(Press-News.org) New Rochelle, NY, July 16, 2014–Experimental drugs proven safe but perhaps not sufficiently effective in initial testing or against a first disease target may sit gathering dust on the shelves of pharmaceutical companies. An NIH-sponsored effort based on a crowdsourcing strategy to establish collaborations between industrial and academic partners to test and develop these therapeutic compounds was met with an overwhelming response and has led to clinical testing of a broad range of pilot projects and a newly announced round of funding opportunities. These findings are described in a Review article in the preview issue of the new journal Drug Repurposing, Rescue, and Repositioning, a peer-reviewed publication from Mary Ann Liebert, Inc., publishers. The article is available free on the Drug Repurposing, Rescue, and Repositioning website.
Christine M. Colvis, PhD and Christopher P. Austin, MD, National Center for Advancing Translational Sciences, National Institutes of Health (NIH), Bethesda, MD, explain that the Center does not focus on a particular disease or organ system, allowing it to support a broad scope of projects that link indications with unmet medical needs to the mechanisms of action of new drug compounds that are ready to move into patient testing. In the article "The NIH-Industry New Therapeutic Uses Pilot Program: Demonstrating the Power of Crowdsourcing") the authors state that among the new funding opportunity announcements released by the Center in May were 12 therapeutic agents for pediatric indication consideration.
"This article describes not only how targeted crowdsourcing can link up the assets, the know-how, and the creativity that drug repurposing needs, but also how such a program can be organized to serve the best interests of all concerned parties," says journal Editor Hermann Mucke, PhD, H.M. Pharma Consultancy, Vienna, Austria. "Pharmaceutical companies and academia must collaborate to leverage their huge potential synergies in compound re-development, and by arranging and mentoring this pilot program NCATS has firmly established its role as a mediator in drug repurposing."
INFORMATION:
About the Journal
Drug Repurposing, Rescue, and Repositioning, a dynamic new peer-reviewed journal, presents techniques and tools for finding new uses for approved drugs — particularly for disorders where no animal model, physiologic abnormality, biochemical pathway, or molecular target has been identified. Led by Editor-in-Chief Aris Persidis, Biovista, Inc., and Editor Hermann Mucke, H.M. Pharma Consultancy e.U, the Journal provides a new interdisciplinary platform for scientific contributions to the field of drug repurposing including original research papers, reviews, case studies, application-oriented technology assessments, and reports in methodology and technology application. The Journal is published quarterly online with Open Access options and in print. A sample issue may be viewed on the Drug Repurposing, Rescue, and Repositioning website
About the Publisher
Mary Ann Liebert, Inc., publishers is a privately held, fully integrated media company known for establishing authoritative peer-reviewed journals in many areas of science and biomedical research, including ASSAY and Drug Development Technologies, Big Data, and Biotechnology Law Report. Its biotechnology trade magazine, Genetic Engineering & Biotechnology News (GEN), was the first in its field and is today the industry's most widely read publication worldwide. A complete list of the firm's 80 journals, books, and newsmagazines is available on the Mary Ann Liebert, Inc., publishers website.
Mary Ann Liebert, Inc. 140 Huguenot St., New Rochelle, NY 10801-5215
Phone: (914) 740-2100 (800) M-LIEBERT Fax: (914) 740-2101
http://www.liebertpub.com
Contact: Kathryn Ruehle, Mary Ann Liebert, Inc., (914) 740-2100, kruehle@liebertpub.com
NIH turns to crowdsourcing to repurpose drugs
Initial success exceeds expectations
2014-07-16
ELSE PRESS RELEASES FROM THIS DATE:
What do Google searches tell us about our climate change fears?
2014-07-16
Republicans search the Net for information about the weather, climate change and global warming during extremely hot or cold spells. Democrats Google these terms when they experience changes in the average temperatures. These are some of the surprising findings from a study by Corey Lang of the University of Rhode Island in the US, published in Springer's journal Climatic Change. He tracked how the temperature fluctuations and rainfall that Americans experience daily in their own cities make them scour the Internet in search of information about climate change and global ...
An anti-glare, anti-reflective display for mobile devices?
2014-07-16
If you've ever tried to watch a video on a tablet on a sunny day, you know you have to tilt it at just the right angle to get rid of glare or invest in a special filter. But now scientists are reporting in the journal ACS Applied Materials & Interfaces that they've developed a novel glass surface that reduces both glare and reflection, which continue to plague even the best mobile displays today.
Valerio Pruneri and colleagues note that much effort has been poured into anti-reflective and anti-glare technology. In the highly competitive digital age, any bonus feature ...
Fundamental research is paving the way for development of first vaccine for heart disease
2014-07-16
DETROIT — Researchers at Wayne State University have made a fundamental discovery and, in subsequent collaboration with scientists at La Jolla Institute for Allergy and Immunology (LIAI), are one step closer to the goal of developing the world's first T-cell peptide-based vaccine for heart disease — the number one killer in the nation.
Atherosclerosis is a chronic inflammatory disease of the arterial walls, which thicken due to accumulation of fatty materials such as cholesterols and triglycerides. Blocking of arteries supplying blood to the heart is the underlying cause ...
Decoding dengue
2014-07-16
Scientists have discovered a new pathway the dengue virus takes to suppress the human immune system. This new knowledge deepens our understanding of the virus and could contribute to the development of more effective therapeutics.
For years, the conventional approach to target the dengue virus was through vector control, which was regarded to be the most effective method. This is because the mechanics of the virus have been elusive, which in turn hampered the development of effective treatments and vaccines.
Fortunately a new study, published in the prestigious journal ...
Aqueous two-phase systems enable multiplexing of homogeneous immunoassays
2014-07-16
A new protein biomarker test platform developed by researchers at the University of Michigan and Indiana University promises to improve diagnostic testing. The test can accurately and simultaneously measure multiple proteins that indicate the presence of diseases like graft-versus-host disease (bone marrow transplant rejection) in only two hours, no washing steps, and using only a minute volume of blood plasma. A report on this new technology can be found online in the journal TECHNOLOGY.
The protein test uses a micropatterning method developed in Shuichi Takayama's Micro/Nano/Molecular ...
Tracking the breakup of Arctic summer sea ice
2014-07-16
As sea ice begins to melt back toward its late September minimum, it is being watched as never before. Scientists have put sensors on and under ice in the Beaufort Sea for an unprecedented campaign to monitor the summer melt.
The international effort hopes to figure out the physics of the ice edge in order to better understand and predict open water in Arctic seas.
"This has never been done at this level, over such a large area and for such a long period of time," said principal investigator Craig Lee, an oceanographer at the University of Washington's Applied Physics ...
Breast cancer: DMP is largely consistent with guidelines
2014-07-16
On 16 July 2014 the German Institute for Quality and Efficiency in Health Care (IQWiG) published the results of a literature search for evidence-based clinical practice guidelines on the treatment of people with breast cancer. The aim of the report is to identify those recommendations from current guidelines of high methodological quality that may be relevant for the planned revision of the disease management programme (DMP). According to the results of the report, there is no compelling need for revision of any part of the DMP. However, IQWiG identified some aspects that ...
Self-assembling nanoparticle could improve MRI scanning for cancer diagnosis
2014-07-16
Scientists have designed a new self-assembling nanoparticle that targets tumours, to help doctors diagnose cancer earlier.
The new nanoparticle, developed by researchers at Imperial College London, boosts the effectiveness of Magnetic Resonance Imaging (MRI) scanning by specifically seeking out receptors that are found in cancerous cells.
The nanoparticle is coated with a special protein, which looks for specific signals given off by tumours, and when it finds a tumour it begins to interact with the cancerous cells. This interaction strips off the protein coating, ...
Improving tumour radiation therapy: When basic ions break DNA down
2014-07-16
Scientists now have a better understanding of how short DNA strands decompose in microseconds. A European team found new fragmentation pathways that occur universally when DNA strands are exposed to metal ions from a family of alkaline and alkaline earth elements. These ions tend to replace protons in the DNA backbone and at the same time induce a reactive conformation leading more readily to fragmentation. These findings by Andreas Piekarczyk, from the University of Iceland, and colleagues have been published in a study in EPJ D. They could contribute to optimising cancerous ...
Researchers advance understanding in immune response to infectious disease
2014-07-16
University of Leicester researchers have released evidence substantiating an unexpected dual role of an important component of the immune system.
Findings by researchers at the University's Department of Infection, Immunity and Inflammation – including three PhD graduates – are published in a paper for the journal 'Medical Microbiology and Immunology'.
The paper presents significant new findings about the protein properdin – an important part of the immune system. It is a positive regulator in the alternative pathway of complement activation – which means it plays a ...
LAST 30 PRESS RELEASES:
Ancient crop discovered in the Canary Islands thanks to archaeological DNA
Placental research may transform our understanding of autism and human brain evolution
Mapping the Universe, faster and with the same accuracy
Study isolates population aging as primary driver of musculoskeletal disorders
Designing a sulfur vacancy redox disruptor for photothermoelectric and cascade‑catalytic‑driven cuproptosis–ferroptosis–apoptosis therapy
Recent advances in dynamic biomacromolecular modifications and chemical interventions: Perspective from a Chinese chemical biology consortium
CRF and the Jon DeHaan Foundation to launch TCT AI Lab at TCT 2025
Canada’s fastest academic supercomputer is now online at SFU after $80m upgrades
Architecture’s past holds the key to sustainable future
Laser correction for short-sightedness is safe and effective for older teenagers
About one in five people taking Ozempic, Wegovy or Mounjaro say food tastes saltier or sweeter than before
Taking semaglutide turns down food noise, research suggests
Type 2 diabetes may double risk of sepsis, large community-based study suggests
New quantum sensors can withstand extreme pressure
Tirzepatide more cost-effective than semaglutide in patients with knee osteoarthritis and obesity
GLP-1 drugs shown cost-effective for knee osteoarthritis and obesity
Interactive apps, AI chatbots promote playfulness, reduce privacy concerns
How NIL boosts college football’s competitive balance
Moffitt researchers develop machine learning model to predict urgent care visits for lung cancer patients
Construction secrets of honeybees: Study reveals how bees build hives in tricky spots
Wheat disease losses total $2.9 billion across the United States and Canada between 2018 and 2021
New funding fuels development of first potentially regenerative treatment for multiple sclerosis
NJIT student–faculty team wins best presentation award for ant swarm simulation
Ants defend plants from herbivores but can hinder pollination
When the wireless data runs dry
Inquiry into the history of science shows an early “inherence” bias
Picky eaters endure: Ecologists use DNA to explore diet breadth of wild herbivores
Study suggests most Americans would be healthier without daylight saving time
Increasing the level of the protein PI31 demonstrates neuroprotective effects in mice
Multi-energy X-ray curved surface imaging-with multi-layer in-situ grown scintillators
[Press-News.org] NIH turns to crowdsourcing to repurpose drugsInitial success exceeds expectations