(Press-News.org) Scientists from InSilico Medicine and its partners successfully established a visual mapping of the molecular pathway cancer progression originating from myeloid derived suppressor cells (MDSC). The damage and immune suppression the cells cause are not fully understood, however this is a major stepping stone in creating necessary transparency. Highly cited MetaCoreTM was the primary interactome analysis tool used for mapping, providing these promising results.
"MDSCs are elicited by tumor-derived factors from precursors present in hematopoietic organs such as the bone marrow and possibly spleen. This population of cells suppresses the activity of various types of immune cells and contributes to tumor progression by promoting tumor angiogenesis and metastasis. But the key transcriptional regulators of MDSC are still poorly defined. Alex and colleagues used bioinformatic tools to investigate the pathway interactome maps in colon and breast cancer models. Several proliferation and invasion-related pathways were identified in infiltrating MDSC. It opens a door to new therapy targeting MDSC in these diseases. " says Qingsong Zhu, COO of InSilico Medicine, Inc.
INFORMATION:
More on the study can be found here: http://www.impactjournals.com/oncotarget/index.php?journal=oncotarget&page=article&op=view&path%5B%5D=2489&path%5B%5D=4445.
About InSilico Medicine
InSilico Medicine was founded in early 2014 and has since developed the OncoFinder and Geroscope. It is a company dedicated to finding novel solutions towards aging and age-related diseases using advances in genomics and big data analysis. Through internal expertise and extensive collaborations with brilliant scientists, institutions, and highly credible pharmaceutical companies, InSilico Medicine seeks to revolutionize personalized science and drug discovery. More can be read about InSilico Medicine, Inc. at http://www.insilicomedicine.com.
First mapping that reveals the molecular pathway for MDSC cancer progression
InSilico Medicine and partners provide a clear, illustrative map that allows scientists to understand MDSC conditions, and furthermore the means to infiltrate them
2014-09-30
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[Press-News.org] First mapping that reveals the molecular pathway for MDSC cancer progressionInSilico Medicine and partners provide a clear, illustrative map that allows scientists to understand MDSC conditions, and furthermore the means to infiltrate them