(Press-News.org) A new approach to skin rejuvenation developed at Massachusetts General Hospital (MGH) may be less likely to have unintended side effects such as scarring and altered pigmentation. In the online journal Scientific Reports, an MGH research team reports that treatment with pulsed electric fields - a noninvasive procedure that does not involve the generation of heat - removed skin cells in an animal model without affecting the supporting extracellular matrix, eventually leading to renewal of the skin surface.
"We showed that non-thermal pulsed electric field or PEF treatment can reset skin metabolism, leading to skin rejuvenation," says lead author Alexander Golberg, PhD, of the MGH Center for Engineering in Medicine. "The main difference between this approach and procedures like ultrasound and lasers is that they operate on the whole tissue, while PEF works on only a cellular level, which we expect will provide more precise treatment results in the future." Golberg is now also on the faculty of the Porter School of Environmental Studies at Tel Aviv University.
The authors note that current therapies aimed at skin rejuvenation that affect all exposed tissue can change skin's structure and function. Even approaches that directly target skin cells - such as fractional and some other types of lasers - can have undesired effects including scarring and discoloration. Long used in food preservation for its ability to kill bacteria, PEF causes the formation of tiny pores in the outer membranes of cells. Within tissues, the kind of cell death induced by PEF causes nearby cells to proliferate and release factors promoting the growth and repair of tissues, and a previous study led Golberg showed in an animal model that PEF-treated skin would regenerate without scarring.
In the current study, the research team first determined the optimal strength, duration and number of PEF pulses required to induce the formation of collagen in the skin of healthy young rats. They then showed that PEF treatment of normal skin induced a number of responses - including the death and subsequent proliferation of skin cells, a temporary increase in the synthesis and density of collagen fibers in the extracellular matrix, increased microcirculation of the treated area, and an overall increase in skin metabolism. Within periods of up to two months after treatment, PEF-induced changes in skin thickness, blood supply, and collagen density had returned to the pre-treatment characteristics of healthy young skin.
"Our results show that the procedure is safe, does not lead to scarring and increases skin metabolism and cell proliferation," says Martin Yarmush, MD, PhD, director of the MGH Center for Engineering in Medicine and corresponding author of the paper. "We now need to investigate the impact of PEF treatment on aged skin, as well as on skin with other forms of damage, and we are looking for funding to help us design, build and test a device for clinical application."
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Additional co-authors of the Scientific Reports paper are Vasily Belov, PhD, and Mikhail Papisov, PhD, MGH Radiology; Hassan Albadawi, MD, and Michael Watkins, MD, MGH Vascular Surgery; Saiqa Khan, MD, Felix Broelsch, MD, and William G. Austen Jr, MGH Plastic and Reconstructive Surgery; Kyle Quinn, PhD, and Irene Georgakoudi, PhD, Tufts University; Martin Mihm, MD, Brigham and Women's Hospital. The study was supported by Shriners Hospitals for Children grant 85120-BOS, and the MGH has filed a patent application for the use of PEF for skin rejuvenation.
Massachusetts General Hospital, founded in 1811, is the original and largest teaching hospital of Harvard Medical School. The MGH conducts the largest hospital-based research program in the United States, with an annual research budget of more than $760 million and major research centers in AIDS, cardiovascular research, cancer, computational and integrative biology, cutaneous biology, human genetics, medical imaging, neurodegenerative disorders, regenerative medicine, reproductive biology, systems biology, transplantation biology and photomedicine.
ANN ARBOR--A University of Michigan researcher and his colleagues are forecasting an average but still large "dead zone" in the Gulf of Mexico this year.
The forecast calls for an oxygen-depleted, or hypoxic, region of 5,483 square miles, roughly the size of Connecticut. It was announced today by the U.S. National Oceanic and Atmospheric Administration, which sponsors the work.
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Only 43 percent of people surveyed understood the definition of sun factor protection (SPF) and only seven percent knew what to look for on a label if they wanted a sunscreen that offers protection against early skin aging.
Details of the study were published June 17, in the journal JAMA Dermatology.
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Good leaders needing to strike a balance between striving to reach goals and keeping their followers with them has deep evolutionary roots, according to a new study from the Universities of Bristol, Harvard and Princeton on schooling fish.
Dr Christos Ioannou and colleagues devised an experiment to determine the behaviours associated with effective leadership using fish called golden shiners (Notemigonus crysoleucas).
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MULTIMEDIA ALERT: Video and audio are available for download on the Mayo Clinic News Network.
The precision medicine study appears online in Oncogene and focuses on kidney cancer and its metastases. Recent studies of the same epigenomic fingerprint in other cancers suggest a common pathway that could help improve the diagnosis and treatment ...
The best sparkling wines take months to ferment to perfection. In recent years, many winemakers have turned to commercial yeast products to give this process a boost. How they ultimately affect bubbly has been an open question, but now scientists have stepped in to find out. They report their findings in ACS' Journal of Agricultural and Food Chemistry.
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