(Press-News.org) 23 May 2014, Paris, France: During EuroPCR 2014, Felix Mahfoud, University Hospital in Homburg, Germany, and Konstantinos Tsioufis, University of Athens, Greece, reflected on the potential future role of modulation of the sympathetic nervous system in patients with difficult-to-control hypertension.
In the context of the SYMPLICITY-HTN-3 clinical trial results, questions were raised about the extent of the procedure's efficacy although the randomised, controlled trial confirmed the safety of renal denervation.
"In terms of efficacy, some studies have shown that renal denervation can achieve a clinically relevant reduction of office and ambulatory blood pressure in patients with difficult-to-control hypertension. There is a need for more research to identify the pathophysiology of the condition and to select the best patients who will benefit from treatment with the procedure," Tsioufis stated.
F. Mahfoud expanded on this, saying that the safety of renal denervation has never been contested as the primary safety endpoint of the study was met. F. Mahfoud said that, although renal denervation with radiofrequency did not show a significant difference with regard to the efficacy endpoint compared to the control group, it is unlikely that the procedure does not work in humans.
Other aspects to be considered are: SYMPLICITY HTN-3 may be underpowered; antihypertensive drugs may have been maximised, but not stabilised; the patient population may differ from Caucasians recruited in previous trials; the results may just be accidental; and the procedure may not have been performed effectively.
The underlying pathophysiology is much more complex than initially thought: "Maybe we are moving away from Symplicity to complexity, in terms of how we deliver energy and where the sweet spots for renal denervation are," F. Mahfoud commented. "On top of it there may be a learning curve for renal denervation; there is a lot more to learn and a lot more to understand," concluded F. Mahfoud.
"Renal denervation was developed as a promising therapy for the treatment of patients who suffer from resistant hypertension lacking treatment alternatives," stated William Wijns, EuroPCR Course Co-director. The physicians all agreed that this condition represents an unmet clinical need, adding that up until now, data from clinical trials and registries confirmed that renal denervation is a safe procedure. Further to this, they said that renal denervation is an option in patients with difficult-to-control hypertension, in whom other treatments have failed.
INFORMATION:
Notes to Editors
For more information on this press release, please contact Isabelle Uzielli, email: iuzielli@europcr.com
Further information on press registration may be found at http://www.europcr.com/page/press/393-press.html
What is EuroPCR?
EuroPCR, the official annual meeting of the European Association for Percutaneous Cardiovascular Interventions (EAPCI), a registered branch of the European Society of Cardiology, is the world-leading course in interventional medicine. PCR has established a distinctive format for educational activities in the field of cardiovascular interventions. Beyond its flagship course in Paris that gathers more than 12,000 participants every year, PCR organises annual courses in Singapore, London, Dubai and Cape Town.
For further information on EuroPCR, AsiaPCR/SingLIVE, PCR London Valves, GulfPCR-GIM, AfricaPCR & PCR, please contact: Anne-Sophie Lartigau at aslartigau@europa-organisation.com.
For more information, please visit http://www.europcr.com
EuroPCR 2014 session defines future horizons for renal denervation
Key procedural and methodological considerations of SYMPLICITY HTN-3 outlined
2014-05-27
ELSE PRESS RELEASES FROM THIS DATE:
New biodiversity study throws out controversial scientific theory
2014-05-27
Researchers have today released ground-breaking findings that dismiss the 'Neutral Theory of Biodiversity'. The theory has dominated biodiversity research for the past decade, and been advocated as a tool for conservation and management efforts.
Professor Sean Connolly from the ARC Centre of Excellence for Coral Reef Studies (Coral CoE) at James Cook University (JCU) is the lead author of the international study, which he says overturns the long-used theory by employing a novel mathematical method. It is the largest study of its kind, covering a broad range of marine ...
Does apolipoprotein E mimetic peptide reduce neuronal apoptosis induced by DBI?
2014-05-27
Because the majority of patients with diffuse brain injury are not suitable candidates for surgery, neuroprotective agents are of great importance. Apolipoprotein E exerts a neuroprotective effect against brain injury, but synthetic apolipoprotein E cannot cross the blood-brain barrier, thus limiting its application.It has been reported that apolipoprotein E (138) mimetic peptide can cross the blood-brain barrier in both normal and injured brain. However, its impact on neurological function following diffuse brain injury is still unclear. Prof. Jianmin Li and team from ...
A novel disease-preventing antioxidant pathway
2014-05-27
Interested in antioxidants? They protect us against aging and cancer. It's one of the reasons we like our green tea and even our broccoli. But there is a new kid on the antioxidant block - uric acid. But wait, you're thinking, doesn't uric acid cause gout? A team in Singapore has recently showed that uric acid is a major intracellular antioxidant, possibly even more important than the antioxidants we try to eat. They also discovered how uric acid helps to prevent aging and disease and how it helps in the treatment of cancer.
Traditionally, uric acid has a bad reputation ...
Immunologists discover immune system precursor cells that fight infection
2014-05-27
The innate immune system recognizes infectious agents such as viruses and bacteria. A group of lymphocytes known as "innate lymphoid cells" or ILCs plays a central role in the defense of the human body against infective agents. Professor Andreas Diefenbach of the Research Center Immunology at the Mainz University Medical Center, working in collaboration with scientists at the University of Freiburg, has discovered previously unidentified ILCs that are able to protect epithelial surfaces, such as those of the intestinal mucosa, against infection. The results provide important ...
Using thoughts to control airplanes
2014-05-27
The pilot is wearing a white cap with myriad attached cables. His gaze is concentrated on the runway ahead of him. All of a sudden the control stick starts to move, as if by magic. The airplane banks and then approaches straight on towards the runway. The position of the plane is corrected time and again until the landing gear gently touches down. During the entire maneuver the pilot touches neither pedals nor controls.
This is not a scene from a science fiction movie, but rather the rendition of a test at the Institute for Flight System Dynamics of the Technische Universität ...
Melatonin makes old bones stronger
2014-05-27
Faleh Tamimi, a professor in McGill's School of Dentistry, is the leader of a research team that has just discovered that melatonin supplements make bones stronger in elderly rats and therefore, potentially, in elderly humans too. "Old rats are tedious to work with because they get sick a lot and that means they also cost a lot more. But if you're interested in diseases like osteoporosis, they're an essential part of the process."
Dem bones, dem bones, dem dry bones – sleep and bone regulation
The process of bone breakdown and buildup is affected by our circadian ...
Intermediaries increase corruption
2014-05-27
This news release is available in Spanish.
In reality, an intermediary participates in many, if not most, cases of corruption. However there has been very scarce empirical evidence that illuminates their role in these situations. This is what a researcher at UC3M has analyzed in collaboration with scientists from Florida State University and Southern Methodist University, in Texas (both in the United States). The results of their study, recently published in Experimental Economics, confirm their suspicions: "Our work showed that the number of persons involved in cases ...
Outgrowing emotional egocentricity
2014-05-27
This news release is available in German. Children are more egocentric than adults. Scientists from the Max Planck Institute for Human Cognitive and Brain Sciences in Leipzig have demonstrated for the first time that children are also worse at putting themselves in other people's emotional shoes. According to the researchers, the supramarginal gyrus region of the brain must be sufficiently developed in children for them to be able to overcome their egocentric take on the world.
When little Philip rejoices at winning the prize in a game, it is almost impossible for ...
People attribute free will to mind, not soul
2014-05-27
PROVIDENCE, R.I. [Brown University] — Across the board, even if they believed in the concept of a soul, people in a new study ascribed free will based on down-to-Earth criteria: Did the actor in question have the capacity to make an intentional and independent choice? The study suggests that while grand metaphysical views of the universe remain common, they have little to do with how people assess each other's behavior.
"I find it relieving to know that whether you believe in a soul or not, or have a religion or not, or an assumption about how the universe works, that ...
HIV can cut and paste in the human genome
2014-05-27
For the first time researchers have succeeded in altering HIV virus particles so that they can simultaneously, as it were, 'cut and paste' in our genome via biological processes. Developed at the Department of Biomedicine at Aarhus University, the technology makes it possible to repair genomes in a new way. It also offers good perspectives for individual treatment of both hereditary diseases and certain viral infections:
"Now we can simultaneously cut out the part of the genome that is broken in sick cells, and patch the gap that arises in the genetic information which ...
LAST 30 PRESS RELEASES:
Results of SWOG S1929 trial show patients with small-cell lung cancer with SLFN11 expression can benefit from PARP inhibitor added to immune checkpoint blockade
UCSF Health Cancer experts featured at premier cancer meeting
Multiple sclerosis more prevalent in Black Americans than previously thought
Sensory adapted dental rooms significantly reduce autistic children’s physiological and behavioral stress during teeth cleanings
Couples’ social networks took long-lasting hit during COVID
AI software can provide ‘roadmap’ for biological discoveries
Study helps explain what drives psoriasis severity and offers clues as to how disease may spread to other body parts
New study finds strengthening protection of existing parks is crucial for biodiversity conservation
Scientists reveal new details of cellular process which prevents spread of cancer
Development of an AI-based mass spectrometric technique capable of determining the monomeric sequence of a polymer
Non-invasive treatment of uterine fibroids research project secures grant at Baton Rouge Health-Tech Catalyst Pitch Night
nTIDE May 2023 Jobs Report: Job numbers rebound bringing people with disabilities close to previous high in employment
American Tinnitus Association elects Wayne State researcher as new chair
Media Alert: American College of Cardiology to host Sports Cardiology Conference
Immunotherapy for brain cancer metastases shows clinical benefit
Commentary calls for equal access to healthcare for DACA recipients and all immigrants
Taming a frenzied immune system
Veterans exposed to Agent Orange may be at increased risk of developing progressive blood cancers
Hispanic women still at higher risk for births with neural tube defects after voluntary folic acid fortification of corn masa flour
Buckle up! A new class of materials is here
Lupus Therapeutics partners to evaluate potential treatment for SLE and lupus nephritis through North American trial network
Sensory adaptations to improve physiological, behavioral distress during dental visits in autistic children
Awareness of racial, ethnic bias and potential solutions to address bias with use of health care algorithms
Reentry services may help stabilize substance use risks after mass prison release
Memory killer cells can improve survival for melanoma patients
HKUST researchers unveil long-sought noncanonical cleavage mechanism in miRNA biogenesis
Immune system discovery could benefit spinal cord injuries
UTHSC researchers’ work on human pangenome aids understanding of common chromosomal abnormality
Mysterious dashes revealed in Milky Way’s center
ASCO: Adding ribociclib to hormone therapy improves outcomes in patients with early breast cancer
[Press-News.org] EuroPCR 2014 session defines future horizons for renal denervationKey procedural and methodological considerations of SYMPLICITY HTN-3 outlined