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On the line: Watching nanoparticles get in shape

New method could advance next-generation applications in medicine, cosmetics, and petroleum recovery

( Liquid structures - liquid droplets that maintain a specific shape - are useful for a variety of applications, from food processing to cosmetics, medicine, and even petroleum extraction, but researchers have yet to tap into these exciting new materials' full potential because not much is known about how they form.

Now, a research team led by Berkeley Lab has captured real-time high-resolution videos of liquid structures taking shape as nanoparticle surfactants (NPSs) - soap-like particles just billionths of a meter in size - jam tightly together, side by side, to form a solid-like layer at the interface between oil and water.

Their findings, recently featured on the cover of Science Advances , could help researchers better optimize liquid structures to advance new biomedical applications such as reconfigurable microfluidics for drug discovery and all-liquid robotics for targeted cancer drug delivery, among others.

In experiments led by co-author Paul Ashby , a staff scientist in Berkeley Lab's Molecular Foundry and Materials Sciences Division, and Yu Chai, a former postdoctoral researcher in the Ashby group who is now an assistant professor at The City University of Hong Kong, the researchers used a special imaging technique called atomic force microscopy (AFM) to take the first-ever real-time movies of the NPSs crowding together and getting jammed at the oil-water interface, a critical step in locking a liquid into a specific shape.

The researchers' movies unveiled a portrait of the NPS interface with unprecedented detail, including the size of each NPS, whether the interface was composed of one or multiple layers, and how much time elapsed, down to the second, for each NPS to attach to and settle into the interface.

The spectacular AFM images also showed the angle at which an NPS "sits" at the interface - an unexpected result. "We were surprised by how rough the interfaces are," Ashby said. "We had always drawn illustrations of a uniform interface with nanoparticles attached at the same contact angle - but in our current study, we found there is actually a lot of variation."

Most nanoscale imaging tools can only investigate immobile samples that are either dry or frozen. Over the past couple of decades, Ashby has focused his research on developing unique AFM capabilities that allow the user to control the probe tip so it gently interacts with fast-moving samples, such as the NPSs of the current study, without touching the underlying liquid - a challenging feat.

"Imaging a liquid structure at the nanoscale, and watching the nanoparticles move around in liquid in real time using an AFM probe - that wouldn't be possible without Paul's extensive expertise," said co-author Thomas Russell , a visiting faculty scientist and professor of polymer science and engineering from the University of Massachusetts who leads the Adaptive Interfacial Assemblies Towards Structuring Liquids program in Berkeley Lab's Materials Sciences Division. "These kinds of capabilities aren't available anywhere else except at the Molecular Foundry."

The researchers next plan to study the effect of self-propelling particles in NPS liquid structures.


Ashby and Russell co-led the study. Researchers from Berkeley Lab; UC Berkeley; The City University of Hong Kong; Hong Kong Polytechnic University; Soochow University and Beijing University of Chemical Technology, China; and Tohoku University, Japan, contributed to the work.

The Molecular Foundry is a DOE Office of Science user facility at Berkeley Lab.

This work was supported by the U.S. Department of Energy Office of Science.

Founded in 1931 on the belief that the biggest scientific challenges are best addressed by teams, Lawrence Berkeley National Laboratory and its scientists have been recognized with 14 Nobel Prizes. Today, Berkeley Lab researchers develop sustainable energy and environmental solutions, create useful new materials, advance the frontiers of computing, and probe the mysteries of life, matter, and the universe. Scientists from around the world rely on the Lab's facilities for their own discovery science. Berkeley Lab is a multiprogram national laboratory, managed by the University of California for the U.S. Department of Energy's Office of Science.

DOE's Office of Science is the single largest supporter of basic research in the physical sciences in the United States, and is working to address some of the most pressing challenges of our time. For more information, please visit


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[] On the line: Watching nanoparticles get in shape
New method could advance next-generation applications in medicine, cosmetics, and petroleum recovery