Contact Information:
Katie Babcock
katie.babcock@utoronto.ca
416-978-7361
University of Toronto



Kredyty mieszkaniowe Kredyty mieszkaniowe

Sprawdź aktualny ranking najlepszych kredytów mieszkaniowych w Polsce - atrakcyjne kredytowanie nieruchomości.
PRESS-NEWS.org - Press Release Distribution
FREE PRESS RELEASES DISTRIBUTION
RSS - Press News Release
Add Press Release

U Of T researchers offer hope for children with previously incurable brain cancer


U Of T researchers offer hope for children with previously incurable brain cancer
2014-04-07
(Press-News.org) Researchers from the University of Toronto's Department of Laboratory Medicine and Pathobiology (LMP) have defined potential treatment targets for a previously incurable form of pediatric brain cancer called Diffuse Intrinsic Pontine Glioma (DIPG).

In groundbreaking research published in Nature Genetics, Dr. Cynthia Hawkins, a professor at LMP and Neuropathologist and Scientist at The Hospital for Sick Children, along with PhD candidates Pawel Buczkowicz and Patricia Rakopoulos, identified three subgroups of DIPG, each having distinct molecular features.

"In the past, DIPGs were considered one disease and were assumed to be similar to adult brain tumours. For this reason, the treatments that were given to adults were also given to children—but these treatments were ineffective," said lead author Buczkowicz. By studying the differences between these tumours, the team can now investigate potential treatments and provide hope for future patients.

Previously, doctors used MRI or CT scans to diagnose and study DIPGs, but the information obtained was limited. In addition, it was difficult to study these tumours because they were rarely biopsied and tissue samples were rare. Hawkins began an autopsy-based study to gain a comprehensive perspective of the disease, an approach that has paid dividends.

DIPGs are most commonly diagnosed in children between the ages of 5 and 9 and account for 10 to 15 percent of all pediatric central nervous system tumours. For over 25 years, children diagnosed with this incurable brainstem tumour have had few treatment options since the cancer cells are intimately intermingled with normal brain cells. These tumours are inoperable, current chemotherapy is ineffective and focal radiation only provides temporary treatment. As Hawkins pointed out, "We're hoping that by having a better genetic characterization of these cancers we can try to better target these tumours and provide a personalized approach to treatment. The ideal is always that we're going to find something that will zap all of the tumour cells and we're going to find a cure. But probably a more realistic interim goal is that we can at least slow it down."

Phase I clinical trials for DIPG could potentially begin within a year.

INFORMATION: END

[Attachments] See images for this press release:
U Of T researchers offer hope for children with previously incurable brain cancer

ELSE PRESS RELEASES FROM THIS DATE:

New research shows huge disparities between the decisions made by coroners

New research shows huge disparities between the decisions made by coroners
2014-04-07
GOVERNMENT plans to overhaul the centuries-old coroner system in England and Wales have been bolstered by the findings of a leading police officer who has become a PhD researcher at the University of Huddersfield. Detailed analysis by ex-Detective Chief Superintendent Max Mclean has shown that there are huge disparities between the decisions made by coroners in differing districts, with the troubling discovery that the deaths of women are considerably less likely to be investigated at an inquest. The result is a "postcode lottery", claims Mr Mclean, who calls for a fully-fledged ...

Disruption of VISTA plays an important role in regulating immune response

2014-04-07
Researchers at the Geisel School of Medicine at Dartmouth have found that the body's immune system response was enhanced when they disrupted VISTA, a protein that prevents the immune system from overreacting. Understanding how checkpoint regulators like VISTA function is important to cancer researchers, who hope to use the immune system to attack tumors. The study, "VISTA deficiency synergizes with a nonredundant immune checkpoint pathway and leads to enhanced immune activation," will be presented on April 7, 2014 at the American Association for Cancer Research Annual Meeting ...

Henry Ford Hospital cited: World's first surgical innovators for patient safety standards

2014-04-07
DETROIT – An innovative kidney transplant technique developed by Henry Ford Hospital is credited as the first in the world to use a new set of patient safety standards coordinated by the University of Oxford in England. The standards are being assembled and offered as a framework for developing, performing and reporting surgical innovations that, unlike new medical treatments, are not under strict regulations and control. One historic example cited by the Oxford group was the introduction of tracheostomy as a surgical method of treating an obstruction in the trachea. ...

Tissue testing during breast cancer lumpectomies

2014-04-07
ROCHESTER, Minn. — Unique laboratory testing during breast cancer lumpectomies to make sure surgeons remove all cancerous tissue spares patients the need for a repeat lumpectomy in roughly 96 percent of cases at Mayo Clinic in Rochester, a success rate much higher than the rate nationally, a Mayo study shows. During the years reviewed, 13.2 percent of breast cancer lumpectomy patients nationally had to return to the operating room within a month of their initial surgery, compared to 3.6 percent at Mayo in Rochester, which uses a technique called frozen section analysis ...

Gene sequencing project discovers mutations tied to deadly brain tumors in young children

2014-04-07
(MEMPHIS, TENN. - April 6, 2014) The St. Jude Children's Research Hospital-Washington University Pediatric Cancer Genome Project has identified new mutations in pediatric brain tumors known as high-grade gliomas (HGGs), which most often occur in the youngest patients. The research appears today as an advance online publication in the scientific journal Nature Genetics. The discoveries stem from the most comprehensive effort yet to identify the genetic missteps driving these deadly tumors. The results provide desperately needed drug development leads, particularly for ...

Renewable energy market share climbs despite 2013 dip in investments

Renewable energy market share climbs despite 2013 dip in investments
2014-04-07
Frankfurt / New York, 7 April 2014 – Renewable energy's share of world electricity generation continued its steady climb last year despite a 14 per cent drop in investments to US$214.4 billion, according to a new report released today. According to Global Trends in Renewable Energy Investment 2014 – produced by the Frankfurt School-UNEP Collaborating Centre for Climate & Sustainable Energy Finance, the United Nations Environment Programme (UNEP) and Bloomberg New Energy Finance — the investment drop of $US35.1 billion was partly down to the falling cost of solar photovoltaic ...

US schoolchildren exposed to arsenic in well water have lower IQ scores

2014-04-07
NEW YORK (April 7, 2014)—A study by researchers at Columbia University reports that schoolchildren from three school districts in Maine exposed to arsenic in drinking water experienced declines in child intelligence. While earlier studies conducted by the researchers in South Asia, and Bangladesh in particular, showed that exposure to arsenic in drinking water is negatively associated with child intelligence, this is the first study to examine intelligence against individual water arsenic exposures in the U.S. Findings are reported online in the journal, Environmental ...

Twitter use linked to infidelity and divorce, MU study finds

2014-04-07
COLUMBIA, Mo. – Twitter and other social networking services have revolutionized the way people create and maintain relationships. However, new research shows that Twitter use could actually be damaging to users' romantic relationships. Russell Clayton, a doctoral student in the University of Missouri School of Journalism, found that active Twitter users are far more likely to experience Twitter–related conflict with their romantic partners. Clayton's results showed that Twitter-related conflict then leads to negative relationship outcomes, including emotional and physical ...

No evidence of AD-associated changes in adolescents carrying genetic risk factors

2014-04-07
Amsterdam, NL, April 7, 2014 – Two studies published in the Journal of Alzheimer's Disease indicate that some of the pathologic changes associated with Alzheimer's disease in older individuals are not apparent in young people who carry the apolipoprotein (APOE) genetic risk factor for developing the disease. In the first study, no differences were found in hippocampal volume or asymmetry between cognitively normal adolescent carriers and non-carriers of the ApoE ɛ4 or ɛ2 allelles. The second study reports no differences in plasma concentrations of amyloid-β ...

Parental obesity and autism risk in the child

2014-04-07
Several studies have looked at possible links between maternal obesity during pregnancy and the risk of developmental disorders in the child. However, paternal obesity could be a greater risk factor than maternal obesity, according to a new study from the Norwegian Institute of Public Health. As the first researcher to study the role of paternal obesity in autism, Dr. Pål Surén emphasises that this is still a theory and requires much more research before scientists can discuss possible causal relationships. "We have a long way to go. We must study genetic factors ...

LAST 30 PRESS RELEASES:

How your brain decides blame and punishment -- and how it can be changed

Uniquely human brain region enables punishment decisions

Pinpointing punishment

Chapman University publishes research on attractiveness and mating

E-cigarettes: Special issue from Nicotine & Tobacco Research

Placental problems in early pregnancy associated with 5-fold increased risk of OB & fetal disorders

UT study: Invasive brood parasites a threat to native bird species

Criminals acquire guns through social connections

Restoring ocean health

Report: Cancer remains leading cause of death in US Hispanics

Twin study suggests genetic factors contribute to insomnia in adults

To be fragrant or not: Why do some male hairstreak butterflies lack scent organs?

International team discovers natural defense against HIV

Bolivian biodiversity observatory takes its first steps

Choice of college major influences lifetime earnings more than simply getting a degree

Dominant strain of drug-resistant MRSA decreases in hospitals, but persists in community

Synthetic biology needs robust safety mechanisms before real world application

US defense agencies increase investment in federal synthetic biology research

Robots help to map England's only deep-water Marine Conservation Zone

Mayo researchers identify protein -- may predict who will respond to PD-1 immunotherapy for melanoma

How much water do US fracking operations really use?

New approach to mammograms could improve reliability

The influence of citizen science grows despite some resistance

Unlocking secrets of how fossils form

What happens on the molecular level when smog gets into the lungs?

Using ultrasound to clean medical instruments

Platinum and iron oxide working together get the job done

Tiny silica particles could be used to repair damaged teeth, research shows

A quantum lab for everyone

No way? Charity's logo may influence perception of food in package

[Press-News.org] U Of T researchers offer hope for children with previously incurable brain cancer
Press-News.org is a service of DragonFly Company. All Rights Reserved.
Issuers of news releases are solely responsible for the accuracy of their content.