Medication shows promise for weight loss in patients with obesity, diabetes
(Press-News.org) SILVER SPRING, Md.--A new study confirms that treatment with Bimagrumab, an antibody that blocks activin type II receptors and stimulates skeletal muscle growth, is safe and effective for treating excess adiposity and metabolic disturbances of adult patients with obesity and type 2 diabetes.
"These exciting results suggest that there may be a novel mechanism for achieving weight loss with a profound loss of body fat and an increase in lean mass, along with other metabolic benefits," said Steve Heymsfield, MD, FTOS, past president of The Obesity Society and corresponding author of the study. Heymsfield is professor and director of the Metabolism and Body Composition Laboratory at the Pennington Biomedical Research Center in Baton Rouge, La.
A total of 75 patients with type 2 diabetes, body mass index between 28 and 40 and glycated hemoglobin A1c levels between 6.5 percent and 10 percent were selected for the phase 2 randomized clinical trial. Patients were injected with either Bimagrumab or a placebo (a dextrose solution) every 4 weeks for 48 weeks. Both groups received diet and exercise counseling. The research took place at nine sites in the United States and the United Kingdom from February 2017 to May 2019.
At the end of the 48-week study, researchers found a nearly 21 percent decrease in body fat in the Bimagrumab group compared to 0.5 percent in the placebo group. The results also revealed the Bimagrumab group gained 3.6 percent of lean mass compared with a loss of 0.8 percent in the placebo group. The combined loss in total body fat and gain in lean mass led to a net 6.5 percent reduction in body weight in patients receiving Bimagrumab compared with 0.8 percent weight loss in their counterparts receiving the placebo.
The sample size of 75 participants was a limitation of the study. There was also a gender imbalance across the groups with more women randomized to Bimagrumab and more men to the placebo.
Partial results of this study were presented during a research forum titled "Emerging Pharmacological Anti-obesity Therapies" at ObesityWeek® 2019 in Las Vegas, Nev.
Other authors of the study include Laura Coleman, Ram Miller, Daniel Rooks, Jens Praestgaard, and Therese Swan, Translational Medicine, Novartis Institutes for Biomedical Research, Cambridge, Mass. Didier Laurent, Olivier Petricoul, and Ronenn Roubenoff, Translational Medicine, Novartis Institutes of Biomedical Research in Basel, Switzerland, along with Thomas Wade of QPS-Miami Research Associates in Miami, Fla; Robert Perry of Panax Clinical Research of Miami; and Bret Goodpaster of Advent Health Research Institute in Orlando, Fla., also co-authored the study.
Heymsfield reported receiving personal fees from Tanita and Medifast outside of the submitted work. Coleman, Miller, Rooks, Roubenoff, Laurent, Praestgaard, Petricoul and Swan reported being employees of Novartis Institutes for Biomedical Research during the conduct of the study. Coleman and Roubenoff reported having a patent for PAT058683-US-PSP pending with Novartis. Rooks and Roubenoff reported being co-authors of a patent for use of Bimagrumab in other indications that is no longer being developed. Goodpaster reported receiving personal fees from Novartis for work performed during the conduct of the study. No other disclosures were reported.
The paper, titled "Effect of Bimagrumab vs Placebo on Body Fat Mass Among Adults with Type 2 Diabetes and Obesity" is scheduled to be published on Jan. 13, 2021, in JAMA Network Open.
The Obesity Society (TOS) is the leading organization of scientists and health professionals devoted to understanding and reversing the epidemic of obesity and its adverse health, economic and societal effects. Combining the perspective of researchers, clinicians, policymakers and patients, TOS promotes innovative research, education, and evidence-based clinical care to improve the health and well-being of all people with obesity. For more information, visit http://www.obesity.org.
ELSE PRESS RELEASES FROM THIS DATE:
LAWRENCE -- Parents around the world have long told us that breakfast is the most important meal of the day. Soon, basketball coaches may join them.
Researchers at the University of Kansas have published a study showing that eating breakfast can improve a basketball player's shooting performance, sometimes by significant margins. The study, along with one showing that lower body strength and power can predict professional basketball potential, is part of a larger body of work to better understand the science of what makes an elite athlete.
Breakfast and better basketball shooting
Dimitrije Cabarkapa left his native Novi Sad, Serbia, to play basketball at James Madison University. Never a fan of 6 a.m. workouts, he was discussing ...
A team of researchers led by the University of California, Berkeley and the University of Michigan has discovered an antibody that blocks the spread within the body of the dengue virus, a mosquito-borne pathogen that infects between 50 and 100 million people a year. The virus causes what is known as dengue fever, symptoms of which include fever, vomiting and muscle aches, and can lead to more serious illnesses, and even death.
"Protein structures determined at the APS have played a critical role in the development of drugs and vaccines for several diseases, and these new results are key to the development of a potentially effective treatment against flaviviruses." -- Bob Fischetti, group leader with Argonne's X-ray Sciences Division and life sciences ...
The fascinating compound eyes of insects consist of hundreds of individual eyes known as "facets". In the course of evolution, an enormous variety of eye sizes and shapes has emerged, often representing adaptations to different environmental conditions. Scientists, led by an Emmy Noether research group at the University of Göttingen, together with scientists from the Andalusian Centre for Developmental Biology (CABD) in Seville, have now shown that these differences can be caused by very different changes in the genome of fruit flies. The study was published ...
HOUSTON - (Jan. 13, 2021) - Pyrolyzed plastic ash is worthless, but perhaps not for long.
Rice University scientists have turned their attention to Joule heating of the material, a byproduct of plastic recycling processes. A strong jolt of energy flashes it into graphene.
The technique by the lab of Rice chemist James Tour produces turbostratic graphene flakes that can be directly added to other substances like films of polyvinyl alcohol (PVA) that better resist water in packaging and cement paste and concrete, dramatically increasing their compressive strength. ...
CHAMPAIGN, Ill. -- A dramatic decline in bees and other pollinating insects presents a threat to the global food supply, yet it's getting little attention in mainstream news.
That's the conclusion of a study from researchers at the University of Illinois Urbana-Champaign, published this week in a special issue of the Proceedings of the National Academy of Sciences. The study was based on a search of nearly 25 million news items from six prominent U.S. and global news sources, among them The New York Times, The Washington Post and The Associated Press.
The study found "vanishingly low levels of attention to pollinator population topics" over several decades, even compared with ...
Wetlands are the dominant natural source of atmospheric methane, a potent greenhouse gas which is second only to carbon dioxide in its importance to climate change. Anthropogenic climate change is expected to enhance methane emissions from wetlands, resulting in further warming. However, wetland methane feedbacks were not fully assessed in the Intergovernmental Panel on Climate Change (IPCC) Fifth Assessment Report, posing a challenge to meeting the global greenhouse gas mitigation goals set under the Paris Agreement.
To understand how wetland methane cycling may evolve and drive climate feedbacks in the future, scientists are increasingly looking to Earth's past.
"Ice core records indicate ...
People worldwide want their coffee to be both satisfying and reasonably priced. To meet these standards, roasters typically use a blend of two types of beans, arabica and robusta. But, some use more of the cheaper robusta than they acknowledge, as the bean composition is difficult to determine after roasting. Now, researchers reporting in ACS' Journal of Agricultural and Food Chemistry have developed a new way to assess exactly what's in that cup of joe.
Coffee blends can have good quality and flavor. However, arabica beans are more desirable than other types, resulting in a higher market value for blends containing a higher proportion of this variety. In some cases, producers dilute their blends with the less expensive robusta beans, yet that is hard for consumers ...
DURHAM, N.C. -- Biomedical engineers at Duke University have devised an algorithm to remove contaminated microbial genetic information from The Cancer Genome Atlas (TCGA). With a clearer picture of the microbiota living in various organs in both healthy and cancerous states, researchers will now be able to find new biomarkers of disease and better understand how numerous cancers affect the human body.
In the first study using the newly decontaminated dataset, the researchers have already discovered that normal and cancerous organ tissues have a slightly different microbiota composition, that bacteria from these diseased sites can enter the bloodstream, and that this bacterial information could help diagnose ...
Liver transplant priority in the U.S. goes to the sickest patients, which fails to consider other important factors, including how long patients are likely to survive post-transplant.
Researchers with Sylvester Comprehensive Cancer Center at the University of Miami Miller School of Medicine are collaborating with faculty at the University of Pennsylvania to develop a risk score that more comprehensively prioritizes liver cancer patients for transplantation.
Their paper documenting the development and validation of the LiTES-HCC score to predict post-transplant survival for hepatocellular carcinoma, or liver cancer, patients was published in the highly respected peer-reviewed Journal of Hepatology.
Egg cells are among the largest cells in the animal kingdom. If moved only by the random jostlings of water molecules, a protein could take hours or even days to drift from one side of a forming egg cell to the other. Luckily, nature has developed a faster way: cell-spanning whirlpools in the immature egg cells of animals such as mice, zebrafish and fruit flies. These vortices enable cross-cell commutes that take just a fraction of the time. But until now, scientists didn't know how these crucial flows formed.
Using mathematical modeling, researchers now have an answer. The gyres result from the collective behavior of rodlike molecular ...
LAST 30 PRESS RELEASES:
[Press-News.org] Medication shows promise for weight loss in patients with obesity, diabetes