Physical activity over the adult life course and risk of dementia in the Framingham heart study

JAMA Network Open

2025-11-19

(Press-News.org) About The Study: In this cohort study of adults in the Framingham Heart Study Offspring cohort, higher levels of midlife and late-life physical activity were associated with similar reductions in risk of all-cause and Alzheimer disease dementia. These findings may inform future efforts to delay or prevent dementia through timing interventions during the most relevant stages of the adult life course.

Corresponding Author: To contact the corresponding author, Phillip H. Hwang, PhD, MPH, email phhwang@bu.edu.

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(doi:10.1001/jamanetworkopen.2025.44439)

Editor’s Note: Please see the article for additional information, including other authors, author contributions and affiliations, conflict of interest and financial disclosures, and funding and support.

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About JAMA Network Open: JAMA Network Open is an online-only open access general medical journal from the JAMA Network. On weekdays, the journal publishes peer-reviewed clinical research and commentary in more than 40 medical and health subject areas. Every article is free online from the day of publication.

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Physical activity over the adult life course and risk of dementia in the Framingham heart study

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