PRESS-NEWS.org - Press Release Distribution
PRESS RELEASES DISTRIBUTION

Patients with gastrointestinal tumors at higher risk of other cancers

2015-05-01
(Press-News.org) Researchers at UC San Diego School of Medicine conducted the first population-based study that characterizes the association and temporal relationship between gastrointestinal stromal tumors (GIST) and other cancers. The results, published by Cancer on April 30, indicate that one in 5.8 patients with GIST will develop additional malignancies before and after their diagnosis.

Specifically, patients with GIST are more likely to develop other sarcomas, non-Hodgkin's lymphoma, carcinoid tumors, melanoma, colorectal, esophageal, pancreatic, hepatobiliary, non-small cell lung, prostate and renal cell cancers.

"Only 5 percent of patients with gastrointestinal stromal tumors have a hereditary disorder that predisposes them to develop multiple benign and malignant tumors," said Jason K. Sicklick, MD, assistant professor of surgery and UC San Diego Moores Cancer Center surgical oncologist. "The research indicates that these patients may develop cancers outside of these syndromes, but the exact mechanisms are not yet known."

The researchers said further studies are needed to understand the connection between GIST and other cancers, but the findings may have clinical implications.

"Patients diagnosed with gastrointestinal stromal tumors may warrant consideration for additional screenings based on the other cancers that they are most susceptible to contract," said co-author James D. Murphy, MD, assistant professor of radiation oncology and UC San Diego Moores Cancer Center radiation oncologist.

When compared to the United States population, the researchers found that people with GIST had a 44 percent increased prevalence of cancers occurring before a GIST diagnosis and a 66 percent higher risk of developing cancers after diagnosis. The most common tumors were those of the genitourinary tract, breast, respiratory and blood.

Non-Hispanic patients had a higher incidence of other cancers before a GIST diagnosis. Patients whose tumors were smaller than 10 centimeters had a higher probability of a second cancer than patients whose growth was larger. People with tumors smaller than 2 cm had the greatest likelihood of developing additional malignancies, both before and after diagnosis.

INFORMATION:

Co-authors include Grace L. Ma, Joel M. Baumgartner, Lisa Madlensky, Adam M. Burgoyne, Chih-Min Tang and Maria Elena Martinez, all at UC San Diego Moores Cancer Center.

Funding for this research came, in part, from the National Institutes of Health (KL2 RR031978 and K08 CA168999), the GIST Research Fund and a UC San Diego Academic Senate Health Sciences Research Grant.



ELSE PRESS RELEASES FROM THIS DATE:

Study finds housing market cycles have become longer

2015-05-01
ALEXANDRIA, VA, MAY 1, 2015 -- A statistical analysis of data from 20 industrial countries covering the period 1970 to 2012 suggests housing market pricing cycles -- normal, boom and bust phases -- have become longer over the last four decades. The study also found that longer down phases can have dire consequences on national and international economies. While relatively short-lived housing booms tend to deflate, more prolonged booms are likely to spiral out of control. Similarly, compared to short housing busts, longer housing busts are more likely to turn into chronic ...

The language of invention: Most innovations are rephrasings of past technologies

2015-05-01
Most new patents are combinations of existing ideas and pretty much always have been, even as the stream of fundamentally new core technologies has slowed, according to a new paper in the Journal of the Roayl Society Interface by Santa Fe Institute researchers Hyejin Youn, Luis Bettencourt, Jose Lobo, and Deborah Strumsky. Youn and colleagues reached those conclusions sifting through the records of the United States Patent and Trademark Office. Dating back to 1790, the records feature an elaborate system of technology codes -- a vocabulary of sorts, in which any new invention ...

A feel for flight: How bats are teaching scientists to build better aircraft

A feel for flight: How bats are teaching scientists to build better aircraft
2015-05-01
NEW YORK, NY (May 1, 2015) -- Bats are masters of flight in the night sky, capable of steep nosedives and sharp turns that put our best aircrafts to shame. Although the role of echolocation in bats' impressive midair maneuvering has been extensively studied, the contribution of touch has been largely overlooked. A study published April 30 in Cell Reports shows, for the first time, that a unique array of sensory receptors in the wing provides feedback to a bat during flight. The findings also suggest that neurons in the bat brain respond to incoming airflow and touch signals, ...

How to reset a diseased cell

2015-05-01
In proof-of-concept experiments, researchers at University of California, San Diego School of Medicine demonstrate the ability to tune medically relevant cell behaviors by manipulating a key hub in cell communication networks. The manipulation of this communication node, reported in this week's issue of Proceedings of the National Academy of Sciences, makes it possible to reprogram large parts of a cell's signaling network instead of targeting only a single receptor or cell signaling pathway. The potential clinical value of the basic science discovery is the ability ...

Species' evolutionary choice: Disperse or adapt?

2015-05-01
Dispersal and adaptation are two fundamental evolutionary strategies available to species given an environment. Generalists, like dandelions, send their offspring far and wide. Specialists, like alpine flowers, adapt to the conditions of a particular place. Ecologists have typically modeled these two strategies, and the selective pressures that trigger them, by holding one strategy fixed and watching how the other evolves. New research published in the journal Evolution illustrates the dramatic interplay during the co-evolution of dispersal and adaptation strategies. "This ...

The ER docs said 'stop smoking,' and they did!

2015-05-01
WASHINGTON --An intervention in the emergency department designed to encourage tobacco cessation in smokers appears to be effective. Two and a half times more patients in the intervention group were tobacco-free three months after receiving interventions than those who did not receive the interventions, according to a study published online Friday in Annals of Emergency Medicine ( END ...

A practical gel that simply 'clicks' for biomedical applications

2015-05-01
(BOSTON) -- If you opt to wear soft contact lenses, chances are you are using hydrogels on a daily basis. Made up of polymer chains that are able to absorb water, hydrogels used in contacts are flexible and allow oxygen to pass through the lenses, keeping eyes healthy. Hydrogels can be up to 99 percent water and as a result are similar in composition to human tissues. They can take on a variety of forms and functions beyond that of contact lenses. By tuning their shape, physical properties and chemical composition and infusing them with cells, biomedical engineers have ...

Use wipes in the kitchen to reduce risk of food poisoning by 99 percent

2015-05-01
Consumers can reduce the risk of Campylobacter food poisoning by up to 99.2% by using disinfectant wipes in the kitchen after preparing poultry. This is according to research published today (Friday 01 May) in the Society for Applied Microbiology's Journal of Applied Microbiology. Dr Gerardo Lopez and his colleagues at the University of Arizona in the USA used antibacterial wipes on typical counter top materials - granite, laminate, and ceramic tile - to see if they reduce the risk of the cook and their family or guests ingesting harmful bacteria. The results from Dr ...

Beyond chicken fingers & fries: New evidence in favor of healthier kids' menus

2015-05-01
Contrary to popular belief, more healthy kids' meals were ordered after a regional restaurant chain added more healthy options to its kids' menu and removed soda and fries, researchers from ChildObesity180 at Tufts University Friedman School reported today in the journal Obesity. Including more healthy options on the menu didn't hurt overall restaurant revenue, and may have even supported growth. Researchers examined outcomes before and after the Silver Diner, a full-service family restaurant chain, made changes to its children's menu in order to make healthier items ...

New research into health benefits of coffee

2015-05-01
New research has brought us closer to being able to understand the health benefits of coffee. Monash researchers, in collaboration with Italian coffee roasting company Illycaffè, have conducted the most comprehensive study to date on how free radicals and antioxidants behave during every stage of the coffee brewing process, from intact bean to coffee brew. The team observed the behaviour of free radicals - unstable molecules that seek electrons for stability and are known to cause cellular and DNA damage in the human body - in the coffee brewing process. For the ...

LAST 30 PRESS RELEASES:

Thirty-year mystery of dissonance in the “ringing” of black holes explained

Less intensive works best for agricultural soil

Arctic rivers project receives “national champion” designation from frontiers foundation

Computational biology paves the way for new ALS tests

Study offers new hope for babies born with opioid withdrawal syndrome

UT, Volkswagen Group of America celebrate research partnership

New Medicare program could dramatically improve affordability for cancer drugs – if patients enroll

Are ‘zombie’ skin cells harmful or helpful? The answer may be in their shapes

University of Cincinnati Cancer Center presents research at AACR 2025

Head and neck, breast, lung and survivorship studies headline Dana-Farber research at AACR Annual Meeting 2025

AACR: Researchers share promising results from MD Anderson clinical trials

New research explains why our waistlines expand in middle age

Advancements in muon detection: Taishan Antineutrino Observatory's innovative top veto tracker

Chips off the old block

Microvascular decompression combined with nerve combing for atypical trigeminal neuralgia

Cutting the complexity from digital carpentry

Lung immune cell type “quietly” controls inflammation in COVID-19

Fiscal impact of expanded Medicare coverage for GLP-1 receptor agonists to treat obesity

State and sociodemographic trends in US cigarette smoking with future projections

Young adults drive historic decline in smoking

NFCR congratulates Dr. Robert C. Bast, Jr. on receiving the AACR-Daniel D. Von Hoff Award for Outstanding Contributions to Education and Training in Cancer Research

Chimpanzee stem cells offer new insights into early embryonic development

This injected protein-like polymer helps tissues heal after a heart attack

FlexTech inaugural issue launches, pioneering interdisciplinary innovation in flexible technology

In Down syndrome mice, 40Hz light and sound improve cognition, neurogenesis, connectivity

Methyl eugenol: potential to inhibit oxidative stress, address related diseases, and its toxicological effects

A vascularized multilayer chip reveals shear stress-induced angiogenesis in diverse fluid conditions

AI helps unravel a cause of Alzheimer's disease and identify a therapeutic candidate

Coalition of Autism Scientists critiques US Department of Health and Human Services Autism Research Initiative

Structure dictates effectiveness, safety in nanomedicine

[Press-News.org] Patients with gastrointestinal tumors at higher risk of other cancers