Traditional Chinese medicines stall progression of diabetes

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The Endocrine Society
Traditional Chinese medicines stall progression of diabetes Clinical trial found herbs comparable to prescriptions for controlling prediabetes Chevy Chase, MD—Traditional Chinese herbal medicines hold promise for slowing the progression from prediabetes to an official diabetes diagnosis, according to new research accepted for publication in the Endocrine Society's Journal of Clinical Endocrinology & Metabolism (JCEM).

Prediabetes is diagnosed an individual has developed elevated blood sugar levels, but glucose levels have not yet risen to the point of developing type 2 diabetes. People who are prediabetic face a heightened risk of developing type 2 diabetes as well as heart disease and stroke. According to the Centers for Disease Control and Prevention, about 79 million American adults age 20 years or older have prediabetes.

"With diabetes evolving into a serious public health burden worldwide, it is crucial to take steps to stem the flood of cases," said one of the study's authors, Chun-Su Yuan, MD, PhD, of the University of Chicago. "Patients often struggle to make the necessary lifestyle changes to control blood sugar levels, and current medications have limitations and can have adverse gastrointestinal side effects. Traditional Chinese herbs may offer a new option for managing blood sugar levels, either alone or in combination with other treatments."

During the double-blind, randomized, placebo-controlled trial, 389 participants at 11 research sites in China were randomly assigned to take either a capsule containing a mixture of 10 Chinese herbal medicines or a placebo. For a year, subjects took capsules of either the Chinese herb mixture, called Tianqi, or the placebo three times a day before meals. All participants received a month of lifestyle education at the outset of the trial and met with nutritionists several times during the course of the study. Subjects' glucose tolerance was measured on a quarterly basis.

At the end of the trial, 36 participants in the Tianqi group and 56 in the placebo group had developed diabetes. The analysis found taking Tianqi reduced the risk of diabetes by 32.1 percent compared with the placebo, after adjusting for age and gender. The overall reduction in risk was comparable to that found in studies of diabetes medications acarbose and metformin, and study participants reported few side effects from the Tianqi herbs. Tianqi includes several herbs that have been shown to lower blood glucose levels and improve control of blood glucose levels after meals.

"Few controlled clinical trials have examined traditional Chinese medicine's impact on diabetes, and the findings from our study showed this approach can be very useful in slowing the disease's progression," said one of the study's lead authors, Xiaolin Tong, MD, PhD, of Guang'anmen Hospital in Beijing, China, said. "More research is needed to evaluate the role Chinese herbal medicine can play in preventing and controlling diabetes."

### Other authors of the study include: F. Lian, X. Chen, Y. Bai and Z. Zhen of Guang'anmen Hospital; G. Li and Y. An of Fuwai Hospital of Cardiovascular Disease in Beijing; X. Wang of Beijing Pinggu Hospital of Traditional Chinese Medicine in Beijing; C. Piao of the Affiliated Hospital to Changchun University of Chinese Medicine in Changchun, China; J. Wang of Beijing Mentougou Hospital of Traditional Chinese Medicine in Beijing; Y. Hong of Hangzhou Hospital of Traditional Chinese Medicine in Hangzhou, China; Z. Ba of Qinghai Hospital of Traditional Chinese Medicine in Quinghai, China; S. Wu of First Teaching Hospital of Tianjin University of Traditional Chinese Medicine in Tianjin, China; X. Zhou of Guangzhou Tianhe Hospital of Traditional Chinese Medicine in Guangzhou, China; J. Lang of Foshan Hospital of Traditional Chinese Medicine in Foshan, China; Y. Liu of Beijing Huimin Hospital in Beijing; R. Zhang of Yangquan First Municipal People's Hospital in Yangquan, China; J. Hao and Q. Wang of Guangzhou Huangpu Hospital of Traditional Chinese Medicine in Guangzhou; Z. Zhu of First Affiliated Hospital of Guangzou University of Chinese Medicine in Guangzhou; H. Li of Shenzhen Hospital of Traditional Chinese Medicine in Shenzhen, China; H.F. Liu of Dongzhimen Hospital affiliated to Beijing University of Chinese Medicine in Beijing; A. Cao of Beijing Changping Hospital of Traditional Chinese Medicine in Beijing; Z. Yan of China Academy of Chinese Medical Sciences in Beijing; and C. Yu and C.-Z. Wang of the Tang Center for Herbal Medicine Research at the University of Chicago.

The study, "Chinese Herbal Medicine Tianqi Reduces Progression from Impaired Glucose Tolerance to Diabetes: A Double-Blind, Randomized, Placebo-Controlled, Multicenter Trial," appears in the February issue of JCEM.

Founded in 1916, the Endocrine Society is the world's oldest, largest and most active organization devoted to research on hormones and the clinical practice of endocrinology. Today, the Endocrine Society's membership consists of over 17,000 scientists, physicians, educators, nurses and students in more than 100 countries. Society members represent all basic, applied and clinical interests in endocrinology. The Endocrine Society is based in Chevy Chase, Maryland. To learn more about the Society and the field of endocrinology, visit our site at http://www.endocrine.org. Follow us on Twitter at https://twitter.com/#!/EndoMedia.