NIH turns to crowdsourcing to repurpose drugs

Initial success exceeds expectations

2014-07-16

(Press-News.org) New Rochelle, NY, July 16, 2014–Experimental drugs proven safe but perhaps not sufficiently effective in initial testing or against a first disease target may sit gathering dust on the shelves of pharmaceutical companies. An NIH-sponsored effort based on a crowdsourcing strategy to establish collaborations between industrial and academic partners to test and develop these therapeutic compounds was met with an overwhelming response and has led to clinical testing of a broad range of pilot projects and a newly announced round of funding opportunities. These findings are described in a Review article in the preview issue of the new journal Drug Repurposing, Rescue, and Repositioning, a peer-reviewed publication from Mary Ann Liebert, Inc., publishers. The article is available free on the Drug Repurposing, Rescue, and Repositioning website.

Christine M. Colvis, PhD and Christopher P. Austin, MD, National Center for Advancing Translational Sciences, National Institutes of Health (NIH), Bethesda, MD, explain that the Center does not focus on a particular disease or organ system, allowing it to support a broad scope of projects that link indications with unmet medical needs to the mechanisms of action of new drug compounds that are ready to move into patient testing. In the article "The NIH-Industry New Therapeutic Uses Pilot Program: Demonstrating the Power of Crowdsourcing") the authors state that among the new funding opportunity announcements released by the Center in May were 12 therapeutic agents for pediatric indication consideration.

"This article describes not only how targeted crowdsourcing can link up the assets, the know-how, and the creativity that drug repurposing needs, but also how such a program can be organized to serve the best interests of all concerned parties," says journal Editor Hermann Mucke, PhD, H.M. Pharma Consultancy, Vienna, Austria. "Pharmaceutical companies and academia must collaborate to leverage their huge potential synergies in compound re-development, and by arranging and mentoring this pilot program NCATS has firmly established its role as a mediator in drug repurposing."

INFORMATION: About the Journal Drug Repurposing, Rescue, and Repositioning, a dynamic new peer-reviewed journal, presents techniques and tools for finding new uses for approved drugs — particularly for disorders where no animal model, physiologic abnormality, biochemical pathway, or molecular target has been identified. Led by Editor-in-Chief Aris Persidis, Biovista, Inc., and Editor Hermann Mucke, H.M. Pharma Consultancy e.U, the Journal provides a new interdisciplinary platform for scientific contributions to the field of drug repurposing including original research papers, reviews, case studies, application-oriented technology assessments, and reports in methodology and technology application. The Journal is published quarterly online with Open Access options and in print. A sample issue may be viewed on the Drug Repurposing, Rescue, and Repositioning website

About the Publisher Mary Ann Liebert, Inc., publishers is a privately held, fully integrated media company known for establishing authoritative peer-reviewed journals in many areas of science and biomedical research, including ASSAY and Drug Development Technologies, Big Data, and Biotechnology Law Report. Its biotechnology trade magazine, Genetic Engineering & Biotechnology News (GEN), was the first in its field and is today the industry's most widely read publication worldwide. A complete list of the firm's 80 journals, books, and newsmagazines is available on the Mary Ann Liebert, Inc., publishers website.

Mary Ann Liebert, Inc. 140 Huguenot St., New Rochelle, NY 10801-5215 Phone: (914) 740-2100 (800) M-LIEBERT Fax: (914) 740-2101 http://www.liebertpub.com Contact: Kathryn Ruehle, Mary Ann Liebert, Inc., (914) 740-2100, kruehle@liebertpub.com

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NIH turns to crowdsourcing to repurpose drugs

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