PRESS-NEWS.org - Press Release Distribution
PRESS RELEASES DISTRIBUTION

Heart attack patients could be treated more quickly after Manchester research

2014-07-25
(Press-News.org) Heart attack patients could be treated more quickly after Manchester research

Clinical judgement, combined with an electrocardiogram (ECG) and blood test on arrival, is effective in reducing unnecessary hospital admissions for chest pain, a new study shows. The findings of a research group in Manchester, published in the Emergency Medicine Journal, could potentially make a huge difference to a large number of patients. Chest pain is the most common reason for emergency hospital admission. In Manchester, the incidence of premature death due to heart disease and stroke is amongst the highest in England. Previous research has shown that typical symptoms in patients presenting to emergency departments have not been useful in differentiating between heart conditions requiring immediate hospital admission (acute coronary syndromes; ACS), and non-cardiac conditions. This is because the symptoms of patients with heart disease can be similar to those experienced by patients with non-cardiac conditions, such as indigestion. However, the role of overall clinical judgement has not been extensively studied. The latest research, led by Dr Richard Body, Consultant in Emergency Medicine at Manchester Royal Infirmary, assessed the diagnostic accuracy of emergency doctors' clinical judgement for acute coronary syndromes – both alone and in combination with the tests available on arrival – ECG and a blood test which detects a protein called troponin. The study was undertaken at Stockport NHS Foundation Trust, where doctors in the emergency department recorded their overall clinical judgement for ACS using a five-point Likert scale (from 'definitely ACS' to 'definitely not' ACS). This data was then compared with patients' outcomes, including heart attack or the occurrence of major adverse cardiac events within 30 days. The results showed that for patients who are suspected to have an ACS, clinical judgement cannot be relied upon by itself to rule out or rule in that diagnosis. However, when combined with an ECG and troponin test clinical judgement appeared to be an effective tool and the results suggest that at least 25 per cent of patient admissions could have avoided. The study also suggested that this was the case regardless of whether the clinician was a consultant or junior doctor. Dr Rick Body, who is also National Institute for Health Research Postdoctoral Research Fellow and Honorary Lecturer in Cardiovascular Medicine at The University of Manchester, said: "I think the beauty of this technique is its simplicity. For years we've been working hard to improve our technology and our tests for heart attacks. This research suggests that, if the initial tests are normal and the doctor thinks that the diagnosis of a heart attack is unlikely, it may be perfectly safe to reassure patients that they do not have a heart attack without relying on further tests and observation in hospital.

"It is still early days but the study, which was funded through an NIHR Clinical Lecturer grant and a College of Emergency Medicine Research Grant, could potentially make a huge difference to large numbers of patients.

"In order to ensure the safety of patients, further research is still vital to ensure that our findings can be repeated with different groups of doctors and patients. We will also need to know if doctors would be confident enough in their judgement to use the technique in practice."

INFORMATION: The delivery of the study was supported by the National Institute for Health Research (NIHR) Clinical Research Network.


ELSE PRESS RELEASES FROM THIS DATE:

Test increases odds of correct surgery for thyroid cancer patients

2014-07-25
PITTSBURGH -- The routine use of a molecular testing panel developed at UPMC greatly increases the likelihood of performing the correct initial surgery for patients with thyroid nodules and cancer, report researchers from the University of Pittsburgh Cancer Institute (UPCI), partner with UPMC CancerCenter. The test, available at the UPMC/UPCI Multidisciplinary Thyroid Center and other diagnostic testing agencies, improved the chances of patients getting the correct initial surgery by 30 percent, according to the study published this month in the Annals of Surgery. "Before ...

Brain tumor causes and risk factors elude scientists

2014-07-25
Today, nearly 700,000 people in the U.S. are living with a brain tumor, and yet, when it comes to pinpointing causes or risk factors, scientists are still searching for answers. "Right now, we don't know who, we don't know when, and we don't know why people develop brain tumors," said Elizabeth M. Wilson, MNA, President and CEO, American Brain Tumor Association. "It's frustrating for the brain tumor community, and it's why the American Brain Tumor Association funds research to pursue answers to these questions, and it's why we host this national conference to provide ...

Is Europe putting cancer research at risk?

2014-07-25
The European Society for Medical Oncology (ESMO), the leading pan-European association representing medical oncology professionals, has expressed concern that the proposed EU General Data Protection Regulation [1] could make cancer research impossible and add a significant burden to both doctors and cancer patients. The proposed wording of the regulation [2] stipulates 'explicit and specific patient consent', meaning that researchers would have to approach patients every single time research is planned in order to consult their data or use tissue samples stored for research ...

Informed consent: False positives not a worry in lung cancer study

Informed consent: False positives not a worry in lung cancer study
2014-07-25
PROVIDENCE, R.I. [Brown University] — The U.S. Preventive Services Task Force recently recommended computerized tomography (CT) lung screening for people at high risk for cancer, but a potential problem with CT is that many patients will have positive results on the screening test, only to be deemed cancer-free on further testing. Many policymakers have expressed concern that this high false-positive rate will cause patients to become needlessly upset. A new study of National Lung Screening Trial participant responses to false positive diagnoses, however, finds that those ...

Exposure to dim light at night may make breast cancers resistant to tamoxifen

2014-07-25
PHILADELPHIA — For rats bearing human breast tumors, exposure to dim light at night made the tumors resistant to the breast cancer drug tamoxifen, according to data published in Cancer Research, a journal of the American Association for Cancer Research. The negative effects of dim light exposure on tamoxifen treatment were overcome by giving rats a melatonin supplement during the night. "Resistance to tamoxifen is a growing problem among patients with hormone receptor-positive breast cancer," said Steven M. Hill, PhD, professor of structural and cellular biology and the ...

Total darkness at night is key to success of breast cancer therapy -- Tulane study

Total darkness at night is key to success of breast cancer therapy -- Tulane study
2014-07-25
Exposure to light at night, which shuts off nighttime production of the hormone melatonin, renders breast cancer completely resistant to tamoxifen, a widely used breast cancer drug, says a new study by Tulane University School of Medicine cancer researchers. The study, "Circadian and Melatonin Disruption by Exposure to Light at Night Drives Intrinsic Resistance to Tamoxifen Therapy in Breast Cancer," published in the journal Cancer Research, is the first to show that melatonin is vital to the success of tamoxifen in treating breast cancer. Principal investigators and ...

Zerenex™ (ferric citrate) long-term Phase 3 study results published in JASN

2014-07-25
New York, NY - July 24, 2014 -- Keryx Biopharmaceuticals, Inc. (Nasdaq:KERX) (the "Company") announced the publication of results from the long-term, randomized, active control Phase 3 study of Zerenex (ferric citrate), the Company's investigational oral ferric iron-based phosphate binder, for the treatment of hyperphosphatemia in patients with end-stage renal disease (ESRD) on dialysis. The PERFECTED study (PhosphatE binding and iRon delivery with FErric CiTrate in EsrD) was published online today in the Journal of the American Society of Nephrology (JASN). This Phase ...

New research suggests Saharan dust is key to the formation of Bahamas' Great Bank

New research suggests Saharan dust is key to the formation of Bahamas Great Bank
2014-07-25
MIAMI – A new study suggests that Saharan dust played a major role in the formation of the Bahamas islands. Researchers from the University of Miami (UM) Rosenstiel School of Marine and Atmospheric Science showed that iron-rich Saharan dust provides the nutrients necessary for specialized bacteria to produce the island chain's carbonate-based foundation. UM Rosenstiel School Lewis G. Weeks Professor Peter Swart and colleagues analyzed the concentrations of two trace elements characteristic of atmospheric dust – iron and manganese – in 270 seafloor samples collected along ...

Overweight and obese preschoolers lose more weight when parent is also treated

Overweight and obese preschoolers lose more weight when parent is also treated
2014-07-24
BUFFALO, N.Y. – Primary care treatment of overweight and obese preschoolers works better when treatment targets both parent and child compared to when only the child is targeted, according to research published this week in Pediatrics and conducted at the University at Buffalo and Women and Children's Hospital of Buffalo. Children enrolled in this study were overweight or obese and had one parent who participated in the study who also was overweight or obese, according to body mass index (BMI) measurements, calculated based on height and weight. During the course of the ...

NYSCF scientists one step closer to cell therapy for multiple sclerosis patients

2014-07-24
NEW YORK, NY (July 24, 2014) – Scientists at The New York Stem Cell Foundation (NYSCF) Research Institute are one step closer to creating a viable cell replacement therapy for multiple sclerosis from a patient's own cells. For the first time, NYSCF scientists generated induced pluripotent stem (iPS) cells lines from skin samples of patients with primary progressive multiple sclerosis and further, they developed an accelerated protocol to induce these stem cells into becoming oligodendrocytes, the myelin-forming cells of the central nervous system implicated in multiple ...

LAST 30 PRESS RELEASES:

Next top model: Competition-based AI study aims to lower data center costs

Innovative startup awarded $10,000 to tackle cardiovascular disparities

Study compares indoor transmission-risk metrics for infectious diseases

Micro-expression detection in ASD movies: a YOLOv8-SMART approach

Machine learning on blockchain: A new approach to engineering computational security

Vacuum glazing: A promising solution for low-carbon buildings

Racial and ethnic differences in out-of-pocket spending for maternity care

Study reveals racial and ethnic disparities in maternity care spending

Changes in food insecurity among US adults with low income during the COVID-19 pandemic

After NIH decision to cap indirect costs, prominent molecular biologist calls for swift action, petition signatures

Omitting race from lung function equations increases detection of asthma in Black children

The role of solute carrier family transporters in hepatic steatosis and hepatic fibrosis

Cold sore discovery IDs unknown trigger for those annoying flare-ups

Health organizations join forces on Rare Disease Day for idiopathic pulmonary fibrosis

How many languages can you learn at the same time? – Ghanaian babies grow up speaking two to six languages

Virginia Tech to lead $10 million critical mineral research coalition in Appalachia

CFRP and UHPC: New insights into strengthening reinforced concrete beams under thermocyclic distress

Armsworth receives SEC Faculty Achievement Award

Novel network dynamic approach presents new way for aeroengine performance evaluation

Gene therapy developed for maple syrup urine disease shows promise, new UMass Chan study reports

Ursodeoxycholic acid for the management of drug-induced liver injury: Role of hepatoprotective and anti-cholestatic mechanisms

Hepatic biliary adenofibroma: Histological characteristics, diagnostic challenges, and its role as a precursor to intrahepatic cholangiocarcinoma

Unlocking the role of long non-coding RNAs in liver disease progression

McMaster researchers uncover blood metabolites that may influence early childhood development

Why don’t pandas eat more meat? Molecules found in bamboo may be behind their plant-based diet

Development of 'transparent stretchable substrate' without image distortion could revolutionize next-generation displays

Improving the scope of wearable monitors

Zeroing in: SMU project to boost indoor localization capabilities for the public agencies

E. coli strain in Egyptian dairy products also found in Japan school outbreak

Quantum computing “a marathon, not a sprint”

[Press-News.org] Heart attack patients could be treated more quickly after Manchester research