PRESS-NEWS.org - Press Release Distribution
PRESS RELEASES DISTRIBUTION

NIH scientists explore 1510 influenza pandemic and lessons learned

2010-11-13
(Press-News.org) History's first recognized influenza pandemic originated in Asia and rapidly spread to other continents 500 years ago, in the summer of 1510. A new commentary by researchers at the National Institute of Allergy and Infectious Diseases, part of the National Institutes of Health, explores the 1510 pandemic and what we have learned since then about preventing, controlling and treating influenza.

Prior to that time, regional and local epidemics of respiratory infectious diseases and pneumonia had occurred, but no outbreaks had yet been recorded on a worldwide scale. The 1510 pandemic first arose in Asia, but it spread quickly to Africa and Europe via trade routes. Although the disease—which was then referred to by various descriptive terms such as "gasping oppression"—was highly infectious, the death rate was low, and the pandemic ended quickly.

The authors concede that the emergence of new pandemic influenza viruses remains as unpredictable as it was 500 years ago. But they outline a host of scientific and public health advances that have taken place since then—from the study of microbiology to the development of vaccines and treatment—that now allow us to better plan and prepare for both seasonal and pandemic influenza. For example, scientists at NIAID and elsewhere are currently researching the possibility of a universal influenza vaccine, which would aim to protect individuals from all strains of flu.

###

For more information about NIAID research on influenza, visit the NIAID Flu Web portal at http://www.niaid.nih.gov/topics/Flu/Pages/default.aspx.

ARTICLE: DM Morens et al. Pandemic influenza's 500th anniversary (http://dx.doi.org/10.1086/657429). Clinical Infectious Diseases. DOI: 10.1086/657429 (2010).

Anthony S. Fauci, M.D., Director, NIAID, and David M. Morens, M.D., Senior Advisor to the NIAID Director, are available to comment on this article.

CONTACT: To schedule interviews, please contact Nalini Padmanabhan, 301-402-1663, niaidnews@niaid.nih.gov.

NIAID conducts and supports research—at NIH, throughout the United States, and worldwide—to study the causes of infectious and immune-mediated diseases, and to develop better means of preventing, diagnosing and treating these illnesses. News releases, fact sheets and other NIAID-related materials are available on the NIAID Web site at http://www.niaid.nih.gov.

The National Institutes of Health (NIH)—The Nation's Medical Research Agency—includes 27 Institutes and Centers and is a component of the U. S. Department of Health and Human Services. It is the primary federal agency for conducting and supporting basic, clinical and translational medical research, and it investigates the causes, treatments and cures for both common and rare diseases. For more information about NIH and its programs, visit http://www.nih.gov.

END



ELSE PRESS RELEASES FROM THIS DATE:

Mathematical model of the life cycle of red blood cells may predict risk of anemia

2010-11-13
A collaboration between a physician-researcher at Massachusetts General Hospital (MGH) and a mathematician from Harvard University has led to development of a mathematical model reflecting how red blood cells change in size and hemoglobin content during their four-month lifespan. In their report published online in PNAS Early Edition, John Higgins, MD, MGH Center for Systems Biology and Department of Pathology, and L. Mahadevan, PhD, Harvard School of Engineering and Applied Sciences (SEAS), also describe how their model may be used to provide valuable clinical information. "This ...

Addex highlights strength of allosteric modulation technology platform

2010-11-13
Geneva, Switzerland, 12 November 2010 – Allosteric modulation company Addex Pharmaceuticals (SIX:ADXN) announced today that data on a total of nine therapeutic programs will be presented during Society for Neuroscience 2010 (November 13-17, San Diego, USA), highlighting the strength of its allosteric modulation technology platform. The data being presented cover multiple receptor types and therapeutic areas, including Parkinson's disease, schizophrenia, anxiety, Alzheimer's disease and depression. "The data generated by Addex and our partners, Ortho-McNeil-Janssen and ...

Virus component helps improve gene expression without harming plant

2010-11-13
COLLEGE STATION -- A virus that normally deforms or kills plants like tomatoes, peppers and eggplants isn't all bad: A gene within the virus has been found useful for allowing foreign genes to be introduced into a plant without harmful effects, according to Texas AgriLife Research scientists. The technology ultimately could lead the way toward a "cheap, green alternative" for pharmaceutical development, said Dr. Herman Scholthof, AgriLife Research virologist. Scholthof and colleague Drs. Yi-Cheng Hsieh and Veria Alvarado collaborated with scientists at the John Innes ...

Key player in detoxification pathway isolated after decades of searching

2010-11-13
Chemical reactions are happening all over the place all the time--on the sun, on the Earth and in our bodies. In many cases, enzymes help make these reactions occur. One family of enzymes, called cytochrome P450s (P450), is important because they help us eliminate toxins. We know P450s are important to life of all kinds because they have been found in animals, plants, fungi and bacteria, but they are of special interest to humans because they are responsible for metabolism of about 75 percent of known pharmaceuticals. "The reactions that P450s perform to detoxify a ...

No difference in nonsuicide mortality between 2 anti-psychotic drugs

2010-11-13
PHILADELPHIA - The potential for harmful side effects associated with anti-psychotic medications for treating schizophrenia is a frustration for mental-health professionals who must balance this with the positive benefits of drugs. For example, the issue of the antipsychotic drug ziprasidone lengthening the QTc interval, a possible indicator of life-threatening heart arrhythmias, has demanded much attention among clinicians since the drug was introduced in 2001. Ziprasidone (marketed as Geodon and Zeldox by Pfizer Inc.) was the fifth second-generation anti-psychotic ...

30 years on in the epicenter of the African AIDS epidemic

2010-11-13
The impact of 30 years of HIV on an area once described as the epicentre of the African AIDS epidemic will be discussed at a lecture hosted by the University of East Anglia (UEA) in London this month. Progressive declines in agricultural production, with dire consequences for rural livelihoods, were originally predicted as a result of the long-term effects of HIV and AIDS in central and south western Uganda. However, recent research has shown that those forecasts have not come true. The lecture "30 years into the HIV epidemic in South West Uganda and the rural economy ...

Anesthetics and Alzheimer's disease

2010-11-13
Amsterdam, The Netherlands and San Antonio, TX, USA, November 12, 2010 – There is growing global concern regarding the potential neurotoxicity of anesthetics. Biophysical and animal model studies have identified molecular changes simulating Alzheimer's disease (AD) pathology after exposure to inhaled anesthetics. This research has alerted anesthesiologists, neuropsychologists, surgeons and other clinicians to initiate in-depth clinical research on the role of anesthetics in post operative cognitive decline. AD is a devastating disease commonly found in elderly persons ...

Catastrophic drought looms for capital city of Bolivia

Catastrophic drought looms for capital city of Bolivia
2010-11-13
Catastrophic drought is on the near-term horizon for the capital city of Bolivia, according to new research into the historical ecology of the Andes. If temperatures rise more than 1.5 to 2 degrees Celsius (3 to 5 degrees Fahrenheit) above those of modern times, parts of Peru and Bolivia will become a desert-like setting. The change would be disastrous for the water supply and agricultural capacity of the two million inhabitants of La Paz, Bolivia's capital city, scientists say. The results, derived from research funded by the National Science Foundation (NSF) and ...

Myocarditis can attack hearts without warning

2010-11-13
James "Jimmy" Armstrong hadn't missed a "Mac" in 28 years. At 44, he's one of the youngest "goats" in the Chicago Yacht Club. Sailors receive the designation of "goat" once they've completed 20 or more "Macs", the 333-mile boat race from Chicago to Mackinac, Mich. Armstrong has sailed the race every year since he was 16. But, he wasn't among the sailors this past July. Instead, he was in intensive care awaiting heart transplant following a harrowing experience spurred by severe case of myocarditis—a little-known condition causing inflammation of the heart muscle. "I ...

Cystic fibrosis gene typo is a double whammy

2010-11-13
CHAPEL HILL – An imbalance of salt and water in patients with cystic fibrosis makes their lungs clog up with sticky mucus that is prone to infection. The cause of the offending imbalance is a well-known genetic error, one that blocks the molecular expressway for tiny chloride ions to move across the surface of the lungs. But how does that same gene mutation upset a parallel roadway controlling the flow of the other component of salt, sodium ions? Now, researchers at the University of North Carolina at Chapel Hill School of Medicine have found the answer, demonstrating ...

LAST 30 PRESS RELEASES:

Quality and quantity? The clinical significance of myosteatosis in various liver diseases

Expert consensus on clinical applications of fecal microbiota transplantation for chronic liver disease (2025 edition)

Insilico Medicine to present three abstracts at the 2026 Crohn’s & Colitis Congress highlighting clinical, preclinical safety, and efficacy data for ISM5411, a novel gut-restricted PHD1/2 inhibitor fo

New imaging technology detects early signs of heart disease through the skin

Resurrected ancient enzyme offers new window into early Earth and the search for life beyond it

People with obesity may have a higher risk of dementia

Insilico Medicine launches science MMAI gym to train frontier LLMs into pharmaceutical-grade scientific engines

5 pre-conference symposia scheduled ahead of International Stroke Conference 2026

To explain or not? Need for AI transparency depends on user expectation

Global prevalence, temporal trends, and associated mortality of bacterial infections in patients with liver cirrhosis

Scientists discover why some Central Pacific El Niños die quickly while others linger for years

CNU research explains how boosting consumer trust unlocks the $4 billion market for retired EV batteries

Reimagining proprioception: when biology meets technology

Chungnam National University study finds climate adaptation can ease migration pressures in Africa

A cigarette compound-induced tumor microenvironment promotes sorafenib resistance in hepatocellular carcinoma via the 14-3-3η-modified tumor-associated proteome

Brain network disorders study provides insights into the role of molecular chaperones in neurodegenerative diseases

Making blockchain fast enough for IoT networks

Chemotherapy rewires gut bacteria to curb metastasis

The hidden microbial communities that shape health in space

Arctic cloud and ice formation affected by Russian river runoff as region studied for first time

Study reveals synergistic effect of CDK2 and CDK4/6 combination therapy

Living walls boost biodiversity by providing safe spaces for urban wildlife

New AI method revolutionizes the design of enzymes

Smartwatch use enhances the detection of heart arrythmias, increasing the quality of care.

MAN PPK2: A “universal” enzyme for the production of RNA building blocks

Sniffing out the cause of keratoderma-associated foot odor

Tuning color through molecular stacking: A new strategy for smarter pressure sensors

Humans use local dialects to communicate with honeyguides

Theory-breaking extremely fast-growing black hole

ŌURA and National University of Singapore open Joint Lab to advance research in personalized preventive health

[Press-News.org] NIH scientists explore 1510 influenza pandemic and lessons learned