Hydroxychloroquine blood levels predict clotting risk in patients with lupus
2021-01-06
(Press-News.org) The antimalarial drug hydroxychloroquine is frequently prescribed to treat symptoms of the autoimmune disease lupus. In addition to decreasing disease flares, the drug can also prevent blood clots, which are a major problem in individuals with lupus. A new study in Arthritis & Rheumatology shows that monitoring patients' blood levels of hydroxychloroquine can predict their clotting risk.
In 739 patients, clotting occurred in 38 patients (5.1%). Average hydroxychloroquine blood levels were lower in patients who developed clots, and clotting rates were reduced by 12% for every 200 ng/mL increase in the most recent hydroxychloroquine blood level.
The finding may help clinicians determine the optimal dosing of hydroxychloroquine in patients with lupus.
"Hydroxychloroquine blood levels can be used to monitor adherence, benefits, and risks in lupus," said lead author Michelle Petri, MD, MPH, of the Johns Hopkins University School of Medicine.
INFORMATION:
ELSE PRESS RELEASES FROM THIS DATE:
2021-01-06
Individuals face a higher risk of dying following hip fractures. A new study published in the Journal of Bone and Mineral Research has found that living alone after experiencing a hip fracture may further elevate this risk.
For the study, researchers examined information on hip fractures from all hospitals in Norway from 2002 to 2013, and they combined the data with the 2001 National Population and Housing Census.
During 12.8 years of follow-up in 12,770 men and 22,067 women with hip fractures at ages 50 to 79 years, higher rates of death were seen in both men and women living alone versus those living with a partner (a 37% higher risk in men and a 23% higher risk in women).
INFORMATION: ...
2021-01-06
Findings from a recent study of individuals with depression suggest that Mindfulness-Based Cognitive Therapy (MBCT) can improve how patients feel about themselves in difficult situations in ways that may help protect against relapse of depressive symptoms. The findings are published in Counselling and Psychotherapy Research.
For the study, 68 individuals were randomized the MBCT or a waiting list. Patients who received MBCT were more likely to experience reductions in feelings of self-inadequacy and improvements in self-reassurance. Also, individuals with improvements in self-reassurance were less likely to experience depressive relapse within 2 years after the MBCT intervention.
"Self-criticism makes people vulnerable to depression. This study ...
2021-01-06
By late fall, much of the Midwest is a pleasing landscape of dry, harvested corn fields. It makes for a bucolic rural scene on highway drives. But the corn litter that's left over doesn't seem useful, at least to untrained eyes.
But to those in the know, that corn residue is a valuable resource. Scattered leaves, husks, kernels, and cobs can serve as food to grazing cattle. When managed well, corn residue can increase farm income, provide affordable food for cattle, and efficiently use the land to feed people.
Morgan Grabau, a member of the American Society of Agronomy, studies ...
2021-01-06
Researchers from University of Texas at San Antonio and University of Southern California published a new paper in the Journal of Marketing that examines the difficult choices industry incumbents and new entrants face during times of potentially disruptive technological change.
The study, forthcoming in the Journal of Marketing, is titled "Leapfrogging, Cannibalization, and Survival during Disruptive Technological Change: The Critical Role of Rate of Disengagement" and is authored by Deepa Chandrasekaran, Gerard Tellis, and Gareth James.
In July 2020, Tesla became the world's most valuable automaker, surpassing Toyota in market value for the first time. Ironically, it was Toyota that in 1997 released the Prius, the world's first ...
2021-01-06
Antibiotics are not necessary for patients after most routine endoscopic sinus surgeries despite the common practice to prescribe them, according to a team led by researchers at Massachusetts Eye and Ear.
In a new randomized controlled trial, patients who underwent endoscopic sinus surgery had no differences in outcomes including symptoms and infections whether they took an antibiotic or placebo after surgery. The only reported difference in outcomes was in side effects, with patients in the antibiotic group 10 times more likely to report symptoms like diarrhea.
The ...
2021-01-06
WEST LAFAYETTE, Ind. - A novel form of a drug used to treat osteoporosis that comes with the potential for fewer side effects may provide a new option for patients.
The work is supported by the National Institutes of Health and is published in Biophysical Journal.
Purdue University innovators developed a stabilized form of human calcitonin, which is a peptide drug already used for people with osteoporosis. Researchers at Purdue created a prodrug form of the peptide hormone to increase its effectiveness as an osteoporosis treatment.
In humans, calcitonin is the hormone responsible for normal calcium homeostasis. When prescribed to osteoporosis patients, calcitonin inhibits bone resorption, ...
2021-01-05
Researchers at Scripps Institution of Oceanography and Skaggs School of Pharmacy and Pharmaceutical Sciences at the University of California San Diego have broken down the genomic and life history traits of three classes of viruses that have caused endemic and global pandemics in the past and identify natural products - compounds produced in nature - with the potential to disrupt their spread.
In a review appearing in the Journal of Natural Products, marine chemists Mitchell Christy, Yoshinori Uekusa, and William Gerwick, and immunologist Lena Gerwick describe the basic biology of three families of RNA viruses and how they infect human cells. These viruses use RNA instead of DNA to store their ...
2021-01-05
BUFFALO, N.Y. - The human body is filled with friendly bacteria. However, some of these microorganisms, such as Veillonella parvula, may be too nice. These peaceful bacteria engage in a one-sided relationship with pathogen Porphyromonas gingivalis, helping the germ multiply and cause gum disease, according to a new University at Buffalo-led study.
The research sought to understand how P. gingivalis colonizes the mouth. The pathogen is unable to produce its own growth molecules until it achieves a large population in the oral microbiome (the community of microorganisms ...
2021-01-05
The human papillomavirus infection, or HPV, is the most common sexually transmitted infection in the U.S., according to the Centers for Disease Control and Prevention. HPV is associated with health problems including genital warts and cancers, but a vaccine has been available since 2006 to help stop the virus. The CDC reports more than 12 years of data supports the HPV vaccine is safe and effective, yet HPV vaccination rates across the U.S. still remain low.
Social media has a history of being a popular place for sexual health discussions, and the HPV vaccine is one of the most discussed vaccines on the internet. Monique Luisi, an assistant professor in the University of Missouri School of Journalism, has studied more than 6,500 public HPV vaccine-related posts ...
2021-01-05
While humanity is facing the COVID-19 pandemic, the citrus industry is trying to manage its own devastating disease, Huanglongbing (HLB), also known as citrus greening disease. HLB is the most destructive citrus disease in the world. In the past decade, the disease has annihilated the Florida citrus industry, reducing orange production for juice and other products by 72%. Candidatus Liberibacter asiaticus (CLas) is the microbe associated with the disease. It resides in the phloem of the tree and, like many plant pathogens, is transmitted by insects during feeding events. Disease progression can be slow but catastrophic. Symptoms begin with blotchy leaves, yellow shoots, and stunting, ...
LAST 30 PRESS RELEASES:
[Press-News.org] Hydroxychloroquine blood levels predict clotting risk in patients with lupus
