PRESS-NEWS.org - Press Release Distribution
PRESS RELEASES DISTRIBUTION

Macrophages target tumor cells following monoclonal antibody therapy

2014-01-16
(Press-News.org) Contact information: Corinne Williams
press_releases@the-jci.org
Journal of Clinical Investigation
Macrophages target tumor cells following monoclonal antibody therapy Monoclonal antibodies directed against tumor antigens have proven effective for treating some forms of cancer. Despite the increasing use of monoclonal antibody therapy, it is not clear how these antibodies drive tumor removal.

In this issue of the Journal of Clinical Investigation, Marjolein van Egmond and colleagues at the VU University Medical Center found that macrophage populations mediate tumor cell removal following monoclonal antibody treatment by actively phagocytosing tumor cells. Macrophage-dependent tumor cell removal required both the high affinity and low affinity Fc receptors.

This study suggests that monoclonal antibody therapies that are optimized to enhance macrophage recruitment and activity may enhance removal of circulating tumor cells in cancer patients.

INFORMATION:

TITLE: Macrophages eliminate circulating tumor cells after monoclonal antibody therapy

AUTHOR CONTACT: Marjolein van Egmond
VU University Medical Center, Amsterdam, , NLD
Phone: +3120 4445975; Fax: ; E-mail: m.vanegmond@vumc.nl

View this article at: http://www.jci.org/articles/view/66776?key=5bbe1c588bfc574caed3

END



ELSE PRESS RELEASES FROM THIS DATE:

Targeting a cell cycle inhibitor promotes beta cell replication

2014-01-16
Targeting a cell cycle inhibitor promotes beta cell replication One of the factors underlying the development of type 2 diabetes is loss of β cell mass, resulting in decreased insulin production. Once lost, β cell mass cannot be restored. In ...

Unraveling misfolded molecules using 'reprogrammed' yeast protein

2014-01-16
Unraveling misfolded molecules using 'reprogrammed' yeast protein Implications for new brain disease therapies PHILADELPHIA - At the heart of brain diseases such as amyotrophic lateral sclerosis (ALS), Alzheimer's disease, and Parkinson's ...

The symphony of life, revealed

2014-01-16
The symphony of life, revealed A new imaging technique captures the vibrations of proteins, tiny motions critical to human life BUFFALO, N.Y. — Like the strings on a violin or the pipes of an organ, the proteins in the human body vibrate in different patterns, scientists ...

How metabolism and brain activity are linked

2014-01-16
How metabolism and brain activity are linked Study sheds light on why diet may help control seizures in epilepsy patients A new study by scientists at McGill University and the University of Zurich shows a direct link between metabolism in brain cells and ...

Study identifies drug that could improve treatment of PTSD

2014-01-16
Study identifies drug that could improve treatment of PTSD New study identifies drug that could improve treatment of post-traumatic stress disorder CAMBRIDGE, Mass-- Nearly 8 million Americans suffer from posttraumatic stress disorder (PTSD), a condition ...

Preventing cell death from infection: Scientists demonstrate method to find new therapies

2014-01-16
Preventing cell death from infection: Scientists demonstrate method to find new therapies LA JOLLA, CA—January 16, 2014—Scientists at The Scripps Research Institute (TSRI) have demonstrated the power of a new drug discovery technique, which allows them to find—relatively ...

5,900 natural gas leaks discovered under Washington, D.C.

2014-01-16
5,900 natural gas leaks discovered under Washington, D.C. A dozen locations had concentrations high enough to trigger explosion DURHAM, NC – More than 5,893 leaks from aging natural gas pipelines have been found under the streets of Washington, D.C. by a research team from Duke ...

Scientists discover 2 proteins that control chandelier cell architecture

2014-01-16
Scientists discover 2 proteins that control chandelier cell architecture Chandelier cells, a group of powerful inhibitory neurons, are important in epilepsy and schizophrenia Cold Spring Harbor, NY – Chandelier cells are neurons that use their unique shape to ...

Research sheds new light on heritability of disease

2014-01-16
Research sheds new light on heritability of disease Study explores the role DNA plays to predispose individuals to diseases BOSTON - A group of international researchers, led by a research fellow in the Harvard Medical School-affiliated ...

Immune cells may heal an injured heart

2014-01-16
Immune cells may heal an injured heart The immune system plays an important role in the heart's response to injury. But until recently, confusing data made it difficult to distinguish the immune factors that encourage the heart to heal following ...

LAST 30 PRESS RELEASES:

Oil rig study reveals vital role of tiny hoverflies

Children’s Hospital of Philadelphia researchers boost widespread use of dental varnish across pediatric network

iRECODE: A new computational method that brings clarity to single-cell analysis

New NUS-MOH study: Singapore’s healthcare sector carbon emissions 18% lower than expected, a milestone in the city-state’s net zero journey

QUT scientists create material to turn waste heat into clean power

Major new report sets out how to tackle the ‘profound and lasting impact’ of COVID-19 on cardiovascular health

Cosmic crime scene: White dwarf found devouring Pluto-like icy world

Major report tackles Covid’s cardiovascular crisis head-on

A third of licensed GPs in England not working in NHS general practice

ChatGPT “thought on the fly” when put through Ancient Greek maths puzzle

Engineers uncover why tiny particles form clusters in turbulent air

GLP-1RA drugs dramatically reduce death and cardiovascular risk in psoriasis patients

Psoriasis linked to increased risk of vision-threatening eye disease, study finds

Reprogramming obesity: New drug from Italian biotech aims to treat the underlying causes of obesity

Type 2 diabetes may accelerate development of multiple chronic diseases, particularly in the early stages, UK Biobank study suggests

Resistance training may improve nerve health, slow aging process, study shows

Common and inexpensive medicine halves the risk of recurrence in patients with colorectal cancer

SwRI-built instruments to monitor, provide advanced warning of space weather events

Breakthrough advances sodium-based battery design

New targeted radiation therapy shows near-complete response in rare sarcoma patients

Does physical frailty contribute to dementia?

Soccer headers and brain health: Study finds changes within folds of the brain

Decoding plants’ language of light

UNC Greensboro study finds ticks carrying Lyme disease moving into western NC

New implant restores blood pressure balance after spinal cord injury

New York City's medical specialist advantage may be an illusion, new NYU Tandon research shows

Could a local anesthetic that doesn’t impair motor function be within reach?

1 in 8 Italian cetacean strandings show evidence of fishery interactions, with bottlenose and striped dolphins most commonly affected, according to analysis across four decades of data and more than 5

In the wild, chimpanzees likely ingest the equivalent of several alcoholic drinks every day

Warming of 2°C intensifies Arctic carbon sink but weakens Alpine sink, study finds

[Press-News.org] Macrophages target tumor cells following monoclonal antibody therapy