long thought to be caused by an overindulgent lifestyle, but now scientists at The University of Nottingham have confirmed ...

Researchers analyze growth potential in African bank loans

2013-12-02
Researchers analyze growth potential in African bank loans In Africa, small women-owned business owners find it easier to obtain loans than their male counterparts. The reason for this distortion is that politicians and foreign aid organisations with their focus on bank ...

Congenital heart defects affects long-term developmental outcome

2013-12-02
Congenital heart defects affects long-term developmental outcome Approximately one percent of all newborns in Switzerland are diagnosed with a congenital heart defect, roughly half of them require open heart surgery. Most children, including those with the most severe ...

LAST 30 PRESS RELEASES:

South Africa and China establish record-breaking 12,900 km ultra-secure quantum satellite link

A rule-changer for ceramic fuel cells

Good vibrations: Scientists discover a groundbreaking method for exciting phonon-polaritons

CNIC scientists discover a type of immune cell that produces defensive "shields" in the skin

Science behind “Polly want a cracker” could guide future treatment design for speech disorders

Brain imaging reveals surprises about learning

Scientists see the first steps of DNA unwinding

Earliest stages and possible new cause of stomach cancer revealed

Unique cell shape keeps lymphatic vessels and plant leaves stable

New understanding of B cell mutation strategies could have implications for vaccines

Sea level rise after the last ice age: More knowledge

New mechanism behind adaptive immunity revealed. It could impact how we design vaccines.

Hyperuricemia: Current state and prospects

What happens in the male mouse brain during sex

Prescription stimulant use, misuse, and use disorder among US adults ages 18 to 64

Suicide and self-harm events with GLP-1 receptor agonists in adults with diabetes or obesity

Pregnancy irreversibly remodels the mouse intestine

Blocking gut cannabinoids may prevent leaky gut

Plant patch can detect stress signals in real time

NFL’s Buffalo Bills continue CPR education kicking off year 3 of the HeartBEAT initiative

Team finds regional, age-related trends in exposure to drug-resistant pathogen

Euclid opens data treasure trove, offers glimpse of deep fields

Pacific oyster may colonize the Baltic Sea

New material allows amputees to adjust fit of prosthetic limbs throughout the day, using a smartphone

E-cigarettes linked to lower cardiac risks compared to tobacco cigarettes in people with HIV

High levels of traumatic stress found in caregivers of adult cancer patients

New carbon-negative material could make concrete and cement more sustainable

Researchers optimize a method using seawater that produces mineral deposits while trapping carbon dioxide

How might ACL surgery increase the risk of knee osteoarthritis?

Is the “honesty” of flowering plants to their pollinators genetic?

[Press-News.org] JCI early table of contents for Dec. 2, 2013