A pill for obesity?

Harvard stem cell scientists convert white fat to brown fat

2014-12-08

(Press-News.org) Harvard Stem Cell Institute researchers at Harvard and Massachusetts General Hospital have taken what they are describing as "the first step toward a pill that can replace the treadmill" for the control of obesity - though it of course would not provide all the additional benefits of exercise. Chad Cowan, an HSCI Principal Faculty Member and his HSCI team report that they have created a system using human stem cells to screen for compounds that have the potential to turn white, or 'bad', fat cells into brown, or 'good' fat cells, and have already identified two compounds that can accomplish that in human cells.

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University of Tennessee research offers explanation for Titan dune puzzle

2014-12-08

Titan, Saturn's largest moon, is a peculiar place. Unlike any other moon, it has a dense atmosphere. It has rivers and lakes made up of components of natural gas, such as ethane and methane. It also has windswept dunes that are hundreds of yards high, more than a mile wide and hundreds of miles long--despite data suggesting the body to have only light breezes. Research led by Devon Burr, an associate professor in the Earth and Planetary Sciences Department at the University of Tennessee, Knoxville, shows that winds on Titan must blow faster than previously thought to ...

UEA research could revolutionize genomic sequencing of drug-resistant bacteria

2014-12-08

New nanopore DNA sequencing technology on a device the size of a USB stick could be used to diagnose infection - according to new research from the University of East Anglia and Public Health England. Researchers tested the new technology with a complex problem - determining the cause of antibiotic resistance in a new multi-drug resistant strain of the bacterium that causes Typhoid. The results, published today in the journal Nature Biotechnology, reveal that the small, accessible and cost effective technology could revolutionise genomic sequencing. Current technology ...

Genetic errors linked to aging underlie leukemia that develops after cancer treatment

2014-12-08

For a small percentage of cancer patients, treatment aimed at curing the disease leads to a form of leukemia with a poor prognosis. Conventional thinking goes that chemotherapy and radiation therapy induce a barrage of damaging genetic mutations that kill cancer cells yet inadvertently spur the development of acute myeloid leukemia (AML), a blood cancer. But a new study at Washington University School of Medicine in St. Louis challenges the view that cancer treatment in itself is a direct cause of what is known as therapy-related AML. Rather, the research suggests, ...

Disorder in gene-control system is a defining characteristic of cancer, study finds

2014-12-08

BOSTON and CAMBRIDGE -- The genetic tumult within cancerous tumors is more than matched by the disorder in one of the mechanisms for switching cells' genes on and off, scientists at Dana-Farber Cancer Institute and the Broad Institute of MIT and Harvard report in a new study. Their findings, published online today in the journal Cancer Cell, indicate that the disarray in the on-off mechanism - known as methylation - is one of the defining characteristics of cancer and helps tumors adapt to changing circumstances. The researchers also showed that derangement in ...

New agent causes small cell lung tumors to shrink in pre-clinical testing

2014-12-08

BOSTON -- Small cell lung cancer - a disease for which no new drugs have been approved for many years - has shown itself vulnerable to an agent that disables part of tumor cells' basic survival machinery, researchers at Dana-Farber Cancer Institute and the Massachusetts Institute of Technology reported. In a study published today in the journal Cancer Cell, the investigators found that the agent THZ1 caused human-like small cell lung tumors in mice to shrink significantly, with no apparent side effects. The compound is now being developed into a drug for testing ...

Organic mulch lets insect pollinators do their job

2014-12-08

COLUMBUS, OH - As interest in organic agricultural and horticultural practices continues to grow, so does the need to identify alternative weed control practices. Mulching, a common practice used to control weeds and reduce the need for tillage, can also reduce insect pollinators' exposure to harmful pesticides; however, finding the right mulch materials that allow pollinators to flourish can be challenging. Caitlin E. Splawski, from The Ohio State University Department of Horticulture and Crop Science, researched the effects of several types of organic mulch on squash ...

Baking soda is the best: Chemistry Life Hacks, Vol. 4 (video)

2014-12-08

WASHINGTON, Dec. 8, 2014 -- There's probably a box of it in your fridge or cupboard, and it has a million uses: baking soda. Reactions is back with volume four of its popular Chemistry Life Hacks series, with tips on how to de-skunk your dog, clean your kitchen and supercharge your washing machine. Check out the latest in the series that's one-part MacGyver, one-part Mendeleev here: http://youtu.be/85diRmuk-ow. Subscribe to the series at Reactions YouTube, and follow us on Twitter @ACSreactions to be the first to see our latest videos. The American Chemical Society ...

Half of US kids exposed to traumatic social or family experiences during childhood

2014-12-08

Nearly half of all children in the United States are exposed to at least one social or family experience that can lead to traumatic stress and impact their healthy development - be it having their parents divorce, a parent die or living with someone who abuses alcohol or drugs - increasing the risk of negative long-term health consequences or of falling behind in school, suggests new research led by the Johns Hopkins Bloomberg School of Public Health. The study reports on new data showing the magnitude of these adverse experiences in the child population in the U.S., ...

Voters more inclined than consumers to pay for food safety

2014-12-08

Voters are more willing to pay for a decreased risk of food-related illness than consumers, but female consumers are more willing to pay than male consumers, according to an international team of researchers. "The question is, what would consumers prefer?" said Amit Sharma, associate professor of hospitality management and finance, Penn State. "Would they prefer a market-driven, or a policy-driven approach? Either of those two approaches could lead to some price increase. Improving quality costs money, and food safety is no different." Sharma and colleagues wanted to ...

Animal research sheds light on harmful mood disorders in new mothers

2014-12-08

In the days shortly after giving birth, most mothers experience a period of increased calmness and decreased stress responses, but around 20% of mothers experience anxiety. Some women may become depressed, and around one in a thousand can develop psychosis. The latest evidence indicates that these distressing responses to motherhood are still poorly understood, but that animal research could provide valuable clues to their causes. Writing in the British Journal of Pharmacology, Dr David Slattery and Dr Clara Perani highlight that anxiety, depression and psychosis during ...

BioCompNet: a deep learning workflow enabling automated body composition analysis toward precision management of cardiometabolic disorders

Nonlinear association between systemic immune-inflammation index and in-hospital mortality in critically ill patients with chronic obstructive pulmonary disease and atrial fibrillation: a cross-sectio

A pill for obesity?

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