PRESS-NEWS.org - Press Release Distribution
PRESS RELEASES DISTRIBUTION

Cutting costs: Sustainability matters even in complex networks

2015-08-11
(Press-News.org) Every day, we expend energy when we con­trol the net­works in our lives. For example, to drive our car, we utilize a net­work whose com­po­nents include the car's accel­er­ator, steering wheel, and brake. Knowing how much that effort "costs" can help deter­mine which com­po­nents to manipulate--and to what degree--to ensure the smoothest, safest ride as you acclerate from 55 to 90 miles per hour.

On Monday, North­eastern researchers revealed just such a mea­suring strategy in a new paper pub­lished in Nature Physics.

"We pro­vide a metric--called 'con­trol energy'--to char­ac­terize the amount of effort needed to con­trol real-world com­plex sys­tems," says first author Gang Yan, a post­doc­toral research asso­ciate in Northeastern's Center for Com­plex Net­work Research, which is directed by Albert-Laszlo Barabasi, Robert Gray Dodge Pro­fessor of Net­work Sci­ence and the paper's cor­re­sponding author.

These self-organized net­works, unlike an engi­neered one under your car's hood, include cel­lular net­works, social net­works, and mobile-sensor net­works. That makes poten­tial appli­ca­tions of Yan's metric wide-ranging: from helping to iden­tify key points in the meta­bolic path­ways of bac­te­rial cells that new drugs might target to deter­mining the most crit­ical areas to mon­itor and pro­tect in an online secu­rity system.

"Esti­mating the con­trol energy, or effort, is key in exe­cuting most con­trol appli­ca­tions, from con­trol­ling dig­ital devices to under­standing the con­trol prin­ci­ples of the cell," says Barabasi. "These results have mul­tiple appli­ca­tions in many dif­ferent domains where con­trol of the net­work becomes a key objective."

A net­work com­prises points of con­nec­tion, or "nodes"--individual units, such as a metabo­lite, a gene, a person, or even a gas pedal--and the links or inter­ac­tions tying those nodes to one another. "Driver nodes" are the select nodes that net­work admin­is­tra­tors zap with external sig­nals in order to con­trol the system. The con­di­tion of a driver node--for example, a gene coding a pro­tein or a person expressing his opinion about a polit­ical candidate--evolves over time as a result of both the node's internal dynamics and how it con­nects with its neighbors.

Pre­vious studies of the con­trol mech­a­nisms of com­plex sys­tems focused on iden­ti­fying these driver nodes, says Yan. His finding goes fur­ther, enabling a kind of net­work cost-benefit analysis. With it, net­work sci­en­tists could iden­tify not only the min­imum number of driver nodes to target for input sig­nals but also the "cheapest," most energy-efficient ones.

"It would be extremely dif­fi­cult to con­trol a large net­work by inputting sig­nals to only one driver node," says Yan. "But it's not prac­tical to input sig­nals to all the nodes--that would take a huge toll on the system. Our finding pro­vides a way to make a tradeoff between the number of driver nodes and the cost of con­trol­ling the system."

Barabasi, who co-authored a break­through Nature paper describing an algo­rithm to ascer­tain the number of driver nodes required to con­trol com­plex net­works, points to the impor­tant insights of Yan and his col­leagues in the appli­ca­tion of control.

"Most net­works are not func­tional if they cannot con­trol them­selves," he says. "Indeed, that need for con­trol deter­mines the system's archi­tec­ture, whether the net­work is a brain, a cell, or a tech­no­log­ical system. A key ques­tion in this process is the amount of effort needed to con­trol the system. The paper by Yan and his col­leagues offers fun­da­mental results on this sub­ject, by showing that moving a system in some direc­tions can be easy, but in others can be excru­ci­at­ingly dif­fi­cult or costly."

INFORMATION:

Geor­gios Tsekenis, now a post­doc­toral research fellow at Har­vard Uni­ver­sity, is the paper's co-first author. Researchers Baruch Barzel, Jean-Jacques Slo­tine, and Yang-Yu Liu from Bar-Ilan Uni­ver­sity, the Mass­a­chu­setts Insti­tute of Tech­nology, Har­vard Med­ical School, and the Dana Farber Cancer Insti­tute, respec­tively, also con­tributed to the paper.



ELSE PRESS RELEASES FROM THIS DATE:

New report recommends research priorities for Antarctic and Southern Ocean science

2015-08-11
WASHINGTON -- An initiative to better understand how melting ice sheets will contribute to sea-level rise, efforts to decode the genomes of organisms to understand evolutionary adaptations, and a next-generation cosmic microwave background experiment to address fundamental questions about the origin of the universe are the top research goals for Antarctic and Southern Ocean science recommended in a new report from the National Academies of Sciences, Engineering, and Medicine. The report, which offers a strategic vision to guide the U.S. Antarctic Program at the National ...

Vortioxetine in depression: No hint of added benefit

2015-08-11
Vortioxetine (trade name: Brintellix) has been approved since December 2013 for the treatment of depression in adults, but did not become actually available before May 2015. The German Institute for Quality and Efficiency in Health Care (IQWiG) examined in a dossier assessment whether this drug offers an added benefit over the appropriate comparator therapy. Such an added benefit cannot be derived from the dossier because it contained no data evaluable for the assessment. SSRI is drug component of comparator therapy The Federal Joint Committee (G-BA) distinguished between ...

Insulin degludec plus liraglutide: No hint of added benefit in type 2 diabetes

2015-08-11
The fixed-ratio combination of the two drugs insulin degludec and liraglutide (trade name: Xultophy) has been approved since September 2014 for adults with type 2 diabetes mellitus. It is given as an injection in addition to other blood-glucose lowering drugs when these alone or in combination with basal insulin are insufficient to lower blood glucose levels. The German Institute for Quality and Efficiency in Health Care (IQWiG) examined in a dossier assessment whether this fixed-ratio combination offers an added benefit over the appropriate comparator therapy. Such ...

One technique therapists use that really helps depressed patients

2015-08-11
COLUMBUS, Ohio - Some depressed patients may be hoping for answers from their therapists, but a new study suggests questions may be the key. Researchers examined how cognitive therapy for depression achieves its positive effects. Their study is the first to show that depressed patients see substantial improvements in their depressive symptoms when their therapists use a technique called "Socratic questioning." These are a series of guided questions in which the therapist asks a patient to consider new perspectives on themselves and their place in the world. "People ...

C-sections could influence babies' ability to focus

2015-08-11
Being delivered through a caesarean section influences at least one form of babies' ability to concentrate. It slows their spatial attention, which plays a role in how well they are able to prioritize and focus on a particular area or object that is of interest. These are the findings of Scott Adler and Audrey Wong-Kee-You of York University in Canada, published in Springer's journal Attention, Perception, & Psychophysics. Very early birth factors such as birth weight and a mother's age impact the development of a child. However, very little is known about how the actual ...

Chitin of insects and crustaceans found to be active against pathogenic microorganisms

2015-08-11
The study specifically concentrated on chitosan extracted from chitin in the carapaces of insects and crustaceans. The biopolymer was first discovered in 1859 but only recently has it become possible to establish its production within desired parameters, when researchers from the Bioengineering Center of RAS designed narrow-dispersion chitosan. This gave an opportunity to modern scientists to customize the biological properties of certain types of the biopolymer. "We found that some forms of chitosan are toxic. They can disrupt the membranes of pathogenic microorganisms" ...

Researchers develop fast test for invasive carp

2015-08-11
A Case Western Reserve University graduate student turned a research paper into a field test that quickly determines whether an Asian carp invading Lake Erie is sterile or can reproduce. If proven successful, the technique could save money and time in the effort to keep the carp out of the Great Lakes, where the fish could grow unchecked and devour food supplies and habitat critical to native species.. Grass carp, the species Ctenopharyngodon idella, have been introduced throughout the Midwest and South to clear ponds choked with weeds. Also called the white amur, fertile ...

NYU study examines top high school students' stress and coping mechanisms

2015-08-11
Over time selective high schools have oriented themselves to address a context of increasingly competitive college admissions School work, college applications, extracurricular activities, and parental expectations all contribute to teenagers' stress Youth, schools, and experts identified substance use as a common strategy for coping with stress "School, homework, extracurricular activities, sleep, repeat--that's what it can be for some of these students," says Noelle Leonard, PhD, a senior research scientist at the New York University College of Nursing (NYUCN). ...

Research pours cold water on ice bath recovery theory

2015-08-11
If the thought of a post workout ice bath is enough to make you shiver, new research from QUT and The University of Queensland (UQ) will warm your heart. The comprehensive study found cold water immersion after strength training hindered muscle adaptation - pouring cold water on the long-held theory that an ice bath helps speed up recovery. Dr Llion Roberts, from UQ's School of Human Movement and Nutrition Sciences, and Dr Jonathan Peake, from QUT's School of Biomedical Sciences, led the research, with colleagues from the Queensland Academy of Sport, Norwegian School ...

Common class of 'channel blocking' drugs may find a role in cancer therapy

2015-08-11
Drugs called ion channel blockers, which are commonly used to treat cardiac, neurological, and psychiatric disorders, might prove useful in cancer therapy, according to research findings in fruit flies and mice by UC San Francisco scientists that led to unconventional treatment of a case of metastatic brain cancer. Ion channels, proteins that form pores in cell membranes, play central roles in organs in which conduction of electrical signals is vital, such as the brain and heart, but they are found in cells throughout the body. Although about 20 percent of FDA-approved ...

LAST 30 PRESS RELEASES:

Lurie Children’s campaign urges parents to follow up right away if newborn screening results are abnormal

Does drinking alcohol really take away the blues? It's not what you think

Speed of risk perception is connected to how information is arranged

High-risk pregnancy specialists analyze AI system to detect heart defects on fetal ultrasound exams

‘Altar tent’ discovery puts Islamic art at the heart of medieval Christianity

Policy briefs present approach for understanding prison violence

Early adult mortality is higher than expected in US post-COVID

Recycling lithium-ion batteries cuts emissions and strengthens supply chain

Study offers new hope for relieving chronic pain in dialysis patients

How does the atmosphere affect ocean weather?

Robots get smarter to work in sewers

Speech Accessibility Project data leads to recognition improvements on Microsoft Azure

Tigers in the neighborhood: How India makes room for both tigers and people

Grove School’s Arthur Paul Pedersen publishes critical essay on scientific measurement literacy

Moffitt study finds key biomarker to predict KRASG12C inhibitor effectiveness in lung cancer

Improving blood transfusion monitoring in critical care patients: Insights from diffuse optics

Powerful legal and financial services enable kleptocracy, research shows

Carbon capture from constructed wetlands declines as they age

UCLA-led study establishes link between early side effects from prostate cancer radiation and long-term side effects

Life cycles of some insects adapt well to a changing climate. Others, not so much.

With generative AI, MIT chemists quickly calculate 3D genomic structures

The gut-brain connection in Alzheimer’s unveiled with X-rays

NIH-funded clinical trial will evaluate new dengue therapeutic

Sound is a primary issue in the lives of skateboarders, study shows

Watch what you eat: NFL game advertisements promote foods high in fat, sodium

Red Dress Collection Concert hosted by Sharon Stone kicks off American Heart Month

One of the largest studies on preterm birth finds a maternal biomarker test significantly reduces neonatal morbidities and improves neonatal outcomes

One of the largest studies of its kind finds early intervention with iron delivered intravenously during pregnancy is a safe and effective treatment for anemia

New Case Western Reserve University study identifies key protein’s role in psoriasis

First-ever ethics checklist for portable MRI brain researchers

[Press-News.org] Cutting costs: Sustainability matters even in complex networks