PRESS-NEWS.org - Press Release Distribution
PRESS RELEASES DISTRIBUTION

Study finds risk factor for blood clots occurs in more than 10 percent of transgender men using testosterone

2021-02-18
(Press-News.org) WASHINGTON--A potentially dangerous side effect of testosterone therapy for transgender men is an increase in red blood cells that can raise the risk of blood clots, heart attack or stroke, according to a new study published in the Endocrine Society's Journal of Clinical Endocrinology & Metabolism.

Gender diverse people make up an estimated 0.6% of the U.S. population and are defined as having gender identity that is not aligned with their sex recorded at birth. Transgender men often undergo testosterone therapy as part of their gender-affirming treatment. Erythrocytosis, a condition where your body makes too many red blood cells, is a common side effect of testosterone therapy that can increase the risk of blood clots, heart attack or stroke.

"Erythrocytosis is common in transgender men treated with testosterone, especially in those who smoke, have high body mass index (BMI) and use testosterone injections," said lead study author Milou Cecilia Madsen, M.D., of the VU University Medical Center Amsterdam in the Netherlands. "A reasonable first step in the care of transgender men with high red blood cells while on testosterone therapy is to advise them to quit smoking, switch injectable testosterone to gel, and if BMI is high, to lose weight."

The researchers analyzed the medical and laboratory records of 1,073 transgender men using testosterone from the Amsterdam Cohort of Gender study (ACOG). Eleven percent of transgender men using testosterone showed erythrocytosis during 20 years of follow-up. However, less than one percent of these men had very high levels of red blood cells with a high risk of complications.

INFORMATION:

Other authors of the study include: Dennis van Dijk, Chantal Maria Wiepjes, Elfi Barbara Conemans, Abel Thijs and Martin den Heijer of the VU University Medical Center Amsterdam.

The manuscript received no external funding.

The manuscript, "Erythrocytosis in Trans Men Using Testosterone: A Long-Term Follow-Up Study on Prevalence and Determinants," was published online, ahead of print.

The authors will be presenting related research at ENDO 2021, the Endocrine Society's annual meeting.

Endocrinologists are at the core of solving the most pressing health problems of our time, from diabetes and obesity to infertility, bone health, and hormone-related cancers. The Endocrine Society is the world's oldest and largest organization of scientists devoted to hormone research and physicians who care for people with hormone-related conditions.

The Society has more than 18,000 members, including scientists, physicians, educators, nurses and students in 122 countries. To learn more about the Society and the field of endocrinology, visit our site at http://www.endocrine.org. Follow us on Twitter at @TheEndoSociety and @EndoMedia.



ELSE PRESS RELEASES FROM THIS DATE:

Increasingly fragmented tiger populations may require 'genetic rescue'

2021-02-18
Despite being one of the world's most charismatic species, tigers face uncertain futures primarily due to habitat fragmentation, human-wildlife conflict and poaching. As global tiger populations decline, so does their genetic diversity. But until now it's been unclear how the animals' dwindling numbers are affecting them at the genetic level. To find out, researchers at Stanford University, the National Centre for Biological Sciences, India, and various zoological parks and NGOs sequenced 65 genomes from four of the surviving tiger subspecies. Their findings confirmed that strong genetic differences exist between different tiger subspecies but showed, surprisingly, that these differences emerged relatively recently, ...

Transit-oriented development causing displacement: study

Transit-oriented development causing displacement: study
2021-02-18
Transit-oriented development--which concentrates high-density housing, commercial activities and public spaces around a rapid transit station--can both be a boon and a bane for communities, suggests a new UBC study. "Transit-oriented development (TOD) can reduce traffic congestion and air pollution, encourage active mobility, and revitalize a neighbourhood," explains study author Craig E. Jones, a PhD candidate in geography and the research coordinator for the Housing Research Collaborative at UBC's faculty of applied science. "However, it can also cause gentrification through the demolition of affordable rental housing. It can tailor the area towards condo ...

TGen-led study confirms cell-free DNA in urine as potential method for cancer detection

2021-02-18
PHOENIX, Ariz. and DUARTE, Calif. -- Feb. 17, 2021 -- Urinalysis has long been a staple of physical exams to detect and manage a number of diseases and disorders, but not cancer. What if it were that easy, though, and cancer was detected in its very earliest stages when the disease responds more favorably to treatment and improved outcomes are more likely? That was the question posed by scientists at the Translational Genomics Research Institute (TGen), an affiliate of City of Hope, who have found a way of zeroing in on early-stage cancer by analyzing short strands of cell-free DNA in urine. Their study's findings were published today in the scientific journal Science ...

Cone snail venom shows potential for treating severe malaria

Cone snail venom shows potential for treating severe malaria
2021-02-18
Severe forms of malaria such as Plasmodium falciparum may be deadly even after treatment with current parasite-killing drugs. This is due to persistent cyto-adhesion of infected erythrocytes even though existing parasites within the red blood cells are dead. As vaccines for malaria have proved less than moderately effective, and to treat these severe cases of P. falciparum malaria, new avenues are urgently needed. Latest estimates indicate that more than 500 million cases of malaria and more than 400,000 deaths are reported worldwide each year. Anti-adhesion drugs may hold the key to significantly improving survival rates. Using venom from the Conus nux, a species of sea snail, a first-of-its-kind study ...

'Classic triad' of symptoms misses positive COVID-19 cases, study finds

2021-02-18
Extending the symptoms that trigger a PCR test for COVID-19 could help detect around a third more cases of the disease. New research led by researchers at King's College London and published in the Journal of Infection suggests that restricting testing to the 'classic triad' of cough, fever and loss of smell which is required for eligibility for a PCR test through the NHS may have missed cases. Extending the list to include fatigue, sore throat, headache and diarrhoea would have detected 96% of symptomatic cases. A team of researchers at King's College London and the Coalition for Epidemic Preparedness Innovations (CEPI) analysed data from more than 122,000 UK adult users of the ZOE COVID Symptom Study app. These users reported experiencing ...

Improving stroke treatment with a modified therapeutic molecule

Improving stroke treatment with a modified therapeutic molecule
2021-02-18
A research team from the Institut national de la recherche scientifique (INRS) has improved the protective effect of a molecule against ischemic stroke, which is caused by an interruption of blood flow to the brain. The results of the study, conducted in collaboration with a Spanish team, were published in the Communications Biology of Nature Research journal. Every year in Quebec, about 20,000 people have a stroke. Also known as a "cerebral infarction", this sudden neurological deficit can lead to psychological and physical after-effects. These effects result from an increase in glutamate in the brain, which destroys neurons. "Glutamate is an essential neurotransmitter for neuronal communication, learning and memory ...

D-Wave demonstrates performance advantage in quantum simulation of exotic magnetism

2021-02-18
BURNABY, BC - (February 18, 2021) -- D-Wave Systems Inc., the leader in quantum computing systems, software, and services, today published a milestone study in collaboration with scientists at Google, demonstrating a computational performance advantage, increasing with both simulation size and problem hardness, to over 3 million times that of corresponding classical methods. Notably, this work was achieved on a practical application with real-world implications, simulating the topological phenomena behind the 2016 Nobel Prize in Physics. This performance advantage, exhibited in a complex quantum simulation of materials, is a meaningful step in the journey toward applications advantage in quantum computing. The work by scientists at D-Wave ...

New crystalline ice form

New crystalline ice form
2021-02-18
Ice is a very versatile material. In snowflakes or ice cubes, the oxygen atoms are arranged hexagonally. This ice form is called ice one (ice I). "Strictly speaking, however, these are not actually perfect crystals, but disordered systems in which the water molecules are randomly oriented in different spatial directions," explains Thomas Loerting from the Institute of Physical Chemistry at the University of Innsbruck, Austria. Including ice I, 18 crystalline forms of ice were known so far, which differ in the arrangement of their atoms. The different types of ice, known as polymorphs, form depending on pressure and temperature and have very different properties. For example, their melting points differ by several ...

Gulf war illness not caused by depleted uranium from munitions, study shows

Gulf war illness not caused by depleted uranium from munitions, study shows
2021-02-18
DALLAS - Feb. 18, 2021 - Inhalation of depleted uranium from exploding munitions did not lead to Gulf War illness (GWI) in veterans deployed in the 1991 Persian Gulf War, a new study co-authored by a leading researcher of the disease at UT Southwestern suggests. The findings, published today in Scientific Reports, help eliminate a long-suspected cause of GWI that has attracted international concern for three decades. Using high-precision multicollector mass spectrometry for the first time in such a study, END ...

(Re)Shaping cities to combat inequality

(Re)Shaping cities to combat inequality
2021-02-18
[Vienna, Feb 18, 2021] Communities worldwide are trying to address inequality. One promising approach could be to look at the design of a city, according to research with real-world data in the journal Nature Communications. An international team of scientists, including members of the Complexity Science Hub Vienna (CSH), show that urban planning directly influences the formation of social networks in a city and subsequently the socio-economic equality or inequality of its citizens. "We know how important social networks are for our social and economic outcomes," explains CSH researcher Johannes Wachs, one of the authors of the paper. Social relations provide individuals with essential access to resources, information, economic opportunities and other forms ...

LAST 30 PRESS RELEASES:

Pink skies

Monkeys are world’s best yodellers - new research

Key differences between visual- and memory-led Alzheimer’s discovered

% weight loss targets in obesity management – is this the wrong objective?

An app can change how you see yourself at work

NYC speed cameras take six months to change driver behavior, effects vary by neighborhood, new study reveals

New research shows that propaganda is on the rise in China

Even the richest Americans face shorter lifespans than their European counterparts, study finds

Novel genes linked to rare childhood diarrhea

New computer model reveals how Bronze Age Scandinavians could have crossed the sea

Novel point-of-care technology delivers accurate HIV results in minutes

Researchers reveal key brain differences to explain why Ritalin helps improve focus in some more than others

Study finds nearly five-fold increase in hospitalizations for common cause of stroke

Study reveals how alcohol abuse damages cognition

Medicinal cannabis is linked to long-term benefits in health-related quality of life

Microplastics detected in cat placentas and fetuses during early pregnancy

Ancient amphibians as big as alligators died in mass mortality event in Triassic Wyoming

Scientists uncover the first clear evidence of air sacs in the fossilized bones of alvarezsaurian dinosaurs: the "hollow bones" which help modern day birds to fly

Alcohol makes male flies sexy

TB patients globally often incur "catastrophic costs" of up to $11,329 USD, despite many countries offering free treatment, with predominant drivers of cost being hospitalization and loss of income

Study links teen girls’ screen time to sleep disruptions and depression

Scientists unveil starfish-inspired wearable tech for heart monitoring

Footprints reveal prehistoric Scottish lagoons were stomping grounds for giant Jurassic dinosaurs

AI effectively predicts dementia risk in American Indian/Alaska Native elders

First guideline on newborn screening for cystic fibrosis calls for changes in practice to improve outcomes

Existing international law can help secure peace and security in outer space, study shows

Pinning down the process of West Nile virus transmission

UTA-backed research tackles health challenges across ages

In pancreatic cancer, a race against time

Targeting FGFR2 may prevent or delay some KRAS-mutated pancreatic cancers

[Press-News.org] Study finds risk factor for blood clots occurs in more than 10 percent of transgender men using testosterone