PRESS-NEWS.org - Press Release Distribution
PRESS RELEASES DISTRIBUTION

Role of endoplasmic reticulum stress in the loss of RGCs in diabetic retinopathy

2014-01-03
(Press-News.org) Contact information: Meng Zhao
eic@nrren.org
86-138-049-98773
Neural Regeneration Research
Role of endoplasmic reticulum stress in the loss of RGCs in diabetic retinopathy

Endoplasmic reticulum stress is closely involved in the early stage of diabetic retinopathy. According a study published in the Neural Regeneration Research (Vol. 8, No. 33, 2013), endoplasmic reticulum stress played an important role in the hyperglycemia-induced death of ganglion cells and impairment of retinal microvessels. Tauroursodeoxycholic acid treatment effectively inhibited the activation of the endoplasmic reticulum stress pathway, and provided effective protection against diabetic retinopathy. The C/ERB homologous protein was shown to co-localize with glial fibrillary acidic protein-positive glial cells in the retina of diabetic rats, and subsequently provided evidence for the activation of glial cells in diabetic retinopathy.



INFORMATION:



Article: " Role of endoplasmic reticulum stress in the loss of retinal ganglion cells in diabetic retinopathy," by Liping Yang1, Lemeng Wu1, Dongmei Wang1, Ying Li1, Hongliang Dou1, Mark O.M.Tso1, 2, Zhizhong Ma1 (1 Department of Ophthalmology, Peking University Third Hospital, Key Laboratory of Vision Loss and Restoration, Ministry of Education, Beijing 100191, China; 2 Wilmer Eye Institute, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA)

Yang LP, Wu LM, Wang DM, Li Y, Dou HL,Tso MO, Ma ZZ. Role of endoplasmic reticulum stress in the loss of retinal ganglion cells in diabetic retinopathy. Neural Regen Res. 2013;8(33):3148-3158.



ELSE PRESS RELEASES FROM THIS DATE:

Novel exfoliation method developed by NUS chemists paves the way for 2-dimensional materials to be used in printable photonics and electronics

2014-01-03
Novel exfoliation method developed by NUS chemists paves the way for 2-dimensional materials to be used in printable photonics and electronics Versatility of new technique shows promise as new benchmark in exfoliation chemistry of 2-dimensional chalcogenides Singapore, ...

Fear of childbirth predicts postpartum depression

2014-01-03
Fear of childbirth predicts postpartum depression Expectant women with prenatally diagnosed fear of childbirth are at an increased risk of postpartum depression, according to a study of over 500,000 mothers in Finland. Women with a ...

25 years of DNA on the computer

2014-01-03
25 years of DNA on the computer A review of the computer simulations of nuclear DNA DNA carries out its activities "diluted" in the cell nucleus. In this state it synthesises proteins and, even though it looks like ...

Higher vitamin D levels in pregnancy could help babies become stronger

2014-01-03
Higher vitamin D levels in pregnancy could help babies become stronger Children are likely to have stronger muscles if their mothers had a higher level of vitamin D in their body during pregnancy, according to new research from the Medical Research Council ...

Nordic study: Few persons with metabolic syndrome adhere to nutrition recommendations

2014-01-03
Nordic study: Few persons with metabolic syndrome adhere to nutrition recommendations Adherence to dietary recommendations is weak among people suffering from metabolic syndrome or having increased risk for metabolic syndrome, according to the Nordic SYSDIET study led by ...

University of East Anglia scientists make advance in cancer research

2014-01-03
University of East Anglia scientists make advance in cancer research A protein that has been at the centre of cancer drug design for the last 20 years should not be given up on according to new research from the University of East Anglia (UEA). The most advanced ...

Important mutation discovered in dairy cattle

2014-01-03
Important mutation discovered in dairy cattle Scientists have discovered a mutation with a built-in dilemma for dairy cattle breeders. The deleted gene sequence has a positive effect on milk yield but causes embryonic death in dairy cattle. Scientists have found ...

Another step towards understanding the quantum behavior of cold atoms

2014-01-03
Another step towards understanding the quantum behavior of cold atoms A UPV/EHU-University of the Basque Country researcher has explored the quantum effects produced when bosons and fermions are mixed at a very low temperature This news release is available in Spanish. ...

The entropy of nations

2014-01-03
The entropy of nations Global energy inequality lessens, but for how long? The 18th century writer Adam Smith provided a workable metaphor for the way society utilizes resources. In his book "The Wealth of Nations," he argued that even as individuals strive, through ...

A novel look at how stories may change the brain

2014-01-03
A novel look at how stories may change the brain Neuroscience research finds reading can boost brain function Many people can recall reading at least one cherished story that they say changed their life. Now researchers at Emory University have detected what may ...

LAST 30 PRESS RELEASES:

Millions of women rely on contraceptives, but new Rice study shows they may do more than just prevent pregnancy

Hot days make for icy weather, Philippine study finds

Roxana Mehran, MD, receives the most prestigious award given by the European Society of Cardiology

World's first clinical trial showing lubiprostone aids kidney function

Capturing language change through the genes

Public trust in elections increases with clear facts

Thawing permafrost raised carbon dioxide levels after the last ice age

New DNA test reveals plants’ hidden climate role

Retinitis pigmentosa mouse models reflect pathobiology of human RP59

Cell’s ‘antenna’ could be key to curing diseases

Tiny ocean partnership between algae and bacteria reveals secrets of evolution

Scientists uncover cellular “toolkit” to reprogram immune cells for cancer therapy

Blocking protein control pathway slows rhabdomyosarcoma growth in mice

2026 Hertz Fellowship Application Now Open

The gut immune system is altered in mouse model of Alzheimer’s, providing a new target for therapeutics

ADHD drugs are being prescribed too quickly to preschoolers

UCLA scientists develop off-the-shelf immunotherapy for metastatic kidney cancer

Extreme heat linked to spike in domestic violence calls in New Orleans, study finds

Mount Sinai-Duke University study identifies DNA variants that increase testosterone production in PCOS patients

Physiology-guided complete revascularization in older patients with myocardial infarction

Metals and sulfate in air pollution mixture may contribute most to asthma hospitalizations

Understanding the profound yet hidden effects of neglect on white matter structures

SEOULTECH researchers develop revolutionary 3D-printed smart materials create high-performance pressure sensors for wearables

Pusan National University scientists develop self-deploying material for next-gen robotics

Remote screening for asymptomatic atrial fibrillation

Inflammation may explain why women with no standard modifiable risk factors have heart attacks and strokes

Unusual carbon dioxide-rich disk detected around young star challenges planet formation models

Treetop Tutorials: Orangutans learn how to build their beds by peering at others and a lot of practice!

Scientists uncover key protein in cellular fat storage

Study finds significant health benefits from gut bugs transfer

[Press-News.org] Role of endoplasmic reticulum stress in the loss of RGCs in diabetic retinopathy