PRESS-NEWS.org - Press Release Distribution
PRESS RELEASES DISTRIBUTION

Role of endoplasmic reticulum stress in the loss of RGCs in diabetic retinopathy

2014-01-03
(Press-News.org) Contact information: Meng Zhao
eic@nrren.org
86-138-049-98773
Neural Regeneration Research
Role of endoplasmic reticulum stress in the loss of RGCs in diabetic retinopathy

Endoplasmic reticulum stress is closely involved in the early stage of diabetic retinopathy. According a study published in the Neural Regeneration Research (Vol. 8, No. 33, 2013), endoplasmic reticulum stress played an important role in the hyperglycemia-induced death of ganglion cells and impairment of retinal microvessels. Tauroursodeoxycholic acid treatment effectively inhibited the activation of the endoplasmic reticulum stress pathway, and provided effective protection against diabetic retinopathy. The C/ERB homologous protein was shown to co-localize with glial fibrillary acidic protein-positive glial cells in the retina of diabetic rats, and subsequently provided evidence for the activation of glial cells in diabetic retinopathy.



INFORMATION:



Article: " Role of endoplasmic reticulum stress in the loss of retinal ganglion cells in diabetic retinopathy," by Liping Yang1, Lemeng Wu1, Dongmei Wang1, Ying Li1, Hongliang Dou1, Mark O.M.Tso1, 2, Zhizhong Ma1 (1 Department of Ophthalmology, Peking University Third Hospital, Key Laboratory of Vision Loss and Restoration, Ministry of Education, Beijing 100191, China; 2 Wilmer Eye Institute, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA)

Yang LP, Wu LM, Wang DM, Li Y, Dou HL,Tso MO, Ma ZZ. Role of endoplasmic reticulum stress in the loss of retinal ganglion cells in diabetic retinopathy. Neural Regen Res. 2013;8(33):3148-3158.



ELSE PRESS RELEASES FROM THIS DATE:

Novel exfoliation method developed by NUS chemists paves the way for 2-dimensional materials to be used in printable photonics and electronics

2014-01-03
Novel exfoliation method developed by NUS chemists paves the way for 2-dimensional materials to be used in printable photonics and electronics Versatility of new technique shows promise as new benchmark in exfoliation chemistry of 2-dimensional chalcogenides Singapore, ...

Fear of childbirth predicts postpartum depression

2014-01-03
Fear of childbirth predicts postpartum depression Expectant women with prenatally diagnosed fear of childbirth are at an increased risk of postpartum depression, according to a study of over 500,000 mothers in Finland. Women with a ...

25 years of DNA on the computer

2014-01-03
25 years of DNA on the computer A review of the computer simulations of nuclear DNA DNA carries out its activities "diluted" in the cell nucleus. In this state it synthesises proteins and, even though it looks like ...

Higher vitamin D levels in pregnancy could help babies become stronger

2014-01-03
Higher vitamin D levels in pregnancy could help babies become stronger Children are likely to have stronger muscles if their mothers had a higher level of vitamin D in their body during pregnancy, according to new research from the Medical Research Council ...

Nordic study: Few persons with metabolic syndrome adhere to nutrition recommendations

2014-01-03
Nordic study: Few persons with metabolic syndrome adhere to nutrition recommendations Adherence to dietary recommendations is weak among people suffering from metabolic syndrome or having increased risk for metabolic syndrome, according to the Nordic SYSDIET study led by ...

University of East Anglia scientists make advance in cancer research

2014-01-03
University of East Anglia scientists make advance in cancer research A protein that has been at the centre of cancer drug design for the last 20 years should not be given up on according to new research from the University of East Anglia (UEA). The most advanced ...

Important mutation discovered in dairy cattle

2014-01-03
Important mutation discovered in dairy cattle Scientists have discovered a mutation with a built-in dilemma for dairy cattle breeders. The deleted gene sequence has a positive effect on milk yield but causes embryonic death in dairy cattle. Scientists have found ...

Another step towards understanding the quantum behavior of cold atoms

2014-01-03
Another step towards understanding the quantum behavior of cold atoms A UPV/EHU-University of the Basque Country researcher has explored the quantum effects produced when bosons and fermions are mixed at a very low temperature This news release is available in Spanish. ...

The entropy of nations

2014-01-03
The entropy of nations Global energy inequality lessens, but for how long? The 18th century writer Adam Smith provided a workable metaphor for the way society utilizes resources. In his book "The Wealth of Nations," he argued that even as individuals strive, through ...

A novel look at how stories may change the brain

2014-01-03
A novel look at how stories may change the brain Neuroscience research finds reading can boost brain function Many people can recall reading at least one cherished story that they say changed their life. Now researchers at Emory University have detected what may ...

LAST 30 PRESS RELEASES:

Thirty-year mystery of dissonance in the “ringing” of black holes explained

Less intensive works best for agricultural soil

Arctic rivers project receives “national champion” designation from frontiers foundation

Computational biology paves the way for new ALS tests

Study offers new hope for babies born with opioid withdrawal syndrome

UT, Volkswagen Group of America celebrate research partnership

New Medicare program could dramatically improve affordability for cancer drugs – if patients enroll

Are ‘zombie’ skin cells harmful or helpful? The answer may be in their shapes

University of Cincinnati Cancer Center presents research at AACR 2025

Head and neck, breast, lung and survivorship studies headline Dana-Farber research at AACR Annual Meeting 2025

AACR: Researchers share promising results from MD Anderson clinical trials

New research explains why our waistlines expand in middle age

Advancements in muon detection: Taishan Antineutrino Observatory's innovative top veto tracker

Chips off the old block

Microvascular decompression combined with nerve combing for atypical trigeminal neuralgia

Cutting the complexity from digital carpentry

Lung immune cell type “quietly” controls inflammation in COVID-19

Fiscal impact of expanded Medicare coverage for GLP-1 receptor agonists to treat obesity

State and sociodemographic trends in US cigarette smoking with future projections

Young adults drive historic decline in smoking

NFCR congratulates Dr. Robert C. Bast, Jr. on receiving the AACR-Daniel D. Von Hoff Award for Outstanding Contributions to Education and Training in Cancer Research

Chimpanzee stem cells offer new insights into early embryonic development

This injected protein-like polymer helps tissues heal after a heart attack

FlexTech inaugural issue launches, pioneering interdisciplinary innovation in flexible technology

In Down syndrome mice, 40Hz light and sound improve cognition, neurogenesis, connectivity

Methyl eugenol: potential to inhibit oxidative stress, address related diseases, and its toxicological effects

A vascularized multilayer chip reveals shear stress-induced angiogenesis in diverse fluid conditions

AI helps unravel a cause of Alzheimer's disease and identify a therapeutic candidate

Coalition of Autism Scientists critiques US Department of Health and Human Services Autism Research Initiative

Structure dictates effectiveness, safety in nanomedicine

[Press-News.org] Role of endoplasmic reticulum stress in the loss of RGCs in diabetic retinopathy