(Press-News.org) NEW HYDE PARK, NY – A recent study by investigators from LIJ Medical Center demonstrated that using magnetic resonance imaging (MRI) in men with an elevated prostate specific antigen (PSA) resulted in a prostate cancer detection rate that was twice as high as data reported in the March 1999 Prostate journal that analyzed men undergoing the standard 12-core biopsy with an elevated PSA. Physicians in the recent trial used a targeted approach to evaluate prostate cancer that combines MR imaging and transrectal ultrasound fusion guided prostate biopsy.
Given the limitations of the PSA blood test and the standard 12-core ultrasound biopsies for detecting prostate cancer, researchers evaluated the initial 105 men eligible for the clinical trial using a new targeted prostate fusion biopsy method. The study, which will appear in the June issue of the Journal of Urology, showed that prostate cancer was detected in 62 percent of men tested in the latest trial vs. 30 percent in the general population as reported in the 1999 Prostate journal.
"The results of the phase III clinical trial show that a target fusion biopsy detects more clinically significant prostate cancer," said Art Rastinehad, DO, principal investigator of the study and director of interventonal urologic oncology at North Shore-LIJ's Arthur Smith Institute for Urology, in New Hyde Park, NY. "This is the type of cancer that patients may benefit from treatment compared to other patients with low grade and low volume prostate cancer."
Investigators used the UroNav system, which combines MRI and ultrasound imaging to better identify areas not revealed by the standard, 12-core biopsy procedure. A field generator, similar to a GPS device, is placed over the patient's hip to guide the biopsy. The MRI and ultrasound images are overlaid in real-time, which provide an evaluation of 100 percent of the prostate gland to get the most accurate diagnosis possible.
"The study also showed that in situations when the 12-core biopsy did not detect cancer, the fusion biopsy detected cancer in 15 percent of cases and in these cases, 85 percent were clinically significant," Dr. Rastinehad said.
Dr. Rastinehad credits the quality of the multiparametric prostate MR imaging as one of the key factors in the outcomes of the study, which resulted in excellent prostate cancer detection rates as compared to data from other institutions using the fusion biopsy technology.
"The MRI creates the road map to target specific areas within the prostate," Dr Rastinehad said. "Some patients with previous multiple negative prostate biopsies have cancer outside the usual areas sampled on the standard biopsy so the new technology takes away the mystery of a diagnosis."
Dr. Rastinehad noted the challenge in the study was trying to reproduce the high quality MRI results the National Institutes of Health has established, extending thanks for researches there for assistance in LIJ's research.
"Our study results are very promising," Dr. Rastinehad. "There is no question that a targeted approach will yield more cancer and actually more clinical significant cancer. Our next challenge is to perform a randonmized control trial to see if MR imaging for screening combined with a fusion biopsy can be applied to the broader patient population."
INFORMATION:
To view the abstract: "Improving Detection of Clinically Significant Prostate Cancer: Magnetic Resonance Imaging/Transrectal Ultrasound Fusion Guided Prostate Biopsy."
A copy of the study is available is available on request.
Acknowledgements: Invivo provided research equipment. NIH Molecular Imaging Program, Urological Oncology Branch and Center for Image Guided Oncology assisted with initial program support.
Study shows image fusion-guided biopsy improves accuracy of prostate cancer diagnosis
2014-05-21
ELSE PRESS RELEASES FROM THIS DATE:
Too cute to resist: Do whimsical products make consumers overspend?
2014-05-21
Babies are cute. Kittens are cute. But for some people, products that emphasize baby features like chubby cheeks and large eyes cause them to be more careful and restrained. According to a new study in the Journal of Consumer Research, products that are cute in a playful and whimsical way can bring out more indulgent behavior.
"We were not convinced that all cute products would lead to the restrained behavior that stems from baby-cuteness. Our research examined whether there are indeed different types of cuteness, and if these differences could lead to more or less indulgent ...
Buying a BMW: How do social expectations influence your purchases?
2014-05-21
People who drive BMWs and wear expensive suits must surely occupy roles of power and authority. According to a new study in the Journal of Consumer Research, when we can separate societal expectations of power from how power makes us feel, we have better control over what it means to be powerful.
"When a person is placed into a powerless or powerful role, they sometimes conform to the expectations of that role. But when they are focused on the internal feeling of having or lacking power, we observed the opposite patterns of behavior," write authors Derek D. Rucker (Kellogg ...
What makes things cool? When breaking the rules can boost your cool factor
2014-05-21
Coolness helps sell everything from fashion and music to electronics and cigarettes. According to a new study in the Journal of Consumer Research, people and brands become cool by understanding what is considered normal, obeying the rules considered necessary, and then diverging from the rules considered expendable.
"Our research explores how brands and people become cool in the eyes of consumers. We reasoned that brands could become cool by breaking rules that seemed unnecessary or unfair, but not by breaking legitimate rules," write authors Caleb Warren (Texas A&M University) ...
The brand tourism effect: When do lower status consumers boost luxury brands?
2014-05-21
When people purchase luxury items like expensive watches and high-end automobiles, they often consider themselves members of a select group of consumers. According to a new study in the Journal of Consumer Research, when outsiders show an interest in a luxury brand, they help improve its overall value.
"Just as tourists boost the pride of citizens toward their home country and reinforce the attractiveness and desirability of the place they visit, brand tourists (as fans of the brand) inspire feelings of membership pride and enhance brand image," write authors Silvia Bellezza ...
Admitting our faults: When does self-acceptance trump self-destruction?
2014-05-21
When face-to-face with our failures, it's hard not to deny the consequences of our shortcomings—and sometimes we make problems worse by engaging in the behaviors we have been trying so hard to avoid. According to a new study in the Journal of Consumer Research, practicing self-acceptance may be the best way to boost our self-worth and avoid self-deprecating behaviors and consequences.
"Consider the person who has just realized that they are poorly prepared financially for retirement," write authors Soo Kim and David Gal (both Kellogg School of Management, Northwestern ...
Partners in crime: When do friends conspire to eat more chocolate?
2014-05-21
As a human race we strive for perfection, knowing that no one is perfect. A new study in the Journal of Consumer Research offers insight into why we surround ourselves with people who help bring out our best but don't make us feel terrible when we stray from perfection.
"In a situation requiring two people to use self-control, either both indulge, both abstain, or one indulges while the other abstains. Our research looks at how these different outcomes impact people who are friends," write authors Michael L. Lowe (Texas A&M University) and Kelly L. Haws (Vanderbilt University).
In ...
Shopping online: Why do too many photos confuse consumers?
2014-05-21
When shopping online, we often have the option of clicking on additional product photos taken from different angles or showing additional features. According to a new study in the Journal of Consumer Research, looking at more photos when making product comparisons can ultimately inhibit us from noticing what differentiates them in the first place.
"The intuition that 'seeing more is always better' does not consider the possibility that when presented with too many product photos, the way we process information is altered," write authors Jayson Shi Jia (University of ...
UNC researchers find new target for chronic pain treatment
2014-05-21
CHAPEL HILL, N.C. (May 21, 2014) – Researchers at the UNC School of Medicine have found a new target for treating chronic pain: an enzyme called PIP5K1C. In a paper published today in the journal Neuron, a team of researchers led by Mark Zylka, PhD, Associate Professor of Cell Biology and Physiology, shows that PIP5K1C controls the activity of cellular receptors that signal pain.
By reducing the level of the enzyme, researchers showed that the levels of a crucial lipid called PIP2 in pain-sensing neurons is also lessened, thus decreasing pain.
They also found a compound ...
Cancer avatars for personalized medicine
2014-05-21
Researchers at University of California, San Diego School of Medicine and Moores Cancer Center have used computer simulations of cancer cells – cancer avatars – to identify drugs most likely to kill cancer cells isolated from patients' brain tumors.
The findings, published in May 21 online issue of the Journal of Translational Medicine, may help researchers stratify cancer patients for clinical trials according to their cancers' genomic signatures and predicted sensitivities to different cancer drugs.
Such an approach would allow scientists to selectively test cancer ...
Rhythmic bursts of electrical activity from cells in ear teach brain how to hear
2014-05-21
PITTSBURGH, May 21, 2014 – A precise rhythm of electrical impulses transmitted from cells in the inner ear coaches the brain how to hear, according to a new study led by researchers at the University of Pittsburgh School of Medicine. They report the first evidence of this developmental process today in the online version of Neuron.
The ear generates spontaneous electrical activity to trigger a response in the brain before hearing actually begins, said senior investigator Karl Kandler, Ph.D., professor of otolaryngology and neurobiology, Pitt School of Medicine. These patterned ...