PRESS-NEWS.org - Press Release Distribution
PRESS RELEASES DISTRIBUTION

Aging-US: High-CBD Cannabis sativa extracts modulate ACE2 expression in COVID-19

'The Aging-US authors developed over 800 new C. sativa cultivars and hypothesized that high-CBD C. sativa extracts may be used to down-regulate ACE2 expression in target COVID-19 tissues'

Aging-US: High-CBD Cannabis sativa extracts modulate ACE2 expression in COVID-19
2021-03-08
(Press-News.org) Aging-US published "In search of preventive strategies: novel high-CBD Cannabis sativa extracts modulate ACE2 expression in COVID-19 gateway tissues" which reported that Cannabis sativa, especially those high in the anti-inflammatory cannabinoid cannabidiol, has been found to alter gene expression and inflammation and harbour anti-cancer and anti-inflammatory properties.

Working under a Health Canada research license, the Aging-US authors developed over 800 new C. sativa cultivars and hypothesized that high-CBD C. sativa extracts may be used to down-regulate ACE2 expression in target COVID-19 tissues.

Using artificial 3D human models of oral, airway and intestinal tissues, they identified 13 high-CBD C. sativa extracts that decrease ACE2 protein levels.

Some C. sativa extracts down-regulate serine protease TMPRSS2, another critical protein required for SARS-CoV-2 entry into host cells.

While their most effective extracts require further large-scale validation, their study is important for future analyses of the effects of medical cannabis on COVID-19. The extracts of their most successful novel high-CBD C. sativa lines, pending further investigation, may become a useful and safe addition to the prevention/treatment of COVID-19 as an adjunct therapy.

Dr. Olga Kovalchuk and Dr. Igor Kovalchuk said, "There is a global pandemic of the COVID-19 disease, which is caused by the zoonotic severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2)."

Similar to other respiratory pathogens, SARS-CoV-2 is transmitted through respiratory droplets from coughing and sneezing. However, aerosol transmission and close-contact transmission cannot be ruled out as means of disease spread.

An in-depth analysis of The Cancer Genome Atlas and Functional Annotation of The Mammalian Genome Cap Analysis of Gene Expression datasets revealed that ACE2 is expressed in oral mucosa and enriched in the epithelial cells of the tongue.

High levels of ACE2 expression in oral epithelial tissues suggests that the oral cavity could be highly susceptible to SARS-CoV-2 infection and thus an important target for prevention strategies.

Similarly, numerous studies have reported high levels of ACE2 in the lower respiratory tract; higher levels of ACE2 expression, such as those seen in smokers and patients with chronic obstructive pulmonary disease, are associated with higher COVID-19 predisposition and enhanced disease severity.

Using artificial 3D human tissue models, the authors show that high-CBD C. sativa extracts may down-regulate ACE2 expression in target COVID-19 tissues, suggesting an importance of these extracts in COVID-19 prevention.

The Kovalchuk/Kovalchuk Research Team concluded in their Aging-US Research Output, "While our most efficacious extracts require further validation through large-scale analyses, our study is important for future analyses of the effects of medical cannabis on COVID-19. Given the current dire and rapidly developing epidemiological situation, every possible therapeutic opportunity needs to be considered and researched."

INFORMATION:

Sign up for free Altmetric alerts about this article

DOI - https://doi.org/10.18632/aging.202225

Full Text - https://www.aging-us.com/article/202225/text

Correspondence to: Olga Kovalchuk email: olga.kovalchuk@uleth.ca and Igor Kovalchuk email: igor.kovalchuk@uleth.ca

Keywords: COVID-19, SARS-CoV2, ACE2 receptor, medical cannabis, CBD

About Aging-US

Launched in 2009, Aging-US publishes papers of general interest and biological significance in all fields of aging research as well as topics beyond traditional gerontology, including, but not limited to, cellular and molecular biology, human age-related diseases, pathology in model organisms, cancer, signal transduction pathways (e.g., p53, sirtuins, and PI-3K/AKT/mTOR among others), and approaches to modulating these signaling pathways.

To learn more about Aging-US, please visit http://www.Aging-US.com or connect with @AgingJrnl

Aging-US is published by Impact Journals, LLC please visit http://www.ImpactJournals.com or connect with @ImpactJrnls

Media Contact
18009220957x105
MEDIA@IMPACTJOURNALS.COM


[Attachments] See images for this press release:
Aging-US: High-CBD Cannabis sativa extracts modulate ACE2 expression in COVID-19

ELSE PRESS RELEASES FROM THIS DATE:

Aging-US: DNA- and telomere-damage does not limit lifespan: evidence from rapamycin

Aging-US: DNA- and telomere-damage does not limit lifespan: evidence from rapamycin
2021-03-08
Aging-US published "DNA- and telomere-damage does not limit lifespan: evidence from rapamycin" which reported that failure of rapamycin to extend lifespan in DNA repair mutant and telomerase-knockout mice, while extending lifespan in normal mice, indicates that neither DNA damage nor telomere shortening limits normal lifespan or causes normal aging. Dr. Mikhail V. Blagosklonny said, "As a provocative title has recently announced, 'rapamycin fails to extend lifespan in DNA repair -deficient mice' [1]. The word 'fails' implies bad news. Rapamycin tried but failed. Yet, it is expected that the anti-aging ...

Cognitive fatigue changes functional connectivity in brain's fatigue network

Cognitive fatigue changes functional connectivity in brains fatigue network
2021-03-08
East Hanover, NJ. March 8, 2021. Kessler Foundation researchers have demonstrated changes in the functional connectivity within the 'fatigue network' in response to cognitive fatigue. This finding, the first of its kind, was reported in Scientific Reports on December 14, 2020 in the open access article, "Using functional connectivity changes associated with cognitive fatigue to delineate a fatigue network" (doi: 10.1038//s41598-020-78768-3). The authors are Glenn Wylie, DPhil, Brian Yao, PhD, Helen M. Genova, PhD, Michele H. Chen, PhD, and John DeLuca, PhD, of Kessler Foundation. All have faculty appointments at Rutgers New Jersey Medical School. Dr. Wylie is also a research scientist at The Department of Veterans' Affairs War-related Injury and Illness ...

Study of coronavirus variants predicts virus evolving to escape current vaccines

2021-03-08
A new study of the U.K. and South Africa variants of SARS-CoV-2 predicts that current vaccines and certain monoclonal antibodies may be less effective at neutralizing these variants and that the new variants raise the specter that reinfections could be more likely. The study was published in Nature on March 8, 2021. A preprint of the study was first posted to BioRxiv on January 26, 2021. David Ho (Credit: Columbia University Irving Medical Center) The study's predictions are now being borne out with the first reported results of the Novavax vaccine, says the study's lead author David ...

Study finds two servings of fish per week can help prevent recurrent heart disease

2021-03-08
Hamilton, ON (March 8, 2021) - An analysis of several large studies involving participants from more than 60 countries, spearheaded by researchers from McMaster University, has found that eating oily fish regularly can help prevent cardiovascular disease (CVD) in high-risk individuals, such as those who already have heart disease or stroke. The critical ingredient is omega-3 fatty acids, which researchers found was associated with a lower risk of major CVD events such as heart attacks and strokes by about a sixth in high-risk people who ate two servings of fish rich in omega-3 each week. "There is a significant protective benefit of fish consumption in people with cardiovascular disease," said lead co-author Andrew Mente, associate ...

3D printing materials for printing aorta model to study optimal CT scanning protocols

2021-03-08
Personalised 3D printed models created from cardiac imaging data, mainly from cardiac CT images have been increasingly used in cardiovascular disease, primarily in the preoperative planning and simulation of complex surgical procedures, as well as medical education. 3D printed models are proved to be highly accurate in replicating normal anatomy and cardiac pathology with reported differences less than 0.5 mm between 3D printed models and original sources images. Further to these applications, a new research direction of utilising 3D printed models is to study the optimal CT scanning protocols in cardiovascular disease with the aim of reducing radiation dose while preserving diagnostic image quality. To achieve ...

Finding key to low-cost, fast production of solid-state batteries for EVs

Finding key to low-cost, fast production of solid-state batteries for EVs
2021-03-08
A new fabrication technique could allow solid-state automotive lithium-ion batteries to adopt nonflammable ceramic electrolytes using the same production processes as in batteries made with conventional liquid electrolytes. The melt-infiltration technology developed by materials science researchers at the Georgia Institute of Technology uses electrolyte materials that can be infiltrated into porous yet densely packed, thermally stable electrodes. The one-step process produces high-density composites based on pressure-less, capillary-driven infiltration of a molten solid electrolyte into porous bodies, including multilayered electrode-separator stacks. "While the melting point of traditional ...

These sea slugs sever their own heads and regenerate brand-new bodies

2021-03-08
You've heard of animals that can lose and then regenerate a tail or limb. But scientists reporting in the journal Current Biology on March 8 have now discovered two species of sacoglossan sea slug that can do even better, shedding and then regenerating a whole new body complete with the heart and other internal organs. The researchers also suggest that the slugs may use the photosynthetic ability of chloroplasts they incorporate from the algae in their diet to survive long enough for regeneration. "We were surprised to see the head moving just after autotomy," said Sayaka Mitoh of Nara ...

Insatiable demand for cannabis has created a giant carbon footprint

Insatiable demand for cannabis has created a giant carbon footprint
2021-03-08
It's no secret that the United States' $13 billion cannabis industry is big business. Less obvious to many is the environmental toll this booming business is taking, in the form of greenhouse gas emissions from commercial, mostly indoor production. A new study by Colorado State University researchers provides the most detailed accounting to date of the industry's carbon footprint, a sum around which there is only limited understanding. What is clear, though, is that consumer demand for cannabis is insatiable and shows no signs of stopping as more states sign on to legalization. The study, ...

Economic benefits of protecting nature now outweigh those of exploiting it, global data reveal

2021-03-08
The economic benefits of conserving or restoring natural sites "outweigh" the profit potential of converting them for intensive human use, according to the largest-ever study comparing the value of protecting nature at particular locations with that of exploiting it. A research team led by the University of Cambridge and the Royal Society for the Protection of Birds (RSPB) analysed dozens of sites - from Kenya to Fiji and China to the UK - across six continents. A previous breakthrough study in 2002 only had information for five sites. The findings, published in the journal Nature Sustainability, come just weeks after a landmark report by Cambridge Professor Partha Dasgupta called for the value of biodiversity to be placed at the heart of global economics. For the latest ...

Sea level rise up to four times global average for coastal communities

2021-03-08
Coastal populations are experiencing relative sea-level rise up to four times faster than the global average - according to new research from the University of East Anglia. A new study published today in Nature Climate Change is the first to analyse global sea-level rise combined with measurements of sinking land. The impact of subsidence combined with sea-level rise has until now been considered a local issue rather than a global one. But the new study shows that coastal inhabitants are living with an average sea level rise of 7.8 mm - 9.9 mm per year over the past twenty years, compared with a global average rise of 2.6mm a year. And the impacts are far larger than the global numbers reported ...

LAST 30 PRESS RELEASES:

Are lifetimes of big appliances really shrinking?

Pink skies

Monkeys are world’s best yodellers - new research

Key differences between visual- and memory-led Alzheimer’s discovered

% weight loss targets in obesity management – is this the wrong objective?

An app can change how you see yourself at work

NYC speed cameras take six months to change driver behavior, effects vary by neighborhood, new study reveals

New research shows that propaganda is on the rise in China

Even the richest Americans face shorter lifespans than their European counterparts, study finds

Novel genes linked to rare childhood diarrhea

New computer model reveals how Bronze Age Scandinavians could have crossed the sea

Novel point-of-care technology delivers accurate HIV results in minutes

Researchers reveal key brain differences to explain why Ritalin helps improve focus in some more than others

Study finds nearly five-fold increase in hospitalizations for common cause of stroke

Study reveals how alcohol abuse damages cognition

Medicinal cannabis is linked to long-term benefits in health-related quality of life

Microplastics detected in cat placentas and fetuses during early pregnancy

Ancient amphibians as big as alligators died in mass mortality event in Triassic Wyoming

Scientists uncover the first clear evidence of air sacs in the fossilized bones of alvarezsaurian dinosaurs: the "hollow bones" which help modern day birds to fly

Alcohol makes male flies sexy

TB patients globally often incur "catastrophic costs" of up to $11,329 USD, despite many countries offering free treatment, with predominant drivers of cost being hospitalization and loss of income

Study links teen girls’ screen time to sleep disruptions and depression

Scientists unveil starfish-inspired wearable tech for heart monitoring

Footprints reveal prehistoric Scottish lagoons were stomping grounds for giant Jurassic dinosaurs

AI effectively predicts dementia risk in American Indian/Alaska Native elders

First guideline on newborn screening for cystic fibrosis calls for changes in practice to improve outcomes

Existing international law can help secure peace and security in outer space, study shows

Pinning down the process of West Nile virus transmission

UTA-backed research tackles health challenges across ages

In pancreatic cancer, a race against time

[Press-News.org] Aging-US: High-CBD Cannabis sativa extracts modulate ACE2 expression in COVID-19
'The Aging-US authors developed over 800 new C. sativa cultivars and hypothesized that high-CBD C. sativa extracts may be used to down-regulate ACE2 expression in target COVID-19 tissues'