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Small labeling pair for single-molecule super-resolution imaging

2015-09-10

(Press-News.org) This news release is available in German.

Protein labeling with synthetic fluorescent probes is a key technology in chemical biology and biomedical research. The target proximity achieved by small-molecule probes is essential to exploit the full potential of super-resolution fluorescence microscopy. Single-molecule localization techniques provide high spatial resolution by reporting on the position of the fluorophore and thus only indirectly on the target molecule itself. Large labels, such as antibodies, can misleadingly position a fluorophore tens of nanometers away from the target. Since single-molecule localization microscopy can achieve almost the ultimate spatial precision ( END

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New species of human relative discovered

2015-09-10

An international research team, which includes NYU anthropologists Scott Williams and Myra Laird, has discovered a new species of a human relative. Homo naledi, uncovered in a cave outside of Johannesburg, South Africa, sheds light on the diversity of our genus and possibly its origin. "This discovery is unprecedented in the sheer number of hominins collected from such a small area in the virtual absence of other animal remains," says Williams, an assistant professor in NYU's Department of Anthropology. "That makes this site unique. Moreover, the announcement describes ...

New DNA testing for liver cancer could improve survival

2015-09-10

Bethesda, MD (Sept. 10, 2015) -- Detection of small fragments of tumor DNA, known as circulating tumor DNA, in a patient's pre-surgery serum samples predicts early recurrence of hepatocellular carcinoma and may guide treatment, according to a study1 published in Cellular and Molecular Gastroenterology and Hepatology, the basic and translational science journal of the American Gastroenterological Association. Hepatocellular carcinoma -- the most common type of liver cancer -- is the third leading cause of cancer deaths worldwide. "We uncovered that circulating tumor DNA ...

How genetic testing can improve care for children with epilepsy

2015-09-10

The steps involved in evaluating and diagnosing patients with epilepsy are complicated. In a new and extensive literature review of available information, experts provide insights on the valuable role of genetic testing in the diagnosis and care of pediatric epilepsy. Epilepsy is a common neurological disorder that affects up to 1.5% of the world's population and is more commonly diagnosed in children than adults. Most cases of epilepsy have been considered "idiopathic" or of unknown cause, but recent advances in genetic testing are providing insights on the potential ...

First new cache-coherence mechanism in 30 years

2015-09-10

In a modern, multicore chip, every core -- or processor -- has its own small memory cache, where it stores frequently used data. But the chip also has a larger, shared cache, which all the cores can access. If one core tries to update data in the shared cache, other cores working on the same data need to know. So the shared cache keeps a directory of which cores have copies of which data. That directory takes up a significant chunk of memory: In a 64-core chip, it might be 12 percent of the shared cache. And that percentage will only increase with the core count. Envisioned ...

Fossil trove adds a new limb to human family tree

2015-09-10

MADISON, Wis. -- Working in a cave complex deep beneath South Africa's Malmani dolomites, an international team of scientists has brought to light an unprecedented trove of hominin fossils -- more than 1,500 well-preserved bones and teeth -- representing the largest, most complete set of such remains found to date in Africa. The discovery of the fossils, cached in a barely accessible chamber in a subterranean labyrinth not far from Johannesburg, adds a new branch to the human family tree, a creature dubbed Homo naledi. The remains, scientists believe, could only have ...

AGA recommends all patients with colorectal cancer get tested for Lynch syndrome

2015-09-10

Bethesda, MD (Sept. 10, 2015) --All colorectal cancer patients should undergo tumor testing to see if they carry Lynch syndrome, the most common inherited cause of colorectal cancer, according to a new guideline1 published in Gastroenterology, the official journal of the American Gastroenterological Association. "Approximately 50,000 Americans are expected to die from colorectal cancer this year, and hereditary syndromes account for a small, but important fraction of those diagnoses," said Joel H. Rubenstein, MD, AGAF, lead author of the guideline, research scientist ...

Financial distress can hinder success of academically prepared minority students

2015-09-10

A new study of more than 500 Black and Latino college students has confirmed that many encounter obstacles after enrolling in college without adequate financial resources. "Students were surveyed in the fall, winter and spring of freshman year," said Micere Keels, associate professor in comparative human development at the University of Chicago, who led the study. "At each time-point, approximately 35 percent reported having difficulty paying their bills, being upset that they did not have enough money and being concerned that they would not be able to afford to complete ...

Cancer preventative surgery could become a thing of the past, new research suggests

2015-09-10

Amsterdam, September 10, 2015 - Surgery to remove the breasts of women at increased risk of developing breast cancer may not be necessary in the future, according to research published in EBioMedicine. Two new studies looking at the effect the menstrual cycle has on the development of breast and ovarian cancer reveal alternative prevention strategies that may render surgery unnecessary. Breast cancer is the most common cancer in women worldwide and ovarian cancer is the deadliest gynaecological cancer. Women who have inherited mutations in genes called BRCA1 and BRCA2 ...

New species of human relative discovered in S.A. cave

2015-09-10

The discovery of a new species of human relative was announced today, 10 September 2015, by the University of the Witwatersrand (Wits University), the National Geographic Society and the Department of Science and Technology (DST) and the National Research Foundation of South Africa (NRF). Besides shedding light on the origins and diversity of our genus, the new species, Homo naledi, appears to have intentionally deposited bodies of its dead in a remote cave chamber, a behaviour previously thought limited to humans. Consisting of more than 1 550 numbered fossil elements, ...

Drunk, distracted drivers are double dangers

2015-09-10

An accident waiting to happen: that's what an intoxicated driver is whose attention is further distracted by anything from a text message to dashboard controls. Such distractions are just too much to handle safely, even for people who drive while still within the legal alcohol limits, say Nicholas van Dyke and Mark Fillmore of the University of Kentucky in the US. Their study provides some of the first evidence on the degree to which distractions influence the ability of intoxicated drivers to safely control their vehicles. The findings are published in Springer's journal ...

Polyherbal dietary supplement MD-1 ameliorates severity of type 2 diabetes mellitus in high-fat diet-fed C57BL/6J mice by attenuating adipose tissue inflammation

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