(Press-News.org) September 30, 2014—(BRONX, NY)—Medications are the leading cause of allergy-related sudden deaths in the U.S., according to an analysis of death certificates from 1999 to 2010, conducted by researchers at Montefiore Medical Center and Albert Einstein College of Medicine of Yeshiva University. The study, published online today in the Journal of Allergy and Clinical Immunology, also found that the risk of fatal drug-induced allergic reactions was particularly high among older people and African-Americans and that such deaths increased significantly in the U.S. in recent years.
Anaphylaxis is the term used for a severe, potentially life-threatening allergic reaction that can occur within seconds or minutes following exposure to an allergen. Until now, data on trends in anaphylactic deaths—or even the number of yearly deaths from anaphylactic shock—has not been well-defined. One reason: unlike countries such as the UK, the U.S. doesn't maintain a national registry for anaphylaxis deaths.
"Anaphylaxis-related deaths in the U.S. have not been well understood in recent years," said Elina Jerschow , M.D., M.Sc. director, Drug Allergy Center, Allergy and Immunology Division of Medicine, Montefiore Medical Center, and assistant professor of medicine, Albert Einstein College, the lead author of the study. "We hope these findings will help in identifying specific risk factors and allow physicians to formulate preventative approaches."
Dr. Jerschow and colleagues analyzed death certificates from the U.S. National Mortality Database and found that medication-related anaphylaxis was the most common cause of death (58.8 percent). Additional causes identified included unspecified anaphylaxis (19.3 percent), venom (15.2 percent) and food (6.7 percent). Further analyses revealed fatal anaphylaxis due to medications, food and unspecified allergens was significantly associated with African American race and older age; and fatal anaphylaxis rates due to venom was more common in white, older men.
Of the 2,458 deaths identified between 1999-2010, culprit drugs were not specified in most of the cases (approximately 74 percent). However, among those with an identified culprit drug, nearly half were antibiotics, followed by radiocontrast agents used during diagnostic imaging procedures and chemotherapeutics that are used in treatment of cancer.
During the years studied, there was a significant increase in fatal drug anaphylaxis, from 0.27 per million in 1999-2001 to 0.51 per million in 2008-2010. The increase in medication-related anaphylaxis deaths likely relates to increased medication and radiocontrast use, enhanced diagnosis and coding changes.
"Anaphylaxis has been dubbed 'the latest allergy epidemic,'" said Dr. Jerschow. "The U.S. and Australia have some of the highest rates of severe anaphylaxis among developed countries. We hope these results bring increased awareness of the need for a better understanding of anaphylaxis deaths."
INFORMATION:
In addition to Dr. Jerschow, authors include Moira M. Scaperotti B.S., and Aileen P. McGinn, Ph.D., both at Einstein, and Robert Lin, M.D., M.Sc., at Weill Cornell Medical College. This research was supported in part by the Clinical and Translational Science Award from the National Institutes of Health to Albert Einstein College of Medicine (UL1 TR001073). The researchers report no conflicts of interest.
About Montefiore Medical Center
As the University Hospital for Albert Einstein College of Medicine, Montefiore is a premier academic medical center nationally renowned for its clinical excellence, scientific discovery and commitment to its community. Recognized among the top hospitals nationally and regionally by U.S. News & World Report, Montefiore provides compassionate, patient- and family-centered care and educates the healthcare professionals of tomorrow. The Children's Hospital at Montefiore is consistently named in U.S. News' "America's Best Children's Hospitals." With four hospitals, 1,491 beds and 90,000 annual admissions, Montefiore is an integrated health system seamlessly linked by advanced technology. State-of-the-art primary and specialty care is provided through a network of more than 130 locations across the region, including the largest school health program in the nation and a home health program. Montefiore's partnership with Einstein advances clinical and translational research to accelerate the pace at which new discoveries become the treatments and therapies that benefit patients. The medical center derives its inspiration for excellence from its patients and community, and continues to be on the frontlines of developing innovative approaches to care. For more information please visit http://www.montefiore.org and http://www.montekids.org. Follow us on Twitter; like us on Facebook; view us on YouTube.
About Albert Einstein College of Medicine of Yeshiva University
Albert Einstein College of Medicine of Yeshiva University is one of the nation’s premier centers for research, medical education and clinical investigation. During the 2013-2014 academic year, Einstein is home to 743 M.D. students, 275 Ph.D. students, 103 students in the combined M.D./Ph.D. program, and 313 postdoctoral research fellows. The College of Medicine has more than 2,000 full-time faculty members located on the main campus and at its clinical affiliates. In 2013, Einstein received more than $150 million in awards from the National Institutes of Health (NIH). This includes the funding of major research centers at Einstein in aging, intellectual development disorders, diabetes, cancer, clinical and translational research, liver disease, and AIDS. Other areas where the College of Medicine is concentrating its efforts include developmental brain research, neuroscience, cardiac disease, and initiatives to reduce and eliminate ethnic and racial health disparities. Its partnership with Montefiore Medical Center, the University Hospital and academic medical center for Einstein, advances clinical and translational research to accelerate the pace at which new discoveries become the treatments and therapies that benefit patients. Through its extensive affiliation network involving Montefiore, Jacobi Medical Center –- Einstein’s founding hospital, and three other hospital systems in the Bronx, Brooklyn and on Long Island, Einstein runs one of the largest residency and fellowship training programs in the medical and dental professions in the United States. For more information, please visit www.einstein.yu.edu, read our blog, follow us on Twitter, like us on Facebook, and view us on YouTube.
Comprehensive Study of allergic deaths in US finds medications are main culprit
Montefiore/Einstein research indicates higher prevalence among older people and African-Americans
2014-09-30
ELSE PRESS RELEASES FROM THIS DATE:
The cultural side of science communication
2014-09-30
EVANSTON, Ill. --- Do we think of nature as something that we enjoy when we visit a national park and something we need to "preserve?" Or do we think of ourselves as a part of nature? A bird's nest is a part of nature, but what about a house?
The answers to these questions reflect different cultural orientations. They are also reflected in our actions, our speech and in cultural artifacts.
A new Northwestern University study, in partnership with the University of Washington, the American Indian Center of Chicago and the Menominee tribe of Wisconsin, focuses on science ...
Rating the planet's oceans
2014-09-30
The most comprehensive assessment conducted by the Ocean Health Index rates the Earth's oceans at 67 out of 100 in overall health. In addition, for the first time, the report assessed the Antarctic and the 15 ocean regions beyond national jurisdiction (high-seas areas) — all critical regions for maintaining a healthy climate, safeguarding biodiversity and providing sustainable food sources.
In the third annual update of the index, a partnership led by scientists from UC Santa Barbara's National Center for Ecological Analysis and Synthesis (NCEAS) and Conservation International ...
New diagnostic approach for autism in Tanzania
2014-09-30
PROVIDENCE, R.I. [Brown University] — Autism is no stranger to the children of Tanzania. What is rare in the East African nation is access to clinical services, including reliable diagnosis and evidence-based treatments. There is no autism diagnostic measure, for example, validated for use in Swahili, a major language of the region. In a small new study, however, researchers at Brown University and the University of Georgia (UGA) describe a culturally compatible diagnostic approach that they implemented at two sites in the country and found to be effective for making diagnoses.
The ...
This week from AGU: Measuring Antarctic ice loss, Indian Ocean program, Oregon landslides
2014-09-30
This week from AGU: Measuring Antarctic ice loss, Indian Ocean program, Oregon landslides
From AGU's blogs: Scientists use fiber-optic cables to measure ice loss in Antarctic
Researchers installed moorings containing fiber-optic cables hundreds of meters down into the McMurdo Ice Shelf in West Antarctica to collect temperature information about the base of the ice shelf, where the thick platform of floating ice meets the ocean. The sensors were able to measure mere millimeters of ice loss at the interface, demonstrating that the new fiber-optic method could be ...
Depression increasing across the country
2014-09-30
SAN DIEGO, Calif. (Sept. 30, 2014)— A study by San Diego State University psychology professor Jean M. Twenge shows Americans are more depressed now than they have been in decades.
Analyzing data from 6.9 million adolescents and adults from all over the country, Twenge found that Americans now report more psychosomatic symptoms of depression, such as trouble sleeping and trouble concentrating, than their counterparts in the 1980s.
"Previous studies found that more people have been treated for depression in recent years, but that could be due to more awareness and less ...
Disease decoded: Gene mutation may lead to development of new cancer drugs
2014-09-30
ANN ARBOR—The discovery of a gene mutation that causes a rare premature aging disease could lead to the development of drugs that block the rapid, unstoppable cell division that makes cancer so deadly.
Scientists at the University of Michigan and the U-M Health System recently discovered a protein mutation that causes the devastating disease dyskeratosis congenita, in which precious hematopoietic stem cells can't regenerate and make new blood. People with DC age prematurely and are prone to cancer and bone marrow failure.
But the study findings reach far beyond the ...
New guidelines for treatment of hypothyroidism endorse current therapy
2014-09-30
WASHINGTON (Sept. 30, 2014) — Levothyroxine is considered the gold standard therapy for an underactive thyroid gland (hypothyroidism), and a new review of therapies for the condition — including combining levothyroxine with another agent — has not altered that assessment, say a team of investigators.
1Their analysis, published as a set of guidelines in the journal Thyroid, finds insufficient consistent data exist to recommend a change in use of levothyroxine — whether generic, or sold under various trade names, such as Synthroid® — as the only drug needed to treat hypothyroidism.
"Levothyroxine ...
A new dimension for integrated circuits: 3-D nanomagnetic logic
2014-09-30
This news release is available in German.
Electrical engineers at the Technische Universität München (TUM) have demonstrated a new kind of building block for digital integrated circuits. Their experiments show that future computer chips could be based on three-dimensional arrangements of nanometer-scale magnets instead of transistors. As the main enabling technology of the semiconductor industry – CMOS fabrication of silicon chips – approaches fundamental limits, the TUM researchers and collaborators at the University of Notre Dame are exploring "magnetic computing" ...
Medicaid and Uninsured patients obtain new patient appointments most easily at FQHCs
2014-09-30
PHILADELPHIA – Federally Qualified Health Centers (FQHCs) granted new patient appointments to Medicaid beneficiaries and uninsured patients at higher rates than other primary care practices (non-FQHCs), in addition to charging less for visits, according to results of a new 10-state University of Pennsylvania study published this month in Medical Care.
Using data from a previous "secret shopper" study conducted in 2012 and 2013, the investigators found that FQHCs — community health clinics that receive federal funding to provide primary care access to underserved populations ...
UCI study uncovers important process for immune system development
2014-09-30
Irvine, Calif., Sept. 30, 2014 — Research by UC Irvine immunologists reveals new information about how our immune system functions, shedding light on a vital process that determines how the body's ability to fight infection develops.
In the online version of Nature Immunology, neurology professor Dr. Michael Demetriou, postdoctoral scholar Raymond Zhou and other Institute for Immunology colleagues describe a critical mechanism underlying how T cells are created, selected and released into the bloodstream.
A T cell is a type of blood cell called a lymphocyte that protects ...
LAST 30 PRESS RELEASES:
CMD-OPT model enables the discovery of a potent and selective RIPK2 inhibitor as preclinical candidate for the treatment of acute liver injury
Melatonin receptor 1a alleviates sleep fragmentation-aggravated testicular injury in T2DM by suppression of TAB1/TAK1 complex through FGFR1
Single-cell RNA sequencing reveals Shen-Bai-Jie-Du decoction retards colorectal tumorigenesis by regulating the TMEM131–TNF signaling pathway-mediated differentiation of immunosuppressive dendritic ce
Acta Pharmaceutica Sinica B Volume 15, Issue 7 Publishes
New research expands laser technology
Targeted radiation offers promise in patients with metastasized small cell lung cancer to the brain
A high clinically translatable strategy to anti-aging using hyaluronic acid and silk fibroin co-crosslinked hydrogels as dermal regenerative fillers
Mount Sinai researchers uncover differences in how males and females change their mind when reflecting on past mistakes
CTE and normal aging are difficult to distinguish, new study finds
Molecular arms race: How the genome defends itself against internal enemies
Tiny chip speeds up antibody mapping for faster vaccine design
KTU experts reveal why cultural heritage is important for community unity
More misfolded proteins than previously known may contribute to Alzheimer’s and dementia
“Too much going on”: Autistic adults overwhelmed by non-verbal social cues
What’s driving America’s deep freezes in a warming world?
A key role of brain protein in learning and memory is deciphered by scientists
Heart attacks don’t follow a Hollywood script
Erin M. Schuman wins 2026 Nakasone Award for discovery on neural synapse function and change during formation of memories
Global ocean analysis could replace costly in-situ sound speed profiles in seafloor positioning, study finds
Power in numbers: Small group professional coaching reduces rates of physician burnout by nearly 30%
Carbon capture, utilization, and storage: A comprehensive review of CCUS-EOR
New high-temperature stable dispersed particle gel for enhanced profile control in CCUS applications
State gun laws and firearm-related homicides and suicides
Use of tobacco and cannabis following state-level cannabis legalization
Long-term obesity and biological aging in young adults
Eindhoven University of Technology and JMIR Publications announce unlimited open access publishing agreement
Orphan nuclear receptors in metabolic dysfunction-associated steatotic liver disease development
A technological breakthrough for ultra-fast and greener AI
Pusan National University researchers identify key barriers hindering data-driven smart manufacturing adoption
Inking heterometallic nanosheets: A scalable breakthrough for coating, electronics, and electrocatalyst applications
[Press-News.org] Comprehensive Study of allergic deaths in US finds medications are main culpritMontefiore/Einstein research indicates higher prevalence among older people and African-Americans