PRESS-NEWS.org - Press Release Distribution
PRESS RELEASES DISTRIBUTION

Comparison of drug-releasing stents show similar safety outcomes after 2 years

2014-03-31
(Press-News.org) A comparison of the safety of biodegradable polymer biolimus-eluting stents vs durable polymer everolimus-eluting stents finds similar outcomes for measures including death and heart attack after two years, according to a JAMA study released online to coincide with presentation at the 2014 American College of Cardiology Scientific Sessions.

Recent studies have raised concerns about the safety of biodegradable polymer drug-eluting stents (BP-DES) compared with durable polymer everolimus-eluting stents (DP-EES). The NOBORI Biolimus-Eluting vs XIENCE/PROMUS Everolimus-Eluting Stent Trial (NEXT) is a study evaluating the efficacy and safety of biodegradable polymer biolimus-eluting stents (BP-BES) vs. DP-EES. The primary efficacy outcome of target-lesion revascularization (restoration of blood flow in coronary arteries) at 1 year demonstrated noninferiority (not worse than) of BP-BES compared with DP-EES. However, the advantages of BP-BES could emerge beyond 1 year when polymer has fully degraded, according to background information in the article. Masahiro Natsuaki, M.D., of Saiseikai Fukuoka General Hospital, Fukuoka, Japan, and colleagues examined outcomes of this trial after two years.

Of 3,235 patients, 1,617 were randomly assigned to receive BP-BES and 1,618 to DP-EES. The researchers found that treatment outcomes with BP-BES were noninferior to DP-EES for death or heart attack (7.8 percent vs 7.7 percent, respectively) and target-lesion revascularization (TLR) (6.2 percent vs 6.0 percent). The rates of death or heart attack and TLR were not significantly different between the groups at 2 years.

"In NEXT, the safety and efficacy outcomes of BP-BES were noninferior to those of DP-EES at 2 years. However, 2 years is not long enough to confirm the long-term safety of BP-BES, and the study was underpowered for the interim analysis. Follow-up at 3 years will be important," the authors write. INFORMATION: (doi:10.1001/jama.2014.3584 Available pre-embargo to the media at http://media.jamanetwork.com)

Editor's Note: Please see the article for additional information, including other authors, author contributions and affiliations, financial disclosures, funding and support, etc.


ELSE PRESS RELEASES FROM THIS DATE:

Six new Dracula ants from Madagascar: Minor workers become queens in Mystrium

Six new Dracula ants from Madagascar: Minor workers become queens in Mystrium
2014-03-31
Six new species of Dracula ants from the Malagasy region have been discovered by scientists at the California Academy of Sciences. The discoveries, by postdoctoral fellow Masashi Yoshimura from Japan and curator of entomology Brian L. Fisher, represent a completely new twist in the typically rigid caste system of ants, where anatomy is typically destiny. The study was published in the open access journal ZooKeys. "The genus Mystrium is the most mysterious group within the bizarre Dracula ants," said Yoshimura. Mystrium species have unique features such as long, spatulate ...

Study further illuminates heart-healthy benefits of Mediterranean diet

2014-03-31
(WASHINGTON, March 31, 2014) – New research further illuminates the heart-healthy benefits of the Mediterranean diet, tying the eating plan to lower levels of platelets and white blood cells, two markers of inflammation. Inflammation has an association with greater risk of heart attack and stroke. Study, results are published online today in Blood, the Journal of the American Society of Hematology (ASH). The Mediterranean diet, characterized by generous servings of foods such as greens, whole grains, fish, and olive oil, has long been hailed as a heart-healthy eating ...

Scientists discover a number of novel genetic defects which cause oesophageal cancer

2014-03-31
A team of scientists from the Cancer Science Institute of Singapore (CSI Singapore) at the National University of Singapore and National University Cancer Institute Singapore (NCIS), and their collaborators from the Cedars-Sinai Medical Centre, UCLA School of Medicine, demonstrated that a number of novel genetic defects are able to induce oesophageal cancer. The research group, led by Professor H. Phillip Koeffler, Senior Principal Investigator at CSI Singapore and Deputy Director of NCIS, has conducted a successful comprehensive genomic study of oesophageal squamous ...

What will climate policy mean for coal?

2014-03-31
Limiting climate change to 2°C means shutting down coal power plants - an unpopular proposition for coal power companies. But a new study shows that delaying climate policies could prove even worse for power plant owners. Coal power plants are a major source of greenhouse gas emissions, and new plants are planned around the world, particularly in India and China. These new power plants are built to run for 30-50 years, paying off only after years of operation. But stringent climate policies could make the cost of emission so high that coal power generation is no longer ...

Online self-injury information often inaccurate, study finds

2014-03-31
People seeking help or information online about cutting and other forms of self-injury are likely finding falsehoods and myths, according to new research from the University of Guelph. Only about 10 per cent of websites providing information about non-suicidal self-injury (NSSI) are endorsed by health or academic institutions, according to a study published recently in JAMA Pediatrics, a journal of the American Medical Association. It's a troubling finding, says lead author Stephen Lewis, a Guelph psychology professor. "This is a salient public health issue," he said. People ...

Tamiflu-resistant influenza: Parsing the genome for the culprits

2014-03-31
Tamiflu is one of the few available treatments for those who come down with the flu. But the virus quickly develops resistance; multiplying at a rate of several generations a day, these tiny pathogens rapidly accumulate genetic mutations. Because of this, they have a good chance of developing counterattacks to the antiviral. How can these infinitesimal variations be identified within the immensity of the virus' genetic code? EPFL researchers have created a computer tool that can shed light on the flu virus' formidable adaptability. They were able to find mutations that ...

Using different scents to attract or repel insects

Using different scents to attract or repel insects
2014-03-31
Flowering plants attract pollinating insects with scent from their flowers and bright colours. If they have become infested with herbivores like caterpillars, they attract beneficial insects like parasitic wasps with the help of scent signals from their leaves. The wasps then lay their eggs in the caterpillars and kill the parasites. Floral and foliar scents can, however, mutually reduce their attractiveness. That's why flowering plants face a dilemma: should they use their resources to attract pollinating insects and, by extension, for reproduction or should they invest ...

'Cosmic barometer' could reveal violent events in universe's past

2014-03-31
Exploding stars, random impacts involving comets and meteorites, and even near misses between two bodies can create regions of great heat and high pressure. Researchers from Imperial College London have now developed a method for analysing the pressure experienced by tiny samples of organic material that may have been ejected from dying stars before making a long journey through the cosmos. The researchers have investigated a type of aromatic hydrocarbon called dimethylnaphthalene, which should enable them to identify violent events in the history of the universe. Samples ...

Hearing loss affects old people's personality

Hearing loss affects old peoples personality
2014-03-31
The researchers studied 400 individuals 80-98 years old over a six-year period. Every two years, the subjects were assessed in terms of physical and mental measures as well as personality aspects such as extraversion, which reflects the inclination to be outgoing, and emotional stability. The results show that even if the emotional stability remained constant over the period, the participants became less outgoing. Interestingly, the researchers were not able to connect the observed changes to physical and cognitive impairments or to age-related difficulties finding social ...

Mild hypothermia for treatment of diffuse axonal injury: A quantitative DTI analysis

Mild hypothermia for treatment of diffuse axonal injury: A quantitative DTI analysis
2014-03-31
Mild hypothermia has been shown to exert apparent neuroprotective effects in animal models of diffuse axonal injury. However, the clinical efficacy of mild hypothermia is controversial. Thus, a noninvasive, accurate, and objective technique is urgently required to verify the effect of mild hypothermia in diffuse axonal injury and its prognosis. Fractional anisotropy values in diffusion tensor imaging (DTI) can quantitatively reflect the consistency of nerve fibers after brain damage, where higher values generally indicate less damage to nerve fibers. Therefore, Guojie Jing ...

LAST 30 PRESS RELEASES:

Women’s brain regions may lose ability to synchronize after sexual assault

Quitting smoking, even late in life, linked to slower cognitive decline

Critical raw materials are a vital new currency; Europe’s e-waste is the vault

Anesthesiologist-led care helps hip-fracture patients get to surgery faster, with fewer complications

Two-dose recombinant shingles vaccine is effective even accounting for prior receipt of live shingles vaccine

Excessive daytime sleepiness may raise risk of cognitive problems after surgery

Flipping the switch on sperm motility offers new hope for male infertility

Twisting sound: Scientists discover a new way to control mechanical vibrations in metamaterial

Drip by drip: The hidden blueprint for stalagmite growth

mRNA therapy restores sperm production and fertility in mice

New way to weaken cancer cells could supercharge prostate cancer treatment

How sound—but not touch—shapes rhythm in the brain

Exploring the therapeutic potential of hypothermia

Research alert: Bioengineering breathes new life into failed cancer treatment

AI, health, and health care today and tomorrow – the JAMA Summit Report on artificial intelligence

Large genetic study links cannabis use to psychiatric, cognitive and physical health

Social media use trajectories and cognitive performance in adolescents

Music for the brain: Study tests the effect of slow-tempo relaxing music to address delirium in critically ill older adults 

AI models predict sepsis in children, allow preemptive care

Liraglutide vs semaglutide vs dulaglutide in veterans with type 2 diabetes

Antenatal corticosteroids and infectious diseases throughout childhood

New lab-grown human embryo model produces blood cells

Life after near death: Research reveals how to improve support for near-death experiencers

Illinois Chat is launched for campus community

FAU receives $3M federal grant to prevent substance use in at-risk youth

New report shows action to improve gender equity linked to career gains and better business performance

Kiwis could help manage chronic constipation

Breast, lung, and bladder cancer phase 3 trials led by Dana-Farber presented at ESMO Congress 2025

New open-source software allows for efficient 3D printing with multiple materials

Decoding the secrets of ‘chemo brain’

[Press-News.org] Comparison of drug-releasing stents show similar safety outcomes after 2 years