INFORMATION:
The Lancet Diabetes & Endocrinology: 2015 ERA-EDTA Congress media alert
2015-05-29
(Press-News.org) The Lancet Diabetes & Endocrinology is pleased to announce that the following paper will be published to coincide with presentation at the 52nd ERA-EDTA Congress, taking place in London, UK, May 28 - 31, 2015.
Estimated glomerular filtration rate and albuminuria for prediction of cardiovascular outcomes: a collaborative meta-analysis, Coresh et al
The usefulness of estimated glomerular filtration rate (eGFR, a test used to check how well the kidneys are filtering blood) and albuminuria (excess protein levels in the urine, which can be a sign of kidney damage) for prediction of cardiovascular outcomes is controversial. This meta-analysis of 637?315 participants aimed to assess the addition of creatinine-based eGFR and albuminuria to traditional risk factors for prediction of cardiovascular mortality, coronary disease, stroke, and heart failure. Although creatinine-based eGFR and albuminuria (measured as albumin-to-creatinine ratio, ACR, or semi-quantitative dipstick proteinuria) independently improved cardiovascular prediction in general, the improvement was particularly evident for cardiovascular mortality and heart failure. ACR outperformed eGFR and most of the modifiable traditional risk factors for these two outcomes, as well as stroke. The discrimination improvement with ACR was especially evident in individuals with diabetes or hypertension but remained significant for cardiovascular mortality and heart failure even in those without either of these disorders. As a result, the authors say that creatinine-based eGFR and albuminuria should be taken into account for cardiovascular prediction, especially when they are already assessed for clinical purposes (eg, in individuals with chronic kidney disease, diabetes, or hypertension), or when cardiovascular mortality and heart failure are the outcomes of interest (eg, as stated by European guidelines for cardiovascular prevention). ACR could have particularly broad implications for cardiovascular prediction. In populations with chronic kidney disease, the simultaneous assessment of eGFR and ACR could facilitate improved cardiovascular risk classification, supporting current guidelines for chronic kidney disease.
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Myriad significantly advances the myChoice HRD companion diagnostic test
2015-05-29
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SALT LAKE CITY, Utah, May 29, 2015 - Myriad Genetics, Inc. (NASDAQ: MYGN) today announced new clinical studies on its myChoice HRD companion diagnostic test at the 2015 American Society of Clinical Oncology annual ...
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2015-05-29
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2015-05-28
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The new normal? Addressing gun violence in America
2015-05-28
Article Spotlight features summaries written in collaboration with authors of recently published articles by the Journals Program of the American Psychological Association. The articles are nominated by the editors as noteworthy to the scientific community.
Mass shootings have a significant impact on our individual and collective psyche, especially when they happen at schools. Despite the fact that children die every day from gun violence, school shootings upset us in ways that are difficult to comprehend. In our minds, schools serve as safe havens for children. When ...
Scientists use unmanned aerial vehicle to study gray whales from above
2015-05-28
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A new mechanism protecting the liver from dangerous inflammation
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Alain Beschin, from the Vrije Universiteit Brussel, Belgium, and colleagues studied the immune response to trypanosome parasites in mice, where they frequently cause liver inflammation and failure. They focused on the role of monocytes, immune ...
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