PRESS-NEWS.org - Press Release Distribution
PRESS RELEASES DISTRIBUTION

Multiple sclerosis drug serves as model for potential drugs to treat botulism poisoning

2010-11-18
(Press-News.org) Scientists are reporting that variants of a drug already approved for treating multiple sclerosis show promise as a long sought treatment for victims of bioterrorist attack with botulinum neurotoxin — which is 10,000 times deadlier than cyanide and the most poisonous substance known to man. The potential drugs also could be useful in treating other forms of botulism poisoning as well as Alzheimer's disease, multiple sclerosis, and myasthenia gravis, they say in an article in ACS Chemical Biology, a monthly journal.

Kim D. Janda and colleagues explain that the lack of any approved drug treatment for botulism poisoning leaves a major gap in defenses against bioterrorism and biological warfare. People exposed to botulism toxin develop paralysis, cannot breathe, and may require months of treatment on respirators. "The numbers of medical care units capable of providing supportive care for recovery in the event of a bioterrorism incident would be limited," they note.

The scientists knew that the multiple sclerosis drug diaminopyridine showed promise for working inside nerve cells to counteract the effects of diaminopyridine botulism toxin. However, diaminopyridine itself had disadvantages, including its ability to pass into the brain and have toxic effects on brain tissue. They modified the molecular structure of diaminopyridine to produce two new substances that did not enter the brain and showed good potential as botulism treatments in mice that had been paralyzed by the toxin.

INFORMATION: The authors acknowledged funding from the National Institute of Allergy and Infectious Diseases.

ARTICLE FOR IMMEDIATE RELEASE "Symptomatic Relief of Botulinum Neurotoxin/ A Intoxication with Aminopyridines: A New Twist on an Old Molecule"

DOWNLOAD FULL TEXT ARTICLE http://pubs.acs.org/stoken/presspac/presspac/full/10.1021/cb1002366

CONTACT:
Kim Janda, Ph.D.
Departments of Chemistry and Immunology,
Skaggs Institute for Chemical Biology and
Worm Institute of Research & Medicine (WIRM)
The Scripps Research Institute
10550 North Torrey Pines Road, La Jolla, California 92037
Phone: (858) 784-2516
Email: kdjanda@scripps.edu


ELSE PRESS RELEASES FROM THIS DATE:

Being faced with gender stereotypes makes women less likely to take financial risks

2010-11-18
Last year Nicholas Kristof declared in his New York Times column what banks need to fix their problems: Not just a bailout, but also "women, women, and women." Women are generally thought to be less willing to take risks than men, so he speculated that the banks could balance out risky men by employing more women. Stereotypes like this about women actually influence how women make financial decisions, making them more wary of risk, according to a new study published in Psychological Science, a journal of the Association for Psychological Science. Anecdotally, many people ...

New technology gives on-site assessments in archaeology

New technology gives on-site assessments in archaeology
2010-11-18
DURHAM, N.C. – The ability to tell the difference between crystals that formed naturally and those formed by human activity can be important to archaeologists in the field. This can be a crucial bit of information in determining the ancient activities that took place at a site, yet archaeologists often wait for months for the results of laboratory tests. Now, however, an international team of physicists, archaeologists and materials scientists has developed a process that can tell in a matter of minutes the origin of samples thousands of years old. The new device is ...

Novel approach shows promise for cystic fibrosis, say UAB researchers

2010-11-18
Birmingham, Ala. – An investigational drug targeting a defective protein that causes cystic fibrosis has been shown to improve lung function in a small study of CF patients, according to findings published Nov. 18, 2010, in the New England Journal of Medicine. The investigational drug, VX-770, appeared to improve function of what is known as CFTR--the faulty protein responsible for CF. It is among the first compounds being developed for CF that specifically targets the root cause of cystic fibrosis. Patients who took VX-770 for 28 days showed improvements in several key ...

IQ scores fail to predict academic performance in children with autism

2010-11-18
New data show that many children with autism spectrum disorders have greater academic abilities than previously thought. In a study by researchers at the University of Washington, 90 percent of high-functioning children with autism spectrum disorders showed a discrepancy between their IQ score and their performance on reading, spelling and math tests. "Academic achievement is a potential source of self-worth and source of feeling of mastery that people may not have realized is available to children with autism," said Annette Estes, research assistant professor at the ...

As Arctic temperatures rise, tundra fires increase, researchers find

As Arctic temperatures rise, tundra fires increase, researchers find
2010-11-18
CHAMPAIGN, Ill. — In September, 2007, the Anaktuvuk River Fire burned more than 1,000 square kilometers of tundra on Alaska's North Slope, doubling the area burned in that region since record keeping began in 1950. A new analysis of sediment cores from the burned area revealed that this was the most destructive tundra fire at that site for at least 5,000 years. Models built on 60 years of climate and fire data found that even moderate increases in warm-season temperatures in the region dramatically increase the likelihood of such fires. The study was published this October ...

Hearing loss study reveals role of bone hardness in tissue function

2010-11-18
Scientists are reporting the first direct evidence that a subtle change in the physical properties of a tissue can affect its function. The finding has immediate implications for understanding several rare hearing disorders, they said, and ultimately could offer insight into such conditions as osteoporosis, arthritis, cardiovascular disease and cancer. In their study, the scientists discovered that blocking the function of a particular molecule in the ear bone of mice decreased the hardness of the bone, causing hearing loss. Reactivating the molecule restored the bone's ...

National Zoo and partners first to breed critically endangered tree frog

National Zoo and partners first to breed critically endangered tree frog
2010-11-18
As frogs around the world continue to disappear—many killed by a rapidly spreading disease called chytridiomycosis, which attacks the skin cells of amphibians—one critically endangered species has received an encouraging boost. Although the La Loma tree frog, Hyloscirtus colymba, is notoriously difficult to care for in captivity, the Panama Amphibian Rescue and Conservation Project is the first to successfully breed this species. "We are some of the first researchers to attempt to breed these animals into captivity and we have very little information about how to care ...

Antimatter atoms stored for the first time

Antimatter atoms stored for the first time
2010-11-18
Atoms of antimatter have been trapped and stored for the first time by the ALPHA collaboration, an international team of scientists working at CERN, the European Organization for Nuclear Research near Geneva, Switzerland. Scientists from the U.S. Department of Energy's Lawrence Berkeley National Laboratory and the University of California at Berkeley have made key contributions to the ongoing international effort. ALPHA stored atoms of antihydrogen, consisting of a single negatively charged antiproton orbited by a single positively charged anti-electron (positron). While ...

Antimatter atoms produced and trapped at CERN

2010-11-18
Geneva, 17 November 2011. The ALPHA experiment at CERN has taken an important step forward in developing techniques to understand one of the Universe's open questions: is there a difference between matter and antimatter? In a paper published in Nature today, the collaboration shows that it has successfully produced and trapped atoms of antihydrogen. This development opens the path to new ways of making detailed measurements of antihydrogen, which will in turn allow scientists to compare matter and antimatter. Antimatter – or the lack of it – remains one of the biggest ...

Pelletized manure reduces toxic runoff

2010-11-18
Madison WI November 17 2010 – There is considerable amount of uncertainty concerning the environmental impacts that animal hormones have on surface water. Higher concentrations of hormones in waterways have been found to cause physiological and sexual impairment in fish and other aquatic species. However, a study from the University of Delaware that examined estrogen concentrations runoff from agricultural fields fertilized with chicken manure found that it is as much about the application of the manure as it is about the measurement of the types of estrogen. The study ...

LAST 30 PRESS RELEASES:

Breathable yet protective: Next-gen medical textiles with micro/nano networks

Frequency-engineered MXene supercapacitors enable efficient pulse charging in TENG–SC hybrid systems

Developed an AI-based classification system for facial pigmented lesions

Achieving 20% efficiency in halogen-free organic solar cells via isomeric additive-mediated sequential processing

New book Terraglossia reclaims language, Country and culture

The most effective diabetes drugs don't reach enough patients yet

Breast cancer risk in younger women may be influenced by hormone therapy

Strategies for staying smoke-free after rehab

Commentary questions the potential benefit of levothyroxine treatment of mild hypothyroidism during pregnancy

Study projects over 14 million preventable deaths by 2030 if USAID defunding continues

New study reveals 33% gap in transplant access for UK’s poorest children

Dysregulated epigenetic memory in early embryos offers new clues to the inheritance of polycystic ovary syndrome (PCOS)

IVF and IUI pregnancy rates remain stable across Europe, despite an increasing uptake of single embryo transfer

It takes a village: Chimpanzee babies do better when their moms have social connections

From lab to market: how renewable polymers could transform medicine

Striking increase in obesity observed among youth between 2011 and 2023

No evidence that medications trigger microscopic colitis in older adults

NYUAD researchers find link between brain growth and mental health disorders

Aging-related inflammation is not universal across human populations, new study finds

University of Oregon to create national children’s mental health center with $11 million federal grant

Rare achievement: UTA undergrad publishes research

Fact or fiction? The ADHD info dilemma

Genetic ancestry linked to risk of severe dengue

Genomes reveal the Norwegian lemming as one of the youngest mammal species

Early birds get the burn: Monash study finds early bedtimes associated with more physical activity

Groundbreaking analysis provides day-by-day insight into prehistoric plankton’s capacity for change

Southern Ocean saltier, hotter and losing ice fast as decades-long trend unexpectedly reverses

Human fishing reshaped Caribbean reef food webs, 7000-year old exposed fossilized reefs reveal

Killer whales, kind gestures: Orcas offer food to humans in the wild

Hurricane ecology research reveals critical vulnerabilities of coastal ecosystems

[Press-News.org] Multiple sclerosis drug serves as model for potential drugs to treat botulism poisoning