University of Cincinnati research unveils possible new combo therapy for head and neck cancer

Washington, DC - January 22, 2021 - New research shows that non-steroidal anti-inflammatory drugs (NSAIDs) reduced both antibody and inflammatory responses to SARS-CoV-2 infection in mice. The study appears this week in the Journal of Virology, a publication of the American Society for Microbiology. The research is important because "NSAIDs are arguably the most commonly used anti-inflammatory medications," said principal investigator Craig B. Wilen, Assistant Professor of Laboratory Medicine and Immunology, Yale University School of Medicine. In addition to taking NSAIDs for chronic conditions such as arthritis, people take them "for shorter periods of time during infections, and [during] ...

UPTON, NY - New results from an atmospheric study over the Eastern North Atlantic reveal that tiny aerosol particles that seed the formation of clouds can form out of next to nothingness over the open ocean. This "new particle formation" occurs when sunlight reacts with molecules of trace gases in the marine boundary layer, the atmosphere within about the first kilometer above Earth's surface. The findings, published in the journal Nature Communications, will improve how aerosols and clouds are represented in models that describe Earth's climate so scientists can understand how the particles--and the processes that control them--might ...

Millions of students around the world could benefit if their educators adopted a more flexible and practical approach, say Swansea University experts. After analysing the techniques current being used in higher education, the researchers are calling for a pragmatic and evidence-based approach instead. Professor Phil Newton, director of learning and teaching at of Swansea University Medical School, said: "Higher education is how we train those who carry out important professional roles in our society. There are now more than 200 million students in HE worldwide and this number is likely to double again over the next decade. "Given the size, impact, importance and cost of ...

Researchers at the Consejo Nacional de Investigaciones Científicas y Técnicas (CONICET) in Argentina have found that, since the 1990s, up to 25% of reported bee species are no longer being reported in global records, despite a large increase in the number of records available. While this does not mean that these species are all extinct, it might indicate that these species have become rare enough that no one is observing them in nature. The findings appear January 22 in the journal One Earth. "With citizen science and the ability to share data, records are going up exponentially, but the number of species reported in these records is going down," says first ...

Although electric vehicles that reduce greenhouse gas emissions attract many drivers, the lack of confidence in charging services deters others. Building a reliable network of charging stations is difficult in part because it's challenging to aggregate data from independent station operators. But now, researchers reporting January 22 in the journal Patterns have developed an AI that can analyze user reviews of these stations, allowing it to accurately identify places where there are insufficient or out-of-service stations. "We're spending billions ...

On January 22 in Current Biology, a team of Harvard-led researchers presented the most complete genome yet assembled of one of the major Rafflesiaceae lineages, Sapria himalayana. The species is found in Southeast Asia and its mottled red and white flower is about the size of a dinner plate. (It's more famous cousin, Rafflesia arnoldii, produces blossoms nearly three feet in diameter, the largest in the world.) The genetic analysis revealed an astonishing degree of gene loss and surprising amounts of gene theft from its ancient and modern hosts. These findings bring unique perspectives into the number and kind of genes it takes to be an endoparasite (an organism that is completely dependent on its host for all nutrients), along ...

What The Study Did: In this observational study, the spread of SARS-CoV-2 infection during a period of lockdown in southwest Germany was particularly low in children ages 1 to 10 years old. Overall, this large SARS-CoV-2 prevalence study in children is instructive for how ad hoc mass testing provides the basis for rational political decision-making in a pandemic setting. Authors: Burkhard Tönshoff, M.D., of the University Children's Hospital in Heidelberg, Germany, and Klaus-Michael Debatin, M.D., of Ulm University Medical Center in Ulm, Germany, are the corresponding authors. To ...

A new international study led by astrophysicist Eric Agol from the University of Washington has measured the densities of the seven planets of the exoplanetary system TRAPPIST-1 with extreme precision, the values obtained indicating very similar compositions for all the planets. This fact makes the system even more remarkable and helps to better understand the nature of these fascinating worlds. This study has just been published in the Planetary Science Journal. The TRAPPIST-1 system is home to the largest number of planets similar in size to our Earth ever found outside our solar system. Discovered in 2016 by a research team led by Michaël Gillon, astrophysicist at the University of Liège, the system offers an insight into the immense ...

ITHACA, NY - Biologists have long wondered how complex organisms contain a variety of dramatically different types of cells with specialized functions, even though all of those cells are genetically identical. New research reveals how proteins, called "pioneer transcription factors," help turn on key genes that give cell types their unique properties and functions. These pioneer factors, it turns out, help unspool tightly wound coils of DNA so that genetic blueprints in genes can be read and proteins that play roles in biological processes can be made. The study in fruit flies, "Pioneer-like Factor GAF Cooperates with PBAP (SWI/SNF) and NURF (ISWI) to Regulate Transcription," was published Dec. 10 in the journal Genes & Development. "We know pretty ...

January 22, 2021 - Patients with substance use disorders (SUDs) being treated for serious medical conditions are more likely to leave the hospital against medical advice (AMA) than those without addiction. A special type of contract with healthcare providers might enable patients to consent in advance to life-saving medical care - even if they later refuse treatment, according to a commentary in the Journal of Addiction Medicine, the official journal of the American Society of Addiction Medicine (ASAM). The journal is published in the Lippincott portfolio by Wolters Kluwer. The Substance Use Advance Directive (SUAD) "has the potential to greatly improve the current state of treatment for life-threatening comorbid conditions in SUD patients through ...