Neurodegeneration and stroke after GLP-1RAs in diabetes and obesity

JAMA Network Open

2025-07-15

(Press-News.org) About The Study: In this cohort study, the use of glucagon-like peptide 1 receptor agonists (GLP-1RAs) semaglutide and tirzepatide was associated with a lower risk of dementia, stroke, and all-cause mortality in adults with type 2 diabetes and obesity. These findings suggest potential neuroprotective and cerebrovascular benefits of GLP-1RAs beyond glycemic control, warranting further trials to confirm these outcomes.

Corresponding author: To contact the corresponding author, James Cheng-Chung Wei, M.D., Ph.D., email jccwei@gmail.com.

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(doi: 10.1001/jamanetworkopen.2025.21016)

Editor’s Note: Please see the article for additional information, including other authors, author contributions and affiliations, conflict of interest and financial disclosures, and funding and support.

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About JAMA Network Open: JAMA Network Open is an online-only open access general medical journal from the JAMA Network. On weekdays, the journal publishes peer-reviewed clinical research and commentary in more than 40 medical and health subject areas. Every article is free online from the day of publication.

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Neurodegeneration and stroke after GLP-1RAs in diabetes and obesity

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