(Press-News.org) HIV research findings made possible by a test developed at University of Colorado Skaggs School of Pharmacy and Pharmaceutical Sciences (CU School of Pharmacy)
AURORA, Colo (July 28, 2014) An influential new test, discovered and developed in the Colorado Antiviral Pharmacology Laboratory at the CU School of Pharmacy, helps monitor the effectiveness of the HIV prevention drug called Truvada (a combination of tenofovir/emtricitabine), which is taken once daily to prevent HIV infection.
A study presented during the AIDS 2014 Conference and published in Lancet Infectious Diseases on the efficacy and safety of prophylactic use of Truvada to protect against HIV infection relied on a test developed at the school. The test measures the amount of tenofovir-diphosphate (a metabolite of tenofovir) in red blood cells, using a dried blood spot. Because of a long half-life, high amounts of the metabolite in the dried blood spot correspond with consistent dosing of Truvada and low amounts correspond with inconsistent dosing. The new test was used in the iPrEx open label extension study (iPrEx OLE) published in Lancet Infectious Diseases to estimate patterns of tablet use during the study. The new test showed a continuous gradient of increasing efficacy (fewer HIV infections) with increasing drug concentrations. Dr. Peter Anderson, whose laboratory developed the test, said, "Participants in the study who had tablet use consistent with 4 or more tablets per week, as determined by the new test, had no HIV infections (estimated 100% efficacy)."
The US Centers for Disease Control and Prevention (CDC) and the World Health Organization (WHO) recently issued guidelines recommending the use of antiretroviral medicines as an additional method of preventing HIV infection. "Findings from iPrEX OLE are particularly important in relation to emerging guidelines recommending widespread use of PrEP," said Protocol Chair Robert Grant, MD, PGH of the Gladstone Institutes, the University of California at San Francisco and the San Francisco AIDS Foundation.
INFORMATION:
Since its inception in 1911, the University of Colorado Skaggs School of Pharmacy and Pharmaceutical Sciences has experienced numerous milestones and is ranked in the top 20 percent of all schools of pharmacy in the country, and twelfth in the nation for total NIH funding. Committed to pharmaceutical education, research and patient care, the School educates students in the properties of medicinal agents, the biology of disease, the actions of drugs, and best practices for clinical and therapeutic uses of drugs. Located at the Anschutz Medical Campus, the University of Colorado is the only completely new education, research and patient care facility in the nation today.
HIV research findings made possible by a test developed at CU School of Pharmacy
2014-07-28
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