PRESS-NEWS.org - Press Release Distribution
PRESS RELEASES DISTRIBUTION

CRISPR/Cas-based diagnostics and gene therapy

2021-04-26
(Press-News.org) Announcing a new article publication for BIO Integration journal. In this mini review article the authors Meiyu Qiu and Pei Li from Korea Advanced Institute of Science and Technology (KAIST), Daejeon, Republic of Korea summarize CRISPR/Cas-based Diagnostics and Gene Therapy. Clustered regularly interspaced short palindromic repeats (CRISPR) technology, an easy, rapid, cost-effective, and precise gene-editing technique, has revolutionized diagnostics and gene therapy. Fast and accurate diagnosis of diseases is essential for point-of-care-testing (POCT) and specialized medical institutes. The CRISPR-associated (Cas) proteins system shed light on the new diagnostics methods at point-of-care (POC) owning to its advantages. In addition, CRISPR/Cas-based gene-editing technology has led to various breakthroughs in gene therapy. It has been employed in clinical trials for a variety of untreatable diseases, including cancer, blood disorders, and other syndromes. Currently, the clinical application of CRISPR/Cas has been mainly focused on ex vivo therapies. Recently, tremendous efforts have been made in the development of ex vivo gene therapy based on CRISPR-Cas9. Despite these efforts, in vivo CRISPR/Cas gene therapy is only in its initial stage. In this review authors discuss milestones in CRISPR/Cas technologies that advance the field of diagnostics and gene therapy. Recent advances of diagnostics and gene therapy based on CRISPR/Cas technology are highlighted and the strength and significant challenges of the CRISPR/Cas technology for its future clinical usage in diagnosis and gene therapy are discussed.

Article reference: Meiyu Qiu and Pei Li, CRISPR/Cas-based Diagnostics and Gene Therapy. BIO Integration, 2021, https://doi.org/10.15212/bioi-2020-0048

BIO Integration is fully open access journal which will allow for the rapid dissemination of multidisciplinary views driving the progress of modern medicine.

As part of its mandate to help bring interesting work and knowledge from around the world to a wider audience, BIOI will actively support authors through open access publishing and through waiving author fees in its first years. Also, publication support for authors whose first language is not English will be offered in areas such as manuscript development, English language editing and artwork assistance.

INFORMATION:

BIOI is now open for submissions; articles can be submitted online at: https://mc04.manuscriptcentral.com/bioi

Please visit http://www.bio-integration.org to learn more about the journal. Editorial Board: https://bio-integration.org/editorial-board/

Please visit http://www.bio-integration.org to learn more about the journal. Editorial Board: https://bio-integration.org/editorial-board/

BIOI is available on the IngentaConnect platform (https://www.ingentaconnect.com/content/cscript/bioi) and at the BIO Integration website (http://www.bio-integration.org).

Submissions may be made using ScholarOne (https://mc04.manuscriptcentral.com/bioi). There are no author submission or article processing fees.

Follow BIOI on Twitter @JournalBio; Facebook (https://www.facebook.com/BIO-Integration-Journal-108140854107716/) and LinkedIn (https://www.linkedin.com/company/bio-integration-journal/).

ISSN 2712-0074 eISSN 2712-0082

Keywords: Clinical trials, CRISPR/Cas, diagnostics, gene therapy, point-of-care-testing. END



ELSE PRESS RELEASES FROM THIS DATE:

Can a newborn's brain discriminate speech sounds?

Can a newborns brain discriminate speech sounds?
2021-04-26
People's ability to perceive speech sounds has been deeply studied, specially during someone's first year of life, but what happens during the first hours after birth? Are babies born with innate abilities to perceive speech sounds, or do neural encoding processes need to age for some time? Researchers from the Institute of Neurosciences of the University of Barcelona (UBNeuro) and the Sant Joan de Déu Research Institute (IRSJD) have created a new methodology to try to answer this basic question on human development. The results, published in the Nature's open-access journal Scientific Reports, ...

Star light, star bright...as explained by math

Star light, star bright...as explained by math
2021-04-26
Not all stars shine brightly all the time. Some have a brightness that changes rhythmically due to cyclical phenomena like passing planets or the tug of other stars. Others show a slow change in this periodicity over time that can be difficult to discern or capture mathematically. KAUST's Soumya Das and Marc Genton have now developed a method to bring this evolving periodicity within the framework of mathematically "cyclostationary" processes. "It can be difficult to explain the variations of the brightness of variable stars unless they follow a regular pattern over time," says Das. "In this study we created methods that can explain the evolution of the brightness of a variable star, even if it ...

Toxic fluorocarbons - Not just in ski waxes

2021-04-26
Per- and polyfluoroalkyl substances (PFAS) in ski wax have been receiving a lot of attention recently, but waxes constitute only a limited part of the problem of the PFAS group of toxicants. PFAS are a large group of man-made fluorocarbon toxicants, and you are most likely full of them. The toxic substances don't break down and instead accumulate, both in nature and in your body. "Due to their extensive use, humans and animals all over the world are continuously exposed to PFAS," says Håkon Austad Langberg, a PhD candidate at the Norwegian University of Science and Technology (NTNU) who has studied several of them in the last few years. PFAS are used in many different products beyond the fluorinated ski wax that ends up in the ground on ski slopes and on trails, ...

Six factors that determine success when working from home

2021-04-26
The corona pandemic has made us all focus on new ways of organizing our work. More and more companies and organizations around the world are considering how to meet their employees' demand for flexibility while at the same time reducing their office space and expensive rents. There are advantages and disadvantages to working from home, and many factors that affect the peoples' experience of it, such as their job function, age and seniority, whether they have children, whether they are a manager or employee, etc. Researchers from DTU Management have identified six main areas that company managers should focus on when developing strategies for remote work in future. Associate Professor at DTU Management Christine ...

Common inflammatory bowel disease treatment blunts COVID-19 vaccine response

2021-04-26
People who take a commonly-prescribed drug for inflammatory bowel disease (IBD) should not assume they are protected after a first dose of COVID-19 vaccine, after a large-scale study found many had poor antibody responses. The research measured antibody responses after vaccination with the Pfizer/BioNTech or the Oxford/AstraZeneca COVID-19 vaccine in 865 people treated with infliximab, an anti-tumour necrosis factor (anti-TNF) biologic drug, prescribed to around two million people worldwide. Anti-TNF drugs are effective treatments for immune-mediated inflammatory ...

When Chauvet Cave artists created its artwork, the Pont d'Arc was already there

When Chauvet Cave artists created its artwork, the Pont dArc was already there
2021-04-26
The Chauvet Cave, which lies by the entrance to the Gorges of the Ardèche, is home to the world's oldest cave paintings, dating back 36,000 years. Their state of preservation and aesthetic qualities earned them a spot on the World Heritage List in 2014, 20 years after their discovery. The location of the cavern--surrounded by a remarkable landscape, next to the Pont d'Arc natural archway--raises the question of whether the people who executed these artworks looked and walked out upon the same landscape as today. Did they see the same natural archway? Scientists from the CNRS, Université Savoie Mont Blanc, and the Muséum National d'Histoire Naturelle1 ...

Freeze! New model to help protect ships from ice accretion

2021-04-26
Researchers from Skoltech (Russia) and their colleagues from SINTEF (Norway) have developed a mathematical model of freezing water droplets moving in cold air. This model is a part of a joint RFBR-supported Russian-Norway research project. The project is focused on predicting ice accretion on ships and other offshore structures operated in Arctic climate, which may interfere with their proper functioning and endanger crew members and cargo. The paper was published in the journal Energies. Ships travel in cold northern waters under constant bombardment by tiny water droplets populating the chilly air. ...

Sounds familiar: A speaker identity-controllable framework for machine speech translation

Sounds familiar: A speaker identity-controllable framework for machine speech translation
2021-04-26
Ishikawa, Japan - Robots today have come a long way from their early inception as insentient beings meant primarily for mechanical assistance to humans. Today, they can assist us intellectually and even emotionally, getting ever better at mimicking conscious humans. An integral part of this ability is the use of speech to communicate with the user (smart assistants such as Google Home and Amazon Echo are notable examples). Despite these remarkable developments, they still do not sound very "human". This is where voice conversion (VC) comes in. A technology used to ...

How COVID-19 impacted UK healthcare

2021-04-26
Just one third of people in the UK managed to access the hospital care they needed at the peak of the first wave of the Covid-19 pandemic - according to new research from the University of East Anglia. A new study published today looks at the extent to which people managed to access NHS healthcare in April 2020, and as lockdown restrictions eased. The researchers found that, despite high levels of unmet need, there was equal access to NHS hospital care for people at different levels of income. And the NHS principle of equal treatment for equal need was upheld. However, people on higher incomes had better access to GP consultations, prescriptions and medical helplines at ...

Smell training, not steroids, best treatment for COVID-19 smell loss

2021-04-26
Steroids should not be used to treat smell loss caused by Covid-19 according to an international group of smell experts, including Prof Carl Philpott from the University of East Anglia. Smell loss is a prominent symptom of Covid-19, and the pandemic is leaving many people with long-term smell loss. But a new study published today shows that corticosteroids - a class of drug that lowers inflammation in the body - are not recommended to treat smell loss due to Covid-19. Instead, the team recommend 'smell training' - a process that involves sniffing at least four different odours twice a day for several months. Smell loss expert Prof Carl Philpott from UEA's Norwich Medical School, said: "The huge rise in smell loss caused by Covid-19 has created an unprecedented worldwide demand for ...

LAST 30 PRESS RELEASES:

CRF and the Jon DeHaan Foundation to launch TCT AI Lab at TCT 2025

Canada’s fastest academic supercomputer is now online at SFU after $80m upgrades

Architecture’s past holds the key to sustainable future

Laser correction for short-sightedness is safe and effective for older teenagers

About one in five people taking Ozempic, Wegovy or Mounjaro say food tastes saltier or sweeter than before

Taking semaglutide turns down food noise, research suggests

Type 2 diabetes may double risk of sepsis, large community-based study suggests

New quantum sensors can withstand extreme pressure

Tirzepatide more cost-effective than semaglutide in patients with knee osteoarthritis and obesity

GLP-1 drugs shown cost-effective for knee osteoarthritis and obesity

Interactive apps, AI chatbots promote playfulness, reduce privacy concerns

How NIL boosts college football’s competitive balance

Moffitt researchers develop machine learning model to predict urgent care visits for lung cancer patients

Construction secrets of honeybees: Study reveals how bees build hives in tricky spots

Wheat disease losses total $2.9 billion across the United States and Canada between 2018 and 2021

New funding fuels development of first potentially regenerative treatment for multiple sclerosis

NJIT student–faculty team wins best presentation award for ant swarm simulation

Ants defend plants from herbivores but can hinder pollination

When the wireless data runs dry

Inquiry into the history of science shows an early “inherence” bias

Picky eaters endure: Ecologists use DNA to explore diet breadth of wild herbivores

Study suggests most Americans would be healthier without daylight saving time

Increasing the level of the protein PI31 demonstrates neuroprotective effects in mice

Multi-energy X-ray curved surface imaging-with multi-layer in-situ grown scintillators

Metasurface enables compact and high-sensitivity atomic magnetometer

PFAS presence confirmed in the blood of children in Gipuzkoa

Why do people believe lies?

SwRI installs private 5G network for research, development, testing and evaluation

A new perspective in bone metabolism: Targeting the lysosome–iron–mitochondria axis for osteoclast regulation

Few military spouses use formal support services during, after deployment

[Press-News.org] CRISPR/Cas-based diagnostics and gene therapy