PRESS-NEWS.org - Press Release Distribution
FREE PRESS RELEASES DISTRIBUTION

Earlier surgical intervention for mitral valve disease is better for most patients

Trends over 25 years show less invasive surgical repair and shorter recovery time

2015-06-09
(Press-News.org) Chicago, June 9, 2015 - A more aggressive approach to treating degenerative mitral valve disease, using earlier surgical intervention and less invasive techniques, is more beneficial to the patient than "watchful waiting," according to an article in the June 2015 issue of The Annals of Thoracic Surgery.

Key points

Earlier surgical intervention using less invasive surgical techniques is better than watchful waiting for patients with degenerative mitral valve disease. Over the 25 years observed, mortality rates remained low, hospital length of stay was shorter, and surgical repair became less invasive in the latter years of the study. Researchers said the key to successful treatment is a timely referral for surgical intervention at an advanced repair center with highly skilled heart teams.

Degenerative mitral valve disease is irreversible. It eventually leads to regurgitation (blood leaking backwards through the valve) and heart failure. While surgical treatment of the disease has evolved, there is still debate about the value of watchful waiting versus early surgical repair for patients without symptoms.

Farhang Yazdchi, MD, MS, and colleagues, from the Cleveland Clinic in Ohio, assessed trends in patient characteristics, timing of intervention, and surgical techniques for mitral valve regurgitation by reviewing the records of 5,902 patients over a 25-year period (January 1, 1985 to January 1, 2011).

They found that improved technology and earlier intervention have led to more patients benefitting from less invasive surgical repair before suffering from disease symptoms, such as atrial fibrillation (irregular, often rapid heart rate) or heart failure.

"Surgery is almost unavoidable in patients with severe degenerative mitral valve regurgitation. Our study has shown that the key to successful treatment is a timely referral for surgical intervention at an advanced repair center with highly skilled heart teams," said Dr. Yazdchi.

The researchers found that patients who were treated in the latter years of the study (2005-2011) were released from the hospital about 2 days sooner than those treated in the earliest years of the study (1985-1997). Two main reasons for the shortened stay were fewer full sternotomies (large chest incisions)--25% in the latter years vs. 93% in the earliest years--and more patients were asymptomatic--44% in the latter years vs. 25% in the earliest years.

"Successful mitral valve repair at the Cleveland Clinic has reached a level of almost 100%, while mortality rates have remained extremely low and hospital length of stay shortened," said Dr. Yazdchi. "Patients who are diagnosed with severe mitral valve regurgitation should seek surgical consultation sooner rather than later, even if they are not having any symptoms.

INFORMATION:

Notes for editors Increasing Disadvantage of "Watchful Waiting" for Repairing Degenerative Mitral Valve Disease doi:10.1016/j.athoracsur.2015.01.065 The Annals of Thoracic Surgery published by Elsevier. http://www.sciencedirect.com/science/article/pii/S0003497515002167

Full text of the article is available to credentialed journalists upon request; contact Cassie McNulty cmcnulty@sts.org at +1 312 202 5865

About The Annals of Thoracic Surgery The Annals of Thoracic Surgery is the official journal of STS and the Southern Thoracic Surgical Association. Founded in 1964, The Society of Thoracic Surgeons is a not-for-profit organization representing more than 6,800 cardiothoracic surgeons, researchers, and allied health care professionals worldwide who are dedicated to ensuring the best possible outcomes for surgeries of the heart, lung, and esophagus, as well as other surgical procedures within the chest. The Society's mission is to enhance the ability of cardiothoracic surgeons to provide the highest quality patient care through education, research, and advocacy.

About Elsevier Elsevier is a world-leading provider of information solutions that enhance the performance of science, health, and technology professionals, empowering them to make better decisions, deliver better care, and sometimes make groundbreaking discoveries that advance the boundaries of knowledge and human progress. Elsevier provides web-based, digital solutions -- among them ScienceDirect, Scopus, Elsevier Research Intelligence and ClinicalKey -- and publishes over 2,500 journals, including The Lancet and Cell, and more than 33,000 book titles, including a number of iconic reference works. Elsevier is part of RELX Group plc, a world-leading provider of information solutions for professional customers across industries. http://www.elsevier.com



ELSE PRESS RELEASES FROM THIS DATE:

Researchers identify unique marker on mom's chromosomes in early embryo

Researchers identify unique marker on moms chromosomes in early embryo
2015-06-09
Athens, Ga. - Researchers in the University of Georgia's Regenerative Bioscience Center are visually capturing the first process of chromosome alignment and separation at the beginning of mouse development. The findings could lead to answers to questions concerning the mechanisms leading to birth defects and chromosome instability in cancer cells. "We've generated a model that is unique in the world," said Rabindranath De La Fuente, an associate professor in the UGA College of Veterinary Medicine. "Because we removed ATRX protein expression only in the oocyte, the female ...

Land management practices to become important as biofuels use grows

2015-06-09
The handling of agricultural crop residues appears to have a large impact on soil's ability to retain carbon, making land management practices increasingly important, especially under a scenario where cellulosic materials become more heavily used as a feedstock for ethanol production, according to a recently published study led by researchers at the U.S. Department of Energy's Argonne National Laboratory. "Plants and soil are carbon sinks," said Argonne climate scientist Beth Drewniak, who led the study. "Soils lock carbon away for long periods of time. But when plant ...

Just add water: Stanford engineers develop a computer that operates on water droplets

2015-06-09
Computers and water typically don't mix, but in Manu Prakash's lab, the two are one and the same. Prakash, an assistant professor of bioengineering at Stanford, and his students have built a synchronous computer that operates using the unique physics of moving water droplets. The computer is nearly a decade in the making, incubated from an idea that struck Prakash when he was a graduate student. The work combines his expertise in manipulating droplet fluid dynamics with a fundamental element of computer science - an operating clock. "In this work, we finally demonstrate ...

Stanford engineers develop state-by-state plan to convert US to 100 percent renewable energy

2015-06-09
One potential way to combat ongoing climate change, eliminate air pollution mortality, create jobs and stabilize energy prices involves converting the world's entire energy infrastructure to run on clean, renewable energy. This is a daunting challenge. But now, in a new study, Mark Z. Jacobson, a professor of civil and environmental engineering at Stanford, and colleagues, including U.C. Berkeley researcher Mark Delucchi, are the first to outline how each of the 50 states can achieve such a transition by 2050. The 50 individual state plans call for aggressive changes ...

Stanford scientists show fMRI memory detectors can be easily fooled

2015-06-09
For the past several years, Anthony Wagner has been developing a computer program that can read a person's brain scan data and surmise, with a high degree of certainty, whether that person is experiencing a memory. The technology has great promise to influence a number of fields, including marketing, medicine and evaluation of eyewitness testimony. Now, Wagner, a professor of psychology and neuroscience at Stanford, and his colleagues have shown that with just a little bit of coaching and concentration, subjects are easily able to obscure real memories, or even create ...

Aimmune Therapeutics announces positive Ph 2 study results for treatment of peanut allergy

2015-06-09
BARCELONA, Spain, June 9, 2015 -- Aimmune Therapeutics, Inc., a privately held biopharmaceutical company developing desensitization treatments for food allergies, announced today that a Phase 2 study (ARC001) evaluating the company's lead investigational product, AR101 for the treatment of peanut allergy, met its primary endpoint and additional endpoint of desensitizing patients to cumulative amounts of peanut protein of 443 mg and 1,043 mg, respectively. Of the 23 active-arm patients who completed the study, 100 percent tolerated exposure to 443 mg cumulative amounts ...

Computer game reduces issues associated with AD/HD in children in China

2015-06-09
Los Angeles, CA (June 9, 2015) Children diagnosed with AD/HD can improve their behavior and social interactions in the classroom by playing a computer game that exercises their concentration, finds new research out today. The study marks the 1000th article published in SAGE Open, a peer-reviewed, open-access journal launched in 2011 which covers the full spectrum of the social and behavioral sciences and the humanities. The software studied in the research syncs with a wireless headband that monitors brainwaves during game-play, and works by adjusting the level of difficulty ...

In Kenya, program changes male attitudes about sexual violence, Stanford study finds

2015-06-09
In Kenya, where rape and violence against women are rampant, a short educational program produced lasting improvements in teenage boys' and young men's attitudes toward women, a study from the Stanford University School of Medicine has found. The boys and men in the study also were more likely to try to halt violence against women after participating in the program. The study will be published online June 9 in the Journal of Interpersonal Violence. The program was developed by No Means No Worldwide, a nonprofit, nongovernmental organization that works in the slums ...

Largest-ever study of parental age and autism finds increased risk with teen moms

2015-06-09
New York, N.Y. (June 9, 2015) - The largest-ever multinational study of parental age and autism risk, funded by Autism Speaks, found increased autism rates among the children of teen moms and among children whose parents have relatively large gaps between their ages. The study also confirmed that older parents are at higher risk of having children with autism. The analysis included more than 5.7 million children in five countries. The study was published today in the journal Molecular Psychiatry. "Though we've seen research on autism and parental age before, this study ...

New study shows intravenous glutamine reduces ischemia reperfusion injuries

2015-06-09
A single dose of intravenous glutamine (GLN) administered immediately after a non-lethal lower limb ischemia reduces the reperfusion inflammatory reaction locally and systemically according to a new study. The study, published today in the OnlineFirst version of the Journal of Parenteral and Enteral Nutrition (JPEN), the research journal of the American Society for Parenteral and Enteral Nutrition (A.S.P.E.N.), used a mice model to compare the effects of GLN on hind limb ischemia reperfusion (IR) injury. The study subjected three groups of mice to 90 minutes of ischemia ...

LAST 30 PRESS RELEASES:

Scientists model 'true prevalence' of COVID-19 throughout pandemic

New breakthrough to help immune systems in the fight against cancer

Through the thin-film glass, researchers spot a new liquid phase

Administering opioids to pregnant mice alters behavior and gene expression in offspring

Brain's 'memory center' needed to recognize image sequences but not single sights

Safety of second dose of mRNA COVID-19 vaccines after first-dose allergic reactions

Changes in disparities in access to care, health after Medicare eligibility

Use of high-risk medications among lonely older adults

65+ and lonely? Don't talk to your doctor about another prescription

Exosome formulation developed to deliver antibodies for choroidal neovascularization therapy

Second COVID-19 mRNA vaccine dose found safe following allergic reactions to first dose

Plant root-associated bacteria preferentially colonize their native host-plant roots

Rare inherited variants in previously unsuspected genes may confer significant risk for autism

International experts call for a unified public health response to NAFLD and NASH epidemic

International collaboration of scientists rewrite the rulebook of flowering plant genetics

Improving air quality reduces dementia risk, multiple studies suggest

Misplaced trust: When trust in science fosters pseudoscience

Two types of blood pressure meds prevent heart events equally, but side effects differ

New statement provides path to include ethnicity, ancestry, race in genomic research

Among effective antihypertensive drugs, less popular choice is slightly safer

Juicy past of favorite Okinawan fruit revealed

Anticipate a resurgence of respiratory viruses in young children

Anxiety, depression, burnout rising as college students prepare to return to campus

Goal-setting and positive parent-child relationships reduce risk of youth vaping

New research identifies cancer types with little survival improvements in adolescents and young adul

Oncotarget: Replication-stress sensitivity in breast cancer cells

Oncotarget: TERT and its binding protein: overexpression of GABPA/B in gliomas

Development of a novel technology to check body temperature with smartphone camera

The mechanics of puncture finally explained

Extreme heat, dry summers main cause of tree death in Colorado's subalpine forests

[Press-News.org] Earlier surgical intervention for mitral valve disease is better for most patients
Trends over 25 years show less invasive surgical repair and shorter recovery time