(Press-News.org) The original Americans came from Siberia in a single wave no more than 23,000 years ago, at the height of the last Ice Age, and apparently hung out in the north - perhaps for thousands of years - before spreading in two distinct populations throughout North and South America, according to a new genomic analysis.
The findings, which will be reported in the July 24 issue of Science, confirm the most popular theory of the peopling of the Americas, but throws cold water on others, including the notion of an earlier wave of people from East Asia prior to the last glacial maximum, and the idea that multiple independent waves produced the major subgroups of Native Americans we see today, as opposed to diversification in the Americas.
This Ice Age migration over a land bridge between Siberia and Alaska is distinct from the arrival of the Inuit and Eskimo, who were latecomers, spreading throughout the Artic beginning about 5,500 years ago.
The findings also dispel the idea that Polynesians or Europeans contributed to the genetic heritage of Native Americans.
The analysis, using the most comprehensive genetic data set from Native Americans to date, was conducted using three different statistical models, two of them created by UC Berkeley researchers. The first, developed by the lab of Yun Song, a UC Berkeley associate professor of statistics and of electrical engineering and computer sciences, takes into account the full DNA information available from the genomes in the study. A second method, developed by Rasmus Nielsen, a UC Berkeley professor of integrative biology, and graduate student Kelley Harris, requires much less computation, but relies on a summary of the genome data. These and a third method developed by researchers at the Wellcome Trust Sanger Institute, England, all yielded consistent results. Song and Nielsen are two of three corresponding authors of the paper.
Modern and ancient genomes
The data consisted of the sequenced genomes of 31 living Native Americans, Siberians and people from around the Pacific Ocean, and the genomes of 23 ancient individuals from North and South America, spanning a time between 200 and 6,000 years ago.
"There is some uncertainty in the dates of the migration and the divergence between the norther and southern Amerindian populations," Song noted, "but as we get more ancient genomes sequenced, we will be able to put more precise dates on the times of migration."
The international team concluded that the northern and southern Native American populations diverged between 11,500 and 14,500 years ago, with the northern branch leading to the present day Athabascans and Amerindians broadly distributed throughout North America. The southern branch peopled Central and South America, as well as part of northern North America.
"The diversification of modern Native Americans appears to have started around 13,000 years ago when the first unique Native American culture appears in the archeological record: the Clovis culture," said Nielsen. "We can date this split so precisely in part because we previously have analyzed the 12,600-year-old remains of a boy associated with the Clovis culture."
One surprise in the genetic data is that both populations of Native Americans have a small admixture of genes from East Asians and Australo-Melanesians, including Papuans, Solomon Islanders and Southeast Asian hunter gatherers.
"It's a surprising finding and it implies that New World populations were not completely isolated from the Old World after their initial migration," said Eske Willerslev from the Centre for GeoGenetics at the Natural History Museum, University of Copenhagen, who headed the study. "We cannot say exactly how and when this gene flow happened, but one possibility is that it came through the Aleutian Islanders living off the coast of Alaska."
Song added that the state-of-the-art statistical methods that his and Nielsen's labs developed "are being made publicly available so that they can be used by others to study complex demographic histories of other populations."
INFORMATION:
Starting antiretroviral therapy early not only prevents serious AIDS-related diseases, but also prevents the onset of cancer, cardiovascular disease, and other non-AIDS-related diseases in HIV-infected people, according to a new analysis of data from the Strategic Timing of AntiRetroviral Treatment (START) study, the first large-scale randomized clinical trial to establish that earlier antiretroviral treatment benefits all HIV-infected individuals. Rates of both serious AIDS-related events and serious non-AIDS-related events were significantly reduced with early therapy.
The ...
The Institute of Medicine has identified interprofessional education (IPE) as a key innovation for achieving the triple aim of better care, better outcomes and reduced health care costs. Yet, a shortage of qualified faculty and difficulty with aligning learners' schedules often prevent sustainable and scalable IPE.
Now, a team of New York University researchers from both the College of Nursing (CoN) and NYU School of Medicine (SoM), are addressing the barriers to wide-spread adoption of IPE.
Led by Maja Djukic, PhD, RN, assistant professor at the CoN, and Marc Triola, ...
The United States now produces about as much crude oil as Saudi Arabia does, and enough natural gas to export in large quantities. That's thanks to hydraulic fracturing, a mining practice that involves a rock-cracking pressurized mix of water, sand and chemicals.
Ongoing research by Stanford environmental scientist Rob Jackson attempts to minimize the risks of "fracking" to underground drinking water sources.
The most recent such study, published in Environmental Science & Technology, finds that at least 6,900 oil and gas wells in the U.S. were fracked less than a mile ...
MADISON, Wis. -- Cognitive scientists have come to view the brain as a prediction machine, constantly comparing what is happening around us to expectations based on experience -- and considering what should happen next.
"These predictions, most of them unconscious, include predicting what we're about to see," says Gary Lupyan, a University of Wisconsin-Madison psychology professor.
Work in Lupyan's lab has demonstrated the predictive process through manipulating the connection between language and vision in the brain. A study published recently in The Journal of Neuroscience ...
MIAMI - Researchers discovered a threatened coral species that lives in deeper waters off the U.S. Virgin Islands is more fertile than its shallow-water counterparts. The new study showed that mountainous star corals (Orbicella faveolata) located at nearly 140 feet (43 meters) deep may produce one trillion more eggs per square kilometer (247 acres) than those on shallow reefs. The findings from scientists at the University of Miami (UM) Rosenstiel School of Marine and Atmospheric Science and the University of the Virgin Islands have important implications for the future ...
ATLANTA - July 21, 2015-If Louisiana, which has some of the highest colon cancer incidence and mortality rates in the nation, had the same risk factors, screening uptake, and survival rates as New Jersey, incidence and mortality from the disease would not only drop, they would drop to levels below that of New Jersey, according to a new study. The study, appearing in Cancer, shows that removing differences in health behavior and survival would close a gap that has appeared over the past several decades.
Decades ago, colorectal cancer incidence and mortality rates were ...
New research provides mathematical evidence that Michelangelo used the Golden Ratio of 1.6 when painting The Creation of Adam on the ceiling of the Sistine Chapel. The Golden Ratio is found when you divide a line into two parts so that the longer part divided by the smaller part is equal to the whole length divided by the longer part.
The Golden Ratio has been linked with greater structural efficiency and has puzzled scientists for centuries due to its frequent occurrence in nature--for example in snail shells and flower petals. The Golden Ratio can also be found in a ...
Sudden cardiac arrest kills an estimated 200,000 people a year in the United States, but many of those lives could be saved if ordinary bystanders simply performed CPR, a new study led by Duke Medicine shows.
The early application of cardio-pulmonary resuscitation (CPR) by an average person nearby, combined with defibrillation by firefighters or police before the arrival of emergency medical services (EMS), was the one intervention that substantially increased survival from cardiac arrest, according to findings reported by Duke researchers and colleagues in the July 21 ...
Two studies in the July 21 issue of JAMA find that use of interventions such as cardiopulmonary resuscitation and automated external defibrillators by bystanders and first responders have increased and were associated with improved survival and neurological outcomes for persons who experienced an out-of-hospital cardiac arrest.
Out-of-hospital cardiac arrest (OHCA) is an increasing health concern worldwide, with poor prognoses. Shinji Nakahara, M.D., Ph.D., of the Kanagawa University of Human Services, Yokosuka, Japan, and colleagues examined the associations between ...
Although some previous studies have suggested an increased risk of bladder cancer with use of the diabetes drug pioglitazone, analyses that included nearly 200,000 patients found no statistically significant increased risk, however a small increased risk could not be excluded, according to a study in the July 21 issue of JAMA. Additional analyses with another large group found that use of pioglitazone was associated with an increase in the risk of prostate and pancreatic cancer, although further investigation is needed to assess whether the associations are causal or due ...