Myriad significantly advances the myChoice HRD companion diagnostic test

Predicts response to PARP inhibitors and platinum-based drugs in clinical studies

2015-05-29

(Press-News.org) .tg {border-collapse:collapse;border-spacing:0;} .tg td{font-family:Arial, sans-serif;font-size:14px;padding:10px 5px;border-style:solid;border-width:1px;overflow:hidden;word-break:normal;} .tg th{font-family:Arial, sans-serif;font-size:14px;font-weight:normal;padding:10px 5px;border-style:solid;border-width:1px;overflow:hidden;word-break:normal;} SALT LAKE CITY, Utah, May 29, 2015 - Myriad Genetics, Inc. (NASDAQ: MYGN) today announced new clinical studies on its myChoice HRD companion diagnostic test at the 2015 American Society of Clinical Oncology annual meeting being held in Chicago, Ill. Myriad's myChoice HRD test is the first and only companion diagnostic to measure three modes of homologous recombination deficiency (HRD) including loss of heterozygosity, telomeric allelic imbalance and large-scale state transitions in cancer cells. The myChoice HRD score is a biomarker that indicates the inability of cancer cells to repair DNA damage and reflects a tumor's sensitivity to DNA-damaging medicines such as PARP (poly-ADP ribose polymerase) inhibitors and platinum-based therapies. "The myChoice HRD companion diagnostic test stems from Myriad's pioneering research and is a real step forward in realizing the goal of personalized medicine for patients with ovarian, breast and pancreatic cancers and possibly other solid tumors," said Jerry Lanchbury, Ph.D., chief scientific officer, Myriad. "Anybody who has ever had cancer or treated patients with cancer will understand the enormous benefit of getting the right treatment to the right patient at the right time. There is mounting evidence that myChoice HRD can help us do that by predicting a therapeutic response to DNA-damaging agents based on patients' unique tumor biology." Below are the key myChoice HRD presentations being highlighted at #ASCO15.

myChoice HRD: Predicting Platinum Response Poster Discussion (Poster 32): Combined Homologous Recombination Deficiency (HRD) Scores and Response to Neoadjuvant Platinum-Based Chemotherapy in Triple Negative and/or BRCA1/2 Mutation-Associated Breast Cancer.

Melinda Telli, M.D. (Stanford University School of Medicine) will present new clinical data that established a homologous recombination (HR) deficiency threshold that can identify 95 percent of patients with mutations in BRCA1/2 and other homologous recombination genes and who have a higher likelihood of responding to treatment with DNA-damaging agents. Specifically, the study validated an HRD threshold score of ?42 (on a scale of 0-100) using a training cohort of 497 breast and 561 ovarian cancer patients. A myChoice HRD test score ?42 represents a positive score or a loss of DNA repair function, while a myChoice HRD score END

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Myriad presents new myRisk hereditary cancer data at 2015 ASCO Annual Meeting

2015-05-29

SALT LAKE CITY, Utah, May 29, 2015 - Myriad Genetics, Inc. (NASDAQ: MYGN) today announced it will highlight several new clinical studies on its myRisk Hereditary Cancer molecular diagnostic test at the 2015 American Society of Clinical Oncology annual meeting being held in Chicago, Ill. The myRisk Hereditary Cancer test assesses 25 genes for mutations associated with eight hereditary cancers. Finding deleterious mutations in these genes can help patients with cancer receive appropriate medical care and reduce the risk of second cancers, while patients without cancer ...

Sharp-eyed Alma spots a flare on famous red giant star

2015-05-29

Super-sharp observations with the telescope Alma have revealed what seems to be a gigantic flare on the surface of Mira, one of the closest and most famous red giant stars in the sky. Activity like this in red giants - similar to what we see in the Sun - comes as a surprise to astronomers. The discovery could help explain how winds from giant stars make their contribution to our galaxy's ecosystem. New observations with Alma have given astronomers their sharpest ever view of the famous double star Mira. The images clearly show the two stars in the system, Mira A and ...

Brain training induces lasting brain & mental health gains for veterans, civilians with brain injury

2015-05-28

In the first study of its kind, veterans and civilians with traumatic brain injury showed improved cognitive performance and psychological and neural health following strategy-based cognitive training. The Department of Defense-funded study, published this week in Neuropsychological Rehabilitation, was conducted by an interdisciplinary team of cognitive neuroscientists, rehabilitation specialists, and neuroimaging experts from the Center for BrainHealth at The University of Texas at Dallas. "Veterans and others who have sustained traumatic brain injuries often experience ...

The new normal? Addressing gun violence in America

2015-05-28

Article Spotlight features summaries written in collaboration with authors of recently published articles by the Journals Program of the American Psychological Association. The articles are nominated by the editors as noteworthy to the scientific community. Mass shootings have a significant impact on our individual and collective psyche, especially when they happen at schools. Despite the fact that children die every day from gun violence, school shootings upset us in ways that are difficult to comprehend. In our minds, schools serve as safe havens for children. When ...

Scientists use unmanned aerial vehicle to study gray whales from above

2015-05-28

One recent spring day, John Durban, a NOAA Fisheries marine mammal biologist, stood on the California coast and launched an unmanned aerial vehicle into the air. The hexacopter--so called because it has six helicopter-type rotors--zipped over the ocean and hovered above a gray whale mother and her calf. The pair was migrating north from their calving grounds off Baja California, Mexico, to their summer feeding grounds in the Arctic. NOAA Fisheries scientists have stood at this point of land each year for the past 22 years, binoculars in hand, to estimate the number of ...

A new mechanism protecting the liver from dangerous inflammation

2015-05-28

Life-threatening liver inflammation can be caused by excess alcohol, fatty foods, toxins, as well as viral, bacterial, and parasite infections. A study published on May 28th in PLOS Pathogens reports that a specific immune cell type in the liver can dampen the immune response, reduce inflammation, and protect against liver damage. Alain Beschin, from the Vrije Universiteit Brussel, Belgium, and colleagues studied the immune response to trypanosome parasites in mice, where they frequently cause liver inflammation and failure. They focused on the role of monocytes, immune ...

Deciphering dark and bright

2015-05-28

The human sensory systems contend with enormous diversity in the natural world. But it has been known for a long time the brain is adapted to exploit statistical regularities that nonetheless arise amongst this diversity. Research publishing this week in PLOS Computational Biology reports that established statistical distributions of visual features, such as visual contrast, spatial scale and depth, differ between dark and bright components of the natural world. For scientists Emily Cooper and Anthony Norcia, gaining a more detailed description of statistical regularities ...

Researchers retrieve 'lost' memories

2015-05-28

Retrograde amnesia is the inability to recall established memories. In humans, amnesia is associated with traumatic brain injury, Alzheimer's disease, and other neurological conditions. Whether memories lost to amnesia are completely erased or merely unable to be recalled remains an open question. Now, in a finding that casts new light on the nature of memory, published in Science, researchers from the RIKEN-MIT Center for Neural Circuit Genetics demonstrated in mice that traces of old memories do remain in the amnestic brain, and that the cellular pathways underlying them ...

Genetically elevated triglyceride level associated with protection against type 2 diabetes

2015-05-28

Elevated plasma triglyceride level is considered a risk factor for type-2 diabetes, but new findings suggest that a genetically-elevated triglyceride level is associated with protection against type-2 diabetes. Yann Klimentidis, an Assistant Professor at the Mel and Enid Zuckerman College of Public Health at the University of Arizona, and colleagues found that triglyceride-increasing alleles are associated with decreased type-2 diabetes incidence. Their findings were published recently in PLOS Genetics. Building on previous studies that hinted to the same association, ...

Understanding taste bud renewal may help cancer patients suffering from taste dysfunction

2015-05-28

Dany Gaillard and colleagues at the University of Colorado Anschutz Medical Campus have discovered a key molecular pathway that aids the renewal of taste buds, a finding that may help cancer patients suffering from an altered sense of taste during treatment. Their findings were published recently in the journal PLOS Genetics. "Many cancer drugs which circulate throughout the entire body, will target a tumor but in the process affect healthy cells," said the study's senior author Linda Barlow, a professor of cell and developmental biology at University of Colorado Anschutz ...

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Myriad significantly advances the myChoice HRD companion diagnostic test

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