Monoclonal antibody therapy for COVID-19 safe, effective for transplant patients
(Press-News.org) ROCHESTER, Minn. -- Treating transplant patients with mild to moderate cases of COVID-19 with monoclonal antibodies is safe and helps prevent serious illness, according to a Mayo Clinic study recently published in Open Forum Infectious Diseases. These results are especially important because transplant patients who are infected with COVID-19 have a higher risk of severe illness and death.
"Monoclonal antibody therapy is really important for the transplant population because they are less likely to develop their own immunity. Providing them with these antibodies helps them recover from COVID-19," says Raymund Razonable, M.D., a Mayo Clinic infectious diseases specialist and the study's senior author.
The retrospective study focused on the first 73 solid organ transplant patients who received monoclonal antibody infusions for treatment of mild to moderate COVID-19 between Nov. 19, 2020, and Jan. 23 at Mayo Clinic. Eleven patients had an emergency department visit and nine patients were hospitalized. Most significantly, no patients required mechanical ventilation, died or experienced organ rejection.
"While we expected monoclonal antibody therapy would be beneficial for patients, we were pleasantly surprised by the results. Only one patient required care in the ICU for non-COVID-19 indication, and, most importantly, there were no deaths," Dr. Razonable says.
Monoclonal antibodies help prevent the virus that causes COVID-19 from attaching to human cells, which helps block the spread of infection. In fall 2020, the Food and Drug Administration authorized the emergency use of bamlanivimab and casirivimab-imdevimab to treat mild to moderate COVID-19 in patients with a high risk of becoming seriously ill. But since the safety and efficacy of these therapies for transplant patients remained unknown due to the limited clinical data, many health care institutions initially hesitated to set up infusion centers, Dr. Razonable says.
The study's results highlight the important role monoclonal antibodies can play in treating transplant patients with mild to moderate COVID-19. Knowing how best to treat these patients remains crucial given that recent studies indicate that COVID-19 vaccines are not as effective for transplant patients.
"It is important that these patients have early access to monoclonal antibody treatment," Dr. Razonable says. "Our data show the outcomes for patients are better if they get infused earlier." The study's lead author is Zachary Yetmar, M.D., Mayo Clinic. Other co-authors are Elena Beam, M.D.; Jack O'Horo, M.D.; Ravindra Ganesh, M.B.B.S., M.D.; Dennis Bierle, M.D.; Lisa Brumble, M.D.; and Teresa Seville, M.D. ? all of Mayo Clinic.
About Mayo Clinic
Mayo Clinic is a nonprofit organization committed to innovation in clinical practice, education and research, and providing compassion, expertise and answers to everyone who needs healing. Visit the Mayo Clinic News Network for additional Mayo Clinic news. For information on COVID-19, including Mayo Clinic's Coronavirus Map tracking tool, which has 14-day forecasting on COVID-19 trends, visit the Mayo Clinic COVID-19 Resource Center.
Heather Carlson Kehren, Mayo Clinic Public Affairs, email@example.com
ELSE PRESS RELEASES FROM THIS DATE:
When herring are filleted, more than half their weight becomes a low-value 'side stream' that never reaches our plates - despite being rich in protein and healthy omega-3 fatty acids. Now, scientists from Chalmers University of Technology, Sweden, have developed a special dipping solution, with ingredients including rosemary extract and citric acid, which can significantly extend the side streams' shelf life, and increase the opportunities to use them as food.
Techniques for upgrading these side-streams to food products such as minces, protein isolates, hydrolysates and oils are already available today, and offer the chance to reduce the current practices of using them for animal feed, ...
For over a century, researchers have known about "the bends", a serious condition affecting scuba divers. However, we still know relatively little about its physiological basis. Doctors do not yet have a definitive test for the bends, instead relying on symptoms to diagnose it. A new study in Frontiers in Physiology is the first to investigate genetic changes in divers with this condition, finding that genes involved in inflammation and white blood cell activity are upregulated. The findings cast light on the processes underlying the bends, and may lead to biomarkers that will help doctors to diagnose the condition more precisely.
The bends, more formally known as decompression sickness, is a potentially lethal condition that can affect divers. Symptoms ...
BOSTON -- Obesity increases one's risk for many diseases and often prevents patients from receiving other necessary medical procedures. One of the most effective ways for patients with severe obesity to lose weight is through bariatric surgery, but it's not clear how often this option is raised. In a new study published in Obesity, investigators from Brigham and Women's Hospital find that eligible patients who discuss bariatric surgery options with their primary care providers or specialists from disciplines ranging from cardiology to urology are more likely to undergo surgery and lose more weight than ...
Previous studies have shown that children with attention difficulties and/or ADHD solve cognitive tasks better when they are exposed to auditory white noise. However, this is the first time that such a link has been demonstrated between visual white noise and cognitive abilities such as memory, reading and non-word decoding in children with reading and writing difficulties.
"The white noise to which we exposed the children, also called visual pixel noise, can be compared with giving children glasses. The effect on reading and memory was immediate," explains Göran Söderlund, Senior Lecturer in Education at the University of Gothenburg and Professor of Special Education at the Western Norway University ...
People who are more prone to boredom and who are socially conservative are more likely to break public-health rules, according to new psychology research.
While previous research demonstrated a connection between being highly prone to boredom and breaking social-distancing rules, this study demonstrated the association was more prominent as participants' social conservatism increased.
"Many public-health measures such as wearing a mask or getting a vaccine have become highly politicized," said James Danckert, professor of psychology at the University of Waterloo. "People who find these ...
PITTSBURGH, June 10, 2021 - Americans are consuming more craft beer with higher alcohol content but are drinking less beer by volume, according to a new analysis led by epidemiologists at the University of Pittsburgh Graduate School of Public Health.
The study, published online and in a coming issue of the journal Substance Use & Misuse, looked at beer purchased in stores between 2004 and 2014. This is the first study to examine trends not only in the volume of beer purchased, but also the "beer specific" alcohol content.
"With the rise in popularity of craft breweries and the acquisition of such breweries by large-scale ...
India's national government has inappropriately prioritised people for covid-19 vaccination
Current approach is causing huge numbers of avertable deaths, warn experts
India's national government has inappropriately prioritised people for covid-19 vaccination, argue doctors and researchers in The BMJ today.
Peter Lloyd-Sherlock and colleagues warn that the government's current approach to vaccination - focusing on younger age groups - "is causing huge numbers of avertable deaths and is deeply inequitable."
From 3 May to 5 June 2021, more first doses were administered to people under 45 than over 60, even though at ...
HOUSTON -- Results from the multi-cohort Phase I/II ARROW clinical trial, conducted by The University of Texas MD Anderson Cancer Center researchers, showed that a once-daily dose of pralsetinib, a highly selective RET inhibitor, was safe and effective in treating patients with advanced RET fusion-positive non-small cell lung cancer (NSCLC) and RET-altered thyroid cancer. The findings for each cohort were published today in The Lancet Oncology and The Lancet Diabetes & Endocrinology, respectively.
"Targeted therapies have dramatically improved care for patients with NSCLC and thyroid cancer driven by oncogenes, and the rapid clinical translation of selective RET inhibitor ...
The moons of planets that have no parent star can possess an atmosphere and retain liquid water. Astrophysicists at LMU have calculated that such systems could harbor sufficient water to make life possible - and sustain it.
Water - in liquid form - is the elixir of life. It made life possible on Earth and is indispensable for the continuing existence of living systems on the planet. This explains why scientists are constantly on the lookout for evidence of water on other solid bodies in the Universe. Up to now, however, the existence of liquid water on planets other than Earth has not been directly proven. However, ...
The increased use of ridesharing apps was linked to a decrease in motor vehicle collisions and impaired driving convictions in Houston, according to published research by The University of Texas Health Science Center at Houston (UTHealth).
The findings were published today in JAMA Surgery.
Christopher Conner, MD, PhD, neurosurgery resident in the Vivian L. Smith Department of Neurosurgery at McGovern Medical School at UTHealth and the study's lead author, said the research is timely as more individuals are utilizing ridesharing apps.
"Automobile accidents are the leading cause of death and disability among young people, so anything we can do to reduce those incidents ...
LAST 30 PRESS RELEASES:
[Press-News.org] Monoclonal antibody therapy for COVID-19 safe, effective for transplant patients