PRESS-NEWS.org - Press Release Distribution
PRESS RELEASES DISTRIBUTION

Role of endoplasmic reticulum stress in the loss of RGCs in diabetic retinopathy

2014-01-03
(Press-News.org) Contact information: Meng Zhao
eic@nrren.org
86-138-049-98773
Neural Regeneration Research
Role of endoplasmic reticulum stress in the loss of RGCs in diabetic retinopathy

Endoplasmic reticulum stress is closely involved in the early stage of diabetic retinopathy. According a study published in the Neural Regeneration Research (Vol. 8, No. 33, 2013), endoplasmic reticulum stress played an important role in the hyperglycemia-induced death of ganglion cells and impairment of retinal microvessels. Tauroursodeoxycholic acid treatment effectively inhibited the activation of the endoplasmic reticulum stress pathway, and provided effective protection against diabetic retinopathy. The C/ERB homologous protein was shown to co-localize with glial fibrillary acidic protein-positive glial cells in the retina of diabetic rats, and subsequently provided evidence for the activation of glial cells in diabetic retinopathy.



INFORMATION:



Article: " Role of endoplasmic reticulum stress in the loss of retinal ganglion cells in diabetic retinopathy," by Liping Yang1, Lemeng Wu1, Dongmei Wang1, Ying Li1, Hongliang Dou1, Mark O.M.Tso1, 2, Zhizhong Ma1 (1 Department of Ophthalmology, Peking University Third Hospital, Key Laboratory of Vision Loss and Restoration, Ministry of Education, Beijing 100191, China; 2 Wilmer Eye Institute, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA)

Yang LP, Wu LM, Wang DM, Li Y, Dou HL,Tso MO, Ma ZZ. Role of endoplasmic reticulum stress in the loss of retinal ganglion cells in diabetic retinopathy. Neural Regen Res. 2013;8(33):3148-3158.



ELSE PRESS RELEASES FROM THIS DATE:

Novel exfoliation method developed by NUS chemists paves the way for 2-dimensional materials to be used in printable photonics and electronics

2014-01-03
Novel exfoliation method developed by NUS chemists paves the way for 2-dimensional materials to be used in printable photonics and electronics Versatility of new technique shows promise as new benchmark in exfoliation chemistry of 2-dimensional chalcogenides Singapore, ...

Fear of childbirth predicts postpartum depression

2014-01-03
Fear of childbirth predicts postpartum depression Expectant women with prenatally diagnosed fear of childbirth are at an increased risk of postpartum depression, according to a study of over 500,000 mothers in Finland. Women with a ...

25 years of DNA on the computer

2014-01-03
25 years of DNA on the computer A review of the computer simulations of nuclear DNA DNA carries out its activities "diluted" in the cell nucleus. In this state it synthesises proteins and, even though it looks like ...

Higher vitamin D levels in pregnancy could help babies become stronger

2014-01-03
Higher vitamin D levels in pregnancy could help babies become stronger Children are likely to have stronger muscles if their mothers had a higher level of vitamin D in their body during pregnancy, according to new research from the Medical Research Council ...

Nordic study: Few persons with metabolic syndrome adhere to nutrition recommendations

2014-01-03
Nordic study: Few persons with metabolic syndrome adhere to nutrition recommendations Adherence to dietary recommendations is weak among people suffering from metabolic syndrome or having increased risk for metabolic syndrome, according to the Nordic SYSDIET study led by ...

University of East Anglia scientists make advance in cancer research

2014-01-03
University of East Anglia scientists make advance in cancer research A protein that has been at the centre of cancer drug design for the last 20 years should not be given up on according to new research from the University of East Anglia (UEA). The most advanced ...

Important mutation discovered in dairy cattle

2014-01-03
Important mutation discovered in dairy cattle Scientists have discovered a mutation with a built-in dilemma for dairy cattle breeders. The deleted gene sequence has a positive effect on milk yield but causes embryonic death in dairy cattle. Scientists have found ...

Another step towards understanding the quantum behavior of cold atoms

2014-01-03
Another step towards understanding the quantum behavior of cold atoms A UPV/EHU-University of the Basque Country researcher has explored the quantum effects produced when bosons and fermions are mixed at a very low temperature This news release is available in Spanish. ...

The entropy of nations

2014-01-03
The entropy of nations Global energy inequality lessens, but for how long? The 18th century writer Adam Smith provided a workable metaphor for the way society utilizes resources. In his book "The Wealth of Nations," he argued that even as individuals strive, through ...

A novel look at how stories may change the brain

2014-01-03
A novel look at how stories may change the brain Neuroscience research finds reading can boost brain function Many people can recall reading at least one cherished story that they say changed their life. Now researchers at Emory University have detected what may ...

LAST 30 PRESS RELEASES:

Are lifetimes of big appliances really shrinking?

Pink skies

Monkeys are world’s best yodellers - new research

Key differences between visual- and memory-led Alzheimer’s discovered

% weight loss targets in obesity management – is this the wrong objective?

An app can change how you see yourself at work

NYC speed cameras take six months to change driver behavior, effects vary by neighborhood, new study reveals

New research shows that propaganda is on the rise in China

Even the richest Americans face shorter lifespans than their European counterparts, study finds

Novel genes linked to rare childhood diarrhea

New computer model reveals how Bronze Age Scandinavians could have crossed the sea

Novel point-of-care technology delivers accurate HIV results in minutes

Researchers reveal key brain differences to explain why Ritalin helps improve focus in some more than others

Study finds nearly five-fold increase in hospitalizations for common cause of stroke

Study reveals how alcohol abuse damages cognition

Medicinal cannabis is linked to long-term benefits in health-related quality of life

Microplastics detected in cat placentas and fetuses during early pregnancy

Ancient amphibians as big as alligators died in mass mortality event in Triassic Wyoming

Scientists uncover the first clear evidence of air sacs in the fossilized bones of alvarezsaurian dinosaurs: the "hollow bones" which help modern day birds to fly

Alcohol makes male flies sexy

TB patients globally often incur "catastrophic costs" of up to $11,329 USD, despite many countries offering free treatment, with predominant drivers of cost being hospitalization and loss of income

Study links teen girls’ screen time to sleep disruptions and depression

Scientists unveil starfish-inspired wearable tech for heart monitoring

Footprints reveal prehistoric Scottish lagoons were stomping grounds for giant Jurassic dinosaurs

AI effectively predicts dementia risk in American Indian/Alaska Native elders

First guideline on newborn screening for cystic fibrosis calls for changes in practice to improve outcomes

Existing international law can help secure peace and security in outer space, study shows

Pinning down the process of West Nile virus transmission

UTA-backed research tackles health challenges across ages

In pancreatic cancer, a race against time

[Press-News.org] Role of endoplasmic reticulum stress in the loss of RGCs in diabetic retinopathy