(Press-News.org) There is evidence that under the normal circumstances, astrocytes participate in normal physiological activities and development, maintain neuronal environment, and exhibit therapeutic and repairing effects on brain injury and neurodegenerative disease. Previous studies have found that nerve cells differentiated from adipose-derived stromal cells after chemical induction have reduced viability, which produces influences on subsequent studies and application. Prof. Xiaodong Yuan, Kailuan General Hospital, Hebei United University, China demonstrated that after chemical induction, with increasing time, the apoptotic rate of adipose-derived stromal cells gradually increased, and the number of living cells gradually decreased, and the number of glial fibrillary acidic protein-, caspase-3- and caspase-9positive cells gradually increased and some adipose-derived stromal cells exhibited typical signs of apoptosis after differentiation. Therefore, the authors considered that caspase-dependent apoptosis is an obstacle to the differentiation of adipose-derived stromal cells into astrocytes and inhibiting apoptosis may be an important strategy for increasing the efficiency of induction. Related findings were published in Neural Regeneration Research (Vol. 9, No. 8, 2014).
INFORMATION:Article: " Apoptosis is an obstacle to the differentiation of adipose-derived stromal cells into astrocytes," by Xiaodong Yuan1, Qiaoyu Sun1, Ya Ou1, Shujuan Wang1, Wenli Zhang2, Hongliang Deng1, Xiaoying Wu1, Lili Zhang1 (1 Department of Neurology, Kailuan General Hospital, Hebei United University, Tangshan, Hebei Province, China; 2 Department of Electron Microscopy, Hebei United University, Tangshan, Hebei Province, China)
Yuan XD, Sun QY, Ou Y, Wang SJ, Zhang WL, Deng HL, Wu XY, Zhang LL. Apoptosis is an obstacle to the differentiation of adipose-derived stromal cells into astrocytes. Neural Regen Res. 2014;9(8):837-844.
Contact: Meng Zhao
eic@nrren.org
86-138-049-98773
Neural Regeneration Research
http://www.nrronline.org/
An obstacle to the differentiation of adipose-derived stromal cells into astrocytes
2014-07-11
[Attachments] See images for this press release:
ELSE PRESS RELEASES FROM THIS DATE:
Why anandamide can increase intracellular Ca2+ concentration?
2014-07-11
Evidence exists that cannabinoid receptor type 1 can inhibit voltage-gated calcium channel, decrease intracellular Ca2+ influx, and reduce neurotransmitter release. However, some scholars demonstrated that cannabinoid receptor type 1 can increase extracellular Ca2+ influx and increase neurotransmitter release. Dr. Yi Zhang and his team, Tongji Hospital Affiliated to Tongji Medical College, Huazhong University of Science and Technology, China used whole cell voltage-clamp and calcium imaging in cultured trigeminal ganglion neurons and found that anandamide directly caused ...
Exercise is the best medicine: QUT study
2014-07-11
Women would benefit from being prescribed exercise as medicine, according to a QUT study that revealed moderate to high intensity activity is essential to reducing the risk of death in older women.
Professor Debra Anderson, from QUT's Institute of Health and Biomedical Innovation, said that in addition to conventional treatments for physical and mental health, health professionals should be prescribing tailored exercise programs for older women.
Professor Anderson and QUT's Dr Charlotte Seib co-authored a paper published in the international journal of midlife health ...
'Expressive therapy" intervention assists women living with HIV
2014-07-11
New research from UC San Francisco shows that an "expressive therapy" group intervention conducted by The Medea Project helps women living with HIV disclose their health status and improves their social support, self-efficacy and the safety and quality of their relationships.
"Medication alone is totally insufficient," said the study's first author, Edward L. Machtinger, MD, director of the Women's HIV Program at UCSF. "Over 90 percent of our patients are on effective antiretroviral therapy but far too many are dying from suicide, addiction, and violence. Depression, addiction, ...
Growing up on a livestock farm halves the risk of inflammatory bowel diseases
2014-07-11
New research conducted at Aarhus University has revealed that people who have grown up on a farm with livestock are only half as likely as their urban counterparts to develop the most common inflammatory bowel diseases: ulcerative colitis and Crohn's disease. The study findings have recently been published in the European Journal of Epidemiology.
"It is extremely exciting that we can now see that not only allergic diseases, but also more classic inflammatory diseases appear to depend on the environment we are exposed to early in our lives," relates Vivi Schlünssen, Associate ...
BGI reports a novel gene for salt tolerance found in wild soybean
2014-07-11
Shenzhen, July 10, 2014---A team of researchers from The Chinese University of Hong Kong, BGI and other institutes have identified a gene of wild soybean linked to salt tolerance, with implication for improving this important crop to grow in saline soil. This study published online in Nature Communications provides an effective strategy to unveil novel genomic information for crop improvement.
Soybean is an important crop for the world. Due to domestication and human selection, cultivated soybeans have less genetic diversities than their wild counterparts. Among the lost ...
A new genome editing method brings the possibility of gene therapies closer to reality
2014-07-11
July 3, 2014, Shenzhen, China— Researchers from Salk Institute for Biological Studies, BGI, and other institutes for the first time evaluated the safety and reliability of the existing targeted gene correction technologies, and successfully developed a new method, TALEN-HDAdV, which could significantly increased gene-correction efficiency in human induced pluripotent stem cell (hiPSC). This study published online in Cell Stell Cell provides an important theoretical foundation for stem cell-based gene therapy.
The combination of stem cells and targeted genome editing technology ...
Opening-up the stem cell niche
2014-07-11
For many years scientists have been trying to unravel mechanisms that guide function and differentiation of blood stem cells, those cells that generate all blood cells including our immune system. The study of human blood stem cells is difficult because they can only be found in the bone marrow in specialized "niches" that cannot be recapitulated in a culture dish. Now a group of scientists from Dresden led by stem cell researcher Prof. Claudia Waskow (Technische Universität Dresden) was able to generate a mouse model that supports the transplantation of human blood stem ...
Baboons groom early in the day to get benefits later
2014-07-11
Social animals often develop relationships with other group members to reduce aggression and gain access to scarce resources. In wild chacma baboons the strategy for grooming activities shows a certain pattern across the day. The results are just published in the scientific journal Biology Letters.
Grooming between individuals in a group of baboons is not practiced without ulterior motives. To be groomed has hygienic benefits and is stress relieving for the individual, while grooming another individual can provide access to infants, mating opportunities and high quality ...
A first direct glimpse of photosynthesis in action
2014-07-11
An international team of researchers, including scientists from the Max Planck Institute for Medical Research in Heidelberg, has just a reported a major step in understanding photosynthesis, the process by which the Earth first gained and now maintains the oxygen in its atmosphere and which is therefore crucial for all higher forms of life on earth.
The researchers report the first direct visualization of a crucial event in the photosynthetic reaction, namely the step in which a specific protein complex, photosystem II, splits water into hydrogen and oxygen using energy ...
Molecular snapshots of oxygen formation in photosynthesis
2014-07-11
Researchers from Umeå University, Sweden, have explored two different ways that allow unprecedented experimental insights into the reaction sequence leading to the formation of oxygen molecules in photosynthesis. The two studies have been published in the scientific journal Nature Communications.
"The new knowledge will help improving present day synthetic catalysts for water oxidation, which are key components for building artificial leaf devices for the direct storage of solar energy in fuels like hydrogen, ethanol or methanol," says Johannes Messinger, Professor in ...