PRESS-NEWS.org - Press Release Distribution
PRESS RELEASES DISTRIBUTION

New ORNL hybrid microscope offers unparalleled capabilities

New ORNL hybrid microscope offers unparalleled capabilities
2015-08-10
(Press-News.org) OAK RIDGE, Tenn., Aug. 10, 2015 - A microscope being developed at the Department of Energy's Oak Ridge National Laboratory will allow scientists studying biological and synthetic materials to simultaneously observe chemical and physical properties on and beneath the surface.

The Hybrid Photonic Mode-Synthesizing Atomic Force Microscope is unique, according to principal investigator Ali Passian of ORNL's Quantum Information System group. As a hybrid, the instrument, described in a paper published in Nature Nanotechnology, combines the disciplines of nanospectroscopy and nanomechanical microscopy.

"Our microscope offers a noninvasive rapid method to explore materials simultaneously for their chemical and physical properties," Passian said. "It allows researchers to study the surface and subsurface of synthetic and biological samples, which is a capability that until now didn't exist."

ORNL's instrument retains all of the advantages of an atomic force microscope while simultaneously offering the potential for discoveries through its high resolution and subsurface spectroscopic capabilities.

"The originality of the instrument and technique lies in its ability to provide information about a material's chemical composition in the broad infrared spectrum of the chemical composition while showing the morphology of a material's interior and exterior with nanoscale - a billionth of a meter - resolution," Passian said.

Researchers will be able to study samples ranging from engineered nanoparticles and nanostructures to naturally occurring biological polymers, tissues and plant cells.

The first application as part of DOE's BioEnergy Science Center was in the examination of plant cell walls under several treatments to provide submicron characterization. The plant cell wall is a layered nanostructure of biopolymers such as cellulose. Scientists want to convert such biopolymers to free the useful sugars and release energy.

An earlier instrument, also invented at ORNL, provided imaging of poplar cell wall structures that yielded unprecedented topological information, advancing fundamental research in sustainable biofuels.

Because of this new instrument's impressive capabilities, the researcher team envisions broad applications. "An urgent need exists for new platforms that can tackle the challenges of subsurface and chemical characterization at the nanometer scale," said co-author Rubye Farahi. "Hybrid approaches such as ours bring together multiple capabilities, in this case, spectroscopy and high-resolution microscopy."

Looking inside, the hybrid microscope consists of a photonic module that is incorporated into a mode-synthesizing atomic force microscope. The modular aspect of the system makes it possible to accommodate various radiation sources such as tunable lasers and non-coherent monochromatic or polychromatic sources.

INFORMATION:

Other contributors to the article, titled "Opto-nanomechanical spectroscopic material characterization," are Brian Davison of ORNL and former ORNL researchers Laurene Tetard and Thomas Thundat. The paper is available at http://www.nature.com/nnano/journal/vaop/ncurrent/full/nnano.2015.168.html.

Funding was provided by DOE's BioEnergy Sciences Center at ORNL. BESC is one of three DOE Bioenergy Research Centers established by the DOE's Office of Science in 2007. The centers support multidisciplinary, multi-institutional research teams pursuing the fundamental scientific breakthroughs needed to make production of cellulosic biofuels, or biofuels from nonfood plant fiber, cost-effective on a national scale. The centers are led by ORNL, Lawrence Berkeley National Laboratory and the University of Wisconsin-Madison in partnership with Michigan State University.

UT-Battelle manages ORNL for the DOE's Office of Science. The Office of Science is the single largest supporter of basic research in the physical sciences in the United States, and is working to address some of the most pressing challenges of our time. For more information, please visit http://science.energy.gov/.

Image: http://www.ornl.gov/Image%20Library/Main%20Nav/ORNL/News/News%20Releases/2015/passian_hr.jpg

Cutline: A combination of carefully tuned mechanical and photonic excitations of the sample and probe allow for decoding of chemical and physical properties.

NOTE TO EDITORS: You may read other press releases from Oak Ridge National Laboratory or learn more about the lab at http://www.ornl.gov/news. Additional information about ORNL is available at the sites below:
Twitter - http://twitter.com/oakridgelabnews
RSS Feeds - http://www.ornl.gov/ornlhome/rss_feeds.shtml
Flickr - http://www.flickr.com/photos/oakridgelab
YouTube - http://www.youtube.com/user/OakRidgeNationalLab
LinkedIn - http://www.linkedin.com/companies/oak-ridge-national-laboratory
Facebook - http://www.facebook.com/Oak.Ridge.National.Laboratory


[Attachments] See images for this press release:
New ORNL hybrid microscope offers unparalleled capabilities

ELSE PRESS RELEASES FROM THIS DATE:

Movie theaters in developing economies should consider the big screen

2015-08-10
In emerging economies, where real estate is expensive and space is limited, there has been a boom in multiplex movie theater construction fueled by the conviction that small screens with many show times will increase ticket sales. But new research from the University of Chicago Booth School of Business finds that the strategy doesn't always work. In the paper Quality vs. Variety: Trading Larger Screens for More Shows in the Era of Digital Cinema by Chicago Booth Assistant Professor of Marketing Anita Rao and Stanford University Professor Wesley R. Hartmann, researchers ...

Drug candidate kills cancer cells through overstimulation

Drug candidate kills cancer cells through overstimulation
2015-08-10
A drug candidate that overstimulates proteins crucial for tumor growth shows promise as a new strategy to treat a wide range of cancers. The demands of rapid cell division put a strain on cancer cells, and the approach works by tipping cell stress over the edge. In the August 10 issue of Cancer Cell, American researchers show that the drug candidate inhibits tumor growth in a mouse model of breast cancer and efficiently kills a broad range of human cancer cells. "No prior drug has been previously developed or proposed that actually stimulates an oncogene to promote therapy," ...

Link between hunger and health care costs

2015-08-10
Low-income people who struggle to put food on the table also use the health care system more, which means higher health care costs, according to new research published in CMAJ (Canadian Medical Association Journal). "We know that people who have trouble affording the food they need have poorer health in general as well as more chronic disease," states Dr. Valerie Tarasuk, Department of Nutritional Sciences, University of Toronto, Toronto, Ontario. The term "food insecurity" describes inadequate or insecure access to food because of financial constraints. In Canada in ...

As California wildfires burn, southern plant species are shifting northward

As California wildfires burn, southern plant species are shifting northward
2015-08-10
As California wildfires burn tree canopies and the forest floors they support, the plants that are replacing the understory are increasingly those found in more southern areas of the West, according to a study from the University of California, Davis. "The plants we're finding underneath our forests are becoming more like those seen in Mexico and Southern California," said lead author Jens Stevens, a postdoctoral scholar with the UC Davis John Muir Institute of the Environment. "Under climate change, we're seeing species from drier, warmer areas increasingly taking over. ...

Education intervention with residents improves understanding of transgender issues

2015-08-10
BOSTON-The term "transgender" has made its way into mainstream media thanks to Caitlyn Jenner, previously known as Bruce Jenner, who came out as a transgender woman earlier this year. But for many physicians, or physicians-in-training, who do not typically treat transgender patients for issues specific to their gender identity, it's still a mystery. Joshua Safer, MD, FACP, endocrinologist at Boston Medical Center and associate professor of medicine and molecular medicine at Boston University School of Medicine (BUSM), and his colleague Dylan Thomas, MD, conducted an ...

Seniors at high risk for readmission after ambulatory surgery

2015-08-10
Taking four pain pills an hour instead of four pills a day Need improved, understandable discharge instructions More than 9 million ambulatory surgeries performed annually on seniors CHICAGO --- Patients 65 and older who have ambulatory surgery are much more likely to be readmitted to the hospital within 30 days than younger patients, regardless of their health before surgery, reports a new, large national Northwestern Medicine study. The likely cause, based on previous research, is difficulty understanding medication dosing and discharge instructions, as well ...

Life is but a DREAM

2015-08-10
Results of a 2013 DREAM Challenge - a crowdsourcing initiative for systems biomedicine - have been published in Nature Biotechnology; Hundreds of scientists from around the world pooled their efforts to test how accurately they could predict the effect of toxic compounds in different individuals, or across a population; Combined results achieved a rough estimate of population effects, and methods emerged that may be able to provide real-world benefit in the hazard assessments of new compounds. 10 August 2015 - An international study published in Nature Biotechnology ...

Severe droughts could lead to widespread losses of butterflies by 2050

2015-08-10
Widespread drought-sensitive butterfly population extinctions could occur in the UK as early as 2050 according to a new study published today in the scientific journal Nature Climate Change. However, the authors conclude that substantial greenhouse gas emission reductions combined with better management of landscapes, in particular reducing habitat fragmentation, will greatly improve the chances of drought-sensitive butterflies flying until at least 2100. The study was led by Dr Tom Oliver from the UK's Centre for Ecology & Hydrology (CEH) in collaboration with colleagues ...

Mass. General-led team identifies first gene that causes mitral valve prolapse

2015-08-10
An international research collaboration led by Massachusetts General Hospital (MGH) investigators has identified the first gene in which mutations cause the common form of mitral valve prolapse (MVP), a heart valve disorder that affects almost 2.5 percent of the population. In a paper receiving advance online publication in Nature, the research team reports finding mutations in a gene called DCHS1 in affected members of three families in which MVP is inherited. "This work provides insights into the pathways regulating valve growth and development and implicates a previously ...

New computational method predicts genes likely to be causal in disease

2015-08-10
A new computational method developed by scientists from the University of Chicago improves the detection of genes that are likely to be causal for complex diseases and biological traits. The method, PrediXcan, estimates gene expression levels across the whole genome - a better measure of biological action than single mutations - and integrates it with genome-wide association study (GWAS) data. PrediXcan has the potential to identify gene targets for therapeutic applications faster and with greater accuracy than traditional methods. It is described online in Nature Genetics ...

LAST 30 PRESS RELEASES:

CMD-OPT model enables the discovery of a potent and selective RIPK2 inhibitor as preclinical candidate for the treatment of acute liver injury

Melatonin receptor 1a alleviates sleep fragmentation-aggravated testicular injury in T2DM by suppression of TAB1/TAK1 complex through FGFR1

Single-cell RNA sequencing reveals Shen-Bai-Jie-Du decoction retards colorectal tumorigenesis by regulating the TMEM131–TNF signaling pathway-mediated differentiation of immunosuppressive dendritic ce

Acta Pharmaceutica Sinica B Volume 15, Issue 7 Publishes

New research expands laser technology

Targeted radiation offers promise in patients with metastasized small cell lung cancer to the brain

A high clinically translatable strategy to anti-aging using hyaluronic acid and silk fibroin co-crosslinked hydrogels as dermal regenerative fillers

Mount Sinai researchers uncover differences in how males and females change their mind when reflecting on past mistakes

CTE and normal aging are difficult to distinguish, new study finds

Molecular arms race: How the genome defends itself against internal enemies

Tiny chip speeds up antibody mapping for faster vaccine design

KTU experts reveal why cultural heritage is important for community unity

More misfolded proteins than previously known may contribute to Alzheimer’s and dementia

“Too much going on”: Autistic adults overwhelmed by non-verbal social cues

What’s driving America’s deep freezes in a warming world?

A key role of brain protein in learning and memory is deciphered by scientists

Heart attacks don’t follow a Hollywood script

Erin M. Schuman wins 2026 Nakasone Award for discovery on neural synapse function and change during formation of memories

Global ocean analysis could replace costly in-situ sound speed profiles in seafloor positioning, study finds

Power in numbers: Small group professional coaching reduces rates of physician burnout by nearly 30%

Carbon capture, utilization, and storage: A comprehensive review of CCUS-EOR

New high-temperature stable dispersed particle gel for enhanced profile control in CCUS applications

State gun laws and firearm-related homicides and suicides

Use of tobacco and cannabis following state-level cannabis legalization

Long-term obesity and biological aging in young adults

Eindhoven University of Technology and JMIR Publications announce unlimited open access publishing agreement

Orphan nuclear receptors in metabolic dysfunction-associated steatotic liver disease development

A technological breakthrough for ultra-fast and greener AI

Pusan National University researchers identify key barriers hindering data-driven smart manufacturing adoption

Inking heterometallic nanosheets: A scalable breakthrough for coating, electronics, and electrocatalyst applications

[Press-News.org] New ORNL hybrid microscope offers unparalleled capabilities