Long-term therapy with ETV or TDF demonstrates positive 5-year survival in patients with chronic HBV
Study also identifies hepatocellular carcinoma as major factor affecting mortality
2015-04-23
(Press-News.org) April 23, 2015, Vienna, Austria: Data revealed today at The International Liver Congress™ 2015 show that the long-term use of entecavir (ETV) or tenofovir (TDF) results in excellent 5-year survival for Caucasian patients with chronic hepatitis B (CHB), with more than 95% of patients surviving at 5 years and a significant proportion of deaths coming from liver-unrelated causes.
Long-term ETV or TDF therapy is the most common treatment option in CHB of any severity, but efficacy data have been mainly based upon on-therapy virological remission rates. In this 9-centre, large ongoing cohort study, researchers evaluated the survival in Caucasian CHB patients with or without cirrhosis who have been receiving ETV or TDF.
The study analysed 1,815 adult Caucasians with CHB with or without compensated cirrhosis and no hepatocellular carcinoma (HCC) at baseline who received ETV or TDF for at least 12 months.
In the total patient population, the 5-year overall survival rate was 95%, although it was significantly higher in non-cirrhotic (97%) than cirrhotic patients (92%). When only liver-related deaths or liver transplantation were taken into account, the 5-year survival rate was 97.5%.
This study also showed that the development of HCC plays a major role in mortality, which is something that needs to be considered when managing patients with CHB. In multivariable Cox regression analysis, better overall survival was independently associated with the absence of HCC but not with cirrhosis or gender, while better liver-related survival was associated only with the absence of HCC.
INFORMATION:
About The International Liver Congress™
This annual congress is the biggest event in the EASL calendar, attracting scientific and medical experts from around the world to learn about the latest in liver research. Specialists share research studies and findings, and discuss the hottest topics related to liver disease. This year, the congress is expected to attract approximately 10,000 delegates from all corners of the globe. 2015 is a very special year for EASL and the hepatology community as they will celebrate the 50th annual meeting. The International Liver Congress™ takes place from April 22-26, 2015, Vienna, Austria.
About EASL
Since EASL's foundation in 1966, this not-for-profit organisation has grown to over 4,000 members from more than 100 countries around the world. EASL is the leading liver association in Europe, it attracts the foremost hepatology experts and has an impressive track record in promoting research in liver disease, supporting wider education and promoting changes in European liver policy.
Contact
For more information, please contact the ILC Press Office at:
ilc.press@easloffice.eu or
+44 (0)20 3580 5444
ELSE PRESS RELEASES FROM THIS DATE:
2015-04-23
23 April 2015, Austria, Vienna: Results revealed today at the International Liver Congress™ 2015 show that the daily consumption of capsaicin, the active compound of chilli peppers, was found to have beneficial effects on liver damage.
In the study, capsaicin was found to reduce the activation of hepatic stellate cells (HSCs) in mice models. HSCs are the major cell type involved in liver fibrosis, which is the formation of scar tissue in response to liver damage.
The mice were split into two groups and received capsaicin in their food:
After three days of bile ...
2015-04-23
April 23, 2015, Austria, Vienna: Results revealed today at The International Liver Congress™ 2015, show that in patients with alcohol-induced liver disease (ALD), Baclofen has a positive impact on alcohol consumption and overall measures of liver function and harm.
ALD is a major cause of alcohol-related mortality and helping patients with ALD to stop drinking is a primary goal of treatment. The primary aim of this study was to measure the effectiveness and tolerability of Baclofen in maintaining abstinence in this difficult to treat group, and to determine if this ...
2015-04-23
April 23, 2015, Vienna, Austria: A study revealed today at The International Liver Congress™ 2015 has demonstrated that alginate-enriched bread has the potential to inhibit fat digestion and circulatory lipids in patients with non-alcoholic fatty liver disease (NAFLD).
Alginates are polysaccharides extracted from brown algae that are non-digestible in the upper gastrointestinal tract. Specific alginates are able to inhibit the activity of pancreatic lipase and thus reduce fat digestion and absorption. This study set out to determine if alginate-enriched bread inhibits ...
2015-04-23
April 23, 2015, Vienna, Austria: Data revealed today at The International Liver CongressTM 2015 show that non-alcoholic fatty liver disease (NAFLD) plays a role in the early stages of coronary atherosclerosis and in its more severe form it can also promote the development of coronary artery calcification (CAC).
Findings showed that the impact of NAFLD varies significantly depending on the severity of CAC at baseline. In those without CAC, NAFLD significantly affected the development of atherosclerosis; however, in patients with existing CAC at baseline NAFLD did not ...
2015-04-23
Johns Hopkins Bloomberg School of Public Health researchers say that while a large majority of newborns are exposed in their earliest days to bisphenol A (BPA), a much-studied chemical used in plastics and in food and soda can linings, they can chemically alter and rid their bodies of it.
The findings, published April 23 in The Journal of Pediatrics, challenge the current thinking on BPA toxicology. The U.S. Centers for Disease Control and Prevention has found that more than 92 percent of Americans ages six and older have BPA in their bodies, most likely through the consumption ...
2015-04-23
Shortages of key antibiotics, including gold-standard therapies and drugs used to treat highly resistant infections, are on the rise, according to a new study of shortages from 2001 to 2013 published in Clinical Infectious Diseases and available online. The trends raise serious concerns about the effects on patient care, particularly for infections without effective alternative treatment options.
"We found a tremendous number of drugs that are used to treat life threatening infections that just were not available," said study author Larissa May, MD, of George Washington ...
2015-04-23
Rapid treatment with a new anti-inflammatory could have a major impact on recovery from spinal cord injury, University of Queensland researchers have found.
UQ School of Biomedical Sciences' Dr Marc Ruitenberg and PhD student Ms Faith Brennan said they made the discovery during laboratory trials with an experimental drug.
Ms Brennan said that excessive inflammation caused additional damage in spinal cord injuries and hindered recovery.
"We found that a molecule called C5aR exacerbates inflammation and tissue damage after spinal cord injury," she said.
"Our study ...
2015-04-22
Tick-borne diseases are a major public health problem around the world. Ticks carry and transmit a variety of microbes that cause disease. These illnesses, which include Lyme disease, Rocky Mountain spotted fever, and Tularemia, can cause a variety of symptoms, often serious and sometimes deadly.
Now, just in time for spring and the explosion of ticks in forests, lawns and trails, a new study by researchers from China and the University of Maryland School of Medicine (UM SOM) has uncovered a never-before-seen illness transmitted by ticks. It's possible that the disease ...
2015-04-22
Researchers have pinpointed a primary cause of a rare skull disorder in infants, and the discovery could help wounded soldiers, car-wreck victims and other patients recover from disfiguring facial injuries.
"This has a lot more implication than what we initially thought," said Yang Chai, a lead researcher on the study at the Herman Ostrow School of Dentistry of USC. "We can take advantage of these stem cells not only to repair a birth defect, but to provide facial regeneration for veterans or other people who have suffered traumatic injury."
Chai predicted such treatment ...
2015-04-22
SAN FRANCISCO--More than 143 million Americans living in the 48 contiguous states are exposed to potentially damaging ground shaking from earthquakes, with as many as 28 million people likely to experience strong shaking during their lifetime, according to research discussed at the annual meeting of Seismological Society of America. The report puts the average long-term value of building losses from earthquakes at $4.5 billion per year, with roughly 80 percent of losses attributed to California, Oregon and Washington.
"This analysis of data from the new National Seismic ...
LAST 30 PRESS RELEASES:
[Press-News.org] Long-term therapy with ETV or TDF demonstrates positive 5-year survival in patients with chronic HBV
Study also identifies hepatocellular carcinoma as major factor affecting mortality
