(Press-News.org) Because the majority of patients with diffuse brain injury are not suitable candidates for surgery, neuroprotective agents are of great importance. Apolipoprotein E exerts a neuroprotective effect against brain injury, but synthetic apolipoprotein E cannot cross the blood-brain barrier, thus limiting its application.It has been reported that apolipoprotein E (138) mimetic peptide can cross the blood-brain barrier in both normal and injured brain. However, its impact on neurological function following diffuse brain injury is still unclear. Prof. Jianmin Li and team from the Affiliated Hospital of Hebei United University in China conducted a relevant study. These researchers found that apolipoprotein E-derived therapeutic peptide (0.6mg/kg and 1.2mg/kg) improved synaptic stability and improved learning and memory performance after diffuse brain injury. Furthermore, apolipoprotein E mimetic peptide protected against brain injury by reducing oxidative stress, thereby suppressing the ERK1/2-Bax mitochondrial apoptotic pathway and decreasing neuronal death. These results have been published in the Neural Regeneration Research (Vol. 9, No. 5, 2014).
INFORMATION:
Article: " Apolipoprotein E mimetic peptide protects against diffuse brain injury " by Yaning Zhao1, Jianmin Li2, Qiqun Tang1, Junling Gao1, Changxiang Chen1, Liwei Jing1, Pan Zhang1, Shuxing Li1 (1 College of Rehabilitation, Hebei United University, Tangshan, Hebei Province, China; 2 Affiliated Hospital of Hebei United University, Tangshan, Hebei Province, China)
Zhao YN, Li JM, Tang QQ, Gao JL, Chen CX, Jing LW, Zhang P, Li SX. Apolipoprotein E mimetic peptide protects against diffuse brain injury. Neural Regen Res. 2014;9(5):463-473.
Contact: Meng Zhao
eic@nrren.org
86-138-049-98773
Neural Regeneration Research
http://www.nrronline.org/
Does apolipoprotein E mimetic peptide reduce neuronal apoptosis induced by DBI?
2014-05-27
ELSE PRESS RELEASES FROM THIS DATE:
A novel disease-preventing antioxidant pathway
2014-05-27
Interested in antioxidants? They protect us against aging and cancer. It's one of the reasons we like our green tea and even our broccoli. But there is a new kid on the antioxidant block - uric acid. But wait, you're thinking, doesn't uric acid cause gout? A team in Singapore has recently showed that uric acid is a major intracellular antioxidant, possibly even more important than the antioxidants we try to eat. They also discovered how uric acid helps to prevent aging and disease and how it helps in the treatment of cancer.
Traditionally, uric acid has a bad reputation ...
Immunologists discover immune system precursor cells that fight infection
2014-05-27
The innate immune system recognizes infectious agents such as viruses and bacteria. A group of lymphocytes known as "innate lymphoid cells" or ILCs plays a central role in the defense of the human body against infective agents. Professor Andreas Diefenbach of the Research Center Immunology at the Mainz University Medical Center, working in collaboration with scientists at the University of Freiburg, has discovered previously unidentified ILCs that are able to protect epithelial surfaces, such as those of the intestinal mucosa, against infection. The results provide important ...
Using thoughts to control airplanes
2014-05-27
The pilot is wearing a white cap with myriad attached cables. His gaze is concentrated on the runway ahead of him. All of a sudden the control stick starts to move, as if by magic. The airplane banks and then approaches straight on towards the runway. The position of the plane is corrected time and again until the landing gear gently touches down. During the entire maneuver the pilot touches neither pedals nor controls.
This is not a scene from a science fiction movie, but rather the rendition of a test at the Institute for Flight System Dynamics of the Technische Universität ...
Melatonin makes old bones stronger
2014-05-27
Faleh Tamimi, a professor in McGill's School of Dentistry, is the leader of a research team that has just discovered that melatonin supplements make bones stronger in elderly rats and therefore, potentially, in elderly humans too. "Old rats are tedious to work with because they get sick a lot and that means they also cost a lot more. But if you're interested in diseases like osteoporosis, they're an essential part of the process."
Dem bones, dem bones, dem dry bones – sleep and bone regulation
The process of bone breakdown and buildup is affected by our circadian ...
Intermediaries increase corruption
2014-05-27
This news release is available in Spanish.
In reality, an intermediary participates in many, if not most, cases of corruption. However there has been very scarce empirical evidence that illuminates their role in these situations. This is what a researcher at UC3M has analyzed in collaboration with scientists from Florida State University and Southern Methodist University, in Texas (both in the United States). The results of their study, recently published in Experimental Economics, confirm their suspicions: "Our work showed that the number of persons involved in cases ...
Outgrowing emotional egocentricity
2014-05-27
This news release is available in German. Children are more egocentric than adults. Scientists from the Max Planck Institute for Human Cognitive and Brain Sciences in Leipzig have demonstrated for the first time that children are also worse at putting themselves in other people's emotional shoes. According to the researchers, the supramarginal gyrus region of the brain must be sufficiently developed in children for them to be able to overcome their egocentric take on the world.
When little Philip rejoices at winning the prize in a game, it is almost impossible for ...
People attribute free will to mind, not soul
2014-05-27
PROVIDENCE, R.I. [Brown University] — Across the board, even if they believed in the concept of a soul, people in a new study ascribed free will based on down-to-Earth criteria: Did the actor in question have the capacity to make an intentional and independent choice? The study suggests that while grand metaphysical views of the universe remain common, they have little to do with how people assess each other's behavior.
"I find it relieving to know that whether you believe in a soul or not, or have a religion or not, or an assumption about how the universe works, that ...
HIV can cut and paste in the human genome
2014-05-27
For the first time researchers have succeeded in altering HIV virus particles so that they can simultaneously, as it were, 'cut and paste' in our genome via biological processes. Developed at the Department of Biomedicine at Aarhus University, the technology makes it possible to repair genomes in a new way. It also offers good perspectives for individual treatment of both hereditary diseases and certain viral infections:
"Now we can simultaneously cut out the part of the genome that is broken in sick cells, and patch the gap that arises in the genetic information which ...
'Virtual human' shows that stiff arteries can explain the cause of high blood pressure
2014-05-27
High blood pressure is highly age-related and affects more than 1 billion people worldwide. But doctors can't fully explain the cause of 90 per cent of all cases. A computer model of a "virtual human" suggests that stiff arteries alone are enough to cause high blood pressure.
"Our results suggest that arterial stiffness represents a major therapeutic target. This is contrary to existing models, which typically explain high blood pressure in terms of defective kidney function," says Klas Pettersen, a researcher at the Norwegian University of Life Sciences and first author ...
Why does bacon smell so good? (video)
2014-05-27
WASHINGTON, May 27, 2014 — We all know bacon is delicious, but what is it about cooking bacon that makes it smell so tantalizing? In the American Chemical Society's (ACS') latest Reactions video, the team puts its nose into everyone's favorite breakfast food. We collaborated with the Compound Interest blog to break down the science of that sweet smell. The video is available at http://youtu.be/2P_0HGRWgXw
Subscribe to the series at Reactions YouTube, and follow us on Twitter @ACSreactions to be the first to see our latest videos.
INFORMATION:
The American Chemical ...