(Press-News.org) Contact information: Cara Martinez
cara.martinez@cshs.org
310-423-7798
Cedars-Sinai Medical Center
Ovarian cancer discovery deepens knowledge of survival outcomes
10-gene biomarker identified as a tool in evaluating diagnosis, potential response to treatment and overall prognosis
LOS ANGELES (Dec. 9, 2013) – Researchers in the Women's Cancer Program at Cedars-Sinai's Samuel Oschin Comprehensive Cancer Institute have identified a series of 10 genes that may signify a trifecta of benefits for women diagnosed with ovarian cancer and ultimately reflect improved survival outcomes.
The research, led by Dong-Joo (Ellen) Cheon, PhD, found that the 10-gene biomarker panel may identify the aggressiveness of a patient's disease, help predict survival outcomes and result in novel therapeutic strategies tailored to patients with the most adverse survival outcomes.
When a patient's tumor is identified as having elevated levels of these 10 specific genes, doctors may be able to better predict which treatments would be most effective, said Cheon, whose research was published in Clinical Cancer Research.
That is an important advance because ovarian cancer is the most lethal gynecologic cancer and is often diagnosed in later, more aggressive stages, resulting in poor prognosis and survival. These outcomes differ due to development of tumors that become resistant to chemotherapy. By identifying chemo-resistant tumors and identifying the risk of poor survival outcomes during the diagnostic process, investigators hope to extend lives and improve treatment responses for women with ovarian cancer.
"The ultimate goal is to use the 10-gene biomarker panel to develop a diagnostic kit that will identify patients with the most adverse outcome and provide targeted therapeutic strategies," said Cheon. "Among the biomarkers identified, the gene COL11A1 was shown to be the most abundantly expressed in ovarian cancer progression. But when we blocked expression of COL11A1 in murine cancer cells, tumor growth and spread was significantly reduced."
The 10-gene biomarker panel revealed another promising benefit. The 10 genes associated with the panel all share one common biological process — the formation of a collagen matrix around cancerous cells. This thick, collagen-rich matrix can protect cancer cells from the lethal effect of chemotherapy and serve as an incubator for increasingly aggressive cancer cells. Understanding how this collagen-rich environment may contribute to aggressive tumor cell behavior may ultimately lead to more efficient therapies.
"This data, based on the analysis of nearly 800 ovarian cancer patients, suggests that patients who have elevated levels of genes associated with the biomarker panel have shorter survival and more aggressive forms of disease," said Sandra Orsulic, PhD, senior author of this study, director of women's cancer biology in the Women's Cancer Program and associate professor in the Department of Obstetrics and Gynecology. "These findings indicate that even though patients present with the same disease stage at diagnosis, their survival outcomes differ."
The findings suggest that the 10-gene signature may have both predictive value and biological relevance that may be useful in treating patients.
###
Cedars-Sinai collaborators include Beth Y. Karlan, MD, director of the Women's Cancer Program, director in the Division of Gynecologic Oncology in the Department of Obstetrics and Gynecology, director of the Gilda Radner Hereditary Cancer Program and the Board of Governors Chair in Gynecologic Oncology; Yunguang Tong, PhD, assistant professor in the Department of Medicine; Dror Berel, senior biostatistician in the Biostatistics and Bioinformatics Research Core Xiaojiang Cui, PhD, associate professor in the Women's Cancer Program; Jessica A. Beach, a graduate student in the Graduate Program in Biomedical Sciences and Translational Medicine; Mourad Tighiouart, PhD, associate director in the department of Biostatistics and Bioinformatics; and Ann E. Walts, MD, a research pathologist in the Samuel Oschin Comprehensive Cancer Institute.
Myung-Shin Sim, DrPH, from the John Wayne Cancer Institute at Saint John's Health Center, and Judy Dering, PhD, from the David Geffen School of Medicine at UCLA, contributed to the study.
The research was supported with grants from the American Cancer Society (RSG-10-252-01-TBG), Sandy Rollman Ovarian Cancer Foundation and the Pacific Ovarian Cancer Research Consortium (Developmental Grant, P50 CA083636) and the National Center for Advancing Translational Sciences (UL1TR000124).
Citation: Clinical Cancer Research. 2013 Nov 11: Collagen-remodeling gene signature predicts poor survival.
Ovarian cancer discovery deepens knowledge of survival outcomes
10-gene biomarker identified as a tool in evaluating diagnosis, potential response to treatment and overall prognosis
2013-12-09
ELSE PRESS RELEASES FROM THIS DATE:
REiNS collaboration seeks common outcome measures for neurofibromatosis clinical trials
2013-12-09
REiNS collaboration seeks common outcome measures for neurofibromatosis clinical trials
Initial consensus recommendations for studies of NF appear in special supplement to Neurology
Philadelphia, Pa. (December 9, 2013) - As potentially effective new treatments ...
Peaceful bumblebee becomes invasive
2013-12-09
Peaceful bumblebee becomes invasive
Bombus terrestris invades South America
Bumblebees look cute. They have a thick fur, fly somewhat clumsily and are less aggressive than honeybees or wasps. They are very much appreciated by farmers as keen pollen collectors. ...
Better preparedness against Tamiflu-resistant influenza viruses
2013-12-09
Better preparedness against Tamiflu-resistant influenza viruses
Swedish researchers in Umeå and Uppsala have found that residues of the influenza drug Tamiflu in our environment can make the influenza virus in birds resistant. This can have serious ...
How 'good cholesterol' stops inflammation
2013-12-09
How 'good cholesterol' stops inflammation
Researchers at the University Hospital and the University of Bonn have discovered a central molecular switch
High-density lipoprotein (HDL), known colloquially as "good cholesterol", protects against dangerous deposits ...
ABC transporters enable leaf beetle larvae to accumulate defensive precursors when feeding
2013-12-09
ABC transporters enable leaf beetle larvae to accumulate defensive precursors when feeding
Similar membrane proteins play a crucial role in the transport of toxic substances out of the cell
This news release is available in German. Scientists ...
Recycled plastic proves effective in killing drug-resistant fungi
2013-12-09
Recycled plastic proves effective in killing drug-resistant fungi
IBN and IBM discover new medical application for converted PET bottles
Singapore, December 9, 2013 – Researchers at Singapore's Institute of Bioengineering ...
Reproductive Health Matters announces publication of its latest themed issue: New development paradigm
2013-12-09
Reproductive Health Matters announces publication of its latest themed issue: New development paradigm
London, December 9, 2013 – The world is still underfunding health: so what kind of new development paradigm will succeed in ensuring comprehensive and equitable ...
Life and work -- 1 and the same?
2013-12-09
Life and work -- 1 and the same?
London, Los Angeles CA (09 December, 2013). Flexible workplaces may seem attractive when considering work-life balance but new research being published shows it's not unusual for firms to cash-in, profiting from our "free" time ...
Solar cell degradation observed directly for the first time
2013-12-09
Solar cell degradation observed directly for the first time
X-ray examination shows structural changes in 'plastics' solar cells
This news release is available in German.
With the help of DESY's X-ray light source PETRA III, researchers of ...
Aging out of bounds
2013-12-09
Aging out of bounds
New demographic data show how diversely different species age -- biologists cannot explain why
This news release is available in German.
Despite aging being one the hottest topic in the media recently, scientists have ...
LAST 30 PRESS RELEASES:
Wearable sensor could be used to monitor OSA treatment response
Waitlist deaths dropped under new lung transplant allocation system
Methotrexate as effective as prednisone in pulmonary sarcoidosis
Waist-to-height ratio predicts heart failure incidence
Climate change increases severity of obstructive sleep apnea
USC, UCLA team up for the world’s first-in-human bladder transplant
Two out of five patients with heart failure do not see a cardiologist even once a year and these patients are more likely to die
AI-enabled ECG algorithm performs well in the early detection of heart failure in Kenya
No cardiac safety concerns reported with a pharmaceutically manufactured cannabidiol formulation
Scientists wash away mystery behind why foams are leakier than expected
TIFRH researchers uncover a mechanism enabling glasses to self-regulate their brittleness
High energy proton accelerator on a table-top — enabled by university class lasers
Life, death and mowing – study reveals Britain’s poetic obsession with the humble lawnmower
Ochsner Transplant Institute’s kidney program achieves ELITE Status
Gender differences in primary care physician earnings and outcomes under Medicare Advantage value-based payment
Can mindfulness combat anxiety?
Could personality tests help make bipolar disorder treatment more precise?
Largest genomic study of veterans with metastatic prostate cancer reveals critical insights for precision medicine
UCF’s ‘bridge doctor’ combines imaging, neural network to efficiently evaluate concrete bridges’ safety
Scientists discover key gene impacts liver energy storage, affecting metabolic disease risk
Study finds that individual layers of synthetic materials can collaborate for greater impact
Researchers find elevated levels of mercury in Colorado mountain wetlands
Study reveals healing the ozone hole helps the Southern Ocean take up carbon
Ultra-robust hydrogels with adhesive properties developed using bamboo cellulose-based carbon nanomaterials
New discovery about how acetaminophen works could improve understanding about pain relievers
What genetic changes made us uniquely human? -- The human intelligence evolved from proximal cis-regulatory saltations
How do bio-based amendments address low nutrient use efficiency and crop yield challenges?
Predicting e-bus battery performance in cold climates: a breakthrough in sustainable transit
Enhancing centrifugal compressor performance with ported shroud technology
Can localized fertilization become a key strategy for green agricultural development?
[Press-News.org] Ovarian cancer discovery deepens knowledge of survival outcomes10-gene biomarker identified as a tool in evaluating diagnosis, potential response to treatment and overall prognosis