Clinical trial of antibiotic strategies for uncomplicated acute appendicitis
2021-01-11
(Press-News.org) What The Study Did:
This randomized clinical trial compares the effects of two antibiotic strategies (oral moxifloxacin versus intravenous ertapenem followed by oral levofloxacin) on hospital discharge without surgery and recurrent appendicitis over one year among adults presenting to the emergency department with uncomplicated acute appendicitis.
Authors:
Paulina Salminen, M.D., Ph.D., of Turku University Hospital in Turku, Finland, is the corresponding author.
To access the embargoed study:
Visit our For The Media website at this link
https://media.jamanetwork.com/
(doi:10.1001/jama.2020.23525)
Editor's Note: The article includes conflicts of interest and funding/support disclosures. Please see the article for additional information, including other authors, author contributions and affiliations, conflict of interest and financial disclosures, and funding and support.
INFORMATION:
Media advisory:
The full study and editorial are linked to this news release.
Embed this link to provide your readers free access to the full-text article
This link will be live at the embargo time
https://jamanetwork.com/journals/jama/fullarticle/10.1001/jama.2020.23525?guestAccessKey=5f6b0eb2-50eb-4a97-b06c-00b0630c9d51&utm_source=For_The_Media&utm_medium=referral&utm_campaign=ftm_links&utm_content=tfl&utm_term=011121
ELSE PRESS RELEASES FROM THIS DATE:
2021-01-11
New York, NY--January 11, 2021--Like a longtime couple who can predict each other's every move, a Columbia Engineering robot has learned to predict its partner robot's future actions and goals based on just a few initial video frames.
When two primates are cooped up together for a long time, we quickly learn to predict the near-term actions of our roommates, co-workers or family members. Our ability to anticipate the actions of others makes it easier for us to successfully live and work together. In contrast, even the most intelligent and advanced robots have remained notoriously inept at this sort of social communication. This may be about to change.
The study, conducted at Columbia Engineering's Creative Machines Lab led by Mechanical ...
2021-01-11
The Third Pole centered on the Tibetan Plateau is home to headwaters of over 10 major Asian rivers. These glacier-based water systems, also known as the Asian Water Towers, will have to struggle to quench the thirst of downstream communities despite more river runoff brought on by a warmer climate, according to a recent study published in Nature Climate Change.
By constraining earth system models for precipitation projections, together with estimated glacier melt contributions, the study quantified the wet-season runoff of seven rivers at the Third Pole, and found it would increase 1.0-7.2% by the end of the 21st century for warming in the range of 1.5-4°C. However, the study also showed that rising water demands from the growing population will outweigh ...
2021-01-11
To perform calculations, quantum computers need qubits to act as elementary building blocks that process and store information. Now, physicists have produced a new type of qubit that can be switched from a stable idle mode to a fast calculation mode. The concept would also allow a large number of qubits to be combined into a powerful quantum computer, as researchers from the University of Basel and TU Eindhoven have reported in the journal Nature Nanotechnology.
Compared with conventional bits, quantum bits (qubits) are much more fragile and can lose their information content very quickly. The challenge for quantum computing is therefore to keep the sensitive ...
2021-01-11
Diets rich in healthy and plant-based foods encourages the presence of gut microbes that are linked to a lower risk of common illnesses including heart disease, research has found.
A large-scale international study using metagenomics and blood chemical profiling has uncovered a panel of 15 gut microbes associated with lower risks of common conditions such as obesity and type 2 diabetes. The study has been published today in Nature Medicine from researchers at King's College London, Massachusetts General Hospital (MGH), Harvard T.H. Chan School of Public Health, the University ...
2021-01-11
With the Proof of Concept funding line, the ERC grants recipients of ERC frontier research funds (Starting, Consolidator, Advanced or Synergy grants) with 150.000 Euro to develop promising ideas with commercial or societal potential to the proof of concept stage. With this funding, Olaf Groß and his team in the Metabolism and Inflammation Group at the Institute of Neuropathology of the Medical Center - University of Freiburg will test whether a new class of immune activating drugs they discovered can boost the effectiveness of cancer immunotherapies ...
2021-01-11
Heidelberg/Germany, 11 January 2021 - Development of an in vitro human-derived tissue model for studying virus infection and disease progression in the alveolar cells of the lungs responsible for oxygen and carbon dioxide exchange with the blood might enable the study of possible therapies for acute respiratory distress syndrome (ARDS) triggered by SARS-CoV-2. Researchers in the Netherlands have demonstrated that the SARS-CoV-2 replicates efficiently in their model resembling the human bronchioalveolar system that is thought to play a critical role in progression of infection towards pneumonia and ARDS.
It is already ...
2021-01-11
Two billion years after the Big Bang, the Universe was still very young. However, thousands of huge galaxies, rich in stars and dust, were already formed. An international study, led by SISSA - Scuola Internazionale Superiore di Studi Avanzati, now explains how this was possible. Scientists combined observational and theoretical methods to identify the physical processes behind their evolution and, for the first time, found evidence for a rapid growth of dust due to a high concentration of metals in the distant Universe. The study, published in Astronomy&Astrophysics, offers a new approach to investigate the evolutionary phase of massive objects.
Since their initial discovery 20 years ago, very distant and massive galaxies that form prodigious amount of ...
2021-01-11
Patients with severe COVID-19 disease have significantly shorter telomeres, according to a study conducted by researchers at the Spanish National Cancer Research Centre (CNIO) in collaboration with the COVID-IFEMA Field Hospital, published in the journal Aging. The study, led by Maria A. Blasco and whose first authors are Raúl Sánchez and Ana Guío-Carrión, postulates that telomere shortening as a consequence of the viral infection impedes tissue regeneration and that this is why a significant number of patients suffer prolonged sequelae.
Blasco was already developing a therapy to regenerate lung tissue in pulmonary fibrosis patients; she now believes that this treatment -which should still take at least a year and a half to become available- ...
2021-01-11
NEW YORK, NY (Jan. 11, 2021)--A new study has found that up to 20% of glioblastomas--an aggressive brain cancer--are fueled by overactive mitochondria and may be treatable with drugs currently in clinical trials.
Mitochondria are responsible for creating the energy that fuels all cells. Though they are usually less efficient at producing energy in cancer, tumor cells in this newly identified type of glioblastoma rely on the extra energy provided by overactive mitochondria to survive.
The study, by cancer scientists at Columbia University's Vagelos College ...
2021-01-11
For some years, an active substance from the leaves of an ornamental plant has been regarded as a possible forerunner of a new group of potent drugs. So far, however, it has been very laborious to manufacture it in large quantities. That could now change: Researchers at the University of Bonn (Germany) have identified a bacterium that produces the substance and can also be easily cultivated in the laboratory. The results are published in the journal Nature Communications.
The coralberry currently once again adorns many living rooms: In winter it bears bright red fruits, which make it a popular ornamental plant at this time of year. For pharmacists, however, it is interesting for a different reason: It contains ...
LAST 30 PRESS RELEASES:
[Press-News.org] Clinical trial of antibiotic strategies for uncomplicated acute appendicitis
