(Press-News.org) Women in counties with repeatedly lower cervical cancer screening rates suffer nearly double the rate of cervical cancer diagnoses, particularly of late-stage disease, and death from cervical cancer, according to a new analysis from researchers at MUSC Hollings Cancer Center.
Trisha Amboree, Ph.D., is part of a team of researchers that has previously shown that cervical cancer incidence and death rates are higher in low-income and rural U.S. counties. Those papers analyzed the numbers but couldn’t explore the reasons why incidence and death were higher.
“We know that higher screening uptake prevents disease and subsequent mortality,” she said.
In the absence of a national screening registry in the U.S., there has been no way to tie individual screening histories to cancer outcomes nationally, so researchers look at county-level metrics to assess this with measurable outcomes.
“In the previous papers, we didn't have any individual-level screening data. This paper helps to contextualize our previous findings to say what we're seeing is at least probably partially a result of repeatedly low screening.”
Timely screening can identify precancerous lesions for removal before they develop into cancer and also allows medical providers to diagnose cancer at an early stage, when it is far more likely that someone can be treated successfully. The current paper published in JAMA Network Open looked at county-level screening data from 2004 through 2016, broken into three time periods. The researchers labeled counties as repeatedly low-screening if in at least two of the three time periods fewer than 70% of eligible women in that county were screened. They were labeled as repeatedly high-screening if at least 80% were screened. Nationally, the cervical cancer screening goal is 79.2%.
Most counties fell into the in-between category. But when comparing the repeatedly low-screening counties with the repeatedly high-screening counties, the researchers found that diagnosis of distant-stage cervical cancer was 84% higher in low-screening counties, and deaths were 96% higher in low-screening counties.
The researchers also showed that nearly all the low-screening counties were rural, and all of them had an annual median household income of less than $75,000.
This latest analysis reinforces the need for improved access to screening and treatment, particularly in rural and low-income counties, the researchers said.
Cervical cancer screening in South Carolina
The current paper looks at data from a national database that covers about a third of the U.S. population, including states as varied as California, New York, Texas, Georgia and Idaho.
South Carolina data isn’t part of this national database, but it’s likely that the trends that the researchers uncovered are observed here as well, Amboree said.
Gynecologists or family physicians generally perform cervical cancer screenings. But the South Carolina Area Health Education Consortium reports that 14 counties in South Carolina have no obstetrician-gynecologists. Several counties have only a handful – or as few as one – family practice physicians.
Hollings supplements this lack of screening options through its Mobile Health Unit, which offers cervical cancer screening and travels to medically underserved areas of the state.
Current screening recommendations from the U.S. Preventive Services Task Force for average-risk women are that those ages 21 to 65 should receive a Pap smear every three years, or those ages 30 to 65 years should receive HPV testing (alone or with a Pap) every five years.
###
About MUSC Hollings Cancer Center
MUSC Hollings Cancer Center is South Carolina’s only National Cancer Institute-designated cancer center with the largest academic-based cancer research program in the state. With more than 230 faculty cancer scientists from 20 academic departments, it has an annual research funding portfolio of more than $50 million and sponsors more than 200 clinical trials across the state. Hollings specialists include surgeons, medical oncologists, radiation oncologists, radiologists, pathologists, psychologists and other clinical providers equipped to provide the full range of cancer care from diagnosis to survivorship. Hollings offers state-of-the-art cancer screenings, diagnostics, therapies and surgical techniques within its multidisciplinary clinics. Dedicated to preventing and reducing the cancer burden statewide, the Hollings Office of Community Outreach and Engagement works with community organizations to bring cancer education and prevention information to affected populations throughout the state. For more information, visit hollingscancercenter.musc.edu
END
(Santa Barbara, Calif.) — On May 12, 2008, the magnitude 7.9 Wenchuan Earthquake shook central China, its destructive tremors spreading from the flank of the Longmen Shan, or Dragon's Gate Mountains, along the eastern margin of the Tibetan Plateau.
Over 69,000 people died in the disaster, nearly a third are thought to be from geohazards like the more than 60,000 landslides that rushed down the slopes of the Longmen Shan.
After more than a decade and a half of work, scientists finally have an account of the fate of the landslide debris. Surveys of a reservoir downstream of the epicenter revealed how and how quickly the region’s ...
The discovery of new fossils and a new species of ancient ancestor may help shift the perception of human evolution from linear evolution to that of a tree with many branches, new UNLV research published today in the journal Nature shows.
UNLV anthropologist Brian Villmoare and a team of international scientists discovered new fossils at a field site in Ethiopia that indicate Australopithecus, and the oldest specimens of Homo, coexisted between 2.6 and 2.8 million years ago at the same place in Africa.
The ...
Iceberg calving occurs when masses of ice break away from the edge of glaciers and crash into the ocean. This process is one of the major drivers of the rapid mass loss currently affecting the Greenland ice sheet. An international research team led by the University of Zurich (UZH) and the University of Washington (UW) has now used fiber-optic technology to measure for the first time how the impact of falling ice and its subsequent drift is driving the mixing of glacial melt with warmer subsurface seawater.
“The warmer water increases seawater-induced melt erosion and eats away at the base of the vertical wall of ice at the glacier’s edge. This, in turn, ...
AMHERST, Mass. — An international team of researchers led by the University of Massachusetts Amherst has tracked changes in more than 114,000 rivers in High-mountain Asia over a 15-year period. The paper, published in AGU Advances, reported that nearly 10% of these rivers saw an increase in flow, with an increasing proportion of that water coming from glacial ice melt compared to precipitation.
This water serves billions of people from China, India and Southeast Asia to Turkmenistan; is sensitive to climate change; and plays a key role in the sustainable development of this region through ...
“The ability of PCAIs to mitigate various cancer hallmarks in the various cancer cell lines has been well established.”
BUFFALO, NY – August 13, 2025 – A new research paper was published in Volume 16 of Oncotarget on July 29, 2025, titled “PCAIs stimulate MAPK, PI3K/AKT pathways and ROS-Mediated apoptosis in aromatase inhibitor-resistant breast cancer cells while disrupting actin filaments and focal adhesion.”
In this study, led by first author Jassy Mary ...
INDIANAPOLIS -- Regenstrief Institute’s latest LOINC® content update on August 12, introduces two new linguistic variants: Arabic, for users in Jordan, and Czech, for users in the Czech Republic. With these additions, LOINC is now available in 22 languages.
“Expanding the number of supported languages improves the accessibility and adoption of LOINC around the world,” said Marjorie Rallins, DPM, M.S., executive director of Health Data Standards (HDS) at Regenstrief. “Making LOINC content available in more languages strengthens interoperability by enabling users to work with data in ...
LOS ANGELES — A new drug-releasing system, TAR-200, eliminated tumors in 82% of patients in a phase 2 clinical trial for individuals with high-risk non-muscle-invasive bladder cancer whose cancer had previously resisted treatment.
In the majority of cases, the cancer disappeared after only three months of treatment, and almost half the patients were cancer-free a year later.
“Traditionally, these patients have had very limited treatment options. This new therapy is the most effective one reported to date for the most common form of bladder cancer,” said Sia Daneshmand, MD, director of urologic oncology with Keck ...
A public-private partnership between Commonwealth Fusion Systems (CFS), the U.S. Department of Energy’s (DOE) Princeton Plasma Physics Laboratory (PPPL) and Oak Ridge National Laboratory has led to a new artificial intelligence (AI) approach that is faster at finding what’s known as “magnetic shadows” in a fusion vessel: safe havens protected from the intense heat of the plasma.
Known as HEAT-ML, the new AI could lay the foundation for software that significantly speeds up the design of future fusion systems. Such software could also enable good decision-making during fusion operations by adjusting the plasma so that ...
Late nights, alcohol, and smoking on weekends may be doing more than disrupting your Monday mornings, they could be triggering a newly identified sleep health concern known as ‘social apnea’, warn researchers from Flinders University.
Published in the prestigious American Journal of Respiratory and Critical Care Medicine, the international study introduces social apnea as a novel trend in sleep medicine referring to the weekend spike in Obstructive Sleep Apnea (OSA) severity, driven by lifestyle choices and irregular sleep patterns.
The research, which analysed data from over 70,000 people worldwide, found a consistent ...
Florida Atlantic University’s Charles E. Schmidt College of Science has been awarded a $700,000 grant from the United States Environmental Protection Agency Gulf of America Division to support a novel research project aimed at advancing water quality monitoring in one of Florida’s most critical freshwater ecosystems.
Led by Natalia Malina, Ph.D., principal investigator and an assistant professor in FAU’s Department of Chemistry and Biochemistry within the Charles E. Schmidt College of Science, the three-year project titled, “Developing ...