(Press-News.org) Scientists from InSilico Medicine and its partners successfully established a visual mapping of the molecular pathway cancer progression originating from myeloid derived suppressor cells (MDSC). The damage and immune suppression the cells cause are not fully understood, however this is a major stepping stone in creating necessary transparency. Highly cited MetaCoreTM was the primary interactome analysis tool used for mapping, providing these promising results.
"MDSCs are elicited by tumor-derived factors from precursors present in hematopoietic organs such as the bone marrow and possibly spleen. This population of cells suppresses the activity of various types of immune cells and contributes to tumor progression by promoting tumor angiogenesis and metastasis. But the key transcriptional regulators of MDSC are still poorly defined. Alex and colleagues used bioinformatic tools to investigate the pathway interactome maps in colon and breast cancer models. Several proliferation and invasion-related pathways were identified in infiltrating MDSC. It opens a door to new therapy targeting MDSC in these diseases. " says Qingsong Zhu, COO of InSilico Medicine, Inc.
INFORMATION:
More on the study can be found here: http://www.impactjournals.com/oncotarget/index.php?journal=oncotarget&page=article&op=view&path%5B%5D=2489&path%5B%5D=4445.
About InSilico Medicine
InSilico Medicine was founded in early 2014 and has since developed the OncoFinder and Geroscope. It is a company dedicated to finding novel solutions towards aging and age-related diseases using advances in genomics and big data analysis. Through internal expertise and extensive collaborations with brilliant scientists, institutions, and highly credible pharmaceutical companies, InSilico Medicine seeks to revolutionize personalized science and drug discovery. More can be read about InSilico Medicine, Inc. at http://www.insilicomedicine.com.
First mapping that reveals the molecular pathway for MDSC cancer progression
InSilico Medicine and partners provide a clear, illustrative map that allows scientists to understand MDSC conditions, and furthermore the means to infiltrate them
2014-09-30
ELSE PRESS RELEASES FROM THIS DATE:
Benzodiazepine sedatives linked to higher rates of mortality compared to propofol
2014-09-30
AUDIO:
Sedation is commonly used in the intensive care unit (ICU) to make patients that require mechanical ventilation more comfortable, and less anxious. What many don't realize is that sedation can...
Click here for more information.
Sedation is frequently required for mechanically ventilated intensive care unit (ICU) patients to reduce anxiety, provide comfort, and assist in providing optimal respiratory support. It is estimated that each year, there are nearly 1 million U.S. ...
How to make a 'perfect' solar absorber
2014-09-30
CAMBRIDGE, Mass--The key to creating a material that would be ideal for converting solar energy to heat is tuning the material's spectrum of absorption just right: It should absorb virtually all wavelengths of light that reach Earth's surface from the sun — but not much of the rest of the spectrum, since that would increase the energy that is reradiated by the material, and thus lost to the conversion process.
Now researchers at MIT say they have accomplished the development of a material that comes very close to the "ideal" for solar absorption. The material is a two-dimensional ...
UConn scientists discover how to beat monk parakeets at their own game
2014-09-30
In a study published this week in the online journal PeerJ, University of Connecticut researchers announce they have found a way to prevent Monk Parakeets (Myiopsitta monarchus), an invasive species of parrot, from building huge nests that create power outages and public hazards on utility poles by blocking their access to the electric lines that are the gateway to their nest sites.
The nests, which are built out of sticks and twigs, can weigh up to 200 pounds or more. The damage they cause can cost electric utility companies millions of dollars annually.
But, the brightly ...
Selectively rewiring the brain's circuitry to treat depression
2014-09-30
Philadelphia, PA, September 30, 2014 – On Star Trek, it is easy to take for granted the incredible ability of futuristic doctors to wave small devices over the heads of both humans and aliens, diagnose their problems through evaluating changes in brain activity or chemistry, and then treat behavior problems by selectively stimulating relevant brain circuits.
While that day is a long way off, transcranial magnetic stimulation (TMS) of the left dorsolateral prefrontal cortex does treat symptoms of depression in humans by placing a relatively small device on a person's scalp ...
New material steals oxygen from the air
2014-09-30
Researchers from the University of Southern Denmark have synthesized crystalline materials that can bind and store oxygen in high concentrations. Just one spoon of the substance is enough to absorb all the oxygen in a room. The stored oxygen can be released again when and where it is needed.
We do fine with the 21 per cent oxygen in the air around us. But sometimes we need oxygen in higher concentrations; for example lung patients must carry heavy oxygen tanks, cars using fuel cells need a regulated oxygen supply. Perhaps one day in the future even sunlight-driven "reversible" ...
Low-birth-weight children are particularly vulnerable to environmental influences
2014-09-30
Low birth weight children are more vulnerable to environmental influences than infants born with normal weight. When brought up with a great deal of sensitivity, they will be able to catch up in school, but on average they will not become better students than normal birth weight children. This result, provided by an international psychologist team, has confirmed the so-called diathesis-stress model of development for low birth weight populations. The researchers report their findings in the Journal of Child Psychology and Psychiatry.
Theories on how environmental factors ...
Genetic test would help 'cut bowel cancer spread'
2014-09-30
Screening families of patients with bowel cancer for a genetic condition would cut their risk of developing bowel, womb, and ovarian cancers, new research has found.
In a major study, Dr Ian Frayling from Cardiff University's School of Medicine and researchers from the University of Exeter's Medical School assessed the effectiveness of introducing a UK-wide screening programme for a genetic condition known as Lynch Syndrome.
Lynch syndrome is a caused by changes in genes which check the spelling in DNA. The condition increases the risk of people developing cancer, ...
Bacteria may have ability to reduce impact of diazepam on UK river environments
2014-09-30
The natural photo degradation of diazepam (valium) and similar medicines – followed by bacterial breakdown – may reduce their potentially harmful impact on the UK's freshwater environment, a team of researchers has said.
Diazepam – used to treat anxiety and other similar conditions – has been detected in rivers across the UK and Europe, having been released from waste water treatment plants. At the levels recorded, it has the potential to produce harmful ecological effects in surface waters, including changing the behaviour of fish shoals and their ability to sense danger ...
Entanglement made tangible
2014-09-30
Quantum entanglement refers to the "pairing" of two subatomic particles in such a way that they form a whole quantum system. Interest in entanglement is increasing today, as it challenges the foundations of quantum mechanics itself, and is also key for achieving quantum information processing and communication. Entanglement is thought to exist up to the everyday, or "macroscopic" realm – according to the predictions of quantum physics – but experimental proposals to show this often involve conditions that are difficult to achieve in today's labs. Publishing in Physical ...
Shape up quickly -- applies to fish, too!
2014-09-30
Fish can live in almost any aquatic environment on Earth, but when the climate changes and temperatures go up many species are pushed to the limit. The amount of time needed to adjust to new conditions could prove critical for how different species cope in the future, reveals a new study from researchers at the University of Gothenburg, published in the scientific journal Proceedings of the Royal Society B.
Climate change continues apace thanks to increasing levels of greenhouse gases in the atmosphere. The greenhouse effect has led not only to an increase in average ...
LAST 30 PRESS RELEASES:
Donors enable record pool of TPDA Awards to Neuroscience 2025
Society for Neuroscience announces Gold Sponsors of Neuroscience 2025
The world’s oldest RNA extracted from woolly mammoth
Research alert: When life imitates art: Google searches for anxiety drug spike during run of The White Lotus TV show
Reading a quantum clock costs more energy than running it, study finds
Early MMR vaccine adoption during the 2025 Texas measles outbreak
Traces of bacteria inside brain tumors may affect tumor behavior
Hypertension affects the brain much earlier than expected
Nonlinear association between systemic immune-inflammation index and in-hospital mortality in critically ill patients with chronic obstructive pulmonary disease and atrial fibrillation: a cross-sectio
Drift logs destroying intertidal ecosystems
New test could speed detection of three serious regional fungal infections
New research on AI as a diagnostic tool to be featured at AMP 2025
New test could allow for more accurate Lyme disease diagnosis
New genetic tool reveals chromosome changes linked to pregnancy loss
New research in blood cancer diagnostics to be featured at AMP 2025
Analysis reveals that imaging is overused in diagnosing and managing the facial paralysis disorder Bell’s palsy
Research progress on leptin in metabolic dysfunction-associated fatty liver disease
Fondazione Telethon announces CHMP positive opinion for Waskyra™, a gene therapy for the treatment of Wiskott-Aldrich syndrome (WAS)
Vaccine Innovation Center, Korea University College of Medicine hosts an invited training program for Ethiopian Health Ministry officials
FAU study finds small group counseling helps children thrive at school
Research team uncovers overlooked layer of DNA that may shape disease risk
Study by Incheon National University could transform skin cancer detection with near-perfect accuracy
New study reveals how brain fluid flow predicts survival in glioblastoma
Cesarean delivery: the technique used for closing the uterus must be reconsidered
The “Great Unified Microscope” can see both micro and nanoscale structures
A new theory of molecular evolution
AI at the speed of light just became a possibility
Researchers identify mangrove tree stems as previously underestimated methane source offsetting blue carbon benefits
100 years of menus show how food can be used as a diplomatic tool to make and break political alliances
Vanishing viscosity limit of a parabolic-elliptic coupled system
[Press-News.org] First mapping that reveals the molecular pathway for MDSC cancer progressionInSilico Medicine and partners provide a clear, illustrative map that allows scientists to understand MDSC conditions, and furthermore the means to infiltrate them