PRESS-NEWS.org - Press Release Distribution
PRESS RELEASES DISTRIBUTION

Moffitt researchers say androgen deprivation therapy may lead to cognitive impairment

New study finds cognitive impairment more likely in men who are receive androgen deprivation therapy and have GNB3 genetic alteration

2015-05-13
(Press-News.org) TAMPA, Fla. -- Cognitive impairment can occur in cancer patients who are treated with a variety of therapies, including radiation therapy, hormone therapy, and chemotherapy. After chemotherapy treatment it is commonly called "chemo brain." Signs of cognitive impairment include forgetfulness, inability to concentrate, problems recalling information, trouble multi-tasking and becoming slower at processing information. The number of people who experience cognitive problems following cancer therapy is broad, with an estimate range of 15 to 70 percent.

There have been several studies analyzing this side effect in breast cancer patients, but few have investigated cognitive impairment following androgen deprivation therapy (ADT) for men being treated prostate cancer. A new Moffitt Cancer Center study indicated that men who are on androgen deprivation therapy have greater odds of experiencing impaired cognitive function.

Androgen deprivation therapy is commonly used to treat prostate cancer, often on an open-ended basis for therapy of advanced prostate cancer. It is estimated that 44 percent of men with prostate cancer undergo ADT at some point. The goal of this type of therapy is to block the male hormones, including testosterone, from stimulating the growth of the prostate cancer cells. However, the side effect of ADT on cognitive function in men with prostate cancer has not been measured as much.

In this study, researchers used formal tests to compare the cognitive ability of 58 prostate cancer patients receiving androgen deprivation therapy to 84 prostate cancer patients who did not receive ADT, and to 88 men without cancer. The research showed that the men treated with ADT were 70 percent more likely to experience cognitive impairment at six months, and more than twice as likely to experience cognitive impairment at the one year time point.

The researchers also reported for the first time a possible genetic link among those individuals who experience cognitive impairment during androgen deprivation therapy. They found that patients who have a particular version of a gene called GNB3 were 14 times more likely to suffer from cognitive problems following androgen deprivation therapy.

"Studies like ours show the importance of identifying genetic predictors of cognitive impairment. This information can be used to further personalize cancer care based on patients' unique characteristics, and to find patients who may be prone to be intolerant of this standard type of treatment" said Mayer Fishman, M.D., Ph.D., senior member of Moffitt's Genitourinary Oncology Program.

The results of this study may have implications for physicians trying to decide on the best therapeutic options for their patients. "The risk of cognitive impairment should be considered when deciding whether or not to receive androgen deprivation therapy for prostate cancer," said Brian Gonzalez, Ph.D., a postdoctoral fellow in the Health Outcomes and Behavior Program at Moffitt.

INFORMATION:

The study was published in the May 11 issue of the Journal of Clinical Oncology. The research was supported by grants received from the National Cancer Institute (R01 CA132803 and R25 CA090314).

About Moffitt Cancer Center

Located in Tampa, Moffitt is one of only 41 National Cancer Institute-designated Comprehensive Cancer Centers, a distinction that recognizes Moffitt's excellence in research, its contributions to clinical trials, prevention and cancer control. Moffitt is the top-ranked cancer hospital in the Southeast and has been listed in U.S. News & World Report's "Best Hospitals" for cancer care since 1999. With more than 4,500 employees, Moffitt has an economic impact in Florida of nearly $1.6 billion. For more information, visit MOFFITT.org, and follow the Moffitt momentum on Facebook, Twitter and YouTube.



ELSE PRESS RELEASES FROM THIS DATE:

Learning entrepreneurship: Starting a business is a matter of adequate training

2015-05-13
Lüneburg. Entrepreneurship as vocation? As a talent, which reveals itself early on and is the requirement for a successful start-up? This is the prevailing - yet wrong - view. Entrepreneurship is an acquired skill. The capacity to think and act in entrepreneurial terms is present in many people - unbeknown to most of them. Action-oriented entrepreneurship training sessions can unlock dormant potential and awaken entrepreneurial spirit. This is the findings of a research team, comprised of scholars from Leuphana University of Lüneburg, the University of Singapore, ...

'Extreme' exposure to secondhand cannabis smoke causes mild intoxication

Extreme exposure to secondhand cannabis smoke causes mild intoxication
2015-05-13
Secondhand exposure to cannabis smoke under "extreme conditions," such as an unventilated room or enclosed vehicle, can cause nonsmokers to feel the effects of the drug, have minor problems with memory and coordination, and in some cases test positive for the drug in a urinalysis. Those are the findings of a Johns Hopkins University School of Medicine study, reported online this month in the journal Drug and Alcohol Dependence. Cannabis is the most widely used illicit drug in the world. "Many people are exposed to secondhand cannabis smoke," says lead author Evan S. Herrmann, ...

Novel biomarkers may provide guide to personalized hepatitis C therapy

2015-05-13
Bethesda, MD (May 13, 2015) -- A simple blood test can be used to predict which chronic hepatitis C patients will respond to interferon-based therapy, according to a report in the May issue of Cellular and Molecular Gastroenterology and Hepatology,1 the basic science journal of the American Gastroenterological Association. "While highly effective direct-acting antivirals have become the new standard of care for patients with hepatitis C, these treatments come with a hefty price tag," said lead study author Philipp Solbach, MD, from Hannover Medical School, Niedersachsen, ...

Research suggests average-sized models could sell more fashion

2015-05-13
New research from the University of Kent suggests the fashion industry could benefit from using average-sized models rather than size zero in marketing campaigns. The research, led by Dr Xuemei Bian, of Kent Business School, considered the impact of using average and zero-sized models in marketing campaigns for both established and fictitious new fashion brands. In three studies, the researchers asked women aged 18-25 which size of model they preferred. The studies also considered the role the women's self-esteem played in their preference. Dr Bian and her team found ...

'Supercool' material glows when you write on it

2015-05-13
ANN ARBOR--A new material developed at the University of Michigan stays liquid more than 200 degrees Fahrenheit below its expected freezing point, but a light touch can cause it to form yellow crystals that glow under ultraviolet light. Even living cells sitting on a film of the supercooled liquid produce crystal footprints, which means that it's about a million times more sensitive than other known molecules that change color in response to pressure. The material could have applications as a new kind of sensor for living cells, while the mechanism behind its unusual ...

Recreational drug use on weekends often morphs into daily use, BU study finds

2015-05-13
More than half of patients who report "weekend-only" drug use end up expanding their drug use to weekdays, too -- suggesting that primary care clinicians should monitor patients who acknowledge "recreational" drug use, says a new study by Boston University public health and medicine researchers. The study, published in the journal Annals of Family Medicine and led by Judith Bernstein, professor of community health sciences at the BU School of Public Health (BUSPH), recommends that clinicians use "caution in accepting recreational drug use as reassuring," and that they ...

Astrology and celebrity: Seasons really do influence personality

2015-05-13
People's personalities tend to vary somewhat depending on the season in which they are born, and astrological signs may have developed as a useful system for remembering these patterns, according to an analysis by UConn researcher Mark Hamilton. Such seasonal effects may not be clear in individuals, but can be discerned through averaging personality traits across large cohorts born at the same time of year. Hamilton's analysis will be published in Comprehensive Psychology on 13 May. Psychologists have known that certain personality traits tend to be associated with certain ...

Nano-policing pollution

Nano-policing pollution
2015-05-13
This news release is available in Japanese. Pollutants emitted by factories and car exhausts affect humans who breathe in these harmful gases and also aggravate climate change up in the atmosphere. Being able to detect such emissions is a critically needed measure. New research by the Nanoparticles by Design Unit at the Okinawa Institute of Science and Technology Graduate University (OIST), in collaboration with the Materials Center Leoben Austria and the Austrian Centre for Electron Microscopy and Nanoanalysis has developed an efficient way to improve methods ...

No link found between PTSD and cancer risk

2015-05-13
(Boston)--In the largest study to date that examines Post Traumatic Stress Disorder (PTSD) as a risk factor for cancer, researchers from Boston University School of Medicine (BUSM), have shown no evidence of an association. The study, which appears in the European Journal of Epidemiology, is consistent with other population-based studies that report stressful life events generally are not associated with cancer incidence. In addition to corroborating results of other studies, this large population sample allowed for important stratified analyses that showed no strong ...

Potential obesity treatment targets the 2 sides of appetite: Hunger and feeling full

2015-05-13
Our bodies' hormones work together to tell us when to eat and when to stop. But for many people who are obese, this system is off-balance. Now scientists have designed a hormone-like compound to suppress hunger and boost satiety, or a full feeling, at the same time. They report in ACS' Journal of Medicinal Chemistry that obese mice given the compound for 14 days had a tendency to eat less than the other groups. In their study, Constance Chollet and colleagues targeted two main receptors in the body that help keep appetite in check. When hormones bind to ghrelin receptors, ...

LAST 30 PRESS RELEASES:

Exercise as an anti-ageing intervention to avoid detrimental impact of mental fatigue

UMass Amherst Nursing Professor Emerita honored as ‘Living Legend’

New guidelines aim to improve cystic fibrosis screening

Picky eaters by day, buffet by night: Butterfly, moth diets sync to plant aromas

Pennington Biomedical’s Dr. Leanne Redman honored with the E. V. McCollum Award from the American Society for Nutrition

CCNY physicists uncover electronic interactions mediated via spin waves

Researchers’ 3D-printing formula may transform future of foam

Nurture more important than nature for robotic hand

Drug-delivering aptamers target leukemia stem cells for one-two knockout punch

New study finds that over 95% of sponsored influencer posts on Twitter were not disclosed

New sea grant report helps great lakes fish farmers navigate aquaculture regulations

Strain “trick” improves perovskite solar cells’ efficiency

How GPS helps older drivers stay on the roads

Estrogen and progesterone stimulate the body to make opioids

Dancing with the cells – how acoustically levitating a diamond led to a breakthrough in biotech automation

Machine learning helps construct an evolutionary timeline of bacteria

Cellular regulator of mRNA vaccine revealed... offering new therapeutic options

Animal behavioral diversity at risk in the face of declining biodiversity

Finding their way: GPS ignites independence in older adult drivers

Antibiotic resistance among key bacterial species plateaus over time

‘Some insects are declining but what’s happening to the other 99%?’

Powerful new software platform could reshape biomedical research by making data analysis more accessible

Revealing capillaries and cells in living organs with ultrasound

American College of Physicians awards $260,000 in grants to address equity challenges in obesity care

Researchers from MARE ULisboa discover that the European catfish, an invasive species in Portugal, has a prolonged breeding season, enhancing its invasive potential

Rakesh K. Jain, PhD, FAACR, honored with the 2025 AACR Award for Lifetime Achievement in Cancer Research

Solar cells made of moon dust could power future space exploration

Deporting immigrants may further shrink the health care workforce

Border region emergency medical services in migrant emergency care

Resident physician intentions regarding unionization

[Press-News.org] Moffitt researchers say androgen deprivation therapy may lead to cognitive impairment
New study finds cognitive impairment more likely in men who are receive androgen deprivation therapy and have GNB3 genetic alteration