PRESS-NEWS.org - Press Release Distribution
PRESS RELEASES DISTRIBUTION

Aging process accompanied by decreased hippocampal synaptophysin

2013-12-06
(Press-News.org) Contact information: Meng Zhao
eic@nrren.org
86-138-049-98773
Neural Regeneration Research
Aging process accompanied by decreased hippocampal synaptophysin Caveolin-1 may be a new target for interfering with age-dependent decline in synaptic plasticity. To explore the relationship between synaptic plasticity in the aging process and changes in learning and memory, Dr. Yang Liu and coworkers from the First Affiliated Hospital, Dalian Medical University, China examined synaptophysin expression in the hippocampus, cortex and cerebellum of rats at different ages, and analyzed the association between synaptophysin expression and cognition and behaviors. Results showed that caveolin-1 and synaptophysin declined with age in the hippocampus, and synaptophysin levels were strongly associated with age-related memory impairment. The researchers have provided the first direct demonstration that caveolin-1 protein expression changes in an age-dependent manner. Synaptophysin revealed a similar expression pattern to that of caveolin-1 in the hippocampus, cortex and cerebellum. This new notion might be helpful in strategic decision-making and preventing aging-induced loss of synaptic plasticity. The relevant study was published in the Neural Regeneration Research (Vol. 8, No. 29, 2013).

### Article: " Downregulation of caveolin-1 contributes to the synaptic plasticity deficit in the hippocampus of aged rats," by Yang Liu1, Zhanhua Liang2, Jing Liu1, Wei Zou3, Xiaoyan Li1, Yachen Wang2, Lijia An4 (1 Regenerative Medicine Center, the First Affiliated Hospital, Dalian Medical University, Dalian 116021, Liaoning Province, China; 2 Department of Neurology, the First Affiliated Hospital, Dalian Medical University, Dalian 116021, Liaoning Province, China; 3 Department of Biology, Liaoning Normal University, Dalian 116023, Liaoning Province, China; 4 School of Life Science and Biotechnology, Dalian University of Technology, Dalian 116024, Liaoning Province, China)

Liu Y, Liang ZH, Liu J, Zou W, Li XY, Wang YC, An LJ. Downregulation of caveolin-1 contributes to the synaptic plasticity deficit in the hippocampus of aged rats. Neural Regen Res. 2013;8(29):2725-2733.



ELSE PRESS RELEASES FROM THIS DATE:

Progesterone changes may cause cognitive impairment of Alzheimer's disease patients

2013-12-06
Progesterone changes may cause cognitive impairment of Alzheimer's disease patients Steroid hormones and their metabolites within the central nervous system are commonly defined as neuroactive steroids or neurosteroids. Although neuroactive steroids have been shown ...

A*STAR scientists discover novel hormone essential for heart development

2013-12-06
A*STAR scientists discover novel hormone essential for heart development This unusual discovery could aid cardiac repair and provide new therapies to common heart diseases and hypertension 1. Scientists at A*STAR's ...

Quantum effects help cells capture light, but the details are obscure

2013-12-06
Quantum effects help cells capture light, but the details are obscure Ultrashort laser pulses reveal that 'coherence' plays a subtle role in energy transfers Sophisticated recent experiments with ultrashort laser pulses support the idea ...

Penn study delivers protein across blood-brain barrier to degrade Alzheimer's plaques

2013-12-06
Penn study delivers protein across blood-brain barrier to degrade Alzheimer's plaques The body is structured to ensure that any invading organisms have a tough time reaching the brain, an organ obviously critical to survival. Known as the blood-brain ...

The heat is on...or off

2013-12-06
The heat is on...or off Having the sense to cut office energy bills Office buildings have an enormous carbon footprint, but often energy is being wasted maintaining empty rooms and spaces at a comfortable temperature. Research to be published in the International Journal of ...

Promising results for Swedish cancer drug candidate

2013-12-06
Promising results for Swedish cancer drug candidate A new study conducted by scientists from the Dana-Farber Cancer Institute at Harvard Medical School and Karolinska Institutet in Sweden presents very promising results for the treatment of the cancer form multiple ...

Surprising discovery: The skin communicates with the liver

2013-12-06
Surprising discovery: The skin communicates with the liver Researchers from the University of Southern Denmark have discovered that the skin is capable of communicating with the liver. The discovery has surprised the scientists, and they say that it may help our understanding ...

Human stem cells predict efficacy of Alzheimer drugs

2013-12-06
Human stem cells predict efficacy of Alzheimer drugs Researchers from the University of Bonn use reprogrammed patient neurons for drug testing Why do certain Alzheimer medications work in animal models but not in clinical trials in humans? A research team ...

New study finds corn oil superior to extra virgin olive oil in lowering cholesterol

2013-12-06
New study finds corn oil superior to extra virgin olive oil in lowering cholesterol Plant sterols naturally found in corn oil linked to heart health benefits WASHINGTON, December 6, 2013 – Corn oil significantly reduces cholesterol with more favorable changes ...

Enzalutamide in prostate cancer: Hints of added benefit

2013-12-06
Enzalutamide in prostate cancer: Hints of added benefit Longer overall survival in patients without visceral metastases / bone complications and pain progression delayed Enzalutamide (trade name: Xtandi) has been approved since ...

LAST 30 PRESS RELEASES:

Different types of depression linked to different cardiometabolic diseases

Ketogenic diet may protect against stress experienced in the womb

Adults 65 years and older not immune to the opioid epidemic, new study finds

Artificial intelligence emerging as powerful patient safety tool in pediatric anesthesia

Mother’s ZIP code, lack of access to prenatal care can negatively impact baby’s health at birth, new studies show

American Society of Anesthesiologists honors John M. Zerwas, M.D., FASA, with Distinguished Service Award

A centimeter-scale quadruped piezoelectric robot with high integration and strong robustness

Study confirms that people with ADHD can be more creative. The reason may be that they let their mind wander

Research gives insight into effect of neurodegenerative diseases on speech rhythm

Biochar and plants join forces to clean up polluted soils and boost ecosystem recovery

Salk scientist Joseph Ecker awarded McClintock Prize for Plant Genetics and Genome Studies

ADHD: Women are diagnosed five years later than men, despite symptoms appearing at the same age.

Power plants may emit more pollution during government shutdowns

Increasing pressures for conformity de-skilling and demotivating teachers, study warns

Researchers develop smarter menstrual product with potential for wearable health monitoring

Microwaves for energy-efficient chemical reactions

MXene current collectors could reduce size, improve recyclability of Li-ion batteries

Living near toxic sites linked to aggressive breast cancer

New discovery could open door to male birth control

Wirth elected Fellow of American Physical Society

The Journal of Nuclear Medicine Ahead-of-Print Tip Sheet: October 10, 2025

Destined to melt

Attitudes, not income, drive energy savings at home

The playbook for perfect polaritons

‘Disease in a dish’ study of progressive MS finds critical role for unusual type of brain cell

Solar-powered method lights the way to a ‘de-fossilized’ chemical industry

Screen time linked to lower academic achievement among Ontario elementary students

One-year outcomes after traumatic brain injury and early extracranial surgery in the TRACK-TBI Study

Enduring outcomes of COVID-19 work absences on the US labor market

Affirmative action repeal and racial and ethnic diversity in us medical school admissions

[Press-News.org] Aging process accompanied by decreased hippocampal synaptophysin