PRESS-NEWS.org - Press Release Distribution
PRESS RELEASES DISTRIBUTION

SLAS Technology April issue dives into reactive oxygen species

2021-04-01
(Press-News.org) Oak Brook, IL - The April edition of SLAS Technology features the cover article "Therapeutic Potential of Reactive Oxygen Species: State of the Art and Recent Advances" by Valeria Graceffa, Ph.D. (Institute of Technology Sligo, Sligo, Ireland).

The cover article explores the therapeutic potential of reactive oxygen species (ROS) including applications ranging from wound healing and hair growth enhancement, to cancer treatment, stem cell differentiation and tissue engineering. At low concentrations, ROS can be utilized as inexpensive and convenient inducers of tissue regeneration, triggering stem cell differentiation and enhancing collagen synthesis. Recent cancer studies have represented ROS as the 'Achilles Heels' of cancers given their high basal levels, leaving tumoral cells unable to sufficiently handle the additional source of oxidative stress. Because of this, higher doses of ROS are used for targeted killing of tumor cells. Lack of understanding of the technicalities between anabolic and cytotoxic effects means limited ROS clinical translation opportunities. While there is ample potential for the use of ROS, new strategies to control temporal pattern of ROS release have yet to be developed.

The April issue of SLAS Technology includes six articles of original research including:

Highly Versatile Cloud-Based Automation Solution for the Remote Design and Execution of Experiment Protocols during the COVID-19 Pandemic Metabolomic Signatures in Pediatric Crohn's Disease Patients with Mild or Quiescent Disease Treated with Partial Enteral Nutrition: A Feasibility Study Acoustic Ejection/Full-Scan Mass Spectrometry Analysis for High-Throughput Compound Plate Quality Control An Emerging Fluorescence-Based Technique for Quantification and Protein Profiling of Extracellular Vesicles Development of an Enhanced Throughput Radial Cell Migration Device A Variable Scheduling Maintenance Culture Platform for Mammalian Cells

Other articles include:

Application of Artificial Intelligence to Address Issues Related to the COVID-19 Virus Therapeutic Potential of Reactive Oxygen Species: State of the Art and Recent Advances Recent Developments in Bacterial Chemotaxis Analysis Based on the Microfluidic System Development of a Gold Nanoparticle-Based Colorimetric Sensor for Water for Injection At-Line Impurity Testing Integrating Mobile Robots into Automated Laboratory Processes: A Suitable Workflow Management System

INFORMATION:

Access to April's SLAS Technology issue is available at https://journals.sagepub.com/toc/jlad/26/2. For more information about SLAS and its journals, visit http://www.slas.org/journals.

SLAS (Society for Laboratory Automation and Screening) is an international professional society of academic, industry and government life sciences researchers and the developers and providers of laboratory automation technology. The SLAS mission is to bring together researchers in academia, industry and government to advance life sciences discovery and technology via education, knowledge exchange and global community building.

SLAS Discovery: Advancing the Science of Drug Discovery, 2019 Impact Factor 2.195. Editor-in-Chief Robert M. Campbell, Ph.D., Twentyeight-Seven Therapeutics, Boston, MA (USA).

SLAS Technology: Translating Life Sciences Innovation, 2019 Impact Factor 2.174. Editor-in-Chief Edward Kai-Hua Chow, Ph.D., National University of Singapore (Singapore).



ELSE PRESS RELEASES FROM THIS DATE:

UTSA criminology professor studies impact of COVID-19on gender-based violence

2021-04-01
(APRIL 1, 2021) -The pandemic has exacerbated risk factors for gender-based violence, such as unemployment and financial strain, substance use, isolation, depression anxiety, and general stress, according to the American Psychological Association. That's inspired The University of Texas at San Antonio criminology and criminal justice professor Kellie Lynch, along with professor TK Logan from the University of Kentucky, to work with the National Coalition Against Domestic Violence on a national survey to investigate the impact of the COVID-19 pandemic on the dynamics of gender-based violence and the experiences of those serving victims of gender-based violence. "The consequences of the COVID-19 pandemic are far-reaching and we still have much to learn about ...

Medical studies without adequate pre-publication review could damage public trust in science

2021-04-01
The public could lose trust in science if scientific and medical researchers choose to bypass the traditional high standards of peer-reviewed medical journals in the rush to get research data released, particularly during crises such as the COVID-19 pandemic. That's the warning from three leading medical communications organizations, that have published a joint statement in the peer-reviewed journal Current Medical Research and Opinion - asserting that the integrity of published scientific and medical research must be protected. Out today, the joint statement from the American Medical ...

The Lancet GH: COVID-19 pandemic worsened pregnancy outcomes for women and babies worldwide

2021-04-01
Review of 40 published studies from 17 countries offers first global assessment of the collateral impact of the COVID-19 pandemic on pregnancy outcomes. Findings reveal overall increase in the chances of stillbirth and maternal death during the pandemic, but chances of pre-term birth decreased in high-income countries. Women requiring surgery for ectopic pregnancies increased almost six-fold during the pandemic across all studies, after accounting for the size of included studies (surgery rate for ectopic pregnancies during pandemic 27/37 vs pre-pandemic 73/272), and symptoms of maternal depression were also increased. Study reveals disproportionate impact ...

Will US public support donating COVID-19 vaccines to low- and middle-income countries?

2021-04-01
The pandemic is affecting every country, but not every country has equal access to the lifesaving COVID-19 vaccines. Recent estimates show that high-income countries -- which have just one-fifth of the global adult population -- have purchased more than half of the world's total vaccine doses, resulting in disparities for low- and middle-income countries. A new study by researchers at Virginia Commonwealth University investigates a key question: Will the U.S. population support donating part of its COVID-19 vaccine stockpile to less prosperous countries? "COVID-19 is a true global pandemic that has touched every nation ...

Houston Methodist among largest providers of monoclonal antibody treatment for COVID-19

2021-04-01
Houston Methodist has been a leader in successfully treating high-risk patients with monoclonal antibodies (mAB) for mild to moderate Covid-19 infection. Among the nation's largest providers of mAB therapy, Houston Methodist has infused nearly 4,000 patients since the FDA's Emergency Use Authorization (EUA) was issued. The hospital system was able to quickly ramp up its program once the EUA was granted by leveraging a number of resources through interdisciplinary collaboration. As more hospitals begin to ramp up for treating Covid-19 with mAB therapy, Houston Methodist's example serves as a valuable model for other medical systems to establish or expand mAB treatment programs and improve patient access to this critical therapy. A commentary outlining the challenges, ...

CU Cancer Center researcher reveals new effects of oxygen deprivation in cancer cells

CU Cancer Center researcher reveals new effects of oxygen deprivation in cancer cells
2021-03-31
A team of University of Colorado School of Medicine researchers recently published a paper offering new insight into the role that oxygen deprivation, or hypoxia, plays in cancer development. CU Cancer Center member Joaquin Espinosa, PhD, is the senior researcher on the paper, which he hopes will help lead to more targeted treatments for cancer.  For their paper published this month in the journal Nature Communications, Espinosa and the rest of the team -- Zdenek Andrysik, PhD; Heather Bender, PhD; and Matthew Galbraith, PhD -- used state-of-the-art genomics technologies to map the response of cancer cells to hypoxia with unprecedented detail, ...

Novel pharmacological strategies to treat alcoholism. Focus on epigenetics

Novel pharmacological strategies to treat alcoholism. Focus on epigenetics
2021-03-31
Abusive alcohol drinking considerably impacts human health. Alcoholism, better defined as Alcohol Use Disorders (AUD), includes a group of pathological entities related to alcohol-induced damage. Individuals with AUD exhibit compulsive alcohol drinking and negative emotional states when alcohol drinking ceases. In the most severe AUD forms, the individuals lose control over consumption despite a decided will to stop. Some controversial issues have arisen as to whether the definition of AUD can help to delimit and characterize clinical entities related to abusive alcohol ingestion. The World Health Organization (WHO) reports that approximately 3,3 million people (5,9% of global ...

COVID-19 antibody tests, even rapid finger pricks, are effective, new study finds

2021-03-31
New findings from a Michigan Medicine study reveal that antibody testing is predictive of prior COVID-19 infection, and rapid screening methods - even from finger pricks - are effective testing tools. Researchers analyzed antibody tests conducted on more than 500 subjects in patient care settings. They found that people who had COVID, including those with mild symptoms, produced antibodies. "For a long time, people were very worried that people with mild COVID did not make immune responses," says Charles Schuler, M.D., a clinical assistant professor of allergy and immunology at Michigan Medicine. "This should give people confidence that the tests that are available to them aren't just random number generators. They're actually giving them ...

Soft "sweat stickers" may streamline diagnosis of cystic fibrosis in children

2021-03-31
New "sweat stickers" may streamline the early diagnosis of cystic fibrosis by enabling scientists to easily gather and analyze sweat from the skin of infants and children. The stickers matched the performance of previous, more cumbersome devices when tested with 51 subjects, suggesting the stickers could address design obstacles that have held back the diagnosis and treatment of cystic fibrosis in pediatric patients. Diagnosing cystic fibrosis in infancy or childhood is critical to achieve good outcomes, as current treatments must be given early to extend lifespans and alter the course of the disease. Many current diagnostics work by detecting levels of chloride in sweat, which are elevated in cystic fibrosis patients. However, these tests must often be repeated and use unwieldy wrist-wrapped ...

Mothers bear the cost of the pandemic shift to remote work

2021-03-31
For many parents, the COVID-19 pandemic has made life's everyday juggling act--managing work, school, extracurricular, and household responsibilities--much, much harder. And according to a new study led by Penn sociologists, those extra burdens have fallen disproportionately on mothers. The research, shared in the April issue of the journal Gender and Society, investigated how shifts in work and school that arose due to the pandemic triggered changes in the division of labor in families. Using data on two-parent households from a nationwide survey conducted in April 2020, the researchers found that ...

LAST 30 PRESS RELEASES:

Innovative risk score accurately calculates which kidney transplant candidates are also at risk for heart attack or stroke, new study finds

Kidney outcomes in transthyretin amyloid cardiomyopathy

Partial cardiac denervation to prevent postoperative atrial fibrillation after coronary artery bypass grafting

Finerenone in women and men with heart failure with mildly reduced or preserved ejection fraction

Finerenone, serum potassium, and clinical outcomes in heart failure with mildly reduced or preserved ejection fraction

Hormone therapy reshapes the skeleton in transgender individuals who previously blocked puberty

Evaluating performance and agreement of coronary heart disease polygenic risk scores

Heart failure in zero gravity— external constraint and cardiac hemodynamics

Amid record year for dengue infections, new study finds climate change responsible for 19% of today’s rising dengue burden

New study finds air pollution increases inflammation primarily in patients with heart disease

AI finds undiagnosed liver disease in early stages

The American Society of Tropical Medicine and Hygiene and the Bill & Melinda Gates Foundation announce new research fellowship in malaria genomics in honor of professor Dominic Kwiatkowski

Excessive screen time linked to early puberty and accelerated bone growth

First nationwide study discovers link between delayed puberty in boys and increased hospital visits

Traditional Mayan practices have long promoted unique levels of family harmony. But what effect is globalization having?

New microfluidic device reveals how the shape of a tumour can predict a cancer’s aggressiveness

Speech Accessibility Project partners with The Matthew Foundation, Massachusetts Down Syndrome Congress

Mass General Brigham researchers find too much sitting hurts the heart

New study shows how salmonella tricks gut defenses to cause infection

Study challenges assumptions about how tuberculosis bacteria grow

NASA Goddard Lidar team receives Center Innovation Award for Advancements

Can AI improve plant-based meats?

How microbes create the most toxic form of mercury

‘Walk this Way’: FSU researchers’ model explains how ants create trails to multiple food sources

A new CNIC study describes a mechanism whereby cells respond to mechanical signals from their surroundings

Study uncovers earliest evidence of humans using fire to shape the landscape of Tasmania

Researchers uncover Achilles heel of antibiotic-resistant bacteria

Scientists uncover earliest evidence of fire use to manage Tasmanian landscape

Interpreting population mean treatment effects in the Kansas City Cardiomyopathy Questionnaire

Targeting carbohydrate metabolism in colorectal cancer: Synergy of therapies

[Press-News.org] SLAS Technology April issue dives into reactive oxygen species